Articles tagged with Stem Cells
A study by Babraham Institute and Weizmann Institute reveals genes are constantly rearranged in cells, changing their positions to fine-tune gene expression. Researchers collected data from over 4,000 individual cells using single-cell Hi-C technology, providing unique insights into genome organisation.
Scientists have identified how cytokinin activates genes to regulate plant growth, allowing for stem cell establishment in grains like rice and corn. The study reveals the mechanism of type-B ARRs in regulating cytokinin response and growing shoots in tissue culture.
Research sheds light on how conserved mechanism regulates development and cancer; implications for new cancer therapies. TUTase enzymes interact with let-7, a small RNA molecule important in development and cancer.
A NUS study found that plants selectively kill part of their roots to withstand cold weather conditions, allowing them to recover faster when temperatures rise. This discovery could lead to novel strategies to improve crop growth and yield under environmental stress.
Researchers at Stanford University School of Medicine discovered a lipid metabolite called prostaglandin E2 that activates muscle stem cells responsible for repairing damage after injury or exercise. Treating mice with PGE2 accelerates muscle repair and strength regain, while nonsteroidal anti-inflammatory drugs inhibit this process.
Researchers conducted a study assessing stem cell transplantation for patients with a rare 'gain of function' STAT1 gene mutation. The treatment showed encouraging results, with five patients being completely cured and disease-free, but the overall success rate was disappointing at 40%. Experts propose adjusting treatment parameters, s...
Rice University scientists have discovered a way to selectively open gaps in blood vessel barriers, allowing large molecule drugs to reach targeted tissues. The technique uses magnets to manipulate nanoparticles and alter the endothelial cell's structure, creating temporary 'leakiness' that can be controlled.
Researchers have successfully 'turned off' the immune response that causes allergic reactions in animals using gene therapy. The treatment, which targets specific immune cells, has shown promise in de-sensitizing the immune system to proteins, potentially treating severe allergies like asthma and peanut allergies.
Researchers at the University of Montreal Hospital Research Centre discovered a way to modify white blood cells to accelerate cutaneous healing. The treatment uses a special protein called MFG-E8 to control macrophage behavior, promoting anti-inflammatory and pro-reparatory reactions.
Researchers have discovered two genetic variants associated with bicuspid aortic valve development, which affects the heart's ability to pump oxygen-rich blood. The study, published in Nature Communications, found that these variants affect a key cardiac transcription factor called GATA4, leading to disruptions in valve formation.
A genetic switch that regulates blood stem cell maturation is dysregulated in acute myeloid leukemia. Researchers have identified a protein, DPF2, that controls this switch and developed a mutated version of the protein that can block its function. This new approach may lead to more effective treatments for leukemia.
A Cedars-Sinai-led team developed a technique that cues bone to regrow its own tissue, potentially replacing bone grafts. The innovative method combines ultrasound, stem cell and gene therapies to mend severely broken bones.
Researchers at UT Southwestern Medical Center discovered that a protein called KROX20 is essential for hair pigmentation and a gene called SCF determines the color of hair. The study found that deleting these genes leads to gray or white hair in mice, providing potential insights into balding and aging.
Researchers at the University of California San Diego have developed biomimetic bone tissues that provide a safe space for donor cells to grow without competition from host cells. This breakthrough technology has shown promising results in mice, with donor cells surviving for up to six months and supplying new blood cells.
Researchers have identified a group of critical cells in the testes that play a key role in repairing damage to produce healthy sperm. These Miwi2-expressing cells are essential for regeneration and may help preserve fertility in pre-pubescent boys undergoing cancer treatment.
Researchers have identified a new approach to protect patients from graft-versus-host disease by activating signal paths in the gut. The key to preventing GVHD is protecting the epithelial cells, which can be achieved by using RIG-I and STING proteins.
Researchers found that TRPM8 and TRPP3 receptors can create more 'good' fat (brown adipose tissue) than 'bad' fat (white adipose tissue), potentially converting bad fat to good. This discovery has implications for treating obesity, diabetes, and related metabolic disorders.
Researchers used patient's own muscle stem cells to create patches that were surgically glued onto the surface of patients' hearts. One year after treatment, patients showed improvements in exercise capacity and heart function, suggesting this cell patch may be a viable therapy for treating heart failure.
A new study by Boston University engineer Wilson Wong outlines a simplified platform to target and program mammalian cells as genetic circuits, enabling researchers to make complex computations. The BLADE platform uses DNA recombinases to allow for more targeted manipulation of cells and their behavior.
Researchers at the University of California, Davis have discovered a possible new route to regenerating beta cells, giving insight into healthy metabolism and diabetes. This discovery could lead to better treatment or cures for diabetes by understanding how these cells mature into functioning beta cells.
Preliminary research suggests that low-calorie sweeteners promote metabolic dysfunction and increase glucose transport into cells. Studies found increased expression of genes markers of fat production and inflammation in human stem cells exposed to sucralose.
Researchers from UConn Health have developed a way to regenerate rotator cuff tendons after they're torn, creating stronger repairs. The nano-textured fabric seeded with stem cells helps the tendons attach better to the bone and heal more evenly.
Scientists at Sylvester Comprehensive Cancer Center have found that p300 protein acts as a tumor suppressor, preventing myelodysplastic syndrome (MDS) from developing into acute myeloid leukemia (AML). Eliminating p300 in mice results in rapid leukemia development.
Researchers have developed a new method to deliver large and diverse cargos directly into cells with high efficiency and no lasting damage. The team used gold pyramid-shaped microstructures and nanosecond laser pulses to create brief pores in the cell membrane, allowing molecules to diffuse into the cell.
A Florida clinic's unproven stem cell treatment blinded three women with macular degeneration, causing vision loss and other complications. The treatment, which involved injecting fat cells into the eyes, lacked proper scientific design and oversight.
Researchers found that intestinal stem cells lose regenerative capacity with age and that reactivating Wnt signaling can restore healthy function in older people. The study suggests a possible therapeutic approach to address imbalances in food and nutrient absorption, which may be linked to diminished Wnt signaling.
Researchers identified autophagy as a critical process for promoting germline stem cell proliferation, specifically by regulating the cell cycle of progenitor cells. The study also found that autophagy is finely tuned in surrounding tissues to maintain germline homeostasis.
Researchers at Columbia University School of Engineering and Applied Science have developed a novel cross-circulation platform that maintains the viability and function of donor lungs for several days. The technology, inspired by an abandoned surgical procedure from the 1960s, enables long-term support of living organs outside the body.
Researchers at Lund University successfully reprogrammed old blood stem cells to function like those of younger individuals, revealing a potential new approach to treating age-related diseases. This breakthrough suggests that epigenetic changes, rather than DNA mutations, underlie the decline in blood cell function with age.
Researchers have discovered a drug combination that can regenerate hair cells in the inner ear, offering a potential new way to treat hearing loss. The treatment involves expanding progenitor cells and stimulating them to become mature hair cells.
Scientists have successfully converted mouse alpha cells into insulin-producing beta cells by blocking the expression of two specific genes. The research suggests that this natural flexibility in cell fate may be exploited to develop a new therapeutic approach for Type 1 diabetes.
A University of East Anglia study reveals that the protein ninein is crucial for normal tissue development in the human gut. The research shows how microtubule rearrangements and the assembly of new Microtubule Organising Centres facilitate cell shape formation, nutrient uptake, and ultimately prevent cancer.
Researchers at Stanford University School of Medicine have developed a cheap and reusable diagnostic 'lab on a chip' with the help of an ordinary inkjet printer. The technology has the potential to enhance diagnostic capabilities around the world, especially in developing countries where access to early diagnostics is limited.
Scientists have identified antiviral T cells that can access HIV's germinal center hideouts using the CXCR5 molecule. These cells have stem cell-like properties and can infiltrate sites of ongoing viral replication, providing a potential target for therapeutic vaccines and HIV suppression.
Researchers at Rice University have developed a new compound of bismuth and carbon nanotubes that improves upon existing cell-tracking agents. The improved Bi4C@US-tubes show up strongly on X-rays taken with computed tomography (CT) scanners, allowing for more efficient tracking of stem cells in the body.
Scientists have developed a method to observe gene editing in real-time, enabling the investigation of CRISPR-Cas9's biological processes and potential applications for treating genetic diseases such as sickle cell anemia and cystic fibrosis.
Researchers have mapped how plant cells determine size and adjust growth to achieve homogeneous cell sizes over time. This breakthrough overturns previous theories in the field, providing insights into factors determining plant size and fruit production.
Researchers discovered that immune cells use an active process to create gaps in blood vessel walls, involving the breakage of thin filaments and rapid reassembly. This process allows immune cells to squeeze through and survey organs for problems or join the fight against pathogens.
Researchers successfully used CRISPR-Cas9 technology to repair genetic mutations in blood stem cells of patients with chronic granulomatous disease, a rare and life-threatening disorder. The engineered cells maintained their gene edits long-term without side effects when implanted into mice.
Researchers have successfully generated epicardium cells using human stem cells and Wnt signaling pathway activation. The new method could potentially repair damaged heart tissue in patients who suffer from heart attacks, according to the study published in Nature Biomedical Engineering.
Researchers at Whitehead Institute have developed a gene pathway that enables the growth of brain organoids with surface folding, a key feature of human brain development. The study also shows potential for modeling Zika virus-caused microencephaly and identifying affected cells.
Researchers aim to remove senescent cells, which accumulate with age, to regrow hair, improve organ function and combat aging. However, hurdles include safety issues, off-target effects and high costs, limiting translation to humans.
Researchers at Kyoto University found that the Myc gene regulates stem cell self-renewal in mice, leading to a slower rate of proliferation and impaired energy production. This discovery may lead to new treatments for infertility by stimulating sperm cell metabolism.
Researchers have developed synthetic stem cells that mimic natural cardiac stem cells, promoting tissue repair and reducing risks of tumor growth and immune rejection. These cells are more durable, can be used off-the-shelf, and can tolerate harsh freezing and thawing.
Researchers discovered a single gene mutation causing two types of heart disease: one causes holes in infants' hearts, and the other leads to heart failure. The study revealed how the GATA4 gene's disruption affects cardiac development and muscle contraction.
A stem cell-based treatment, known as the Cell Bandage, has been trialled in humans and shown to repair damaged meniscus tissue, restoring full knee function. The trial received positive results, with three out of five patients retaining an intact meniscus after 24 months.
Researchers at the Krembil Research Institute have published a paper that challenges the prevailing view of vision recovery after retinal cell transplantation. They found that transplanted photoreceptor cells do not enter the recipient retina, contrary to previous interpretations.
A team of researchers from the University of Toronto has developed a proprietary peptide-hydrogel biomaterial that promotes skin cells to 'crawl' together, closing chronic, non-healing wounds caused by diabetes. The treatment closed wounds 200% faster than no treatment and 60% faster than existing collagen-based products.
Researchers developed a new heart imaging test that analyzes longitudinal strain to predict patient survival after stem cell transplant. The test outperformed conventional biomarkers and detected improvements before changes in traditional echocardiographic measures.
Researchers at Duke University have identified a set of DNA-binding proteins in Arabidopsis roots that work together to trigger stem cell differentiation and create specialized cells with distinct roles. This discovery sheds light on the longstanding question of how plants make so many types of cells from the same genetic instructions.
Researchers at Stanford University School of Medicine found that stem cells can police themselves to reduce scarring by producing a truncated version of a protein. This discovery holds promise for treating muscle diseases like muscular dystrophy and promoting healthy aging.
Researchers at UCLA discovered that cardiac fibroblasts, which give rise to scar tissue after injury, can also produce bone-like cells. By blocking an enzyme involved in bone mineralization, they prevented calcification in mice, offering a potential new approach for treating abnormal calcium deposits in the heart.
Researchers at MD Anderson Cancer Center identified a pathway by which cancer cells spread in the brain, opening up new possibilities for treatment. They found that the gene WNT5A enables glioma stem cells to transition into GdECs, leading to aggressive tumor growth and disease recurrence.
A recent study found that injury in schistosome parasites triggers stem cell growth, which restores aging tissue and aids the parasite's long-term survival. This discovery could lead to new ways to target these worms and improve our understanding of their infection mechanisms.
Researchers at VIB and Ghent University have uncovered a novel protein complex that controls plant tissue repair. This breakthrough could enable the efficient cultivation of crops and make them more resistant to parasites like those found in rice, wheat, and bananas.
Researchers at Hospital for Special Surgery have identified a population of stem cells called ADSCs that are reduced in number in the layer of fat sitting under the skin in patients with scleroderma. The study found that replenishing these cells with antibodies may reverse the fibrosis characteristic of the disease.
Researchers have developed an innovative skin graft process that combines split thickness skin grafts with a specially engineered sheet of stem cells to maximize natural healing power. The new technique shows promising results in treating large or complicated burn injuries, preserving hair follicles and oil glands.
The study found that when mitochondria are disrupted, stem cells lose their ability to self-regenerate, but stressed cells initiate a growth program leading to tissue regeneration. This highlights the fundamental role of functioning mitochondria in regulating intestinal tissue renewal.
A study found that corneal cells' softness indicates their potential for stem-like activity, enabling rapid and cost-effective enrichment of limbal stem cells. This biomarker could improve clinical success rates for corneal transplant patients with naturally low limbal stem cell percentages.
Researchers discovered that leukemia cells don't hide in specific niches but instead move actively throughout the bone marrow. This movement may help them survive treatment and evade targeted therapies.