Articles tagged with Stem Cells
Researchers created a 3D bioengineered tooth bud model using Gelatin Methacrylate (GelMA) hydrogel and postnatal dental stem cells. Decellularized tooth bud extracellular matrix (dTB ECM) was introduced to enhance dental stem cell differentiation, resulting in whole tooth structures upon in vivo implantation
A new study suggests that low-calorie sweeteners can promote metabolic syndrome and increase the risk of prediabetes and diabetes in overweight individuals. The research found that these substances can lead to increased glucose entry into cells through enhanced activity of genes called glucose transporters.
Researchers at University of Illinois Chicago developed chimeric cells that can restore the structural muscle protein dystrophin in people with Duchenne muscular dystrophy, potentially avoiding the need for immunosuppressive drugs.
Researchers at UCLA have created a new method for targeted gene delivery using 'nanospears,' which can enable safer, faster and more cost-effective gene therapies. The nanostructures are biodegradable and can be mass-produced inexpensively, delivering genetic information with minimal impact on cell viability and metabolism.
Researchers at BWH discovered that cell sex influences nanoparticle uptake, response to reprogramming techniques, and paracrine factors. These findings may help develop sex-specific nanomedicines for targeted drug delivery applications.
Researchers have developed a method to create large amounts of fillable and targeted nanovesicles using immune cells. These nanovesicles can be customized with specific ligands to target different types of tumors, enabling more effective cancer treatment.
Researchers have identified a lung stem cell that repairs the organ's gas exchange compartment and restores respiratory function after severe influenza and other respiratory ailments. The discovery provides new insights into lung regeneration and identifies novel genetic and epigenetic pathways important for lung regeneration.
A University of Guelph study found that cardiolipin helps prevent protein misfolding in Parkinson's disease, leading to nerve cell death. Researchers believe cardiolipin may represent a new target for developing therapies to slow the progression of the disease.
Researchers found that S597 slows progression of atherosclerosis in mice with metabolic syndrome by reducing inflammation and immune cell activity. The peptide lowers blood sugar levels without preventing atherosclerosis, offering a novel treatment strategy for protecting against advanced cardiovascular disease.
A new study examines the evolutionary dynamics of cancer development in Barrett's Esophagus patients, revealing influences that lead some cells to remain stable while others become cancerous. The research provides insights into the genetic and chromosomal variations that predict progression to esophageal adenocarcinoma.
Researchers at Karolinska Institutet discover high number of mutations in muscle stem cells impairing cell regeneration, which may result in new medication for building stronger muscles. The study found that physical exercise could clear out cells with many mutations.
A new study shows that injecting cardiac progenitor cells can reverse fatal heart disease caused by Duchenne muscular dystrophy, while also improving limb strength and movement ability. Exosomes secreted by the injected cells unexpectedly restore muscle function in a mouse model of muscular dystrophy.
Researchers found that mature cells in different organs activate the same genes and undergo similar processes when dividing again, leading to potential new targets for cancer treatment. This discovery could support using universal strategies to treat or prevent cancer in various organs.
Scientists at Rice University have successfully used CRISPR/Cas9-based gene editing to repair 20-40% of stem and progenitor cells from patients with sickle cell disease. The study, led by bioengineer Gang Bao, aims to find a cure for the hereditary disease.
Researchers at the University of York have identified a potential link between altered sugar chains and enhanced bone formation in stem cells. By treating cells with a chemical that modifies sugar chains, they found improved bone growth processes, which could pave the way for new osteoporosis treatments.
Researchers at Queen Mary University of London have discovered that cells can 'walk' on liquids using protein nanosheets with strong mechanical properties. This breakthrough could lead to the design of new cell technologies for regenerative medicine and tissue engineering.
PanTHERA CryoSolutions has discovered a small molecule inhibitor that prevents ice recrystallization, a process causing cell death and damage when freezing cells and tissues. This technology results in faster engraftment and increased incidence of engraftment for clinical settings.
Scientists at CRAG have found that plant cells know when to stop growing by detecting their size, allowing for coordinated division, elongation, and differentiation. This process is also linked to the effect of steroid hormones, such as brassinosteroids, on root growth.
Scientists have discovered a protein called Setd7 that regulates stem cell growth and differentiation. Inhibiting this protein allows stem cells to remain undifferentiated, facilitating tissue regeneration and improved muscle function.
Researchers at Howard Hughes Medical Institute have developed a synthetic version of the plant hormone auxin and an engineered receptor to recognize it, enabling precise control over plant growth and development. This breakthrough system, called
A novel hypothesis proposes that animal diversification resulted from a revolution within the animals' own biology, rather than in surrounding chemistry. Cells with stem cell properties are vital for multicellular life, and tumor cells have developed mechanisms to maintain these properties despite high oxygen levels.
Scientists have created new tiny tubes that can help with water filtration and tissue engineering studies. The tubes are inspired by protein structures called microtubules found in cells and are thousands of times smaller than a human hair.
Researchers suggest a biological innovation fueled animal diversification during the Cambrian explosion, rather than atmospheric oxygen changes. Tumor biology insights reveal how stem cells maintain properties in high-oxygen environments, sparking new perspective on tissue renewal.
Researchers at Radboud University Medical Center discovered that mevalonate, a byproduct of cholesterol production, trains the immune system. A Western diet rich in cholesterol can also induce trained immune cells, leading to long-lasting inflammation. Statins may inhibit this training, while boosting it could help weakened immune systems
A team of Canadian researchers has discovered a way to re-program innate immune cells to kill tuberculosis. The innovative work aims to make vaccines more effective against TB and other infectious diseases like the flu. By targeting stem cells in the bone marrow, scientists were able to boost the killing efficiency of macrophages.
Researchers have identified a key gene, Ufbp1, that helps maintain healthy Paneth cells in the small intestine, which are essential for a balanced gut microbiome. The study found that when this gene is knocked out, Paneth cells die and good bacteria levels decrease, leading to inflammatory bowel disease.
A gene therapy approach using AAV vectors reprograms alpha cells into functional insulin-producing beta cells, restoring normal blood glucose levels for an extended period. The strategy shows promise for treating autoimmune diabetes without immunosuppression.
A new removable implant has been developed to control type 1 diabetes, with hundreds of thousands of islet cells protected by a thin hydrogel coating and attached to a polymer thread. This therapy could replace daily insulin injections and offer a more effective management solution for the disease.
A study by Imperial College London has discovered that a drug used to treat iron overload can protect bone marrow areas and allow blood stem cells to survive. This can improve the efficiency of chemotherapy, increasing the five-year survival rate for AML patients over 60 to 5-15 per cent.
Scientists show that transplanted muscle cells loaded with magnetic nanoparticles engraft better onto the existing tissue, leading to improved heart function. The technology could potentially be used to revitalize damaged heart tissue and has shown promising results in mice.
Researchers found that patients with high levels of indoleamine 2,3 dioxygenase (IDO) at diagnosis have lower overall survival rates and early mortality. IDO expression should routinely be measured during bone marrow biopsies to identify potential treatment targets.
Research at Lund University found that HLF gene's failure to shut down leads to inadequate lymphocyte development, resulting in a single type of immune defense. The study aimed to identify mechanisms for breaking down leukemia, an aggressive blood cancer with poor prognosis.
Researchers found that cell cycle proteins are crucial for releasing neutrophil extracellular traps (NETs) in immune cells. This process helps to contain and eliminate fungal infections in mice and human cells.
Researchers at Boston Children's Hospital have successfully reversed type 1 diabetes in a mouse model by infusing pre-treated blood stem cells. The treated cells curbed the autoimmune reaction and reversed hyperglycemia in diabetic mice, with almost all mice cured of diabetes in the short term and one third maintaining normal blood sug...
Researchers have developed a new therapy that blocks the TRF1 protein, which is essential for protecting telomeres in glioblastoma cells. This approach has shown promising results in mouse models, with a significant increase in survival rates and reduction in tumour growth.
A team of SUTD researchers identified over 1800 proteins in young reticulocytes, revealing key changes in protein composition during maturation. These findings provide insights into the transition from a multi-lobular to biconcave shape and increased deformability.
A portable holographic field microscope can rapidly identify diseased cells, including those infected with malaria. The device uses digital camera sensor technology and advanced algorithms to provide quick and accurate diagnosis, reducing the time and cost associated with traditional laboratory testing.
Researchers found that massage increased muscle growth after loss and improved protein manufacture in cells, leading to faster regeneration. Additionally, non-massaged muscles showed accelerated growth, suggesting massage could benefit both injured and healthy limbs.
Basal progenitor cells have been identified as the 'cell of origin' for Barrett's esophagus, a condition that can lead to esophageal adenocarcinoma. The discovery promises to accelerate the development of precise screening tools and therapies.
Scientists at NAIST have discovered a molecular pathway that explains how plant cells cease cell division upon DNA damage. The study found that the transcription factor family MYB3R prevents progression to the M phase of the cell cycle, allowing plants to maintain genome integrity.
Researchers at UCLA have developed a new method called quantitative deformability cytometry (q-DC) to rapidly determine a single cell's stiffness and size. This technique allows for standardized measurements of single cells and could lead to improved cancer treatments by tracking patient progress and predicting drug effectiveness.
Researchers at UW Medicine have developed mini-kidney organoids that can track the early stages of polycystic kidney disease. By manipulating the micro-environment, they found that cyst formation can be increased or decreased.
The nation's public cord blood banks provide benefits for patients and the research community, outweighing costs. Researchers recommend standardizing payment and encouraging diverse collection practices to strengthen the system.
Researchers developed a method to trace the history of beta-cells in zebrafish, revealing dynamic sub-populations with different developmental histories. These findings have implications for understanding diabetes progression and developing effective strategies for beta-cell regeneration and protection.
Scientists have developed a new treatment option using nanogels to encapsulate stem cells, which can repair damaged heart tissue and trigger an immune response. This method has shown increased cell retention and regeneration compared to traditional treatments.
Researchers developed a microfluidic chip-based platform for analyzing live cells using fluorescence microscopy. The platform uses a CMOS image sensor and allows for fully automated systems, making it suitable for high-throughput applications.
Scientists at Temple University are exploring exosome-based treatments for heart disease using a $11.6 million NIH grant. Researchers aim to understand the regenerative capabilities of exosomes and develop novel therapies for patients with heart disease.
Researchers found that calorie-restricted mice develop thicker, longer fur coats and increased blood vessels to insulate against cold temperatures. This adaptation helps them conserve energy and survive in limited food conditions.
Scientists at Kazan Federal University have developed a new tool for cell-free therapy using artificial membrane vesicles, which retain biological properties of donor cells. The study demonstrates that these vesicles can stimulate angiogenesis in vitro and in vivo.
A new method reveals abnormally shortened telomeres in DMD patients' muscle stem cells, leading to early loss of regeneration capacity and disease progression. The finding suggests gene therapy and treatments targeting telomere length could slow or stop the disease.
Scientists have identified a gene that causes blindness in middle age, shedding light on a devastating genetic condition. The study found changes in the RPGR gene damage eye cells and lead to X-linked retinitis pigmentosa, affecting night and peripheral vision before causing complete blindness.
Researchers at Karolinska Institutet have developed a technique to monitor the maturation process of the immune system in leukaemia patients after stem cell transplantation. This study identifies patterns linked to clinical complications and provides new knowledge on the regulation and dysregulation of the immune system.
Id genes have been linked to heart development for the first time, revealing a new tool to create large numbers of cardiac cells to regenerate damaged heart tissue. The study uses CRISPR-Cas9 gene editing and high-throughput microRNA screening to identify the role Id genes play in heart development.
Researchers found that fatty liver disease can cause damage to other organs, particularly the pancreas. The protein fetuin-A produced by the fatty liver triggers an inflammatory response in the pancreas, leading to reduced insulin secretion and worsening of blood glucose regulation.
Scientists have created healthy offspring from genetically infertile male mice using a new technique that removes the extra sex chromosome. The approach has potential for treating human infertility caused by Klinefelter syndrome and Double Y syndrome.
A UTSA professor has received a $1.5 million grant to study spermatogonial stem cells in a cutting-edge way. The goal is to understand how these cells form and support sperm production, leading to earlier diagnoses and more effective treatments for male infertility.
Researchers at UCLA have identified a novel method to activate dormant stem cells in the hair follicle, which could lead to breakthroughs in treating hair loss. By manipulating cellular metabolism, they found that increasing lactate production accelerates hair growth in mice.
A new study by Cedars-Sinai Medical Center suggests that cardiac stem cell infusions could reverse aging in the human heart. Cardiosphere-derived cells secrete tiny vesicles containing RNA and proteins, which may turn back the clock for age-related heart conditions.
A UCI-led study found that a low-calorie diet helps maintain efficient energy processing in cells, which is linked to younger aging. The researchers also discovered that calorie restriction can rejuvenate the biological clock and prevent tissue aging in stem cells.
Researchers at the University of Bergen have successfully transformed skin puncture cells from diabetes patients into insulin-producing cells. The goal is to transplant these cells under the skin, potentially replacing insulin shots and blood sugar measurements.