Articles tagged with Stem Cells
Researchers have identified a new approach to protect patients from graft-versus-host disease by activating signal paths in the gut. The key to preventing GVHD is protecting the epithelial cells, which can be achieved by using RIG-I and STING proteins.
Researchers found that TRPM8 and TRPP3 receptors can create more 'good' fat (brown adipose tissue) than 'bad' fat (white adipose tissue), potentially converting bad fat to good. This discovery has implications for treating obesity, diabetes, and related metabolic disorders.
Researchers used patient's own muscle stem cells to create patches that were surgically glued onto the surface of patients' hearts. One year after treatment, patients showed improvements in exercise capacity and heart function, suggesting this cell patch may be a viable therapy for treating heart failure.
Researchers at the University of California, Davis have discovered a possible new route to regenerating beta cells, giving insight into healthy metabolism and diabetes. This discovery could lead to better treatment or cures for diabetes by understanding how these cells mature into functioning beta cells.
A new study by Boston University engineer Wilson Wong outlines a simplified platform to target and program mammalian cells as genetic circuits, enabling researchers to make complex computations. The BLADE platform uses DNA recombinases to allow for more targeted manipulation of cells and their behavior.
Preliminary research suggests that low-calorie sweeteners promote metabolic dysfunction and increase glucose transport into cells. Studies found increased expression of genes markers of fat production and inflammation in human stem cells exposed to sucralose.
Researchers from UConn Health have developed a way to regenerate rotator cuff tendons after they're torn, creating stronger repairs. The nano-textured fabric seeded with stem cells helps the tendons attach better to the bone and heal more evenly.
Scientists at Sylvester Comprehensive Cancer Center have found that p300 protein acts as a tumor suppressor, preventing myelodysplastic syndrome (MDS) from developing into acute myeloid leukemia (AML). Eliminating p300 in mice results in rapid leukemia development.
Researchers have developed a new method to deliver large and diverse cargos directly into cells with high efficiency and no lasting damage. The team used gold pyramid-shaped microstructures and nanosecond laser pulses to create brief pores in the cell membrane, allowing molecules to diffuse into the cell.
A Florida clinic's unproven stem cell treatment blinded three women with macular degeneration, causing vision loss and other complications. The treatment, which involved injecting fat cells into the eyes, lacked proper scientific design and oversight.
Researchers found that intestinal stem cells lose regenerative capacity with age and that reactivating Wnt signaling can restore healthy function in older people. The study suggests a possible therapeutic approach to address imbalances in food and nutrient absorption, which may be linked to diminished Wnt signaling.
Researchers identified autophagy as a critical process for promoting germline stem cell proliferation, specifically by regulating the cell cycle of progenitor cells. The study also found that autophagy is finely tuned in surrounding tissues to maintain germline homeostasis.
Researchers at Columbia University School of Engineering and Applied Science have developed a novel cross-circulation platform that maintains the viability and function of donor lungs for several days. The technology, inspired by an abandoned surgical procedure from the 1960s, enables long-term support of living organs outside the body.
Researchers at Lund University successfully reprogrammed old blood stem cells to function like those of younger individuals, revealing a potential new approach to treating age-related diseases. This breakthrough suggests that epigenetic changes, rather than DNA mutations, underlie the decline in blood cell function with age.
Researchers have discovered a drug combination that can regenerate hair cells in the inner ear, offering a potential new way to treat hearing loss. The treatment involves expanding progenitor cells and stimulating them to become mature hair cells.
Scientists have successfully converted mouse alpha cells into insulin-producing beta cells by blocking the expression of two specific genes. The research suggests that this natural flexibility in cell fate may be exploited to develop a new therapeutic approach for Type 1 diabetes.
A University of East Anglia study reveals that the protein ninein is crucial for normal tissue development in the human gut. The research shows how microtubule rearrangements and the assembly of new Microtubule Organising Centres facilitate cell shape formation, nutrient uptake, and ultimately prevent cancer.
Researchers at Stanford University School of Medicine have developed a cheap and reusable diagnostic 'lab on a chip' with the help of an ordinary inkjet printer. The technology has the potential to enhance diagnostic capabilities around the world, especially in developing countries where access to early diagnostics is limited.
Scientists have identified antiviral T cells that can access HIV's germinal center hideouts using the CXCR5 molecule. These cells have stem cell-like properties and can infiltrate sites of ongoing viral replication, providing a potential target for therapeutic vaccines and HIV suppression.
Researchers at Rice University have developed a new compound of bismuth and carbon nanotubes that improves upon existing cell-tracking agents. The improved Bi4C@US-tubes show up strongly on X-rays taken with computed tomography (CT) scanners, allowing for more efficient tracking of stem cells in the body.
Scientists have developed a method to observe gene editing in real-time, enabling the investigation of CRISPR-Cas9's biological processes and potential applications for treating genetic diseases such as sickle cell anemia and cystic fibrosis.
Researchers have mapped how plant cells determine size and adjust growth to achieve homogeneous cell sizes over time. This breakthrough overturns previous theories in the field, providing insights into factors determining plant size and fruit production.
Researchers discovered that immune cells use an active process to create gaps in blood vessel walls, involving the breakage of thin filaments and rapid reassembly. This process allows immune cells to squeeze through and survey organs for problems or join the fight against pathogens.
Researchers successfully used CRISPR-Cas9 technology to repair genetic mutations in blood stem cells of patients with chronic granulomatous disease, a rare and life-threatening disorder. The engineered cells maintained their gene edits long-term without side effects when implanted into mice.
Researchers have successfully generated epicardium cells using human stem cells and Wnt signaling pathway activation. The new method could potentially repair damaged heart tissue in patients who suffer from heart attacks, according to the study published in Nature Biomedical Engineering.
Researchers at Whitehead Institute have developed a gene pathway that enables the growth of brain organoids with surface folding, a key feature of human brain development. The study also shows potential for modeling Zika virus-caused microencephaly and identifying affected cells.
Researchers aim to remove senescent cells, which accumulate with age, to regrow hair, improve organ function and combat aging. However, hurdles include safety issues, off-target effects and high costs, limiting translation to humans.
Researchers at Kyoto University found that the Myc gene regulates stem cell self-renewal in mice, leading to a slower rate of proliferation and impaired energy production. This discovery may lead to new treatments for infertility by stimulating sperm cell metabolism.
Researchers have developed synthetic stem cells that mimic natural cardiac stem cells, promoting tissue repair and reducing risks of tumor growth and immune rejection. These cells are more durable, can be used off-the-shelf, and can tolerate harsh freezing and thawing.
A stem cell-based treatment, known as the Cell Bandage, has been trialled in humans and shown to repair damaged meniscus tissue, restoring full knee function. The trial received positive results, with three out of five patients retaining an intact meniscus after 24 months.
Researchers discovered a single gene mutation causing two types of heart disease: one causes holes in infants' hearts, and the other leads to heart failure. The study revealed how the GATA4 gene's disruption affects cardiac development and muscle contraction.
Researchers at the Krembil Research Institute have published a paper that challenges the prevailing view of vision recovery after retinal cell transplantation. They found that transplanted photoreceptor cells do not enter the recipient retina, contrary to previous interpretations.
A team of researchers from the University of Toronto has developed a proprietary peptide-hydrogel biomaterial that promotes skin cells to 'crawl' together, closing chronic, non-healing wounds caused by diabetes. The treatment closed wounds 200% faster than no treatment and 60% faster than existing collagen-based products.
Researchers developed a new heart imaging test that analyzes longitudinal strain to predict patient survival after stem cell transplant. The test outperformed conventional biomarkers and detected improvements before changes in traditional echocardiographic measures.
Researchers at Duke University have identified a set of DNA-binding proteins in Arabidopsis roots that work together to trigger stem cell differentiation and create specialized cells with distinct roles. This discovery sheds light on the longstanding question of how plants make so many types of cells from the same genetic instructions.
Researchers at Stanford University School of Medicine found that stem cells can police themselves to reduce scarring by producing a truncated version of a protein. This discovery holds promise for treating muscle diseases like muscular dystrophy and promoting healthy aging.
Researchers at MD Anderson Cancer Center identified a pathway by which cancer cells spread in the brain, opening up new possibilities for treatment. They found that the gene WNT5A enables glioma stem cells to transition into GdECs, leading to aggressive tumor growth and disease recurrence.
Researchers at UCLA discovered that cardiac fibroblasts, which give rise to scar tissue after injury, can also produce bone-like cells. By blocking an enzyme involved in bone mineralization, they prevented calcification in mice, offering a potential new approach for treating abnormal calcium deposits in the heart.
A recent study found that injury in schistosome parasites triggers stem cell growth, which restores aging tissue and aids the parasite's long-term survival. This discovery could lead to new ways to target these worms and improve our understanding of their infection mechanisms.
Researchers at VIB and Ghent University have uncovered a novel protein complex that controls plant tissue repair. This breakthrough could enable the efficient cultivation of crops and make them more resistant to parasites like those found in rice, wheat, and bananas.
Researchers at Hospital for Special Surgery have identified a population of stem cells called ADSCs that are reduced in number in the layer of fat sitting under the skin in patients with scleroderma. The study found that replenishing these cells with antibodies may reverse the fibrosis characteristic of the disease.
The study found that when mitochondria are disrupted, stem cells lose their ability to self-regenerate, but stressed cells initiate a growth program leading to tissue regeneration. This highlights the fundamental role of functioning mitochondria in regulating intestinal tissue renewal.
Researchers have developed an innovative skin graft process that combines split thickness skin grafts with a specially engineered sheet of stem cells to maximize natural healing power. The new technique shows promising results in treating large or complicated burn injuries, preserving hair follicles and oil glands.
A study found that corneal cells' softness indicates their potential for stem-like activity, enabling rapid and cost-effective enrichment of limbal stem cells. This biomarker could improve clinical success rates for corneal transplant patients with naturally low limbal stem cell percentages.
Researchers discovered that leukemia cells don't hide in specific niches but instead move actively throughout the bone marrow. This movement may help them survive treatment and evade targeted therapies.
Researchers used ECIS to track stem cell transformation into bone tissue cells, revealing age-related differences in conversion rates and calcium secretion. The study provides new insights into the potential of adipose-derived stem cells for osteoporosis treatment.
Researchers found that increasing satellite cell numbers can increase muscle regeneration and stifle degeneration. Muscles with genetically modified TEAD1-expressing fibers showed a six-fold increase in satellite cells, allowing for faster repair after injury.
A study by Purdue University researchers reveals that overactive Notch signaling can drive the formation of cancerous fatty tumors, while normal signaling is required for healthy cell differentiation. The findings suggest a potential new approach for treating a subtype of liposarcomas and other metabolic conditions.
Developing blood cells are caught in fluctuating multi-lineage states before becoming specific cell types, according to a study published in Nature. The research team found that dynamic instability and counteracting gene networks induce mixed-lineage states necessary for cell-type specification.
Researchers developed an algorithm to analyze single-cell sequencing data, revealing the genetic control of blood cell formation. The 'diffusion pseudotime' method orders cells on a virtual timeline, reconstructing developmental paths and gene expression sequences.
A clinical trial has shown that metformin can promote a patient's ability to repair their own damaged blood vessels by increasing vascular stem cells. This could lead to improved treatment options for Type 1 diabetes patients at risk of developing heart disease.
Researchers successfully cultured norovirus in human intestinal cells, a breakthrough that could lead to the development of novel therapeutics and vaccines against this debilitating virus. The study, supported by the National Institute of Allergy and Infectious Diseases, sheds light on the molecular mechanisms behind norovirus infection.
Fascin protein plays a crucial role in deforming the cell nucleus to navigate through tight spaces. The study suggests that this ability may be exploited by cancer cells to invade tissues, making fascin a potential target for therapy.
A novel imaging technique allows visualization and monitoring of structural alterations in neuronal networks after traumatic brain damage, stroke, or aging processes. This enables detection and characterization of diseases like dementia, epilepsy, and metabolic disorders.
Researchers at TSRI have made a breakthrough in treating aqueous deficiency dry eye (ADDE), also known as painful blindness, by injecting regenerative progenitor cells into the lacrimal gland. The treatment shows significant promise in restoring tear production and repairing damaged gland tissue.
A new regenerative bandage heals diabetic foot ulcers faster and promotes healing without cancer risk, according to Northwestern University researchers. The bandage delivers a protein that recruits stem cells and creates new blood vessels, improving wound repair.
Researchers identified new mechanisms controlling stem cell properties in flatworms, including alternative splicing processes that operate only in stem cells. The study also reveals a previously unknown interaction between proteins MBNL and CELF, which may have implications for human regenerative medicine.
Researchers at ETH Zurich study how stem cells differentiate into blood cells, revealing complex mechanisms beyond previously thought protein GATA1 and PU.1 roles. This knowledge is vital for developing effective treatments for life-threatening diseases.
Researchers found that a non-surgical treatment using patient's own bone marrow stem cells improved symptoms and increased physical activity in patients with angina. The treatment involved injecting a 'catalyst' molecule to stimulate stem cell migration into the bloodstream, followed by re-injection of harvested stem cells.
Researchers have discovered that protein pairs are essential for cellular memory, allowing cells to store and recall information. The formation of these pairs enables cells to respond more quickly to environmental stimuli and differentiate into specialized cells.