Articles tagged with Stem Cells
A new material has been developed to transplant bone-forming stem cells into severe bone fractures and speed up the healing process. The bone-like bandage is coated in a protein used for growth and repair, allowing it to enhance the natural ability of bones to heal.
Researchers at Stanford University discovered a cellular compass that guides stem cell division in plants, influencing the formation of tiny pores called stomata. The nuclear position, controlled by proteins, regulates stem cell divisions, ultimately affecting leaf function.
Researchers at EPFL create miniature intestines using stem cells and hydrogel scaffolds, achieving high physiological relevance. The new organoids can regenerate, model inflammatory processes, and host-microbe interactions, opening up exciting perspectives for disease modeling, drug discovery, diagnostics, and regenerative medicine.
Researchers used CRISPR-Cas9 to remove endogenous germline in recipients, allowing for donor-derived spermatogenesis. The approach shows promise for improving livestock and conserving endangered species.
Researchers at UIC develop a unique method for precisely controlling the deposition of hydrogel to coax bone marrow stem cells into specialized cells. This technique allows for more accurate interactions between cells and their surroundings, potentially leading to breakthroughs in regenerative therapeutics.
Salk Institute scientists develop transplantable human insulin-producing pancreatic cell clusters that evade the immune system, providing sustained blood glucose control without immunosuppressants. The cells were created using stem cell technology and a protein called WNT4 to induce a genetic switch that makes them functional.
Researchers at UCalgary have made significant breakthroughs in understanding how skin heals after severe burns, identifying a population of progenitor cells that can regenerate tissue. By modifying genetic programs and wound environments, the study offers hope for developing drugs to promote true regeneration and prevent scarring.
Researchers discovered that DNA damage in moss Physcomitrella patens causes cells to reprogram into stem cells, producing an entire plant body. This phenomenon is a new adaptive strategy for plants under harsh environments.
A new analysis of data from the ALLSTAR study published in the European Heart Journal shows that cell infusions, also known as cardiosphere-derived cells (CDCs), can benefit patients with heart disease by reducing the volume of blood the heart holds and a blood protein that measures heart failure severity. The findings contradict previ...
Joslin Diabetes Center researchers discover targeting renalase protein strengthens beta cells against stress and autoimmune attack. An FDA-approved drug, pargyline, is shown to protect human cells, potentially slowing disease progression in a clinical trial.
Researchers at Ohio State University found that spinal cord injuries in mice cause an acquired bone marrow failure syndrome contributing to chronic immune dysfunction. The study also discovered a potential treatment using the FDA-approved drug Plerixafor to mobilize cells from the bone marrow niche and restore immune function.
Scientists identified two distinct aging paths in yeast cells, with one due to nucleolus decline and the other due to mitochondrial dysfunction. By understanding this master circuit, researchers developed a novel approach to extend lifespan through genetic programming.
Researchers found that arsenic trioxide can restore the body's natural antiviral factories to fight adenovirus infections. The medication has been approved for leukemia treatment and shows promise in inhibiting adenovirus replication without developing resistance.
A clinical trial found that breast augmentation with ASC-enriched fat grafts resulted in significantly better outcomes compared to non-enriched grafts. The study showed improved retention rates and histological appearance of the grafts, making ASCs a promising tool for increasing graft success.
Researchers at the University of Cincinnati found that a strain of E. coli Nissle protects human cells against pathogenic E. coli bacteria. The study suggests that Nissle may be used to develop a treatment for E. coli infections, which affect millions annually.
Researchers found that random movements allow cells to overcome pushing forces and return to the stem cell niche. The team's findings suggest that the dynamics and geometry of tissues play a crucial role in defining stem cell number and dynamics, potentially opening new insights into organ renewal.
Researchers created miniature gut organoids that demonstrate segment-specific gene activity patterns and immune binding sites, shedding light on the causes of inflammatory diseases. These findings have implications for understanding cancer development and human disease.
Researchers at Boston University and Boston Medical Center have assembled the largest repository of patient-derived stem cells from AATD patients. The cells can be used to study genetic diseases and potentially find new treatment approaches for AATD.
A team of UConn engineers has developed a scaffold that generates a controllable electrical field to encourage bone growth, providing a new approach for treating serious injuries. The device uses non-toxic poly(L-lactic acid) polymer and remotely-controlled ultrasound to stimulate bone regeneration.
Researchers found that thorns in citrus plants arise from stem cells, which undergo a programmed arrest to create the sharp pointy end. This discovery may lead to safer fruit harvesting and more fruitful orchards.
Researchers at Texas A&M University have developed a 2D nanosheet that can adsorb near-infrared light and modify cell behavior. This discovery holds promise for controlling cellular functions using light, which could lead to new approaches in cancer treatment and regenerative medicine.
Researchers at Lund University have identified CXCR4 as essential for the survival of leukemia stem cells, which can be controlled by cutting off the gene using CRISPR technology. This discovery reveals a fundamental difference in how leukemia stem cells and normal blood stem cells are regulated.
Researchers at the National University of Singapore have developed a method to rejuvenate fibroblasts by geometrically confining them on micropatterns. The resulting cells recover their ability to contract and exhibit reduced DNA damage and enhanced cytoskeletal gene expression.
Researchers found that stem cells collected from human amniotic membrane can slow the progression of scarring in pulmonary fibrosis by controlling immune cell activity. This pre-clinical study could lead to new treatments for this deadly disease, affecting 13-20 out of every 100,000 people worldwide.
A new method, called localized electroporation, enables repeated, non-destructive sampling of cells to study dynamic processes over time. This allows researchers to investigate how enzymatic activity varies between healthy cells and cancerous tumor biopsies.
A recent clinical trial has demonstrated the ability of a stem cell-based topical solution to regrow hair in individuals with androgenetic alopecia, also known as male-pattern baldness. The study found that the treatment led to significant increases in both hair count and follicle diameter.
Researchers conducted a two-center trial of autologous CD34+ cell therapy in 20 NOCAD patients with persistent angina, showing significant improvement in coronary flow reserve, angina frequency, and quality of life. The results demonstrate the potential of CD34+ cell therapy as a promising therapy for CMD patients with angina and NOCAD.
A bioethicist has sounded the alarm about unlicensed and unproven stem-cell-based 'therapies' being marketed for COVID-19 prevention and treatment. These businesses are taking advantage of hope and desperation, but rigorous clinical trials have not been conducted to establish their safety and efficacy.
Researchers have found that stem cells in planarians can postpone their own death to respond to an injury, allowing them to gather around the site of the wound and mount a response. This unique ability has implications for cancer research and therapies, particularly when examining chemotherapy and surgery options.
Researchers at the University of Illinois used nanostimulators to boost stem cells' regenerative powers, increasing blood flow and oxygen levels in ischemic limbs. The treatment showed improvements in mobility and strength, offering a promising approach for muscle repair.
Northumbria University researchers received funding to advance our understanding of the Sun's impact on planets. They developed nanostimulators that enhance stem cells' regenerative powers, showing improved muscle recovery in mice with ischemia.
Hyperdiploid B-ALL, the most common subtype of pediatric leukemia, arises from a malfunctioning Condensin complex, Aurora B kinase, and mitotic checkpoint in cell division. Researchers have unveiled the molecular mechanisms underlying HyperD-ALL origin and progression.
A new study identifies several small molecules that selectively lengthen telomeres in stem cells, potentially treating telomere diseases such as dyskeratosis congenita. The compounds, including BCH001 and RG7834, boost TERC levels and restore telomere length, showing promise for a clinical treatment.
A new technique developed by researchers at the University of Tokyo allows for the imaging of live cells in greater detail than ever before. The method combines two pre-existing microscopy tools to create virtual color images of molecular structures without needing artificial dyes or fluorescent tags.
Abnormal stem cells in COPD patients drive key features of the disease, including mucins that block airways and fibrosis and inflammation. Researchers have identified specific cells responsible for COPD pathology and are screening them against drug libraries to discover new treatments.
Researchers at the University of Bristol identified new mechanisms by which nanopillar structures kill bacteria, including cell impedance and oxidative stress. This breakthrough aims to develop antimicrobial surfaces for biomedical applications, such as medical implants and devices.
Researchers at Karolinska Institutet and UBC found that a genetically modified variant of ACE2 reduced SARS-CoV-2 viral growth by a factor of 1,000 to 5,000 in cell cultures. The study suggests the potential for a novel drug treatment to help patients with early-stage COVID-19.
Scientists at Leibniz-IZW developed a method to isolate and cryopreserve testicular cells of threatened or endangered felines. The method allows for the safekeeping of gametes, enabling conservation efforts through biobanking and future applications in species preservation.
Researchers found that exercise only improves muscle strength when specific muscle cells age, report Hokkaido University scientists. A cell-aging drug combined with exercise restored FAP aging and improved muscle function and regeneration in mice with chronic inflammatory myopathy.
Researchers have engineered silkworms to produce different variants of E-selectin, a critical adhesion molecule involved in inflammation, cancer, and disease processes. The study found that the connecting arm of E-selectin is crucial for binding, while longer armed proteins are better at tethering blood stem cells.
A bacterial superbug can prevent stem cells in the gut from regenerating the inner lining of the intestine, causing potentially severe disease. This damage impairs tissue repair and recovery from disease, particularly in older adults.
Researchers discovered that keratohyalin granules, which form through phase separation, carry molecular messages that prompt skin cells to flatten and die. This process is crucial for maintaining the skin barrier against pathogens.
Researchers at Stanford University have discovered the invisible pattern that growing neurons follow to form a brain using microscopy and mathematics. The technique could be used to coax stem cells to grow into replacement body parts, such as artificial organs.
A team of Cornell researchers compiled a 'cell atlas' of muscle regeneration, cataloging the activity of almost every type of cell involved in muscle repair. The dataset provides a comprehensive picture of cellular interactions and may lead to improved rehabilitation strategies for patients recovering from muscle injuries.
Researchers have discovered that T follicular helper cells can persist for at least 400 days after infection, supporting antibody production even in late stages. This finding opens up new prospects for creating long-term acquired immunity through vaccination strategies.
Researchers at UConn School of Dental Medicine have discovered a population of stem cells residing along vascular channels in bone that can generate new bone-forming cells. These perivascular cells may regulate bone formation and participate in bone mass maintenance.
Researchers developed a new single-cell sequencing technique to study the regulation of gene transcripts. They found that cells use distinct strategies to control transcript copies, involving both transcription and degradation processes.
Researchers at Karolinska Institutet found that so-called egg stem cells do not exist in the human ovary, contrary to previous reports. The study's comprehensive map of ovarian cells will contribute to the development of new methods for treating female infertility.
A new study by KU Leuven and Harvard University found that specific nutrients can inform stem cells which type of cell they should become. Fatty acids signal to stem cells to develop into bone-forming cells when blood vessels are present, while cartilage is formed without them.
Scientists have successfully used CRISPR/Cas9 base-editing to cure cystic fibrosis in human stem cells, providing a promising new approach for treating genetic diseases. The technique, which repairs mutations without cutting DNA, shows great promise for the future treatment of various genetic disorders.
Researchers found that intestinal stem cells (ISCs) regenerate through the process of de-differentiation, eliminating the need for a reserve stockpile. Under normal conditions, ISCs differentiate into daughter cells, which can then reverse their differentiation to become ISCs.
Researchers at Stanford University have developed a CRISPR-Cas tool that can detect and debug faulty genetic circuits, facilitating more precise treatments for diseases like cancer. The technology allows for greater precision in identifying and eliminating diseased cells, with potential applications beyond cancer treatment.
Researchers created 3D human gut organoids from patient cells to simulate leaky gut conditions, revealing new biomarkers and a potential pathway for tightening the gut lining. The study found that the diabetes drug metformin strengthens the junctions of mini-guts, increasing occludin levels up to six-fold.
The bioprinting research roadmap identifies key areas of progress and development, including advancements in bioinks, 3D printing processes, and crosslinking techniques. The report also highlights the potential for bioprinting to create complex biological models and therapeutic products.
Researchers at Texas A&M University have developed biodegradable hydrogels that create a fertile environment for bone stem cells to grow and proliferate. The study found that the space created by degrading hydrogels enables stem cells to thrive, remodel their local environment, and form intricate cellular networks.
Researchers discover that mature bone marrow stromal cells can transform into regenerative cells after an injury, providing an alternative source for bone healing. This breakthrough suggests that these cells could be generated through transformation of readily available mature stromal cells.
A study published in Circulation reveals that an imbalance in the ratio of active and inactive myosin protein disrupts heart muscle contraction and relaxation, leading to hypertrophic cardiomyopathy. Treatment with a small-molecule drug restores proper contraction and energy consumption in human and rodent heart cells.
Susan Solomon, CEO of The New York Stem Cell Foundation (NYSCF) Research Institute, receives the 2020 ISSCR Public Service Award for her tireless efforts to support stem cell science and researchers. NYSCF has raised over $350 million for stem cell research projects.
Researchers developed a novel cryogel vaccine that primes the immune system to attack and eliminate acute myeloid leukemia cells in mice. The vaccine successfully protected against disease recurrence when combined with chemotherapy.
Researchers have developed a new method to transform stem cells into bone cells using an artificial muscle sheet with shape-memory function. This technology has potential applications in treating complex bone fractures by culturing stem cells on the sheet and adapting them to directly strengthen bones.