Articles tagged with Sperm
Researchers identified over 1,000 genes with age-related methylation changes in human sperm. These changes are associated with increased offspring disease susceptibility for neurodevelopmental disorders. The study found no correlation between paternal BMI or semen quality and age-related methylation changes.
Researchers at the University of California - Riverside have discovered a way to deactivate mosquito sperm, preventing them from swimming to or fertilizing eggs. This breakthrough could help control populations of Culex mosquitoes that transmit infectious diseases like encephalitis and West Nile Virus.
Researchers from Kumamoto University found that synchronizing ovulation and mating in
A recent study published in PNAS reveals that the protein TSKS plays a crucial role in eliminating sperm cytoplasm, enabling a streamlined structure necessary for successful fertilization. The findings suggest potential applications for diagnostic tests and male contraceptives.
Scientists have successfully transformed blood cells into sperm precursors in marmoset embryos using a step-by-step process. The study, published in eLife, opens up new avenues for studying primate biology and developing novel assisted reproductive technologies.
In a mouse study, researchers have identified a potential non-hormonal contraceptive that men can take before sexual activity to prevent pregnancy. The compound temporarily disables an enzyme essential for sperm maturation, rendering sperm immobile and preventing fertilization.
A new experimental contraceptive drug has been developed by Weill Cornell Medicine investigators, demonstrating the possibility of an on-demand male contraceptive. The study found that a single dose of the sAC inhibitor TDI-11861 temporarily stops sperm movement and prevents pregnancies in preclinical models.
Researchers have discovered a new compound that could become an effective non-hormonal male contraceptive by inhibiting the CDK2 protein. The compound, named EF-4-177, showed promising results in mice, with a significant decrease in sperm counts after 28-day exposure.
A study by the University of Freiburg has found that auxin influences the fertility of spreading earthmoss, with PINC protein playing a crucial role. The research reveals that sperm swim better without PINC and that its absence leads to increased abortions in Physcomitrella moss.
A UC Riverside study found that fathers exposed to chemicals in plastics can affect the metabolic health of their offspring for two generations. Paternal DCHP exposure led to high insulin resistance and impaired insulin signaling in F1 offspring, while F2 offspring showed weaker effects.
Research from Texas A&M University reveals that male alcohol use has a significant negative influence on in vitro fertilization (IVF) success rates. The study highlights the importance of expanding fertility and prepregnancy messaging to emphasize the reproductive dangers of alcohol use by both parents.
Researchers from Osaka University have identified a protein called FER1L5 that is crucial for the acrosome reaction, allowing sperm to fertilize eggs. The study found that mice lacking FER1L5 were unable to undergo the acrosome reaction, highlighting the importance of this protein in male fertility.
A study by Rockefeller University scientists found that older male fruit flies are more likely to pass mutations onto their offspring due to less efficient mutation repair mechanisms. This could have implications for inherited-disease risk in humans.
A recent study found that less than four in 100 men who applied to be sperm donors completed the process, with over half withdrawing before samples were released. The research, published in Human Reproduction, also showed that nearly a fifth of applicants were rejected due to health issues or genetic diseases.
Heidelberg researchers decoded genetic regulation of sperm formation across various mammal species, including humans. The study revealed a time-related pattern of gene expression differences, highlighting the rapid evolution of spermatogenesis.
Researchers discovered that radiation damage to paternal DNA is passed on to offspring through a highly error-prone repair mechanism. This leads to structural changes in the paternal chromosomes and causes developmental defects. Histone proteins play a crucial role in shielding damaged chromosomes from accurate repair.
Researchers found that a Mediterranean diet can improve fertility outcomes by reducing inflammation and increasing sperm quality in men. The anti-inflammatory properties of the diet may also enhance couples' chances of conception.
Researchers at the Max Delbrück Center have successfully generated primordial germ cells from stem cells, a world's first for a large mammalian species. This milestone aims to save the northern white rhino subspecies from extinction through lab-grown egg and sperm cells.
Scientists have successfully created primordial germ cell-like cells (PGCLSs) from induced pluripotent stem cells of the northern white rhino Nabire, paving the way to produce artificial gametes. This breakthrough aims to prevent the extinction of the northern white rhinoceros and increase genetic diversity.
A researcher at Oregon State University has discovered a new species of cockroach encased in Dominican amber, with the male specimen displaying well-preserved yellow stripes and spines. The finding also marks the presence of fossilized roach sperm for the first time.
Researchers are developing new male birth control options that could provide a safer and more effective alternative to hormonal methods. Non-hormonal approaches targeting proteins essential for sperm production are showing promise in clinical trials with minimal side effects.
A new non-hormonal gel blocks sperm by reinforcing cervical mucus barrier, demonstrating high effectiveness in reducing uterine sperm numbers. The gel has shown a 98% average decrease in sperm numbers compared to untreated control animals, making it a promising alternative to existing contraceptives.
Research found that male rats exposed to ifosfamide during adolescence had offspring and grand-offspring with increased incidence of diseases, including kidney and testis problems. The study's epigenetic analysis revealed changes passed down through sperm and ova, indicating a potential risk for future generations.
A recent meta-analysis published in Human Reproduction Update reveals a significant worldwide decline in sperm counts of over 50% in the past 46 years. The study also shows an accelerated post-2000 decline in sperm counts globally.
Researchers at John Innes Centre discovered a mechanism of flowering plant sperm compaction using histone protein H2B.8. This mechanism allows for moderate nuclear condensation without compromising gene activity, essential for immotile sperm and pollen tube travel.
A new method of conventional IVF has been successfully developed by Katrin Hinrichs and colleagues, resulting in three healthy foals born to recipient mares. The technique offers a simplified alternative to existing methods like ICSI, which require expensive equipment and training.
Researchers have developed a model of how human embryos are formed, revealing that genes are switched on almost immediately after fertilization. This discovery may also shed light on the origins of cancer, which is often diagnosed at an advanced stage.
Researchers discovered AKG/OXGR1 signaling pathway's role in maintaining epididymal fluid acid-base balance and regulating sperm maturation. AKG supplementation improved sperm capacitation and acrosome reaction rates in aging mice, providing a potential strategy for targeting male fertility disorders.
A recent study found that sperm clustering in viscoelastic fluid offers three biological benefits: reduced direction changes, improved alignment, and increased safety from strong flows. This research may inform studies on infertility and provide better selection of sperm for assisted-reproduction technologies.
Researchers have discovered a new protein called MAIA, which is crucial for human fertilization. The protein helps draw sperm into the egg cytoplasm, paving the way for novel ways to treat infertility.
Researchers generated rat sperm cells inside sterile mice using blastocyst complementation, achieving a proof-of-principle for producing gametes from one animal species in another. This breakthrough may speed up the production of transgenic rats for biomedical research and potentially support animal species conservation efforts.
A new study found that coral spawning events at deeper depths occur at lower intensities than those in shallow waters. The researchers suggest that deep reefs may more often rely on shallow-reef corals to survive.
Research by Jeremy Wang at the University of Pennsylvania has discovered that DOT1L, a stem cell self-renewal factor, is essential for mice to produce sperm throughout their adult lives. The team found that mice lacking DOT1L fail to maintain spermatogonial stem cells and lose the ability to continuously produce sperm.
Researchers discovered that the process of hypercondensation, where DNA is compressed, relies on a second type of protamine, PRM2, which may be crucial for fertility. The study sheds light on the complex mechanism behind sperm development and could lead to new treatments for male infertility.
A UMass Amherst researcher will investigate the link between ambient environmental factors and male fertility, focusing on air pollution and temperature. Her study aims to identify risks associated with these exposures and inform medical and behavioral interventions for men before fertility treatment.
A preliminary study published in eLife suggests that sperm screening can identify potentially harmful new genetic mutations and help prevent them from being passed on to offspring. The study found that 55 mutations were detected in the men's sperm, including 15 passed on to an embryo.
A large-scale study of intrauterine insemination cycles found that frozen sperm samples have similar clinical pregnancy rates to fresh samples. However, time-to-pregnancy was slightly longer for the frozen sperm group. The results provide reassurance to patients undergoing fertility treatment.
During plant spermiogenesis, the number of mitochondria decreases through autophagy, resulting in a characteristic pattern. This process is distinct from animal reproduction, where organelles are removed by neighboring cells through phagocytosis.
Researchers found that zinc ion serves as a master-regulator of various processes in sperm to facilitate fertilization. Zinc helps maintain sperm in the non-capacitated state, preventing premature capacitation during artificial insemination.
A research team discovered that spermatogenesis is impaired at multiple steps when testicular temperatures rise above 34°C, leading to cell death and male infertility. Organ culture experiments showed sharp temperature dependencies between 30°C and 40°C, with meiosis severely affected at 37–38°C.
A study published in Human Reproduction found that men with obesity who lost weight saw a 50% increase in sperm concentration and a 40% increase in sperm count over an 8-week period. This improvement was sustained for up to 52 weeks and even doubled for those who maintained weight loss after a year
A new micro-device has been developed to streamline the Intracytoplasmic Sperm Injection (ICSI) procedure, allowing more IVF clinics to offer this treatment. The device, smaller than a pinhead in size, holds up to 10 eggs and simplifies the injection process.
Researchers at Wayne State University developed a novel technique to measure the age of male sperm, finding a link between sperm epigenetic aging and pregnancy outcomes. The study suggests that older sperm can be associated with lower pregnancy success rates and shorter gestation periods.
Researchers found that frozen testicular tissue from rats can be reimplanted and produce viable sperm after over 20 years, but with reduced fertility. The study has important implications for treatment of boys with cancer and may provide a method to recover lost fertility.
Research reveals that older men with higher BMI display reduced reproductive health, particularly in terms of sperm cell production. The study also highlights the potential biomarkers for diagnosis of testis aging and directions for potential treatment.
A new study reveals funding for fertility preservation policies varies across the UK, with Scotland offering the most inclusive approach. The study highlights the need for standardization of policies to ensure equal access to care for patients.
A new test, RHEOLEX, can quickly detect breeding bull fertility levels using a simple, home pregnancy test-like device. The test mimics the biological process of rheotaxis, in which sperm swim upstream in the reproductive tract, to quantify the sperm's ability.
A large cohort study found that babies born to men who took metformin during sperm development were at increased risk for genital defects in boys. Diabetes control affects sperm quality, so men should discuss alternative treatments with their doctors before conception. The findings suggest a need for further study on treatment of prosp...
Researchers discovered that by four days after mating, close to 20% of fruit fly sperm proteins are female-derived. Female proteins bind to sperm inside the female, potentially supporting their viability.
Researchers at UBC have successfully 3D printed human testicular cells and observed early signs of sperm-producing capabilities. This breakthrough may lead to new fertility treatments for couples with untreatable forms of male infertility.
Researchers find that nearly 20% of sperm proteins are replaced by female-derived proteins after mating, supporting sperm viability during prolonged periods before fertilization. This 'hand-off' reveals that sperm are materially the product of both sexes.
A new study from the University of Georgia reveals that pollen begins expressing its own genome at a specific point in its life cycle. This discovery has significant implications for plant breeding, as it allows researchers to predict how plant species adapt to environmental changes and potentially speed up crop development.
Researchers have clarified the mechanism behind activating genes in drosophila fly sex cells, which may hold clues to understanding diseases. The study's findings suggest that DNA packaging plays a crucial role in regulating gene expression, with abnormal packaging potentially leading to misregulation and disease.
Scientists discovered two new targets, EPPIN domains, to block sperm motility, a complex process that allows sperm to reach the egg. The study demonstrates the feasibility of using mice as models for in vivo trials, simplifying preclinical studies and paving the way for novel male contraceptives.
Researchers found that epigenetic inheritance can affect the genetic composition of a population for multiple generations. Exposure to high temperatures accelerated the rate of evolution, increasing the spread of genes through mating.
Researchers at Washington State University developed a new form of non-hormonal, over-the-counter contraception by blocking prostate-specific-antigen in human ejaculate samples. This prevents semen from liquefying, trapping most sperm and allowing for effective fertilization prevention.
A meta-analysis of 4280 samples found cell phone use associated with reduced sperm motility, viability, and concentration. The study suggests male users should limit daily cell phone use to protect their fertility.
A survey of 121 fertility specialists in Australia, UK, and New Zealand found that endometrial scratching is still offered by 34% of clinics despite lack of evidence, primarily for psychological benefits. Many respondents considered the procedure's drawbacks, including pain and cost.
A recent study suggests that severe COVID-19 may cause long-term damage to the testes, leading to reduced sperm count and quality. The virus's interaction with testicular cells and potential effects on fertility are being explored through an experimental framework.
A Washington State University study found that cannabis vapor exposure lowered sperm counts and slowed movement in male mice and their sons. The study suggests that cannabis use may be detrimental to male reproductive function, contributing to declining human sperm counts.