Articles tagged with Skin Cells
Researchers investigated molecular mechanisms behind squamous cell carcinoma, revealing NUP62's role in regulating ΔNp63α nuclear transport. This mechanism is crucial for maintaining SCC cells' undifferentiated status and proliferation.
Researchers found that local stress induced by crowding leads to differentiation, triggering the movement of stem cells upwards in the tissue. This mechanism helps maintain balanced numbers of stem and differentiated cells, ensuring proper skin function.
A recent study by Case Western Reserve University School of Medicine identified specific lncRNAs that modulate connective tissue proteins like collagen in skin cells. The researchers found that these long non-coding RNAs work with the Wnt/β-catenin pathway to control gene expression, suggesting a new form of genetic control.
Scientists at the University of Edinburgh have identified two molecules, SMAD2 and SMAD3, that enhance cellular reprogramming efficiency. This breakthrough could accelerate production of induced pluripotent stem cells for studying diseases like multiple sclerosis and Parkinson's disease.
The study found that the EGF receptor is crucial for tight junction barrier formation in the epidermis, a process previously understood to be limited to lower layers of the skin. Mechanobiology also plays a role, with cells sensing pressure and tension through connections between each other.
The study identifies a protein called IL-36 as a key player in inducing skin inflammation in response to bacteria on the skin surface. This finding has significant implications for developing alternative treatments for atopic dermatitis, a condition affecting 20% of children and 5% of adults.
Researchers develop algorithm to transform healthy and diseased cells into desired cell types, leveraging gene expression and transcription factor data. The approach aims to regenerate tissue and fight cancer, offering a shortcut to traditional cell transformation techniques.
A study published in ACS Nano describes the real-time visualization of liposomes escaping from blood vessels into surrounding skin cells in living mice. Researchers found that liposomes can invade skin cells within five minutes of injection and remain there for up to seven days.
Melanocyte stem cells can become cancerous when accumulating sufficient genetic mutations, which are activated by UV radiation from the sun. Researchers at Cornell University discovered a key gene, Hgma2, that facilitates melanoma development.
Research reveals that wounds heal more than twice as fast in skin with prior inflammatory experience, thanks to sensitized stem cells. These cells remain active long after the initial inflammation has subsided and are better equipped to migrate into the wound.
A study by Brigham and Women's Hospital researchers identifies a population of tissue resident memory cells that may be driving recurrence in psoriasis. These cells, which live long-term in the skin, can cause misguided immune responses leading to red, inflamed patches on the skin.
New research reveals sepsis disrupts immune system function by impairing TRM recruitment to infected skin, increasing risk of life-threatening secondary infections. In mice, sepsis stymied TRM's ability to recruit bystander T and B cells to fight infection.
Researchers found that calorie-restricted mice develop thicker, longer fur coats and increased blood vessels to insulate against cold temperatures. This adaptation helps them conserve energy and survive in limited food conditions.
Researchers at WashU Medicine convert skin cells from healthy adults into motor neurons, retaining their age and potential for studying neurodegenerative diseases. The technique eliminates ethical concerns and allows for the study of human motor neurons in the lab.
University of Toronto researchers successfully transplanted healthy pancreatic cells under the skin to produce insulin, restoring normal blood sugar levels in a short period. The study's findings suggest that this method could provide a more manageable and efficient way to treat type 1 diabetes.
A USC-led study published in PNAS has revealed a molecular 'how to' guide for driving individual skin cells to self-organize into organoids that can produce hair. The researchers successfully stimulated adult organoids to continue their development and produce 40% more hair than newborn organoids.
Researchers at the University of Bergen have successfully transformed skin puncture cells from diabetes patients into insulin-producing cells. The goal is to transplant these cells under the skin, potentially replacing insulin shots and blood sugar measurements.
Researchers developed Tissue Nanotransfection (TNT) technology to generate any cell type for treatment within the patient's own body. The technology can repair injured tissue and restore organ function in aging tissues, including organs, blood vessels, and nerve cells.
Researchers at the University of Chicago have developed a novel gene therapy approach that uses skin transplants to treat type-2 diabetes and obesity. The method uses CRISPR technology to deliver a hormone that stimulates insulin production, reducing blood glucose levels and promoting weight loss.
Engineered skin grafts from stem cells can regulate blood glucose levels and reverse insulin resistance in diabetic mice. The approach, using CRISPR gene editing, has shown promise for potential long-term treatment of human patients with diabetes.
Healthy skin cells have been found to actively correct tissue flaws created by cancerous cells, eliminating tumors in mouse models. The study highlights the importance of normal cells in maintaining tissue health and functionality.
Researchers have isolated new treatment options for Hidradenitis suppurativa by identifying key inflammatory cells in the skin. Targeting the Th17 pathway with existing medications may provide effective treatments, building on success in treating psoriasis.
The study reveals that even spacing of cell clumps is set by the gentle tug of war among cells as an organism grows, triggering genes that produce follicles and feathers. This discovery could lead to creating artificial skin with hair follicles and sweat pores for grafts.
Researchers at Johns Hopkins University developed a system that considers cellular and molecular factors to determine functional age of cells. The results show that biophysical qualities of cells, such as movement and structural features, are better measures of functional age than other factors.
Researchers reconstructed green turtle skin in a lab to study tumor diseases and grow a virus called ChHV5. This breakthrough helps understand fibropapillomatosis, a deadly tumor disease affecting endangered turtles worldwide.
Researchers have developed a new skin cell model to study the genetic mutation ACTA2-R258C, which is linked to early-onset aortic aneurysm and moyamoya-like cerebrovascular disease. The study found that the mutation disrupts cytoskeleton functions, leading to impaired smooth muscle contraction and increased risk of heart disease.
Researchers at Nagoya University identified a mosaic skin disease caused by sperm cell transmission of keratin mutation. The mutation was found to be identical in the affected daughter and her father, confirming germline transmission. Genetic counseling is crucial for predicting disease risk in future children.
Researchers found that cells under frog skin contribute to regeneration after injury. This discovery could lead to understanding human skin repair mechanisms and developing treatments for scar-free healing.
Researchers develop a class of small molecules that penetrate and darken human skin samples in the laboratory. The drug generates protective tans in red-haired mice, which are more susceptible to skin cancer via UV radiation.
Researchers developed a stem cell-based therapy to generate skin grafts for myelomeningocele defects before birth. The treatment successfully covered large defects and protected the spinal cord, but had some drawbacks, including decreased birth weight and body length.
Researchers discovered that cane toads increase active re-uptake of salts and transport proteins to maintain internal salt levels when shedding their skin. This adaptation helps them regulate water and salt balances, which is crucial for their survival.
Researchers found that methylene blue slowed signs of aging in human skin cells, improving cellular health and reducing damage from reactive oxygen species. The antioxidant also increased cell division rates and reduced senescence markers in older donors.
Researchers at UCSF have discovered that regulatory T cells trigger stem cells to promote healthy hair growth. The study suggests that defects in Tregs could be responsible for alopecia areata and potentially play a role in other forms of baldness.
A team of researchers identified the CD103 molecule as crucial for the long-term residence and potent anti-tumor response of T cells in the skin. This finding supplements a previous discovery that T cells residing in the skin are responsible for a strong protective response against melanoma.
The Estée Lauder Companies Research & Development presents new findings in anti-aging skin and hair research, including the effects of pollen exposure and photo-aging. The studies aim to understand environmental and biological processes driving skin and hair aging.
Researchers at Université de Genève discovered that a lizard's skin color pattern forms a cellular automaton, a natural process generated by biological evolution, using a computational system invented by John von Neumann. Computer simulations implemented the discretisation of Turing's equations, which linked the biology-driven mechanis...
Scientists have identified a molecular switch that converts skin cells into cells making up blood vessels, which could be used to repair damaged vessels in patients with heart disease. The technique boosts levels of an enzyme that keeps cells young and may circumvent the usual aging that cells undergo during culturing.
A study by Stanford researchers identifies a near-global repressor protein, Myt1l, that works to block many cell fates but one. This discovery suggests the possibility of a network of master regulators specific to each cell type.
Researchers discovered that clusters of specialized skin cells migrate over reforming bones and escort bone cells into the right positions to form a branched skeletal network. The process is driven by Sonic hedgehog protein, which interacts with bone-building cells to promote bone patterning.
A new study describes the key mechanism in the brain that allows animals to recognize and react to subtle sensory signals. In a mouse model, detecting a faint screech or a tiny black speck can signal the presence of a hawk, highlighting the importance of multisensory integration.
A new biomechanical eye model mimics mechanical stress on peri-orbital skin, showing how aged cells don't respond well to blinking movement. The study highlights the impact of cyclic mechanical stress on collagen production, energy, and cellular proliferation.
Researchers found that stem cells collected directly from human fat (ASCs) can make more proteins, replicating and maintaining their stability. This discovery holds promise for new therapies against aging-related diseases, with the goal of understanding how ASCs maintain an open chromatin profile with aging.
Researchers at Rockefeller University found that peroxisome positioning plays a crucial role in controlling the balance between stem cell renewal and differentiation. Disrupted peroxisome distribution led to slower cell division, reduced skin cell differentiation, and tissue formation issues in mouse embryos.
Researchers at NHGRI found that iPSCs have the same mutation rate as subcloned cells, providing evidence of their stability and safety. This breakthrough enables further research and potential therapy development using patient-specific iPSCs.
UNC-Chapel Hill researchers have made a breakthrough in treating glioblastoma by using human stem cells to hunt down and kill brain cancer. The new approach shows promise for clinical trials within the next one to two years.
Researchers have created a human stem-cell based system to find drugs for mitochondrial disease. They extracted skin cells from patients with faulty mitochondria and used them to identify a promising potential drug called avanafil. This breakthrough gives the potential for truly personalized treatments for rare diseases.
Researchers have identified a key mechanism behind the aggressive progression of skin infections caused by Community-Associated MRSA strains. The discovery suggests that modifying the bacterial cell envelope could help prevent such infections.
Researchers at Universidad Carlos III de Madrid develop innovative 3D bioprinting technology to produce living human skin, which can be used for transplantation and product testing. The breakthrough technology replicates natural skin structure and uses human cells, eliminating animal-derived collagen.
Researchers found that small solar cells under the skin can generate enough power to fully charge pacemakers or extend their lifespan. This technology has the potential to reduce device replacements and size, saving patients discomfort and stress.
Researchers identified mesenchymal-derived BMPs as a crucial mechanism in determining sweat gland versus hairy cell fates. The study found increased expression of BMP and FGF genes at week 17 in human scalp skin, coinciding with the shift from hair to sweat-bud formation.
Researchers developed a method for generating Leydig cells by directly converting adult skin cells into functional testosterone-producing cells. The approach successfully restored normal testosterone levels in male rodents with hypogonadism, offering a promising alternative to existing therapies.
Researchers used partial cellular reprogramming to reduce signs of aging and extend lifespan in mice with premature aging mutations. The approach altered epigenetic changes, suggesting that aging is a plastic process.
Researchers at the University of Wisconsin-Madison have developed a novel approach to reprogram cells from one type to another using artificial transcription factors. This method enables efficient and unbiased conversion of cells, paving the way for faster research and potential therapeutic applications.
A new study shows that a combination of two topical drugs triggers a robust immune response against precancerous skin lesions, reducing their number by up to 88%. The therapy activates T cells to attack abnormal skin cells, offering a more effective and better-tolerated treatment alternative.
A novel signaling pathway involving CDC-42 GTPase directs the movement of cells during intercalation, a process shaping skin tissue in embryonic C. elegans. The study identifies a key regulator determining polarity and guiding cell migration.
Researchers have developed an innovative skin graft process that combines split thickness skin grafts with a specially engineered sheet of stem cells to maximize natural healing power. The new technique shows promising results in treating large or complicated burn injuries, preserving hair follicles and oil glands.
Scientists tracked epidermal cells' behavior during regrowth of adult limbs in crustacean Parhyale hawaiensis. They identified sequence of events and cell behaviors, including wound closure and extensive cell division.
Izpisua Belmonte's lab aims to generate functional primate organs and tissues in vivo using novel stem cell technologies. His work could lead to new methods for growing transplantable human tissues and overcoming organ rejection issues.
Researchers at Hokkaido University have developed a new method for capturing high-resolution, three-dimensional images of the deep structure of skin in living mice. The study reveals that basal cells divide obliquely in thicker skin and parallel in thinner skin, contributing to the maintenance of epidermis thickness
Researchers at UT Austin use thermal noise imaging to capture nanometer-scale images of collagen fibrils in skin, revealing key properties that affect elasticity. This breakthrough may lead to improved designs for artificial skin and tissues.