Articles tagged with Stem Cell Development
A new study published in Nature Communications reveals that low-risk and high-risk neuroblastoma have distinct cell identities, which can affect survival rates. The researchers identified a progenitor cell type found in fetal adrenal tissue, which may contribute to the development of aggressive neuroblastoma in older children.
Researchers found that astrocytes carrying the AD-associated APOE4 gene released more cholesterol, leading to increased beta-amyloid production in neurons. This study suggests modulating brain cholesterol could be a potential treatment option for Alzheimer's disease.
Researchers have created brain organoids from people with 16p11.2 genomic variations, which exhibit differences in brain size seen in individuals with autism spectrum disorder. The study revealed new information about molecular mechanisms that malfunction when this region is disrupted, providing opportunities for therapeutic intervention.
A USC-led study has mapped the developmental blueprint of human kidneys, shedding light on how cells interact to form filtering units. The research provides a foundation for creating synthetic mini kidneys and could lead to new treatments for kidney diseases.
Researchers at Massachusetts General Hospital have developed pre-epicardial cells from human induced pluripotent stem cells, which support embryonic heart formation and can be used to generate functioning heart tissue. This breakthrough could lead to novel therapies for heart failure, end-stage lung disease, and kidney disease.
Researchers generated brain organoids containing functional optic cups from human induced pluripotent stem cells (iPSCs), demonstrating intrinsic self-patterning ability. The optic cups exhibited light sensitivity, diverse retinal cell types, and connectivity to brain regions.
Scientists at the University of Illinois have developed a method to regulate the Wnt signaling pathway using blue light, allowing them to study its functions in embryonic development and cancer. This approach enables precise control over the pathway's activity, potentially leading to new treatments for tissue repair and cancer research.
Scientists at Princess Margaret Cancer Centre have made a breakthrough discovery in understanding how dormant hematopoietic stem cells are activated, which could lead to new therapeutic targets for various cancers. The team found that lysosomes act as key signaling hubs regulating long-term hematopoietic stem cells.
A new research project aims to create strong, malleable biomaterials that support stem cell growth for improved skull reconstruction surgeries. The $2.4 million grant will help accelerate bone regeneration and reduce complications.
Researchers have developed a new scoring system to evaluate wound healing in mice, using parameters such as re-epithelization and granulation tissue thickness. The system was validated in four different skin wound models, providing a more accurate and reproducible assessment of wound dynamics.
Researchers at the University of Virginia Health System have developed a groundbreaking model of a mammalian embryo using stem cells. The model, which can form heart, muscles, blood vessels and nervous system tissues, marks a major step forward in understanding mammalian development and potentially battling diseases.
Researchers at Harvard University have created a comprehensive molecular atlas of the developing somatosensory cortex, providing insights into how gene activity and regulation change over time. The study sheds light on the complex process of cortical development, including when different neuron populations are established.
USC Stem Cell scientist Leonardo Morsut is designing artificial genetic programs to study embryonic development using a $2.5 million NIH grant. He has developed a synthetic version of the naturally occurring Notch system, allowing him to control cell behavior and signaling networks.
A team of USC Stem Cell scientists has made a groundbreaking discovery about the regeneration of sensory hearing cells in fruit flies. They found that adult flies can produce new JO neurons, which compensate for damaged cells caused by chemotherapy drugs or other stimuli.
Researchers at San Diego Zoo Global have successfully generated induced pluripotent stem cells from frozen fibroblast cell lines of northern and southern white rhinoceroses. This groundbreaking achievement marks the first step towards potentially bringing back this critically endangered species through gamete creation.
Researchers found that Polycomb repressive complex 1 (PRC1) and Polycomb repressive complex 2 (PRC2) maintain the skin-specific gene expression pattern necessary for proper development of the skin. The study suggests that targeting both complexes may be a more effective form of treatment for certain cancers.
Researchers found that a widely used cell type for brain research was misidentified as an endothelial cell, but could be reprogrammed to resemble one using gene expression manipulation. This study highlights the importance of rigorously evaluating stem cell models before embracing them.
Researchers at the University of New South Wales have created adaptive stem cells, called induced multipotent stem cells (iMS), from human fat. These cells can reprogram to act as stem cells and adapt to their surroundings, repairing a range of damaged tissues in mice.
WEHI researchers used 'single cell multi-omics' to identify a previously unknown lymphocyte progenitor, which could give rise to T and B lymphocytes. This discovery adds a new layer to the immune family tree and provides insights into how these cells develop.
Researchers at the Francis Crick Institute found the clock that sets the speed of embryonic development, discovering it's based on protein breakdown and replacement. Human motor neurons take twice as long to form as mouse motor neurons due to slower protein turnover.
A new study has identified a potential therapeutic target, fibronectin (FN1), to improve endocardial function and regenerate cardiac valves, septum, and coronary vessels in children with hypoplastic left heart syndrome. This discovery offers hope for increasing heart chamber size and reducing the need for multiple surgeries.
A new study reveals a network of genes that regulates the formation of the trachea and oesophagus in mice, providing insight into birth defects and potential treatments. The findings identify new genes essential for development, paving the way for lab-grown tissue to replace defective structures.
Researchers developed a model of the early embryonic brain, enabling them to study brain development and create tissue that resembles an embryonic brain. This breakthrough paves the way for faster production of specific nerve cells for stem cell therapy.
Researchers at Lund University have created a new model that mimics the early developmental stages of the human brain, allowing them to study how different regions form and potentially produce specific neural cells for treatment. The model, called MiSTR, enables faster production of neural cells for neurological diseases.
Researchers create a mouse model that can identify different cell types as they emerge and what genes each is turning on, providing a greater understanding of development, aging and disease. This system uses CRISPR gene editing technology and 'barcoding' to track thousands of cells simultaneously.
A new study found that nicotinamide inhibits aggressive cell transformations and reverses the development of fibrous membranes in the retina, potentially treating fibrotic eye diseases. The compound also promotes the transition from mesenchymal to epithelial cells, helping to preserve their original identity.
A study by Kanatsu-Shinohara et al. shows that spermatogonial stem cell transplantation can restore sperm development in infertile mice, offering potential treatment for male infertility. The research uses chemically castrated mice with a Cldn11 gene deficiency.
Scientists from Osaka University created a new cellular model of the human eye using hiPSCs, enabling them to isolate specific cells involved in eye development and study related diseases. The novel model uses PITX2, a key protein during eye development, to track cell expression and differentiate between eye cells.
Researchers found that immune cells from early development, called natural killer cells, are more effective in treating cancer. These cells can be developed from human pluripotent stem cells, providing a new supply of immune cells for immunotherapy.
Researchers developed a new single-cell sequencing technique to study the regulation of gene transcripts. They found that cells use distinct strategies to control transcript copies, involving both transcription and degradation processes.
The bioprinting research roadmap identifies key areas of progress and development, including advancements in bioinks, 3D printing processes, and crosslinking techniques. The report also highlights the potential for bioprinting to create complex biological models and therapeutic products.
Dresden scientists discovered two types of newly formed neurons in zebrafish brains, which have the same cell types as humans. These findings could lead to new therapies for stroke, craniocerebral trauma, and neurodegenerative diseases such as Alzheimer's and Parkinson's.
Scientists from Institut Pasteur have identified a key protein associated with ageing, which is progressively depleted in cells leading to senescence. The discovery sheds light on the mechanisms of senescence and its link to cellular ageing, paving the way for potential therapeutic targets.
A UC Riverside-led research team discovered that neural crest cells originate from the epiblast of chick embryos before the appearance of a definitive ectoderm or mesoderm. This finding provides new insight into the formation of this unique embryonic stem cell population and has implications for human development and health.
Researchers at UC Riverside are part of a US EPA plan to eliminate animal testing by 2035. They're developing a way to test chemicals using lab-grown human tissue, not live animals, to identify musculoskeletal birth defects. This non-animal approach will help reduce animal suffering and improve the accuracy of toxicity predictions.
A four-year study of over 500 research institutions found that promotion, recruitment, and retention of women to senior roles are lacking in STEM. Despite efforts by some institutions to implement supportive policies, the report suggests a persistent need for action to achieve gender equity.
Scientists have developed a retina-on-a-chip technology that recreates the human retina's complex tissue architecture, enabling the efficient study of eye diseases and screening for drug side effects. The tool uses living human cells with an artificial tissue-like system, mimicking the body's environment and blood vessels.
Researchers propose a revised alternative model of mammalian cellular totipotency, highlighting the distinction between genetic and epigenetic aspects. The study's findings suggest that while zygotes are genetically totipotent, they lack epigenetic totipotency and can reprogram to a totipotent state.
Researchers at UCSF and NIH create a new CRISPR technique that allows them to systematically alter gene activity in human neurons, enabling the study of neurological diseases. They discovered that housekeeping genes behave differently in neurons and stem cells, suggesting that these differences may play important roles in disease.
A new experimental system using reprogrammed neurons helps probe genetic and molecular underpinnings of drug-induced neurodevelopmental disorders. The research shows valproic acid causes severe impairments in immature brain cells, but no effects on mature neurons.
Scientists have successfully derived Expanded Potential Stem Cells (EPSCs) from both pig and human cells, offering new opportunities to study human development and regenerative medicine. These EPSCs possess developmental potency, enabling researchers to investigate pregnancy complications and develop treatments for diseases.
Researchers developed stem cell-based disease models to investigate early brain development linked to Down syndrome. They found that inhibiting the OLIG2 gene improved cognitive function in mouse models, suggesting it as a potential prenatal therapeutic target.
Researchers have created a method to track gene expression in cells during development, providing unprecedented detail. This technique could be used to develop future regenerative treatments for diseases like macular degeneration and other neurological disorders.
Researchers used zebrafish and human cells to determine how blood stem cells receive Wnt signaling, discovering the crucial role of the epidermal growth factor receptor. This finding may advance laboratory development of blood stem cells, potentially leading to off-the-shelf treatments for patients with blood diseases.
A new study at the University of Copenhagen found that immature intestinal cells can develop into stem cells based on their surroundings. The discovery may lead to more effective stem cell therapy for non-healing wounds and tissue repair.
Researchers from the University of Edinburgh discovered a protein that switches on an immune response in stem cells, protecting them from viruses. This finding could help develop more efficient stem cell therapies to treat diseases like Parkinson's and diabetes.
Researchers at Hebrew University have discovered a way to transform skin cells into the three major stem cell types that comprise early-stage embryos. This breakthrough has significant implications for modelling embryonic disease, placental dysfunctions, and infertility problems by creating human embryos in a petri dish.
Researchers have identified normal cells that can transform into cancerous cells in the brain, leading to a better understanding of childhood brain tumors. The study used single-cell sequencing technology and mouse models to pinpoint these cells, which were observed much earlier in fetal development than expected.
Researchers discovered a key clue into pancreas development by studying rare patients born without a pancreas. A previously unexpected pathway was identified, confirming its role in human and mouse pancreas formation.
Researchers developed a new machine learning model to describe the dynamics of cell development, estimating selection pressure and formation of new cells. The tool simplifies the interpretation of single-cell time series observations, shedding light on vital questions in biology.
A new review of 12 spaceflight experiments and simulated microgravity studies found that microgravity does not hinder stem cell-dependent tissue regeneration, but rather accelerates it. This valuable in vivo data has implications for human tissue repair and regeneration during spaceflight.
A new study reveals that diabetes impairs the antibacterial activity of multipotent stromal cells (MSCs), leading to diminished capacity to fight off bacterial infections. This finding has significant implications for the use of MSCs as a therapeutic strategy in treating diabetes and other autoimmune disorders.
New advances in stem cell biology and genetic engineering could lead to more effective treatments for Parkinson's disease, including cell replacement therapies. The development of quality-assured stem cells with unlimited production capacity offers a promising approach to alleviating motor symptoms.
A new method of growing stem cells has been discovered using the tropoelastin protein, which could lead to significant cost savings in treatment options. This breakthrough discovery, published in PNAS, uses a cost-effective approach to encourage the growth and recruitment of mesenchymal stem cells.
A study by Salk researchers reveals measurable differences in the patterns and speed of development in stem cells from individuals with autism spectrum disorder. The findings could lead to diagnostic methods to detect ASD at an early stage, potentially allowing for preventive interventions.
Researchers found that reproductive stem cells boost production of non-coding RNA elements to suppress jumping gene activity and activate DNA repair processes, enabling normal egg development. Temperature influences sterility in fruit flies, with a specific temperature range controlling jumping gene invasion intensity.
The new law allows investigational stem cell treatments for patients with certain severe chronic diseases or terminal illnesses, sparking debate over increased access vs. unproven treatments.
Researchers at the Gladstone Institutes have developed a new method to study the earliest stages of human development, mimicking how cells self-organize into distinct populations. By silencing specific genes in human pluripotent stem cells, they created ring patterns that influence cell behavior and future identity.
Researchers report on the most in-depth study to date of how human stem cells can be turned into heart cells, revealing unique patterns of gene activity associated with cardiac cell development. The findings provide new insights into how the heart builds itself and may lead to new approaches for repairing damaged hearts.
Researchers have found that the Wnt pathway likely functions upstream of and activates the Hh pathway in response to injury, enabling proper tissue regeneration. The study suggests a new mechanism for appendage regeneration, with implications for human limb repair and regeneration.