Articles tagged with Stem Cells
Researchers have successfully developed kidney tissue that exhibits the early stages of congenital kidney disease using iPS cells from a patient with a nephrin mutation. The study found that repairing the nephrin mutation can normalize abnormalities and may lead to the development of effective drugs for kidney disease.
Materials engineers are developing environmentally friendly materials, including graphene-based nanofibers, for various applications such as environmental protection, agriculture, medicine, and clothing industry. These nanofibers offer unique properties like conductivity, strength, flexibility, and bio-basis, making them promising for ...
A Stanford-led study identifies uhrf1 and s100a10 as key genes driving rapid deer antler growth, a process that could inform new approaches for treating human bone conditions like osteoporosis. The researchers hope to apply the underlying biology of deer antlers to develop more efficient therapies.
Researchers at the University of Houston have developed a new environment for repairing eyes using hyaluronic acid. By creating an ideal substrate layer with high concentrations of hyaluronic acid, they aim to improve the treatment of patients with limbal stem cell deficiency, which can lead to opaque corneas.
Scientists discovered that mistakes in proofreading the genetic code of retinal cells lead to a form of inherited blindness, retinitis pigmentosa. The study, published in Nature Communications, offers hope for a new gene therapy treatment.
Researchers at Johns Hopkins University have successfully grown human retinas in a dish, providing insights into how cells enable color vision. The study found that thyroid hormone plays a crucial role in determining the fate of these cells, with implications for understanding and potentially treating eye diseases.
The NIH has awarded a $3.6 million grant to study the safety of CRISPR-like therapies in human tissues. A team led by Todd McDevitt will assess the safety and toxicity issues of genome editing, developing platforms to detect adverse effects on physiological function.
Researchers have developed a method to 3D-print cells to produce human tissue such as ligaments and tendons, eliminating the need for additional surgeries and reducing reliance on harvested tissue. The technique involves printing stem cells on hydrogel to form tissue that can grow in vitro before implantation.
A UH biologist is using a new grant to study how defects in cellular cross-talk lead to Crohn's disease. By examining stem cells isolated from patients, she hopes to find new targets for drug development and reduce inflammation in the gastrointestinal tract.
A new approach using umbilical cord blood stem cells has shown promising results in repairing cleft palates in infants. The procedure, performed as part of reconstructive surgery when the infant is a few months old, provides good results in growing new bone to close the upper jaw cleft and may avoid the need for later bone graft surgery.
A new study examines Canadian clinics marketing unproven stem cell treatments, highlighting regulatory gaps and potential risks to patients. The majority of marketed treatments target orthopedic and musculoskeletal conditions, with some companies advertising for a wide range of disorders.
Researchers developed a microtissue model of the heart to study how environmental stress affects normal and abnormal heart tissue. The study found that mutant cells contracted abnormally and arrhythmically under stress, similar to HCM patients.
The study found that dietary cholesterol alters cellular programming, promoting hormone-producing cells and nutrient-handling cells. Low nutrient availability triggers changes in intestinal structure and metabolism with long-term effects on metabolic health.
Researchers identified six main combinations of five Hoxd genes involved in digit development in mice, providing a higher resolution and clarity in understanding how architect genes orchestrate the rhythm of development. This study offers a new perspective on limb patterning motifs and could pave the way for future genetic work.
Researchers at the University of Würzburg have made a breakthrough in treating myocardial infarction, with stem cells found to exist in vascular walls and intracardiac blood vessels. These cells may be able to regenerate damaged cardiac muscle tissue in response to heart attacks.
Researchers identify β-Hydroxybutyrate as a molecule with anti-aging effects on the vascular system. The compound can delay cellular aging and promote cell division, potentially reducing the incidence and severity of human diseases such as cardiovascular disease and Alzheimer's disease.
Researchers identified unique cell populations in human joint cartilage, crucial for cushioning and often lost in arthritis. Stem cell-derived cartilage can be transplanted into arthritic rats to regenerate the superficial zone, potentially leading to better treatments.
Scientists at the Salk Institute have developed a technique to directly convert cells in an open wound into new skin cells, promoting healing and countering the effects of aging. The approach, which relies on reprogramming cells to a stem-cell-like state, shows promising results in treating large ulcers and skin damage.
Researchers at Hebrew University of Jerusalem have developed a new biological drug that has shown a 50% cure rate in lab mice with acute leukemia. The single-molecule drug targets multiple leukemic proteins, making it difficult for cancer cells to evade therapy and reducing the need for multiple treatments.
Researchers developed a new method to distinguish changes in protein synthesis from degradation in single living cells. They found that protein synthesis and degradation rates change significantly during the cell cycle, with nearly half of proteins stopping to be degraded during mitosis.
Research found that STAT3 is constitutively activated in CAEBV-infected T- or NK-cells, promoting cell survival and inflammation. Ruxolitinib inhibition blocks survival and reduces pro-inflammatory cytokine production, suggesting a potential therapeutic target for this fatal disorder.
Researchers at Georgia Institute of Technology developed a molecular matrix that effectively delivers muscle satellite cells to injured muscle tissue, promoting healing and protection from immune reactions. The hydrogel therapy has potential to treat muscular dystrophy patients, including those with Duchene muscular dystrophy.
Researchers at UIC are developing a new exosome-based approach to regenerate bone and tissues, with the goal of reducing side effects and advancing therapies. Engineered exosomes may aid regeneration faster than growth factors, with fewer complications.
Researchers identified a rare pulmonary ionocyte cell type in airway tissue, playing a key role in cystic fibrosis. The new cell subtype expresses CFTR at high levels, challenging previous assumptions about airway function.
The SLAS Technology special issue showcases advancements in cell separation methods, bioreactor systems and automation to improve the manufacturing process of cell-based therapies. These technologies aim to decrease costs and enhance safety while expanding applications beyond oncology.
Harvard researchers create a scale model of a beating heart ventricle using human heart cells and nanofiber scaffolds. The model can be used to study heart function and test new treatments for arrhythmia and other conditions.
A subset of immune cells has been found to create and sustain chronic inflammatory bowel disease, a condition characterized by persistent diarrhea and abdominal pain. These cells could become therapeutic targets to treat Crohn's disease and ulcerative colitis.
A study by Philipp Maass and Anja Weise found that chromosomes 12 and 17 frequently interact with each other across different individuals, resulting in recurrent patterns. This interaction is linked to a human genetic condition, brachydactyly, where the deletion of a specific gene alters chromosomal arrangements and disturbs interactions.
Researchers used single-cell transcriptomics to characterize stromal cells in fat tissue and discovered a subpopulation called Aregs that suppresses adipogenesis. These findings provide potential new avenues for treating metabolic diseases like type-2 diabetes.
Researchers at Tampere University used artificial intelligence and machine learning to differentiate between genetic cardiac diseases from healthy cells. The study successfully identified specific features in cardiomyocyte beating behavior, enabling accurate diagnosis.
Researchers successfully restored cartilage tissue and eliminated pain syndrome in a patient using cell technology-based regenerative medicine. This treatment promises to prolong the lives of natural joints by addressing limited regenerative potential of knee cartilage injuries.
Researchers used periodontal ligament-derived stem cells to create a cell sheet that promoted the formation of both cementum- and PDL-like tissue in dogs. This innovative work combines traditional dental implants with stem cell sheet technology, offering a promising solution for widespread dental health care issues.
In certain fish and frogs, cellular umbrellas shade fragile stem cells from the sun's harmful rays. This discovery highlights an important tool some aquatic animals use to keep crucial blood-cell-producing stem cells safe.
Researchers at Harvard University have discovered that the 'blood stem cell niche' evolved to protect blood stem cells from ultraviolet (UV) rays in sunlight. This finding has significant implications for improving the safety of blood stem cell transplants, a procedure used to treat patients with blood diseases and cancers.
USC researchers have discovered that the precise arrival of progenitor cells determines their form and function in the kidney. The study advances understanding of how to assemble building blocks to fashion kidney tissue, which can lead to breakthroughs in drug development and organ transplantation.
Scientists at Newcastle University successfully printed the first human corneas using a unique gel-like substance and 3D printing technology. The breakthrough could provide an unlimited supply of corneas for transplantation, addressing a significant shortage that affects millions worldwide.
Researchers have engineered a cell-like structure that harnesses photosynthesis to perform metabolic reactions, including energy harvesting and cytoskeleton formation. This innovation opens up new possibilities for building artificial cells that can mimic complex biological behaviors.
A special section in Perspectives in Biology and Medicine examines the newest and most complex issues surrounding stem cells. The issue includes essays on the potential impacts of using a person's own stem cells on patients, health-care systems, and the public trust in science and medicine.
Recent studies suggest tRNAs and tRNA fragments are involved in cellular processes associated with diseases such as cancer, viral infections, and neurodegenerative disorders. Dr. Todd Lowe's lab is characterizing all 500 human tRNA genes to determine their roles in the cell.
Crowdfunding campaigns for unproven stem cell interventions often convey misleading information about treatment efficacy and risks. The study analyzed 408 campaigns, finding that 44% made definitive claims, while 36 mentions of low-risk interventions were reported.
Researchers discovered a connection between genes controlling hair color and innate immune response in mice. Gray hair is associated with activation of the innate immune system, which produces signaling molecules to fight off viruses and bacteria.
Researchers tracked 27 patients for five years after receiving purified CD34+ cell therapy, showing improved pain management and limb salvage. The study suggests a potential new cell therapy for debilitating disease.
Researchers have developed a new way to introduce molecules and therapeutic genes into human cells using ultrafast compression, which can improve cell transfection efficiency. The technique involves compressing cells in microfluidic devices, causing them to take up surrounding fluid and macromolecules.
Salk Institute researchers have generated aggressive glioblastoma multiforme tumors in human cerebral organoids using CRISPR-Cas9 tool. The new model could be used to study tumor progression, investigate new drugs or personalize treatments for patients.
Researchers at Stockholm University discovered a new mechanism regulating stem cells in the fruit fly's intestine and found that a specific protein can slow tumour growth. The study sheds light on how intestinal diseases occur and may contribute to the development of new medicine to prevent and cure them.
Gene editing of bone marrow stem cells has shown promise against HIV in non-human primates. The technique successfully reduced the size of dormant 'viral reservoirs' that pose a risk of reactivation, giving rise to white blood cells resistant to SHIV.
Researchers at UCLA have identified four distinct subtypes of melanoma with varying levels of sensitivity to ferroptosis, a type of self-inflicted cell death. These findings suggest new treatment approaches for dedifferentiated melanomas by combining ferroptosis-inducing drugs with multiple cancer therapies.
Researchers have identified tuft cells as the primary target of norovirus infection, a discovery that could pave the way for new treatments. The study found that administering immune signaling proteins IL-4 and IL-25 increased viral transmission and abundance in mice.
Researchers at the University of Iowa have discovered glandular myoepithelial cells that can regenerate airways after severe injury. These reserve stem cells can develop into new replacement cells in both submucosal glands and the lining of the airway, offering a potential therapeutic target for lung diseases.
Researchers at University of Sydney establish method to identify individual extracellular vesicles (EVs) using resonance-enhanced atomic force microscope infrared spectroscopy. This allows for biomarkers for diverse diseases such as cancers, cardiovascular, kidney and liver disease, dementia, and multiple sclerosis.
A team of computational biologists developed an algorithm to integrate multiple sequencing datasets at single-cell resolution. This approach enables the comparison of single-cell datasets and dissects differences between them.
Researchers from Moscow State University discovered the structure of a key region of the telomerase enzyme, which plays a crucial role in cellular aging and DNA replication. The study's findings have significant implications for developing potential anticancer drugs and understanding the regulation of telomerase activity.
A team of plant geneticists at Cold Spring Harbor Laboratory identified a protein receptor on stem cells that issues different instructions depending on the peptide fragment activating it. This multi-functional receptor has important implications for boosting crop yields, particularly in crops like corn and rice.
Researchers created a 3D bioengineered tooth bud model using Gelatin Methacrylate (GelMA) hydrogel and postnatal dental stem cells. Decellularized tooth bud extracellular matrix (dTB ECM) was introduced to enhance dental stem cell differentiation, resulting in whole tooth structures upon in vivo implantation
A new study suggests that low-calorie sweeteners can promote metabolic syndrome and increase the risk of prediabetes and diabetes in overweight individuals. The research found that these substances can lead to increased glucose entry into cells through enhanced activity of genes called glucose transporters.
Researchers at University of Illinois Chicago developed chimeric cells that can restore the structural muscle protein dystrophin in people with Duchenne muscular dystrophy, potentially avoiding the need for immunosuppressive drugs.
Researchers at BWH discovered that cell sex influences nanoparticle uptake, response to reprogramming techniques, and paracrine factors. These findings may help develop sex-specific nanomedicines for targeted drug delivery applications.
Researchers at UCLA have created a new method for targeted gene delivery using 'nanospears,' which can enable safer, faster and more cost-effective gene therapies. The nanostructures are biodegradable and can be mass-produced inexpensively, delivering genetic information with minimal impact on cell viability and metabolism.
Researchers have developed a method to create large amounts of fillable and targeted nanovesicles using immune cells. These nanovesicles can be customized with specific ligands to target different types of tumors, enabling more effective cancer treatment.
Researchers have identified a lung stem cell that repairs the organ's gas exchange compartment and restores respiratory function after severe influenza and other respiratory ailments. The discovery provides new insights into lung regeneration and identifies novel genetic and epigenetic pathways important for lung regeneration.