Articles tagged with Stem Cells
Researchers at Tokyo Medical and Dental University use genome editing to create a human stem cell model of congenital hepatic fibrosis, uncovering molecular players that contribute to the illness. They identify IL-8 and CTGF as key genes involved in the disease's progression.
Scientists have found that plant cells adjacent to injured areas re-activate their stem cell programs to produce new cells of the correct type. This process, called 'restorative patterning', allows plants to heal wounds more efficiently.
Researchers found that removing the ATDC gene from pancreatic cells prevented the development of pancreatic cancer in mice. The study identified ATDC as a key player in the reprogramming of adult cells into primitive, high-growth cell types, which can lead to cancer.
Researchers at UBC Okanagan have created an automated encapsulation device that encases cells in microgels, protecting them from physical damage and the immune system. The device enables over 85% of cells to survive and can be scaled up for rapid production of cell-encapsulated microgels.
Scientists develop DNA nanodevice that uses near-infrared light to guide stem cells to wounds, promoting muscle tissue regrowth in mice. The system successfully activated receptors, causing cells to move and grow, with treated mice showing increased signs of regeneration.
A new study reveals that flowering plants employ different genetic strategies to maintain a 'core genetic circuitry' that ensures stem cell function, even in the presence of defects
A clinical trial using mesenchymal stromal cells from patient bone marrow shows significant improvements in pain levels and quality of life for osteoarthritis patients. The study, led by Sowmya Viswanathan and Jaskarndip Chahal, found that higher doses of MSCs resulted in more effective outcomes.
A recent study has found that JUUL electronic cigarette products contain dangerously high levels of nicotine, which can be toxic to living cells. The researchers also discovered that flavor chemicals in JUUL pods may make them attractive to youth and could lead to adverse health effects with chronic use.
Researchers discovered that transcription factors ANAC044 and ANAC085 control plant cell cycle arrest in response to DNA damage and abiotic stress. These proteins act as a bridge between SOG1 and Rep-MYB, preventing cell proliferation under hostile conditions.
Researchers found that some patients' skin areas return to normal as they age, eliminating mutant loricrin genes through somatic recombination. This natural process could lead to a new treatment method for genetic diseases like loricin keratoderma.
A review explores how two cell populations respond to organ failure, with one type relying on endoreplication and the other on cell regeneration. This cooperative response allows organs to recover from failure, but also presents tradeoffs that can impact long-term health.
Researchers have successfully targeted the tumor biomarker EpCAM with chimeric antigen receptor-modified T cells, significantly delaying tumor growth in mice. The study suggests that EpCAM could be a promising target for cancer immunotherapy in various tumor types.
The Pediatric Cell Atlas will create a high-resolution data reference for child development, benchmarking healthy and abnormal tissues at the level of single cells. This will provide a standard tool for researchers to better understand childhood illnesses and develop precision treatments.
Researchers at Baylor College of Medicine discovered a new approach to treating age-related diseases by stabilizing telomeres and restoring sirtuin activity. This method shows promise in improving liver disease outcomes in a mouse model.
A new 3D printing method enables the creation of fine-scale mesh structures that allow for precise control over a cell's microenvironment. This could lead to highly uniform cultures of cells with desired properties, making it a promising tool for biomedical research and potential medical applications.
Chronic inflammation, not aging, is the main reason why bones heal more slowly with age. Researchers found that exposure to older mice's blood serum reduces stem cell multiplication and increases inflammation. Treatment with anti-inflammatory drugs restored skeletal stem cell function and bone healing ability in aged mice.
Scientists have discovered that deleting the gene encoding ASCT2, a transporter enzyme responsible for bringing amino acids into cells, prolongs survival of mice with aggressive leukemia. The study found that ASCT2 is required for leukemia development and progression but dispensable for normal blood cell development.
Scientists are working on modifying human breast milk cells to produce specific proteins, such as vaccines, for premature babies. These engineered cells could potentially address birth defects, provide necessary proteins, or even treat certain diseases.
A low-calorie fasting-mimicking diet has been shown to reduce intestinal inflammation and increase intestinal stem cells, promoting the expansion of beneficial gut microbiota. The study suggests that this regimen may have potential in mitigating inflammatory bowel disease (IBD) pathology.
Researchers discovered two types of fat tissue cells that help bone heal: pericytes stimulate blood vessel growth and adventicytes form bone cells. Combination therapy using both cells promotes robust bone repair in mice with skull defects.
Researchers at Linköping University created a hydrogel that mimics the natural environment of cells, allowing for the growth of human liver cells on microchips. This innovation has the potential to simplify early stages of drug development and replace animal experiments.
A Brazilian project aims to assess how patients awaiting kidney transplants react to porcine blood, with the goal of reducing the country's transplant waiting list. The initiative uses gene-edited pigs and CRISPR-Cas9 technology to make organs compatible with human bodies.
A study published in The Journal of Bone & Joint Surgery found that rotator cuff muscle stem cells have a higher propensity to develop into fat cells, leading to fatty infiltration and weakening of the muscles. This genetic basis may explain why rotator cuff tears are difficult to rehabilitate.
Researchers have restored muscle stem cell function in animal models of Duchenne muscular dystrophy, leading to efficient muscle regeneration and preventing progressive loss of muscle strength. The study's findings suggest a new treatment approach may be effective in addressing this complex disease.
A new study identifies key factors involved in cell cycle arrest and illuminates a novel intracellular structure, paving the way for new therapeutic targets to treat kidney fibrosis. The research team found that blocking the formation of TASCCs reduced the severity of kidney fibrotic disease progression in preclinical models.
A clinical trial has shown promise in using stem cells from donors to repair the surface of the eye in patients with limbal stem cell deficiency, a significant cause of sight loss. The trial also sheds light on the causes of sight disorders and offers clues about how eye tissue loss could be repaired.
Scientists from JNCASR and inStem successfully created a synthetic mimic of cytoskeletal networks with structural and temporal programming. The system was developed through reaction-driven controlled growth, enabling precise control over one-dimensional growth and self-repairing features.
Researchers have found that nuclei gained during training persist even when muscle cells shrink due to disuse or disease, allowing for rapid growth when retrained. This discovery has important implications for public health policy and suggests that exercise in early life can help prevent frailty in old age.
Researchers at Heidelberg University have identified bifacial stem cells responsible for forming wood and plant bast fibres. By studying specific cell types in the cambium layer, they discovered that these cells produce both wood and bast tissues bidirectionally.
Researchers created a self-curving cornea by molding cells to form a desired shape, mimicking the natural cornea. The 4D tissue structure was achieved through innovative cell actuators that forced surrounding tissue to move in a predetermined manner.
Researchers at Washington University School of Medicine have developed a new method for producing insulin-producing beta cells from human stem cells, which are more responsive to fluctuating glucose levels. The resulting cells were transplanted into diabetic mice and effectively controlled blood sugar for several months.
Researchers have developed a breakthrough technology to grow human blood vessels as organoids in a petri dish, which can be used to study vascular diseases and identify potential treatments. The discovery has the potential to unravel causes of conditions such as Alzheimer's disease, cardiovascular diseases, and cancer.
Researchers have created a method for modifying blood stem cells to reverse the genetic mutation that causes IPEX, a life-threatening autoimmune syndrome. The approach adds a normal copy of the FoxP3 gene to blood stem cells, restoring proper immune regulation and eliminating symptoms in mice.
Researchers at Johns Hopkins Medicine have identified a cellular protein signal that drives both bone and fat formation in stem cells. Harnessing this signal, WISP-1, could help fractures heal faster, speed surgical recovery and prevent bone loss due to aging or injury.
A new study by Tel Aviv University reveals that a functional heart cell defect may be the underlying cause of peripartum cardiomyopathy (PPCM), a rare form of heart failure. The research found that levels of STAT3 protein were higher in PPCM patients' heart cells than in healthy women, and that a defect in releasing growth factors was ...
Researchers at the University of Tokyo have developed an ultra-soft electronic sensor that can closely monitor beating heart cells without affecting their behavior. This breakthrough device uses a nanomesh sensor to study cardiomyocytes in a more faithful way, paving the way for future embedded medical devices.
A new method for single cell chromatin accessibility profiling has been developed, allowing researchers to profile over 3000 cells from the spleen. The study revealed distinct immune cell types and related transcription factors, providing insights into cellular function and organization.
Researchers at Rutgers University have developed a new model of cardiac muscle cells that can pump together, potentially treating heart failure. The newly created cardiac muscle cells were made to work cohesively through the over-expression of a protein called CREG.
The discovery of protein DEX-1 in the roundworm C. elegans sheds light on the molecular trigger for structural remodeling in response to stress, allowing animals to better withstand challenging conditions. This research has implications for understanding nematode biology and its impact on parasitic species affecting crops.
Researchers at Duke University Medical Center have identified a key player in bone healing - young macrophage cells and their secreted proteins. Introducing these factors into old mice improves fracture repair, providing a potential new treatment for delayed healing.
Researchers at the University of Zurich identified a molecule that plays a key role in graft-versus-host responses, which can be fatal for leukemia patients. Blocking this molecule, GM-CSF, could significantly improve stem-cell transplant outcomes.
Researchers at Penn State have discovered that citrate, a natural product found in bones and citrus fruit, can fuel bone healing by providing extra energy for stem cells. This understanding will help develop slow-release biomaterials to speed up bone repair and reduce inflammation.
A machine-learning algorithm, inDelphi, predicts the precise correction of broken genes by analyzing data from CRISPR-induced breaks. Researchers successfully corrected nearly 200 disease-associated genetic variants, restoring gene function to healthy states.
UTSA scientists create world's most comprehensive digital roadmap for male fertility by analyzing individual cells' gene expression. This innovation could help diagnose and treat infertility issues, as well as inform the development of new contraception methods.
Scientists have discovered a way to detect the early signs of atherosclerosis, leading to blocked arteries, by analyzing changes in blood vessel cells. The study used single-cell RNA-sequencing and lineage labelling to identify unusual cells that express stem cell genes, which could help diagnose and treat cardiovascular diseases.
Materials engineers are developing environmentally friendly materials, including graphene-based nanofibers, for various applications such as environmental protection, agriculture, medicine, and clothing industry. These nanofibers offer unique properties like conductivity, strength, flexibility, and bio-basis, making them promising for ...
A new type of skeletal stem cell has been discovered in the 'resting zone' of the epiphyseal growth plate, which is a crucial cartilaginous tissue for bone growth. These cells are found to be active and produce both cartilage and bone, as well as support blood cell production.
Researchers have successfully developed kidney tissue that exhibits the early stages of congenital kidney disease using iPS cells from a patient with a nephrin mutation. The study found that repairing the nephrin mutation can normalize abnormalities and may lead to the development of effective drugs for kidney disease.
Researchers at the University of Houston have developed a new environment for repairing eyes using hyaluronic acid. By creating an ideal substrate layer with high concentrations of hyaluronic acid, they aim to improve the treatment of patients with limbal stem cell deficiency, which can lead to opaque corneas.
A Stanford-led study identifies uhrf1 and s100a10 as key genes driving rapid deer antler growth, a process that could inform new approaches for treating human bone conditions like osteoporosis. The researchers hope to apply the underlying biology of deer antlers to develop more efficient therapies.
Scientists discovered that mistakes in proofreading the genetic code of retinal cells lead to a form of inherited blindness, retinitis pigmentosa. The study, published in Nature Communications, offers hope for a new gene therapy treatment.
Researchers at Johns Hopkins University have successfully grown human retinas in a dish, providing insights into how cells enable color vision. The study found that thyroid hormone plays a crucial role in determining the fate of these cells, with implications for understanding and potentially treating eye diseases.
Researchers have developed a method to 3D-print cells to produce human tissue such as ligaments and tendons, eliminating the need for additional surgeries and reducing reliance on harvested tissue. The technique involves printing stem cells on hydrogel to form tissue that can grow in vitro before implantation.
The NIH has awarded a $3.6 million grant to study the safety of CRISPR-like therapies in human tissues. A team led by Todd McDevitt will assess the safety and toxicity issues of genome editing, developing platforms to detect adverse effects on physiological function.
A UH biologist is using a new grant to study how defects in cellular cross-talk lead to Crohn's disease. By examining stem cells isolated from patients, she hopes to find new targets for drug development and reduce inflammation in the gastrointestinal tract.
A new approach using umbilical cord blood stem cells has shown promising results in repairing cleft palates in infants. The procedure, performed as part of reconstructive surgery when the infant is a few months old, provides good results in growing new bone to close the upper jaw cleft and may avoid the need for later bone graft surgery.
A new study examines Canadian clinics marketing unproven stem cell treatments, highlighting regulatory gaps and potential risks to patients. The majority of marketed treatments target orthopedic and musculoskeletal conditions, with some companies advertising for a wide range of disorders.
The study found that dietary cholesterol alters cellular programming, promoting hormone-producing cells and nutrient-handling cells. Low nutrient availability triggers changes in intestinal structure and metabolism with long-term effects on metabolic health.
Researchers developed a microtissue model of the heart to study how environmental stress affects normal and abnormal heart tissue. The study found that mutant cells contracted abnormally and arrhythmically under stress, similar to HCM patients.
Researchers identified six main combinations of five Hoxd genes involved in digit development in mice, providing a higher resolution and clarity in understanding how architect genes orchestrate the rhythm of development. This study offers a new perspective on limb patterning motifs and could pave the way for future genetic work.