Articles tagged with Skin Cells
A study published in the Journal of the American Academy of Dermatology found that curettage and cryosurgery is an effective and safe treatment method for basal cell carcinoma. The procedure involves scraping the lesion with a curette followed by freezing, resulting in good outcomes with minimal side effects.
A team of researchers identified TIM-1 as a key player in regulating anti-tumor immunity in melanoma. By targeting TIM-1, the immune system can activate killer T cells to inhibit tumor growth. The study's findings have significant implications for developing new cancer therapies.
Researchers developed CrossDome, a tool that uses genetic and biochemical information to predict T-cell immunotherapy's impact on healthy cells. The tool identified high-risk candidates in cases where treatments mistakenly attacked heart cells.
Researchers developed a new method, photoacoustic spectral analysis (PASA), to analyze the tumor microenvironment without invasive procedures. The technique uses laser light and sound waves to identify different types of tumors with high accuracy.
Researchers at Helmholtz-Zentrum Dresden-Rossendorf have discovered a potential therapeutic approach for curing neurodegenerative diseases using magnetic fields. In vitro trials showed that damaged motor neurons can be restored by exposure to magnetic fields, leading to axonal transport and regeneration of mitochondria.
Scientists have developed an innovative platform using engineered human tissue to study how pathogens carried by mosquitoes impact and infect human cells. This breakthrough holds promise for studying other disease vectors like ticks, which spread Lyme disease.
A team of scientists has discovered that IL-17 protein plays a central role in skin ageing, leading to inflammation and deterioration. Temporary inhibition of IL-17 slows down the appearance of aging symptoms, offering new possibilities for treating skin conditions and facilitating recovery after surgery.
Researchers uncover genetic changes that link blastic plasmacytoid dendritic cell neoplasm (BPDCN) to exposure to ultraviolet radiation, suggesting a potential role for sunlight in its development. The study, published in Nature, sheds light on how cancer cells evolve across multiple tissues.
Researchers at Nanyang Technological University found that cells near wavy shaped wounds moved in a swirling manner, while those near straight wounds moved in straight lines. This discovery reveals that the swirling motion is crucial for gap-bridging and accelerates wound healing in wavy wounds.
A new study presents a chronic wound murine model that characterizes the role of persistent senescent cell accumulation in delayed wound closure. The molecular profiles of senescent cells demonstrate the adverse influence of SASP factors, highlighting a potential root-cause-driven therapeutic strategy.
The study, led by Professor Takashi Miura of Kyushu University, has discovered that interdigitated cell boundaries have a mathematically scaling pattern with self-similarity. The team used the Edwards-Wilkinson model to simulate and understand the molecular mechanism responsible for these dynamics.
New research suggests neural crest cells retain adaptability even after differentiation, enabling them to 'change their mind' and differentiate anew. This hyper-flexibility has significant implications for regenerative medicine, as these cells have immense potential as treatments to replace and repair damaged body tissue.
Humpback whales use sandy bays to remove dead skin cells and barnacles through 'sand rolling' behavior. This exfoliation method helps maintain a healthy bacterial skin community, reducing drag and energy loss.
A team of researchers has developed a method that uses electric stimulation to accelerate wound healing, making it possible for wounds to heal up to three times faster. The technique involves applying an electric field to damaged skin, which helps guide skin cells in the same direction, promoting faster healing.
Infants have a unique homing property that directs certain immune cells to the skin at birth, protecting them from disease-causing bacteria. This skin-homing ability is crucial for lifelong immunity and local tissue development.
Researchers found that a specific type of immune cell can detect and eliminate senescent cells in the skin by targeting human cytomegalovirus antigens. This discovery suggests a potential therapeutic approach to eliminate aging cells, which could have applications in cancer, fibrosis, and degenerative diseases.
Researchers at the Francis Crick Institute have identified a new cell type, named F-Cell, that plays a crucial role in touch sensing in fruit flies. The study published in Nature Cell Biology reveals that F-Cells are recruited to tactile hairs and participate in sending signals to neighbouring epidermal cells.
Researchers from Japan create a new model for estimating transepidermal water loss, providing a more realistic picture of skin water loss. The new method uses confocal laser microscopy and Raman spectroscopy to measure stratum corneum thickness and water content.
A team of researchers developed a transfer-tattoo-like cell sheet that can be directly applied to targeted surfaces, facilitating cutaneous wound healing and promoting skin tissue regeneration. The system leverages natural cell migration between surfaces, eliminating the need for external stimuli and detachment processes.
Researchers have successfully converted pluripotent stem cells into hematopoietic stem and progenitor cells using optimized transcription factors. The resulting PSC-derived cells generated all types of white blood cells in mice without giving rise to tumors or leukemias, suggesting a promising future for PSC-based transplant therapies.
A study by University of Gothenburg researchers found a significant association between methotrexate use and an increased risk of basal cell carcinoma, squamous cell carcinoma, and cutaneous malignant melanoma. The study suggests that higher doses of methotrexate may increase the risk of SCC and BCC, while no dose-response relationship...
Researchers developed bioprinted artificial skin that mimics human skin, reducing animal testing in cosmetics and pharmaceutical industries. The model achieved similar results as traditionally produced models, passing international validation tests, including barrier function and irritant response assessment.
Researchers have developed a system using microvesicles from algae that promote skin cell proliferation and migration, leading to increased collagen synthesis. The findings show promising results for the treatment of wounds and skin regeneration.
A study involving three volunteers found that skin scars treated with hair follicle transplants exhibited profound architectural and genetic shifts towards healthy, uninjured skin. The findings suggest the potential for new therapies to rejuvenate mature scars and restore organ function.
The study shows that RXR ensures hematopoietic stem cells remain youthful and fit, reducing the risk of developing myeloproliferative syndromes. The regulatory action of RXR on these cells is essential for maintaining a balanced production of blood cell types throughout life.
Researchers at UCSF's Cell Design Institute engineered cells with customized adhesion molecules to form complex multicellular ensembles in predictable ways. The discovery represents a major step toward building tissues and organs through regenerative medicine.
Researchers found that glutaminase inhibitor BPTES selectively eliminates senescent dermal fibroblasts, improving skin aging phenotype by increasing collagen density and cell proliferation. The study suggests BPTES as a potential therapeutic agent for skin aging, offering new treatment options.
A team of Berlin scientists has successfully grown stem cells and mini-brains from Sumatran rhino skin cells, paving the way for potential use in assisted reproduction. The next step is to create sperm cells that may help save the critically endangered species from extinction.
Researchers found that knockdown of secreted frizzled-related protein 4 (SFRP4) suppresses SASP and improves age-related skin phenotypes. This suggests a potential candidate for the development of new skin rejuvenation therapies.
Researchers from University of Colorado Boulder develop equation learning technique, WSINDy, to grasp how body rebuilds skin and accelerate wound healing. The method can apply to various phenomena in the natural world, including flocking behavior in birds.
A new stem cell study provides insight into how neurons from individuals with post-traumatic stress disorder (PTSD) respond to stress hormones. The research found that these cells are hypersensitive to the stress hormone hydrocortisone, which could help explain why some people develop PTSD after trauma exposure.
Researchers have successfully created dopaminergic neurons directly from the skin of patients with Parkinson's disease, preserving aged characteristics and cellular defects. This breakthrough allows for modeling PD-related neuronal defects in a larger cohort of patients, aiming to identify disease causes and potential therapies.
Sensory neurons in human skin have been found to regulate melanocytes, influencing pigmentation and cell survival. The study identified a protein called RGMB as a key factor promoting melanocyte survival and darkness.
A new survey of 17,000 Europeans found that 8 in 10 believe tans are attractive and healthy, despite decades of awareness campaigns linking sun exposure to skin cancer and aging. The study also revealed low levels of adherence to sun protection habits, with only 1 in 10 using all forms of protection.
Researchers identified an immune biomarker in newborns that can predict the onset and severity of pediatric atopic eczema. The Barrier dysfunction in Atopic newBorns (BABY) study found elevated levels of TARC at 2 months to be more than twice as likely to develop eczema by age 2.
A new imaging technique called LC-OCT significantly improved the accuracy of basal cell carcinoma (BCC) diagnosis by 12% compared to clinical and dermoscopic examinations. The technique provided detailed 3D images at a cellular level, enabling more accurate differentiation between BCCs and other skin conditions.
Moffitt researchers used computer modeling to demonstrate the impact of skin homeostasis on driver and passenger mutations. They found that larger subclones are likely due to persistence and older age, not selective sweeps.
Extracellular vesicles and exosomes are membrane-bound vesicles that facilitate intercellular exchange of proteins, lipids, and genetic material. They will be highlighted in upcoming events focusing on mitochondrial quality control, skin ageing, and microbiota.
Researchers at Lund University have developed a new method for studying Huntington’s disease by reprogramming skin cells into aged neurons. The results show several defects that explain some of the disease mechanisms in neurons from patients with Huntington’s disease, including problems with protein breakdown and recycling. This innova...
Researchers found that Merkel cell carcinoma (MCC) Glypican-3 (GPC3) is expressed in nearly 70% of MCC tumors and up to 90% of MCPyV-negative cases. GPC3 expression is associated with worse prognosis, including increased risk of death from MCC. This makes GPC3 a promising target for chimeric antigen receptor T cell therapy.
Researchers at the University of São Paulo found that deactivating the light-sensitive protein melanopsin slows melanoma progression in animal experiments. The study, published in Communications Biology, suggests that melanopsin acts as an oncogene in melanoma, a type of skin cancer.
A Northwestern University research team has identified a molecular switch, CDK9, that plays an early and critical role in the differentiation process of skin stem cells. The switch is turned on when specific cellular signals are activated, triggering rapid gene expression and cell fate switching.
The 13th Annual Meeting on Skin Challenges 2022 will highlight the roles of extracellular vesicles in skin ageing and age-related diseases. Therapeutic strategies and anti-ageing potential of these vesicles from various sources, including stem cells and commensal bacteria, will be addressed.
Researchers developed a mathematical model to predict the efficiency of nanoparticle delivery into cells, particularly in stem cells. They found that nanoparticles become trapped in bubble-like vesicles, preventing them from reaching their targets.
A groundbreaking study by Hebrew University researchers has discovered the most primitive blueprint for embryo cell creation. The team identified 14,000 sites in the DNA that control the development of all embryonic organs.
Researchers at Edith Cowan University have found a genetic link between human leukocyte antigens and immunotherapy side effects in non-small cell lung cancer patients. The discovery enables doctors to tailor treatment to individual patients, reducing the risk of toxicities and improving overall outcomes.
The 13th Annual Meeting on Skin Challenges 2022 will discuss recent advances in skin ageing, focusing on extracellular vesicles and their therapeutic potential. Experts will also share findings on the skin microbiome and its role in age-related diseases.
Researchers at the University of California, Irvine have identified SCUBE3 as a potential therapeutic treatment for androgenetic alopecia. The study found that dermal papilla cells produce activating molecules to promote new growth, which are reduced in people with hair loss.
Researchers at the Salk Institute have identified an unexpected molecular target of a common treatment for alopecia, a condition where the immune system attacks hair follicles. They found that glucocorticoid hormones instruct regulatory T cells to activate hair follicle stem cells, leading to hair growth and regeneration.
A new molecule called embigin has been discovered to regulate sebaceous gland progenitor cell function. Embigin binds to fibronectin and directs transport proteins for lipid synthesis, playing a crucial role in sebum production.
Researchers at Kyoto University have discovered the skin's natural protection from nighttime bacterial invasion in mice, which may provide a basis for developing a drug treatment. The team found that epidermal CXCL14 is produced in a circadian rhythm-dependent manner, providing antimicrobial function against Staphylococcus aureus.
Researchers have developed a method to create living human skin on robots, providing a realistic texture and self-healing properties. The skin is made up of collagen and human dermal fibroblasts, which conform to the robot's surface and can even repair wounds with the help of a collagen bandage.
A randomized, placebo-controlled pilot study found that NB-UVB phototherapy decreased mortality in hospitalized COVID-19 patients with no adverse events reported. The treatment was effective in both vaccinated and unvaccinated patients, with reduced pathologic inflammation and improved intracellular killing of pathogens.
Researchers studied naked mole-rats' skin using single-cell RNA-seq to understand its remarkable stability against aging. They found no changes in epidermal gene expression with age and a unique keratinocyte differentiation trajectory that remained intact.
A UNIGE team discovered that cells in curved tissues swell by 50% before returning to normal, opening avenues for in vitro organ culture. This active phenomenon can be harnessed to control spontaneous growth of organoids and develop new materials with volume increase upon folding.
Emory University researchers have identified a mechanism for skin cell death that could lead to new treatments for skin infections, alopecia, hives, and potentially melanoma. The study reveals that a protein called gasdermin A induces pyroptosis in skin cells, serving as an early warning system against bacterial attack.
A study published in JCI Insight reveals that epigenetic drugs targeting BRD4 significantly reduce scarring in patients with scleroderma. The findings could lead to repurposing these drugs for faster relief from debilitating symptoms of this chronic disease.
Researchers found phosphatidylinositol bisphosphate (PIP2) essential for epithelial cell-cell adhesion and maintaining cellular identity. PIP2 regulates epithelial properties by recruiting Par3 to the plasma membrane, facilitating the formation of adherens junctions and preventing epithelial-mesenchymal transformation.
Researchers at Binghamton University have discovered that human skin's unique structure allows it to maximize both durability and flexibility. The team created artificial skin membranes that mimicked the structure of mammalian skin, testing their puncture toughness and deformability.
Scientists at Johns Hopkins Medicine have successfully cultivated human muscle stem cells capable of renewing themselves and repairing muscle tissue damage in mice. The self-renewing stem cells were created by reprogramming laboratory-grown human skin cells, which then differentiated into specific cell types using a nutrient-rich broth.