Articles tagged with Stem Cells
WeHI researchers have developed a new single-cell technique, SIS-seq, to understand the programming behind stem cells making particular cell types. The research uncovered 30 new genes that program stem cells to make dendritic cells that kick-start the immune response.
Researchers used single-cell RNA sequencing to track genetic activity in nearly 20,000 cells as they formed an Arabidopsis leaf. They found a surprising abundance of ambiguity in how cells traversed various identities, particularly early on within the stem cell population. The study reveals that cells may double-back on their developme...
Researchers found that skeletal muscle satellite cells proliferate better in low glucose environments, contrary to conventional wisdom. This discovery could lead to significant breakthroughs in biomedical research and the development of new treatments for muscle loss associated with diabetes.
A clinical trial combining CRISPR technology with UCLA and UCSF expertise aims to directly correct the sickle mutation in blood stem cells, addressing the underlying cause of debilitating sickle cell disease. The goal is to out-compete native sickle cells by correcting 20% of genes.
Researchers at the University of Southampton developed a new technique using gold nanoparticles to detect and enrich skeletal stem cells. The method is simpler, quicker, and up to 50-500 times more effective than existing methods, offering promising areas for bone disease treatment.
The research team identified vinculin as critical for maintaining the quiescent properties of hair follicle stem cells. Vinculin's loss leads to weak cell-cell junctions and dysregulated YAP1 pathway, causing increased cell proliferation and loss of quiescence.
Researchers discovered that plants have a 'potassium-sensitive niche' in the root tip that reacts to potassium deficiency, directing signalling pathways to mediate adaptation. This finding sheds light on how plants adapt to essential nutrient potassium, which is crucial for growth and stress resistance.
Researchers discovered that ferulic acid primed stem cells can repair bone damage caused by radiation. The study found that FA enhances the bone repair effects of skeletal stem cells by activating specific pathways, making it a potential novel strategy in treating irradiated bone injury.
Aging leads to hair follicles adopting atypical senescent type of asymmetric cell division, resulting in the generation of aberrantly differentiating cells. This disruption causes stem cell exhaustion and loss, ultimately leading to hair thinning and hair loss.
Scientists have successfully grown miniature human tear glands in a lab, allowing them to study how cells produce tears and what goes wrong. The model has promise for identifying new treatments for patients with tear gland disorders, such as dry eye disease.
Researchers identified rare cell types in esophagus, stomach and small intestine using scRNA-seq. They found a cell type responsible for water secretion in humans, linking it to cystic fibrosis.
Researchers have successfully grown a lifelike piece of bone tissue from human stem cells, providing unprecedented understanding of the complex process of bone formation. The new organoid contains two types of cells that are essential for successful bone development and offers promising possibilities for personalized medicine.
Researchers discovered that oscillation in muscle tissue is critical for transforming stem cells into muscle cells. The Delta-like1 protein plays a key role in this process, regulating the balance between self-renewal and differentiation.
Researchers from UT Southwestern Medical Center identified the cells responsible for liver tissue maintenance and regeneration, specifically those in zone 2. These cells can evade death, regenerate hepatocytes, and sustain liver function after damage.
Researchers developed a microchip to identify and separate baby mouse heart cells, allowing for the study of their physico-mechanical properties. The findings could provide insights into developing materials that repair heart tissue, with potential applications in cardiac patches, scaffolds, and hydrogels.
Scientists have developed a high-tech fluorescence microscopy technique allowing them to film cells inside the breast for the first time. This new protocol provides detailed instructions on how to capture hi-res movies of cell movement, division and cooperation in hard-to-reach regions of breast tissue.
The JDRF Center of Excellence in New England will focus on accelerating gene editing approaches for beta cell replacement therapy, aiming to solve the problem of immune rejection of beta cells. The center will collaborate with leading Massachusetts-based experts to develop new technologies and strategies to prevent beta cell destructio...
Scientists have successfully grown lab-grown 'mini-bile ducts' that can be used to repair damaged human livers, paving the way for cell therapies to treat liver disease. The technique uses organoids - clusters of cells that mimic tissue architecture and function - to repair bile ducts.
A study reveals how SARS-CoV-2 exploits an immune system defense mechanism to multiply in mucous membrane cells, leading to severe illness. Researchers found that a strong immune response can increase the virus's ability to enter cells, paving the way for infection.
Researchers at Monash University have discovered a factor that triggers muscle stem cells to proliferate and heal, leading to the complete regeneration of muscle and normal movement. The protein, NAMPT, was found to stimulate muscle growth by 'cuddling' muscle stem cells, effectively replacing damaged tissue.
Researchers at Cincinnati Children's Hospital Medical Center have developed a 'map' of bone marrow tissue, providing new insights into how tiny blood vessels organize the bone marrow and regulate blood cell production. This discovery advances understanding of how to control the production of specific blood cells at will.
Scientists discovered that DCM-causing LMNA gene mutations disrupt the 'identity' of heart muscle cells by altering nuclear lamina-genome interactions and epigenetic marks. This disruption leads to abnormal gene regulation and loss of mechanical elasticity in heart cells.
Researchers at MIT have successfully grown structures made of wood-like plant cells in a lab, hinting at the possibility of more efficient biomaterials production. The team demonstrated the concept using zinnia leaves, growing rigid, wood-like structures by controlling the levels of two plant hormones.
Researchers have successfully treated two patients with beta thalassemia and sickle cell disease using CRISPR-Cas9 gene editing, a promising treatment for these severe red blood congenital diseases. The new approach uses the patient's own cells and eliminates the risk of rejection or graft-versus-host disease.
A new biomaterial, CartiScaff, has been developed using the natural cartilage matrix to support cell growth and regeneration. This innovative material shows promise in improving cartilage repair and potentially expanding treatment options for joint injuries.
Researchers at Northwestern University have found evidence deep within the skin about the mechanisms controlling skin repair and renewal. The study revealed that non-coding segments of DNA, previously considered 'genetic junk', play a crucial role in regulating gene expression in epidermal stem cells.
Researchers created novel organoid models for the cervix, identifying key turning points in cancer development and the origin of precancerous cells. They discovered two distinct stem cells controlling epithelial lineages at the cervical transition zone.
Scientists at the University of Washington develop a technique to modify biological polymers with protein-based biochemical messages, triggering cell behavior. The approach uses near-infrared lasers to attach proteins to scaffolds made from collagen or fibrin, creating intricate patterns that control cell growth and signaling.
Scientists regenerate parts of the skull using stem cells, correcting skull shape and reversing learning and memory deficits in young mice with craniosynostosis. The study holds great potential for less invasive therapies for children with this common birth defect.
Researchers found that propylene glycol and vegetable glycerol cause gut inflammation by breaking down zipper-like junctions between cells. Chronic e-cigarette use can lead to a 'leaky gut,' allowing microbes and molecules to seep out, resulting in chronic inflammation.
Researchers designed proteins to form honeycomb structures that block uptake of receptors from cell surfaces. This discovery could enable new materials for modulating cell behavior and treating diseases such as sepsis, COVID-19, heart disease, and diabetes.
Researchers developed a method to predict therapeutic efficacy of stem cell treatment for vascular diseases based on initial distribution and migration of transplanted cells. The method enabled predicting superior therapeutic efficacy when treatment cells form into condensed 'round shape' during initial treatment.
A recent study by Brazilian researcher Emmanuel Albuquerque de Souza shows that maresin and resolvin produced from omega-3 fatty acids can stimulate periodontal ligament stem cells even in the presence of inflammation. This finding has significant implications for regenerative therapy in treating periodontal disease.
Research reveals that telomere shortening, linked to excessive stem cell division, predisposes fat cells to premature senescence and tissue dysfunction. Shorter telomeres in patients with metabolic dysfunction also showed resistance to weight loss treatments.
The 16th World Stem Cell Summit will be co-located with the 7th annual Regenerative Medicine Essentials Course, featuring joint single-track programming on stem cells, biomaterials, cell therapies, clinical trials, and regulatory matters. The event aims to accelerate regenerative medicine and deliver cures.
Researchers successfully rebuilt a whole functioning human thymus from human stem cells and bioengineered scaffolds. The breakthrough could lead to new techniques for growing artificial organs and treating severe immune deficiencies.
Researchers at Gladstone Institutes have identified a potential therapy for calcific aortic valve disease, which affects millions of Americans. The new drug candidate has shown promise in correcting the underlying network that leads to calcification and hardening of the valves.
Researchers found that pre-treating early outgrowth cells with a chemical activator slows the development of atherosclerosis in mice. The study showed that this treatment reduced inflammation and plaque buildup in arteries, providing potential hope for treating cardiovascular diseases.
Researchers have successfully bioprinted miniature human kidneys in a lab using cutting-edge technology. The study validates the use of 3D bioprinted human mini-kidneys for screening drug toxicity, paving the way for new treatments and potentially lab-grown transplants.
A new study from UCLA researchers found that smoking cigarettes causes more severe COVID-19 infection in the airways by blocking immune system messenger proteins. The study used a model of airway tissue created from human stem cells to understand how SARS-CoV-2 virus affects smokers.
An Italian team has successfully recreated the pathological condition of Kabuki syndrome in a test tube, revealing the impact on the cell nucleus and bone formation. The study identifies a potential therapeutic approach by targeting a nuclear protein that responds to mechanical signals.
Langerhans cells play a crucial role in preventing acute graft-versus-host disease by inducing the death of immune cells. Researchers at University of Tsukuba found that enhancing B7 protein expression on Langerhans cells could prevent aGVHD development, leading to improved treatments and patient quality of life.
Scientists have identified a subgroup of stem cells that retains regenerative capacity well beyond geriatric age, suggesting new avenues for improving muscle health in elderly individuals. The discovery provides insight into the FoxO signalling pathway and its role in maintaining youthful gene expression.
Researchers have grown three-dimensional models of key lung tissue, known as 'mini-lungs,' to study how SARS-CoV-2 damages the lungs. The models revealed that viral replication occurs rapidly within six hours, triggering an immune response and leading to cell death and damage.
Researchers at Duke University developed lab-grown mini-lungs that mimic human lung air sacs, allowing for the study of SARS-CoV-2 infection and lung damage. The model enables high-throughput science to screen for new drug candidates and identify self-defense chemicals.
The NIH has awarded a 4D Nucleome grant to Gladstone researchers Benoit Bruneau and Katie Pollard to investigate DNA folding in the developing heart. They aim to identify genetic causes of congenital heart disease, which affects one in 100 live births worldwide.
Researchers found that a protein called Rictor plays a key role in regulating stem cell metabolism, which can help prevent hair loss. The study used a genetic mouse model to demonstrate that the absence of Rictor protein impaired stem cell function and led to hair loss.
Researchers found that estrogen receptor beta is essential for female skeletal muscle growth and regeneration, promoting muscle stem cell proliferation and inhibiting cell death. In contrast, male mice lacking the ERβ gene did not show impaired muscle regenerative capacity, suggesting a gender-specific mechanism.
Researchers at Kumamoto University discovered that damaged muscle fibers leak components that activate dormant satellite cells. These cells then proliferate and regenerate muscle fibers, a highly rational mechanism for tissue repair. The study identifies metabolic enzymes like GAPDH as key activators of satellite cells.
A new study reveals that stem cells contribute to the formation of osteophytes, or pathological bone spurs, in arthritis patients. The researchers identified a specific type of stem cell with activity in the Sox9 gene as the major culprit behind this process.
Forsyth researchers discovered a way to reverse periodontal disease by stimulating stem cells with Maresin-1 and Resolvin-E1, two synthetic lipid mediators. This finding offers new therapeutic possibilities for treating systemic diseases associated with inflammation.
Researchers at the University of Washington and Rice University are working on a novel technology that uses thermofluidic systems to manipulate gene expression in cells within 3D artificial organs. This could lead to the creation of functional artificial liver tissues that can be used for studying disease and developing new treatments.
Researchers discover that hair follicle stem cells can prolong their life by switching metabolic state in response to low oxygen concentration, preventing age-induced hair loss. The team identified Rictor signaling as crucial for this process, which involves a shift from glutamine metabolism to glycolysis.
MarrowQuant, a new digital pathology software, can quantify bone marrow components in histological images without bias. The tool builds maps based on values to complement images, potentially re-examining historical sample collections and old clinical trials.
Researchers have designed a multifunctional cell therapy system to treat ulcerative colitis, with encouraging results obtained in animal models. The system incorporates stem cells, biomaterials, and microparticles that release interferon, aiming to improve cell persistence and biosafety.
A bioelectronic device driven by a machine learning algorithm successfully controlled the membrane voltage of human stem cells for 10 hours. The closed-loop system countered the natural self-regulating feedback process known as homeostasis, which is essential for cell physiology and functions.
Researchers have made significant breakthroughs in understanding the biology of schistosomes, a parasitic flatworm that causes schistosomiasis. By identifying key vulnerabilities, scientists hope to develop new treatments for this deadly disease, which affects up to 250,000 people annually.
A research team led by Prof. Dr. Robert Grosse has found that bundled fibers of actin play a crucial role in the expansion of cell nuclei after division. This process is essential for reorganizing genetic information and processing chromatin.
A team of researchers at Boston University has found that SARS-CoV-2 initially suppresses the lung cells' ability to activate the immune system, triggering a deadly inflammatory pathway. This activation leads to an influx of immune cells and an increase in inflammation in the lungs.
A new material has been developed to transplant bone-forming stem cells into severe bone fractures and speed up the healing process. The bone-like bandage is coated in a protein used for growth and repair, allowing it to enhance the natural ability of bones to heal.