Articles tagged with Sperm
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A new study reveals how viral proteins from symbiotic bacteria manipulate sperm in male insects, causing sterility and preventing the spread of diseases like Zika and dengue. The research could lead to refined techniques to control populations of agricultural pests and insect vectors.
A new screening system enables researchers to investigate sperm cell development and health at the molecular level, identifying a crucial gene Rd3 for maintaining sperm integrity during development. The study uses CRISPR technology to disrupt genes in living animals, revealing its significance in regulating oxidative stress.
A team of researchers has identified the protein ATF7IP2 as crucial for ensuring male fertility. In sperm-forming cells, ATF7IP2 recruits the SETDB1 enzyme to compact X and Y chromosomes, preventing genomic errors. The protein also activates genes on non-sex chromosomes, important in recombination and sorting of chromosomes into sperm ...
Men with low sperm count or none have a higher risk of developing cancer, including at younger ages, compared to fertile men. Families of azoospermic men have a significantly increased risk of five cancers, while families of oligozoospermic men have a higher risk of colon, bone and joint, and testicular cancers.
Researchers at Salk Institute find a new method to interrupt sperm production using an HDAC inhibitor, which blocks fertility without affecting libido. The treatment's reversibility is attributed to its ability to modulate gene expression downstream of retinoic acid.
A McGill-led study found that fathers exposed to environmental toxins like DDT may produce sperm with health consequences for their children, increasing the risk of birth defects and diseases. The study's findings highlight the importance of considering fathers in discussions about child health and development.
A new study in The Lancet found that intracytoplasmic sperm injection (ICSI) does not improve live birth rates compared to conventional IVF for couples with non-severe male factor infertility. ICSI was also shown to be an expensive and invasive procedure with potential risks to offspring health.
A new study emphasizes the importance of strict legal rules governing fertility treatment in the UK, warning that recent court cases could create a common law exception to informed consent. The research highlights the need for rigorous consent regimes to protect vulnerable patients from exploitation and misuse of genetic material.
Researchers have identified a new phenomenon where sperm can induce cell fusion in non-reproductive cells, holding promise for diagnosing male fertility issues. The discovery, dubbed SPICER, shows a correlation between syncytia formation and sperm fertilising potential.
A study of 379 animal studies found no consistent impact of aging on ejaculate traits, contradicting the human trend. In some species, age even improved reproductive traits, such as larger ejaculates and increased sperm viability.
Researchers from Tokyo University of Science discovered that manipulating polyamines enhances the functional profiles of monoclonal antibodies. The study found that controlling polyamine levels increases IgG galactosylation, leading to improved therapeutic efficacy.
Research finds that changes in mouse sperm microRNAs caused by aging may affect offspring growth and development, increasing the risk of neurodevelopmental disorders like autism. The study's findings add to growing literature on paternal aging and its impact on offspring health.
Researchers found that about one in a hundred infertile men with normal semen parameters have a loss of CatSper function, leading to failure of fertilization and medically assisted reproduction. The discovery enables evidence-based treatment and diagnosis of this channelopathy.
Chicken sperm can retain fertility and viability for up to three weeks after refrigeration, making it unsuitable for traditional cryopreservation methods. The study found that removing calcium ions impacts energy metabolism dynamics, inducing a physiological dormancy-like state in the sperm cells.
A new study reveals that paternal alcohol consumption can affect fetal development, causing brain and facial defects in offspring. Researchers recommend that men abstain from drinking for at least three months prior to conception to minimize the risk of birth defects.
Researchers at Texas A&M University found that it takes over a month for negative alcohol effects to wear off, and fathers' sperm are still negatively impacted by drinking even during the withdrawal process. The study suggests that men should abstain from alcohol at least three months prior to conceiving.
A study of 152 male gym enthusiasts found a significant lack of awareness about the risks of gym lifestyle on fertility. High levels of estrogen from protein supplements were linked to fertility issues, prompting a call for men to educate themselves about supplementation.
A study by Bonn researchers found that cylicins play a crucial role in sperm structure and development, leading to defects in head and tail shape. The absence of these proteins renders mice infertile, while similar variants in humans are linked to male infertility.
In a groundbreaking study, researchers observed that serotine bats mate without penetration, using their oversized penises like an extra arm to engage in contact mating. The bats' penises are seven times longer and wider than their partners' vaginas, making penetration impossible.
A comprehensive systematic review of 25 studies over nearly 50 years reveals consistent evidence of associations between insecticide exposure and lower sperm concentration in adult men. The findings warrant concern, particularly given observed downward trends in semen quality.
Researchers redesigned IVF needles to reduce fluid flow damage to eggs, improving oocyte collection and IVF success rates. The study uses computer models and mathematical simulations to optimize the design, which has been successfully tested in cattle, with plans for human trials.
A new mathematical model suggests that mammalian sperm cells exhibit two distinct swimming modes, which may be linked to fertilization. The model captures the interactions between motor kinetics and flagella deformations, revealing a second mode with stronger wave-shaped beating.
A recent study reveals that CAMSAP1 plays a crucial role in regulating the structure and dynamics of manchette microtubule minus-ends, impacting male fertility during spermiogenesis. The absence of CAMSAP1 leads to abnormal sperm development, including reduced sperm quantity, decreased motility, and male infertility.
A large cross-sectional study of over 2,800 young men in Switzerland found an association between mobile phone use and lower sperm concentration. While no link was discovered to poor sperm motility or morphology, the results suggest that reduced semen quality may be linked to increased mobile phone usage.
Researchers found that sperm flagellar waveforms are primarily influenced by viscosity rather than shear rate, promoting energy-efficient beating behavior. Sperm adjust their power generation to respond to fluid dynamics, enabling efficient swimming against the flow in high-viscosity media.
Researchers from Universitatsklinikum Bonn have found that a loss of the structural protein ACTL7B blocks spermatogenesis in male mice, leading to infertility. The study suggests that mutations in the Actl7b gene could be a cause of male infertility in humans.
A research team from Heidelberg University has decoded the structure of a sperm membrane transporter, revealing its role in increasing mobility and fertilization capacity. The findings may lead to new treatments for infertility and contraception methods.
Researchers at Stockholm University have discovered a unique ion transporter, SLC9C1, that activates in response to chemo-attractants, triggering increased sperm motility. This finding provides new insights into the intricate mechanisms governing fertilization.
Researchers discovered that a single mutation in a key synaptonemal complex protein can cause infertility in mice and is likely to have the same effect in humans. This finding may lead to new technologies for treating male infertility by pinpointing the exact location of the defect.
A new specimen collection system has been developed to enhance assisted reproductive technologies by providing a simple one-step method for selecting high-quality sperm for ICSI. The system, known as NovaSort, uses a barrier mesh to isolate mobile sperm without damaging their DNA.
A global fertility crisis affects one in six couples, with half the time originating from men. Researchers highlight the need for targeted treatments and improved diagnoses, citing lifestyle factors such as hormone-disrupting chemicals, poor diet, stress, and smoking as contributing causes.
Research reveals that female fruit flies pre-select for males with superior genes before influencing sperm storage to ensure compatible fertilization. The study provides new insights into the mechanisms and consequences of mate choice, shedding light on genetic variation and species evolution.
A new study reveals that sperm tail movement follows the same mathematical template as zebra stripes and other natural patterns. This discovery, published in Nature Communications, suggests that flagellar undulations can arise spontaneously without external influence, using a reaction-diffusion system first proposed by Alan Turing.
Researchers found that mature sperm carry only 100 organelles with mitochondria but no intact mtDNA. This discovery has important implications for human fertility and germ cell therapy, potentially limiting the risk of accumulating harmful mtDNA mutations.
A team of researchers has generated the first complete sequence of a human Y chromosome, uncovering important genomic features with implications for fertility. The new sequence reveals factors in sperm production and provides insights into medically relevant regions, such as the azoospermia factor region.
A study by Michigan Medicine researchers reveals that modifications to amino acids in sperm may be linked to infertility. The team analyzed the molecular sequence composition of protamines, finding non-arginine amino acids with unexpected post-translational modifications that affect sperm shape and function.
Research by Professor Björn Schumacher investigates the role of male germ cells in genetic mutations. The study suggests that paternal DNA damage can lead to faulty repairs in the genome, resulting in structural variants.
A new AI tool can identify sperm in severely infertile men in seconds, compared to the hours it takes scientists. The algorithm improves antiquated approaches and increases the chance of a couple conceiving their own biological children while reducing stress on sperm and increasing efficiency.
New study finds that men who suffered from mild COVID-19 have lower sperm concentrations and motility even three months after recovery. The researchers believe that the virus may cause permanent damage to male fertility, leading to long-term decline in semen quality.
Researchers developed a noninvasive diagnostic test to identify intact sperm in infertile men with nonobstructive azoospermia. The test uses protein biomarkers AKAP4 and ASPX to visualize well-developed sperm, potentially increasing success rates for surgical sperm extraction. This breakthrough may lead to new male birth control drugs ...
Researchers at São Paulo State University developed a new technique for analyzing male fertility potential using flow cytometry, which can detect and analyze chemical and physical characteristics of human sperm simultaneously. This technique has the potential to enhance the accuracy of fertility prediction and treatment.
A research team at Leibniz-IZW identified molecular markers for testicular cell types in domestic cats and four wild feline species, allowing for the clear identification of Leydig and Sertoli cells, spermatogonia, and advanced germ cell stages. This breakthrough enables the maturation process of male germ cells in vitro.
A study published in Nature Communications reveals a small secreted protein NICOL regulates lumicrine-mediated sperm maturation and male fertility. The research team discovered that mice lacking NICOL were sterile, indicating its importance for the sperm-maturation pathway.
Researchers at Michigan State University are investigating a type of fish that produces sperm with no tails but an electric-powered mating call. They hope to understand the energy-saving mechanism behind this trait and its implications for human health, particularly in relation to a genetic disorder called primary ciliary dyskinesia.
Researchers at Johns Hopkins Medicine found a link between chemical marks on fathers' sperm and autistic traits in their 3-year-old children. The study identified 94 regions of differential DNA methylation associated with high scores on a social responsiveness scale, indicating potential markers for autism risk.
Researchers at Washington State University have identified the Arrdc5 gene as a potential target for male contraception. The study found that when this gene is inactivated, it causes significant infertility in males, characterized by decreased sperm count, slowed mobility, and distorted shape.
A landmark study by University of Cambridge researchers found no difference in psychological wellbeing or quality of family relationships between children born through assisted reproduction and those born naturally. However, mothers who disclosed their child's origins early on reported more positive relationships and lower anxiety and ...
A new study published in Proceedings of the Royal Society B found that time-restricted fasting affects reproduction differently in male and female zebrafish. After returning to normal food consumption levels, females increased offspring production at the cost of reduced egg quality, while male sperm quality also decreased.
Scientists have developed a new microfluidic sperm selection device to improve IVF success rates. The device replicates the natural sperm selection process, resulting in an 85% improvement in DNA integrity and a 90% reduction in sperm cell death.
In a 50-generation evolutionary experiment, male beetles from lineages with intense sexual selection produced lower quality offspring after DNA-damaging radiation. This suggests that males invest more in competition at the expense of DNA repair, impacting future offspring survival and fertility.
A new study has confirmed that chronic THC use can negatively impact male reproductive health, including testicular function and sperm quality. Discontinuing use of THC for at least four months can partially restore these effects, providing a critical window for family planning and conception.
Researchers identified over 1,000 genes with age-related methylation changes in human sperm. These changes are associated with increased offspring disease susceptibility for neurodevelopmental disorders. The study found no correlation between paternal BMI or semen quality and age-related methylation changes.
Researchers at the University of California - Riverside have discovered a way to deactivate mosquito sperm, preventing them from swimming to or fertilizing eggs. This breakthrough could help control populations of Culex mosquitoes that transmit infectious diseases like encephalitis and West Nile Virus.
Researchers from Kumamoto University found that synchronizing ovulation and mating in
A recent study published in PNAS reveals that the protein TSKS plays a crucial role in eliminating sperm cytoplasm, enabling a streamlined structure necessary for successful fertilization. The findings suggest potential applications for diagnostic tests and male contraceptives.
Scientists have successfully transformed blood cells into sperm precursors in marmoset embryos using a step-by-step process. The study, published in eLife, opens up new avenues for studying primate biology and developing novel assisted reproductive technologies.
A new experimental contraceptive drug has been developed by Weill Cornell Medicine investigators, demonstrating the possibility of an on-demand male contraceptive. The study found that a single dose of the sAC inhibitor TDI-11861 temporarily stops sperm movement and prevents pregnancies in preclinical models.
In a mouse study, researchers have identified a potential non-hormonal contraceptive that men can take before sexual activity to prevent pregnancy. The compound temporarily disables an enzyme essential for sperm maturation, rendering sperm immobile and preventing fertilization.
Researchers have discovered a new compound that could become an effective non-hormonal male contraceptive by inhibiting the CDK2 protein. The compound, named EF-4-177, showed promising results in mice, with a significant decrease in sperm counts after 28-day exposure.
A study by the University of Freiburg has found that auxin influences the fertility of spreading earthmoss, with PINC protein playing a crucial role. The research reveals that sperm swim better without PINC and that its absence leads to increased abortions in Physcomitrella moss.