Articles tagged with Skin Cells
A study by Dmitry Gordenin and colleagues found that genomic DNA changes in skin cells accumulate over time, with the amount of damage caused by UV light unrelated to age. Black individuals exhibited less UV damage compared to white donors, possibly due to higher melanin levels.
A KAIST research team used simulations to identify an enzyme that can reverse cellular senescence, a natural process contributing to aging and age-related diseases. By targeting the enzyme PDK1, cells were able to re-enter the cell cycle without proliferating abnormally.
A recent study by MedUni Vienna dermatologists has discovered that skin-resident and inactive T cells survive chemotherapy and radiotherapy intact and go on to cause inflammation after a stem cell transplant. In some cases, these tissue-resident T cells even prove beneficial to the recipient by assuming their role in immune defense.
A recent study has clarified the life history of the devastating plant pathogen Plasmodiophora brassicae, revealing a complex life cycle with a previously unknown sexual stage. The research provides fundamental insights into the pathogen's biology and its interactions with host plants.
Researchers created an artificial skin equivalent that reproduces traction-force balance in the lateral direction, a property controlling skin structure and function. This human-skin equivalent enhances physiological skin function analysis, disease research, and reduces animal testing.
Researchers found that host skin and intestinal T cells survive conditioning regimens and continue to perform their normal functions. These T cells can become activated by donor white blood cells, leading to graft-versus-host disease.
Researchers have found that RNA is critical in the process of cell differentiation, serving as a bridge between genes and epigenetic machinery. Without RNA, the system cannot work, making it essential for life. The study's findings could lead to the development of new RNA-targeted therapies.
Researchers at the University of British Columbia have discovered a key enzyme that contributes to eczema's debilitating effects, offering new hope for treatment. By inhibiting Granzyme B, the study suggests a safer and more effective long-term treatment could prevent skin damage and reduce symptoms.
Researchers at Boston Children's Hospital successfully recreate human skin with hair, nerves, and fat using a novel culture technique. The breakthrough has the potential to revolutionize wound treatment, burn care, and cosmetics testing, as well as aid in the development of new treatments for diseases such as Merkel cell carcinoma.
Researchers at Indiana University School of Medicine have successfully grown hairy skin from human stem cells using a 3D cell culture method. The study shows that skin generated from pluripotent stem cells can integrate into mouse skin, leading to potential applications in skin reconstruction and disease modeling.
A new lab-grown human skin cell model has been developed at Stanford University, allowing researchers to study hair growth and development in greater detail. This breakthrough could potentially provide insights into reversing hair loss and developing new treatments.
Researchers at the University of Pittsburgh School of Medicine have created fully functional mini livers using skin cells from human volunteers. The lab-made organs were then transplanted into rats, with results showing they survived for four days and functioned like a normal liver.
Scientists used ancient DNA to link fragments of Dead Sea Scrolls, revealing new insights into their meaning and historical context. The analysis found that scrolls made from the same animal skin were more likely to belong together.
Researchers found that stem cell treatment eliminates sun-damaged elastin network and replaces it with normal tissues and structures, even in deeper layers of skin. The treatment triggers cellular- and molecular-level pathways involved in skin repair and regeneration.
Scientists studied mouse tail skin expansion from birth to adulthood, finding that it grows by a factor of 15 through self-duplication of developmental progenitors. Cell proliferation rates decreased over time, while single-cell RNA sequencing revealed molecular features of developmental progenitors.
Researchers found that cells protect themselves from mechanical stress by not only deforming cell nuclei but also softening the genetic material itself. This mechanism helps prevent DNA damage and disease, including cancer. The study also reveals that healthy stem cells are more resistant to mechanical stretch than cancer cells.
Scientists have discovered a way to directly reprogram skin cells into light-sensing rod photoreceptors, enabling blind mice to detect light after transplantation. The technique, which took only 10 days to produce functional cells, has the potential to model eye disease and advance therapies for age-related macular degeneration.
Researchers at KAUST have developed a cellular model of neuronal development that relies on L1 retrotransposons to form dopamine-producing neurons. The study reveals the importance of L1 activation in successful reprogramming of skin cells into neuronal cells.
Researchers at Stanford University School of Medicine have successfully rejuvenated old human cells using stem cell technology, rewinding molecular hallmarks of aging and rendering treated cells nearly indistinguishable from their younger counterparts. The study found that exposure to specific proteins, known as Yamanaka factors, can i...
Researchers at University of California, Irvine have published a comprehensive overview of skin cell changes before wound healing. The study provides insights into the underlying mechanisms driving poor wound healing in diabetic patients.
Researchers discovered that keratohyalin granules, which form through phase separation, carry molecular messages that prompt skin cells to flatten and die. This process is crucial for maintaining the skin barrier against pathogens.
A new study reveals that the overlying skin and a layer of non-adhesive cells are required for digit separation during mammalian development. The research identifies epidermal developmental processes beyond connective tissue removal, which may be implicated in other complex syndromes.
A detailed molecular atlas of skin cells has been created, revealing over 50 different cell types and new variations of cell types. The study uncovers how cells are coordinated during hair growth and rest, providing vital knowledge on the flexibility of the skin.
Researchers identified Merkel cell polyomavirus in 7 out of 18 patients with Merkel cell carcinoma, a rare skin cancer. The study suggests that most MCC cases in India are likely caused by UV-linked damages, while some may be virus-positive, offering new targets for therapy and diagnosis.
Researchers found that iPSC-derived thymic epithelium cells can regulate immune response to skin grafts, extending their survival. The introduction of Foxn1 gene helps efficient differentiation of such cells.
Researchers created a potential new adhesive using poly(vinyl alcohol) to improve the adhesion of wearable sensors. The modified compound, 4C3-PVA, was found to be hydrophobic but have less tensile strength compared to other versions.
A new handheld bioprinter has shown promising results in treating full-thickness burns by depositing bioink directly onto wounds. The device uses mesenchymal stromal cells to support local cell growth and reduce inflammation, scarring, and contraction.
Hives affect 1 in 5 people, and researchers used a mathematical model to recreate the patterns of hives. The study suggests that certain mechanisms may inhibit histamine release, adding complexity to the disease. The findings will help create a more detailed picture of how the skin disease develops.
A new treatment approach for cutaneous T-cell lymphoma, a rare blood disease, has been proposed by University of Alberta researcher Robert Gniadecki. He found that cancer cells originate from the blood, not the skin, and suggests treating malignant clones in the blood rather than waiting until they reach the skin.
Researchers have discovered that the force each cell applies to the surface beneath it primarily controls its shape and motion in a collective cell migration. This finding provides new insights into how cells rearrange and migrate as a group, which could lead to the development of new treatments to speed up wound healing.
Researchers report that the leaves of the floating fern Salvinia molesta can efficiently recover air mattress trapped in microstructures due to interconnected wedge-shaped grooves. Artificially fabricated leaf surfaces also exhibit air mattress recovery and could prove useful in various underwater applications.
A team of scientists has created the first living robots, 'xenobots', by assembling frog embryo cells into new life forms. These biodegradable organisms can move, heal themselves, and even carry payloads, promising advances in drug delivery, toxic waste clean-up, and more.
Nano-Pulse Stimulation (NPS) delivers nanosecond pulsed electric fields to cells and tissues, inducing cell death in epidermal or dermal lesions without causing scarring. Researchers used NPS to treat skin lesions, including seborrheic keratosis and warts caused by human papilloma virus.
Researchers at Brigham and Women's Hospital have uncovered a novel pathway explaining why skin thickens in psoriasis, suggesting new strategies for developing therapies. The study found a defect in the epigenetic covering that resulted in loss of DNA methylation hydroxymethylation mark, leading to dysregulated stem cell behavior.
Researchers have found a way to stimulate skin cells to secrete naturally occurring antibiotics called Antimicrobial Peptides, which target and kill bacteria. By modulating caspase-8 levels in the skin, AMP release can be controlled to prevent infections in diabetics and patients with weakened immune systems.
Researchers used gene editing and stem cell reprogramming to correct mutations in a human genetic skin disorder, RDEB, in mice. The corrected skin grafts exhibited significant collagen VII deposition and integration, similar to wild-type skin.
Scientists discovered that reflectin proteins control iridocytes, which contribute to changing visibility and appearance. The proteins fold up when phosphate groups are added, exposing sticky surfaces that allow them to clump together, creating an osmotic motor that responds to neuronal signals.
Researchers found that newly cancerous pigment stem cells migrate up and out of hair follicles to establish melanomas in nearby surface skin before spreading deeper. This discovery sheds new light on the biology of melanoma and suggests potential new ideas for treatment.
Researchers at Rensselaer Polytechnic Institute have developed a way to 3D print living skin complete with blood vessels. The advancement brings researchers closer to creating grafts that are more like the skin our bodies produce naturally, which can accelerate wound healing and improve patient outcomes.
The Society for Laboratory Automation and Screening (SLAS) has chosen 53 life sciences students from 12 countries to receive the SLAS Tony B. Academic Travel Award. The award winners will present their research at the SLAS 2020 International Conference and Exhibition in San Diego, CA, USA.
Researchers discovered that neutrophils can eliminate MRSA bacteria on human skin, preventing them from invading the body. This finding could help explain why some people are only transient carriers of MRSA.
The 'KARAPPO' gene is essential for initiating gemma development in liverwort, triggering cell elongation and asymmetrical cell divisions. This discovery has fundamental implications for understanding vegetative reproduction mechanisms and their potential applications in agriculture and biotechnology.
Researchers have discovered a new species of choanoflagellates that can act together to change shape and swim. The microbes use light-sensing proteins to coordinate their movements, suggesting this ability pre-dates the first animals.
The artificial skin developed by Prof. Gordon Cheng and his team enables robots to perceive their surroundings in greater detail and with more sensitivity, making them safer when operating near people. The system combines hexagonal cells with microprocessors and sensors to detect contact, acceleration, proximity, and temperature.
Researchers at Imperial College London aim to re-engineer stump skin using the tough properties of foot sole skin to reduce rubbing and pain from prosthetics. They found that thicker collagen fibers and different types of keratin are key factors in protecting sole skin from ulcers and blisters.
Research shows exposure to air pollutants like particulate matter is linked to decreased levels of proteins responsible for hair growth and retention. The study found that higher concentrations of PM10-like dust and diesel particulate led to greater decreases in these proteins.
USC researchers have successfully grown human testosterone-producing cells in the lab, paving the way to treat low testosterone with personalized replacement cells. The breakthrough could potentially bypass side effects associated with current treatments, such as infertility and increased risk of prostate cancer.
A stretchable and flexible biofuel cell has been developed to power wearable electronics using human sweat. The device continuously lights an LED and opens avenues for the development of reliable and efficient energy sources. Researchers are now seeking to amplify the voltage provided by the biofuel cell to power larger portable devices.
Researchers from North Carolina State University have shown that exosomes harvested from human skin cells are more effective at repairing sun-damaged skin cells in mice than popular retinol or stem cell-based treatments. The nanometer-sized exosomes can be delivered to the target cells via needle-free injections.
In a small clinical trial, Mayo Clinic researchers showed that senolytic drugs can significantly decrease senescent cell burden in humans. The study found that the combination of dasatinab and quercetin reduced senescent cells in blood, skin, and fat tissue for at least 11 days.
Engineered cell sheets have been designed to effectively treat open skin areas after surgeries, addressing a major challenge in post-operative care. The method involves scanning the surgical site, designing and printing a 3D mold, coating it with gold, seeding cells, and growing a custom-made cell sheet that can be transplanted into mice.
Researchers discovered that master-regulatory proteins SPEECHLESS and SCREAM regulate stomatal differentiation in plants. The exact mechanism of how these proteins interact with MAP kinases MPK3 and MPK6 was unclear until recently.
Researchers at the University of Pennsylvania have identified LSD1 as a key regulator of skin cell turnover and found that blocking it could be an effective treatment method for non-melanoma skin cancers. The study shows that targeting LSD1 can force skin cells to differentiate, potentially turning tumor cells into healthier cells.
Researchers found microneedling improves acne scar appearance by decreasing inflammation and scarring, with increased patient satisfaction when combined with other treatments.
Researchers at McGill University used computer simulations and microscopy to show that pectin and cellulose play a crucial role in sculpting epidermal leaf cells. The study suggests that mechanical forces drive plant cell growth, leading to unique shapes like the jigsaw puzzle-like pattern of leaf skin.
Researchers developed an implantable microneedle skin patch containing an HIV subunit vaccine, which led to sustained intradermal vaccine release and improved antibody responses in mice. The study suggests that microneedle patches may enhance vaccine effectiveness.
The effects of skin aging differ among ethnic groups, with varying levels of damage from environmental factors such as sunlight. Key findings show that patients of color experience changes in pigmentation, while those of European descent have thinner skin and wrinkles.
Johns Hopkins researchers found that laser treatments and retinoic acid share a common molecular pathway that senses loose RNA molecules. This pathway is also involved in mice regenerating hair follicles after a wound.
Researchers have developed a method to generate natural-looking hair that grows through the skin using human induced pluripotent stem cells. This technology has the potential to treat hair loss in millions of people worldwide.
A recent study has improved upon Nobel Laureate Prof. Shinya Yamanaka's cellular reprogramming method, reducing the waiting period from 3-4 weeks to approximately a week. The new method also increases the success rate up to ten-fold, making it easier to apply in clinical settings.