Articles tagged with Stem Cell Development
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Scientists at Karolinska Institutet have discovered a key role for the signal molecule TGF-beta in regulating brain stem cells' development potential. By understanding this mechanism, researchers hope to develop new treatments for neurodegenerative diseases.
Researchers discovered a mutation in adult fruit flies that prevents testicular cells from transforming into ovaries, maintaining sex identity. The study's findings have implications for understanding cell fate conversions and may lead to new therapeutic approaches.
UC San Diego has been designated as one of three 'alpha clinics' by the California Institute for Regenerative Medicine to accelerate clinical development of emerging stem cell therapies. The designation will support the establishment of a comprehensive regenerative medicine clinical hub and attract patients, funding agencies, and study...
Researchers at Harvard University developed a barcoding tool to track the origin of blood cells, revealing that progenitor cells, not blood stem cells, give rise to specific blood cell types. This discovery challenges scientific dogma and has potential applications for blood regeneration therapies.
A new protocol converts stem cells into reliable, insulin-producing cells in about six weeks, a significant improvement over previous methods. The breakthrough could lead to an unlimited supply of insulin-producing cells to treat patients with Type 1 diabetes.
Researchers have developed new genomic editing tools to create genetically identical patient-derived iPSCs for disease modeling. These advancements will improve the accuracy of drug testing and cell-based therapies, revolutionizing human disease modeling and treatment.
Researchers found MSCs in patient's blood after severe trauma, suggesting they are released from bone marrow into bloodstream following organ damage. The study provides conclusive evidence for the mobilization and migration of MSCs in humans.
Researchers have identified biochemical pathways that can inhibit reprogramming of gene activity in adult human cells, increasing the efficiency of stem-cell production. This breakthrough could lead to accelerated development of replacement tissue for failing body parts.
Mayo Clinic researchers discover a strategy to significantly reduce the risk of tumor development using pretreatment with genotoxic etoposide. This approach establishes an adjunctive therapy to harness the clinical value of iPSC-derived cardiac regeneration, providing a promising breakthrough for heart disease treatment.
Researchers developed a powerful single-cell technique to study environmental effects on DNA, mapping epigenetic marks in individual cells. This approach has the potential to enhance clinical applications like cancer therapy and fertility treatments.
Researchers have identified a key gene, ASF1A, that enables cellular reprogramming and the development of stem cells. This finding could lead to the creation of induced pluripotent stem cells derived from adult tissue, offering potential for safer cell-therapy strategies.
The 2014 World Stem Cell Summit will bring together leading scientists, business leaders, and regulators to discuss the future of regenerative medicine. The summit will feature over 200 prominent speakers from more than 40 nations, exploring the latest scientific discoveries and innovative business models.
Researchers at Case Western Reserve University have identified a new class of genetic switches, called seed enhancers, that guide the development of pluripotent stem cells. These enhancers play roles from before birth to adulthood and hold promise for regenerative medicine and disease prevention.
Researchers developed methods to convert stem cells into eye cells that could be used to replace damaged tissue in patients with impaired vision. The studies involved converting cells into nerve cells or introducing stem cells to a growth factor, resulting in tissue resembling the developing eye.
Researchers have identified a novel marker, glycan O-GLcNAc, on the surface of human umbilical cord blood stem cells. This discovery may play a crucial role in cell signaling pathways regulating embryonic development and has potential implications for stem cell therapies.
A new method has been developed to derive large quantities of highly potent mesenchymal stem cells from human embryonic stem cells. These cells display potent immunomodulatory and therapeutic properties, offering promise in regenerative medicine.
A recent study published in Stem Cell Reports identified the earliest arising hematopoietic stem cell (HSC) precursors based on their ability to generate all major blood cell types. This discovery may be beneficial for creating purer, cleaner populations of these precursor cells for clinical treatments.
Two proteins, HIF1α and HIF2α, play a key role in the formation of human stem cells through reprogramming. The findings advance understanding of stem cell development and suggest potential targets for new cancer therapies.
Researchers at UC San Diego have developed a humanized mouse model that can prevent the immune system from rejecting human embryonic stem cells. This breakthrough allows for potential use in developing stem cell therapies and understanding how tumors evade the immune system.
The World Stem Cell Report 2013 presents innovative solutions for accelerating stem cell treatments and eventual cures, addressing regulatory, legal, and ethical roadblocks. The report is a benchmark guide for moving the field forward, supporting the 2013 World Stem Cell Summit.
Scientists at Brigham and Women's Hospital have developed a method to grow extensive numbers of intestinal stem cells, which can then be directed to mature into different types of intestinal cells. This breakthrough could lead to the creation of a new gut for patients with gastrointestinal disorders.
Researchers have discovered that the immune system forms in the embryo's yolk sac before blood stem cells, potentially leading to a better understanding of childhood diseases such as leukaemia. The study provides new insights into the development of immune-competent cells and their relationship with blood stem cells.
The World Stem Cell Report 2013 outlines critical challenges and key action items to overcome them, including regulatory compliance and education for physicians and patients. Key opinion leaders like Paul Knoepfler bring a fresh perspective to the stem cell universe, highlighting areas of progress and need for advancement.
The New York Stem Cell Foundation has awarded $10.5 million to seven researchers to advance their studies in stem cell biology and neuroscience. The new NYSCF – Robertson Investigators will receive funding over five years to expand their laboratories and train other scientists.
Researchers at Weill Cornell Medicine discovered that blood vessel cells can release beneficial molecules to repair and regenerate organs. The study found that endothelial cells possess tissue-specific genes that code for unique growth factors and adhesion molecules.
Researchers at the University of Illinois have characterized stem cells in larval schistosomes, which may help control the parasite's life cycle and potentially lead to its eradication. The study discovered molecular signatures similar to those found in free-living flatworms, allowing schistosome larvae to rapidly reproduce.
A new study by The Endocrine Society finds that early exposure to BPA significantly increases the risk of both prostate cancer and a precancerous condition known as prostate epithelial neoplasia. The study used human prostate stem cells from organ donors to grow prostate tissue in a mouse model.
The 2013 World Stem Cell Report will be published as a special supplement to the peer-reviewed journal Stem Cells and Development. The report delivers an orbital and unique viewpoint on regenerative medicine, featuring content from leading policy-makers, regulators, and experts.
A new stem-cell based drug screening technology has identified a compound that prolongs the life of motor neurons in both normal and ALS-affected cells. The study found kenpaullone, which inhibits HGK, an enzyme associated with motor neuron death, to be more effective than two failed drugs in human clinical trials.
A first-in-humans study demonstrates that cardiopoietic stem cell therapy can improve heart pumping function and fitness in heart failure patients. Patients in the treatment group experienced a significant improvement in ejection fraction, compared to those in the control group.
New York Stem Cell Foundation researchers have developed a quantitative protocol to consistently harvest early-reprogrammed cells, resulting in standardized iPS cell lines. This method enables the derivation of 228 individual iPS cell lines, which can be compared to one another for use in drug screens and cell therapies.
Researchers at the New York Stem Cell Foundation have developed a 3D stem cell culture technique to study Alzheimer's disease. This technique enables the creation of neuron aggregates that can be used to model and study diseases such as Alzheimer's and Parkinson's.
A team of researchers found that a specific histone variant, macroH2A, prevents normal cells from being reprogrammed into cells resembling stem cells. This discovery has broad implications for how cells change during both normal and disease development.
Researchers at Fox Chase Cancer Center found that two antagonistic proteins help keep leukemia at bay by maintaining balance in stem cell production. The study suggests that new compounds could fight cancer by targeting the pathways responsible for regulating these proteins.
Researchers at Georg-August-Universität Göttingen used parthenogenic stem cells to create cardiomyocytes and engineered heart muscle with normal properties. This breakthrough demonstrates the potential of parthenogenic stem cells for tissue engineering and could lead to new cell replacement therapies.
Researchers at the University of Edinburgh discovered that bacteria can change the properties of supporting cells within the nerve system, called Schwann cells, to mimic stem cells. This process enables bacteria to spread throughout the body and potentially aid research into degenerative conditions.
Researchers have identified two proteins, Sip1 and Unc5b, crucial for interneuron development and migration to the cerebral cortex. Disruption of these proteins can lead to brain disorders such as epilepsy, Alzheimer's, and schizophrenia.
Researchers at the University of Sheffield recreated randomly distributed sticky spots in stem cells to maximize adhesion and act as internal scaffolding. The findings will help inform biomaterials development for optimal stem cell growth.
Researchers at Johns Hopkins have successfully converted adult blood cells into induced pluripotent stem cells (iPS) using a virus-free method, achieving efficiencies of 50-60% in laboratory experiments. This breakthrough could lead to new treatments for cancer and regenerative medicine applications.
Researchers at Cedars-Sinai Medical Center are developing a new treatment for ALS using a combination of stem cells and gene therapy. The grant will fund an 18-patient clinical trial for ALS in four years, with the potential to protect damaged motor neurons and deliver the protein GDNF exactly where it's needed.
Scientists at Queen Mary University of London have discovered a novel link between Keratin K15 and FOXM1 genes, which may lead to the development of targeted anti-cancer drugs. This breakthrough could potentially prevent cancer recurrence by targeting cancer stem cells.
Scientists at the University of Liverpool have developed methods to track stem cells in the body, improving understanding of their behavior after transplantation. They use superparamagnetic iron oxide nanoparticles and advanced imaging systems to monitor stem cell movement and behavior.
Researchers at Michigan Medicine developed a new method to generate cardiac muscle patches from stem cells, which can mimic the heart's crucial squeezing action. The engineered cells displayed activity similar to most people's resting heart rate and could potentially be used to help 2.5 million people with arrhythmia.
Researchers have successfully formed human-derived stem cell tissue resembling the retina, a breakthrough that could lead to new treatments for visual impairments. This achievement uses optimized cell culture methods and demonstrates the potential of human embryonic stem cells for regenerative medicine.
Researchers at Northwestern University have identified the molecular trigger of uterine fibroids, a single stem cell mutation that activates other cells to grow uncontrollably. The study suggests a new direction for developing therapies to treat these tumors, which affect an estimated 15 million women in the US.
Researchers at TUM discovered that macrophages can originate from two distinct cell lines: one from hematopoietic stem cells and the other from yolk sac cells. The study reveals that yolk sac-derived macrophages migrate to organs during embryonic development and remain there, while blood-circulating macrophages are replaced by stem cells.
Scientists at DanStem and Hagedorn Research Institute map new knowledge about insulin production, including the Notch signaling mechanism's role in controlling stem cell development. This breakthrough enables researchers to design new experimental methods for cultivating stem cells into insulin-producing beta cells.
A combination approach therapy targeting β-catenin pathway may stamp out CML for good. Leukemia stem cells are vulnerable to treatments aiming at this pathway, unlike normal blood stem cells.
The study reveals that the REST molecule acts as an adapter for genetic switches, coupling molecular on-off switches with neural genes to regulate neuronal development. This mechanism is essential for proper brain function and may be linked to cancer and other diseases.
A team led by Professor Kevin Shakesheff has created an artificial 'womb' that allows for the growth of embryos outside the body, revealing new aspects of embryonic development. By observing critical stages in real-time, scientists have gained insights into the process of head formation and the role of pioneer cells in leading migration.
Researchers have developed a method to overcome the barrier of implantation into the womb and study embryonic development for the first 8 days. This allows them to understand how clusters of extra-embryonic cells signal where to make the head of the embryo.
Researchers found that fat-derived stem cells thrive on stiff surfaces and form myotubes when matured, a crucial step in muscle development. These cells may offer new therapeutic possibilities for muscular dystrophy patients.
Scientists developed a way to deliver therapeutic human cells to diseased areas using superparamagnetic iron oxide nanoparticles. The new process, reported in ACS' journal Langmuir, successfully attaches these nanoparticles to the outside of human cells without causing damage.
Researchers developed a new method for reprogramming human cells into stem cells, increasing efficiency by 100-fold and producing high-quality cells faster. This breakthrough has potential applications in medicine, such as organ replacement, bone replacement, and treatment of neurodegenerative diseases.
Scientists at Gladstone Institutes have gained new insight into the delicate relationship between two proteins that regulate stem cells in the heart and may contribute to certain types of cancer. The study reveals an unexpected cross-talk between Notch and Beta-Catenin, which together control cell growth and fetal development.
A international consortium has developed a novel method to target specific genes in mouse embryonic stem cells, allowing for the disruption of almost 9,000 genes. This resource will enable researchers to study gene activity in models of human disease, advancing our understanding of gene function and its role in mammalian biology.
A team of scientists at A*STAR have discovered a way to convert proteins involved in controlling genes into other types of cells by changing a single amino acid. This breakthrough has implications for generating stem cells more efficiently and could help develop treatments for diseases such as diabetes and Parkinson's disease.
Jason S. Meyer, assistant professor of biology at IUPUI, is honored by the Association for Research in Vision and Ophthalmology (ARVO) for his groundbreaking study on modeling early retinal development using human embryonic and induced pluripotent stem cells.
Cell Press won the PROSE Award for Excellence in Biological & Life Sciences for its 'Article of the Future' format, which offers a personalized reading experience. This award reflects Elsevier's and Cell Press' commitment to evolving scientific publications with new technologies.
Researchers aim to replicate Parkinson's disease in lab cells and investigate inflammation to find new therapies. Led by Fred H. Gage, the team will use human induced pluripotent stem cells derived from patients to study neurodegeneration.