Articles tagged with Stem Cells
Researchers at Baylor College of Medicine discovered a new approach to treating age-related diseases by stabilizing telomeres and restoring sirtuin activity. This method shows promise in improving liver disease outcomes in a mouse model.
A new 3D printing method enables the creation of fine-scale mesh structures that allow for precise control over a cell's microenvironment. This could lead to highly uniform cultures of cells with desired properties, making it a promising tool for biomedical research and potential medical applications.
Chronic inflammation, not aging, is the main reason why bones heal more slowly with age. Researchers found that exposure to older mice's blood serum reduces stem cell multiplication and increases inflammation. Treatment with anti-inflammatory drugs restored skeletal stem cell function and bone healing ability in aged mice.
Scientists have discovered that deleting the gene encoding ASCT2, a transporter enzyme responsible for bringing amino acids into cells, prolongs survival of mice with aggressive leukemia. The study found that ASCT2 is required for leukemia development and progression but dispensable for normal blood cell development.
Scientists are working on modifying human breast milk cells to produce specific proteins, such as vaccines, for premature babies. These engineered cells could potentially address birth defects, provide necessary proteins, or even treat certain diseases.
A low-calorie fasting-mimicking diet has been shown to reduce intestinal inflammation and increase intestinal stem cells, promoting the expansion of beneficial gut microbiota. The study suggests that this regimen may have potential in mitigating inflammatory bowel disease (IBD) pathology.
Researchers discovered two types of fat tissue cells that help bone heal: pericytes stimulate blood vessel growth and adventicytes form bone cells. Combination therapy using both cells promotes robust bone repair in mice with skull defects.
Researchers at Linköping University created a hydrogel that mimics the natural environment of cells, allowing for the growth of human liver cells on microchips. This innovation has the potential to simplify early stages of drug development and replace animal experiments.
A Brazilian project aims to assess how patients awaiting kidney transplants react to porcine blood, with the goal of reducing the country's transplant waiting list. The initiative uses gene-edited pigs and CRISPR-Cas9 technology to make organs compatible with human bodies.
A study published in The Journal of Bone & Joint Surgery found that rotator cuff muscle stem cells have a higher propensity to develop into fat cells, leading to fatty infiltration and weakening of the muscles. This genetic basis may explain why rotator cuff tears are difficult to rehabilitate.
Researchers have restored muscle stem cell function in animal models of Duchenne muscular dystrophy, leading to efficient muscle regeneration and preventing progressive loss of muscle strength. The study's findings suggest a new treatment approach may be effective in addressing this complex disease.
A new study identifies key factors involved in cell cycle arrest and illuminates a novel intracellular structure, paving the way for new therapeutic targets to treat kidney fibrosis. The research team found that blocking the formation of TASCCs reduced the severity of kidney fibrotic disease progression in preclinical models.
A clinical trial has shown promise in using stem cells from donors to repair the surface of the eye in patients with limbal stem cell deficiency, a significant cause of sight loss. The trial also sheds light on the causes of sight disorders and offers clues about how eye tissue loss could be repaired.
Scientists from JNCASR and inStem successfully created a synthetic mimic of cytoskeletal networks with structural and temporal programming. The system was developed through reaction-driven controlled growth, enabling precise control over one-dimensional growth and self-repairing features.
Researchers have found that nuclei gained during training persist even when muscle cells shrink due to disuse or disease, allowing for rapid growth when retrained. This discovery has important implications for public health policy and suggests that exercise in early life can help prevent frailty in old age.
Researchers at Heidelberg University have identified bifacial stem cells responsible for forming wood and plant bast fibres. By studying specific cell types in the cambium layer, they discovered that these cells produce both wood and bast tissues bidirectionally.
Researchers created a self-curving cornea by molding cells to form a desired shape, mimicking the natural cornea. The 4D tissue structure was achieved through innovative cell actuators that forced surrounding tissue to move in a predetermined manner.
Researchers at Washington University School of Medicine have developed a new method for producing insulin-producing beta cells from human stem cells, which are more responsive to fluctuating glucose levels. The resulting cells were transplanted into diabetic mice and effectively controlled blood sugar for several months.
Researchers have developed a breakthrough technology to grow human blood vessels as organoids in a petri dish, which can be used to study vascular diseases and identify potential treatments. The discovery has the potential to unravel causes of conditions such as Alzheimer's disease, cardiovascular diseases, and cancer.
Researchers have created a method for modifying blood stem cells to reverse the genetic mutation that causes IPEX, a life-threatening autoimmune syndrome. The approach adds a normal copy of the FoxP3 gene to blood stem cells, restoring proper immune regulation and eliminating symptoms in mice.
Researchers at Johns Hopkins Medicine have identified a cellular protein signal that drives both bone and fat formation in stem cells. Harnessing this signal, WISP-1, could help fractures heal faster, speed surgical recovery and prevent bone loss due to aging or injury.
A new study by Tel Aviv University reveals that a functional heart cell defect may be the underlying cause of peripartum cardiomyopathy (PPCM), a rare form of heart failure. The research found that levels of STAT3 protein were higher in PPCM patients' heart cells than in healthy women, and that a defect in releasing growth factors was ...
Researchers at the University of Tokyo have developed an ultra-soft electronic sensor that can closely monitor beating heart cells without affecting their behavior. This breakthrough device uses a nanomesh sensor to study cardiomyocytes in a more faithful way, paving the way for future embedded medical devices.
A new method for single cell chromatin accessibility profiling has been developed, allowing researchers to profile over 3000 cells from the spleen. The study revealed distinct immune cell types and related transcription factors, providing insights into cellular function and organization.
Researchers at Rutgers University have developed a new model of cardiac muscle cells that can pump together, potentially treating heart failure. The newly created cardiac muscle cells were made to work cohesively through the over-expression of a protein called CREG.
The discovery of protein DEX-1 in the roundworm C. elegans sheds light on the molecular trigger for structural remodeling in response to stress, allowing animals to better withstand challenging conditions. This research has implications for understanding nematode biology and its impact on parasitic species affecting crops.
Researchers at Duke University Medical Center have identified a key player in bone healing - young macrophage cells and their secreted proteins. Introducing these factors into old mice improves fracture repair, providing a potential new treatment for delayed healing.
Researchers at the University of Zurich identified a molecule that plays a key role in graft-versus-host responses, which can be fatal for leukemia patients. Blocking this molecule, GM-CSF, could significantly improve stem-cell transplant outcomes.
Researchers at Penn State have discovered that citrate, a natural product found in bones and citrus fruit, can fuel bone healing by providing extra energy for stem cells. This understanding will help develop slow-release biomaterials to speed up bone repair and reduce inflammation.
A machine-learning algorithm, inDelphi, predicts the precise correction of broken genes by analyzing data from CRISPR-induced breaks. Researchers successfully corrected nearly 200 disease-associated genetic variants, restoring gene function to healthy states.
UTSA scientists create world's most comprehensive digital roadmap for male fertility by analyzing individual cells' gene expression. This innovation could help diagnose and treat infertility issues, as well as inform the development of new contraception methods.
Scientists have discovered a way to detect the early signs of atherosclerosis, leading to blocked arteries, by analyzing changes in blood vessel cells. The study used single-cell RNA-sequencing and lineage labelling to identify unusual cells that express stem cell genes, which could help diagnose and treat cardiovascular diseases.
Materials engineers are developing environmentally friendly materials, including graphene-based nanofibers, for various applications such as environmental protection, agriculture, medicine, and clothing industry. These nanofibers offer unique properties like conductivity, strength, flexibility, and bio-basis, making them promising for ...
A new type of skeletal stem cell has been discovered in the 'resting zone' of the epiphyseal growth plate, which is a crucial cartilaginous tissue for bone growth. These cells are found to be active and produce both cartilage and bone, as well as support blood cell production.
Researchers have successfully developed kidney tissue that exhibits the early stages of congenital kidney disease using iPS cells from a patient with a nephrin mutation. The study found that repairing the nephrin mutation can normalize abnormalities and may lead to the development of effective drugs for kidney disease.
Researchers at the University of Houston have developed a new environment for repairing eyes using hyaluronic acid. By creating an ideal substrate layer with high concentrations of hyaluronic acid, they aim to improve the treatment of patients with limbal stem cell deficiency, which can lead to opaque corneas.
A Stanford-led study identifies uhrf1 and s100a10 as key genes driving rapid deer antler growth, a process that could inform new approaches for treating human bone conditions like osteoporosis. The researchers hope to apply the underlying biology of deer antlers to develop more efficient therapies.
Scientists discovered that mistakes in proofreading the genetic code of retinal cells lead to a form of inherited blindness, retinitis pigmentosa. The study, published in Nature Communications, offers hope for a new gene therapy treatment.
Researchers at Johns Hopkins University have successfully grown human retinas in a dish, providing insights into how cells enable color vision. The study found that thyroid hormone plays a crucial role in determining the fate of these cells, with implications for understanding and potentially treating eye diseases.
Researchers have developed a method to 3D-print cells to produce human tissue such as ligaments and tendons, eliminating the need for additional surgeries and reducing reliance on harvested tissue. The technique involves printing stem cells on hydrogel to form tissue that can grow in vitro before implantation.
The NIH has awarded a $3.6 million grant to study the safety of CRISPR-like therapies in human tissues. A team led by Todd McDevitt will assess the safety and toxicity issues of genome editing, developing platforms to detect adverse effects on physiological function.
A UH biologist is using a new grant to study how defects in cellular cross-talk lead to Crohn's disease. By examining stem cells isolated from patients, she hopes to find new targets for drug development and reduce inflammation in the gastrointestinal tract.
A new approach using umbilical cord blood stem cells has shown promising results in repairing cleft palates in infants. The procedure, performed as part of reconstructive surgery when the infant is a few months old, provides good results in growing new bone to close the upper jaw cleft and may avoid the need for later bone graft surgery.
A new study examines Canadian clinics marketing unproven stem cell treatments, highlighting regulatory gaps and potential risks to patients. The majority of marketed treatments target orthopedic and musculoskeletal conditions, with some companies advertising for a wide range of disorders.
The study found that dietary cholesterol alters cellular programming, promoting hormone-producing cells and nutrient-handling cells. Low nutrient availability triggers changes in intestinal structure and metabolism with long-term effects on metabolic health.
Researchers developed a microtissue model of the heart to study how environmental stress affects normal and abnormal heart tissue. The study found that mutant cells contracted abnormally and arrhythmically under stress, similar to HCM patients.
Researchers identified six main combinations of five Hoxd genes involved in digit development in mice, providing a higher resolution and clarity in understanding how architect genes orchestrate the rhythm of development. This study offers a new perspective on limb patterning motifs and could pave the way for future genetic work.
Researchers at the University of Würzburg have made a breakthrough in treating myocardial infarction, with stem cells found to exist in vascular walls and intracardiac blood vessels. These cells may be able to regenerate damaged cardiac muscle tissue in response to heart attacks.
Researchers identify β-Hydroxybutyrate as a molecule with anti-aging effects on the vascular system. The compound can delay cellular aging and promote cell division, potentially reducing the incidence and severity of human diseases such as cardiovascular disease and Alzheimer's disease.
Researchers identified unique cell populations in human joint cartilage, crucial for cushioning and often lost in arthritis. Stem cell-derived cartilage can be transplanted into arthritic rats to regenerate the superficial zone, potentially leading to better treatments.
Scientists at the Salk Institute have developed a technique to directly convert cells in an open wound into new skin cells, promoting healing and countering the effects of aging. The approach, which relies on reprogramming cells to a stem-cell-like state, shows promising results in treating large ulcers and skin damage.
Researchers at Hebrew University of Jerusalem have developed a new biological drug that has shown a 50% cure rate in lab mice with acute leukemia. The single-molecule drug targets multiple leukemic proteins, making it difficult for cancer cells to evade therapy and reducing the need for multiple treatments.
Researchers developed a new method to distinguish changes in protein synthesis from degradation in single living cells. They found that protein synthesis and degradation rates change significantly during the cell cycle, with nearly half of proteins stopping to be degraded during mitosis.
Research found that STAT3 is constitutively activated in CAEBV-infected T- or NK-cells, promoting cell survival and inflammation. Ruxolitinib inhibition blocks survival and reduces pro-inflammatory cytokine production, suggesting a potential therapeutic target for this fatal disorder.
Researchers at Georgia Institute of Technology developed a molecular matrix that effectively delivers muscle satellite cells to injured muscle tissue, promoting healing and protection from immune reactions. The hydrogel therapy has potential to treat muscular dystrophy patients, including those with Duchene muscular dystrophy.
Researchers at UIC are developing a new exosome-based approach to regenerate bone and tissues, with the goal of reducing side effects and advancing therapies. Engineered exosomes may aid regeneration faster than growth factors, with fewer complications.
Researchers identified a rare pulmonary ionocyte cell type in airway tissue, playing a key role in cystic fibrosis. The new cell subtype expresses CFTR at high levels, challenging previous assumptions about airway function.
Harvard researchers create a scale model of a beating heart ventricle using human heart cells and nanofiber scaffolds. The model can be used to study heart function and test new treatments for arrhythmia and other conditions.
The SLAS Technology special issue showcases advancements in cell separation methods, bioreactor systems and automation to improve the manufacturing process of cell-based therapies. These technologies aim to decrease costs and enhance safety while expanding applications beyond oncology.
A subset of immune cells has been found to create and sustain chronic inflammatory bowel disease, a condition characterized by persistent diarrhea and abdominal pain. These cells could become therapeutic targets to treat Crohn's disease and ulcerative colitis.