Articles tagged with Stem Cells
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
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Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers at Georgia Institute of Technology developed a molecular matrix that effectively delivers muscle satellite cells to injured muscle tissue, promoting healing and protection from immune reactions. The hydrogel therapy has potential to treat muscular dystrophy patients, including those with Duchene muscular dystrophy.
Researchers at UIC are developing a new exosome-based approach to regenerate bone and tissues, with the goal of reducing side effects and advancing therapies. Engineered exosomes may aid regeneration faster than growth factors, with fewer complications.
Researchers identified a rare pulmonary ionocyte cell type in airway tissue, playing a key role in cystic fibrosis. The new cell subtype expresses CFTR at high levels, challenging previous assumptions about airway function.
The SLAS Technology special issue showcases advancements in cell separation methods, bioreactor systems and automation to improve the manufacturing process of cell-based therapies. These technologies aim to decrease costs and enhance safety while expanding applications beyond oncology.
Harvard researchers create a scale model of a beating heart ventricle using human heart cells and nanofiber scaffolds. The model can be used to study heart function and test new treatments for arrhythmia and other conditions.
A subset of immune cells has been found to create and sustain chronic inflammatory bowel disease, a condition characterized by persistent diarrhea and abdominal pain. These cells could become therapeutic targets to treat Crohn's disease and ulcerative colitis.
Researchers used single-cell transcriptomics to characterize stromal cells in fat tissue and discovered a subpopulation called Aregs that suppresses adipogenesis. These findings provide potential new avenues for treating metabolic diseases like type-2 diabetes.
A study by Philipp Maass and Anja Weise found that chromosomes 12 and 17 frequently interact with each other across different individuals, resulting in recurrent patterns. This interaction is linked to a human genetic condition, brachydactyly, where the deletion of a specific gene alters chromosomal arrangements and disturbs interactions.
Researchers at Tampere University used artificial intelligence and machine learning to differentiate between genetic cardiac diseases from healthy cells. The study successfully identified specific features in cardiomyocyte beating behavior, enabling accurate diagnosis.
Researchers successfully restored cartilage tissue and eliminated pain syndrome in a patient using cell technology-based regenerative medicine. This treatment promises to prolong the lives of natural joints by addressing limited regenerative potential of knee cartilage injuries.
In certain fish and frogs, cellular umbrellas shade fragile stem cells from the sun's harmful rays. This discovery highlights an important tool some aquatic animals use to keep crucial blood-cell-producing stem cells safe.
Researchers at Harvard University have discovered that the 'blood stem cell niche' evolved to protect blood stem cells from ultraviolet (UV) rays in sunlight. This finding has significant implications for improving the safety of blood stem cell transplants, a procedure used to treat patients with blood diseases and cancers.
Researchers used periodontal ligament-derived stem cells to create a cell sheet that promoted the formation of both cementum- and PDL-like tissue in dogs. This innovative work combines traditional dental implants with stem cell sheet technology, offering a promising solution for widespread dental health care issues.
USC researchers have discovered that the precise arrival of progenitor cells determines their form and function in the kidney. The study advances understanding of how to assemble building blocks to fashion kidney tissue, which can lead to breakthroughs in drug development and organ transplantation.
Researchers have engineered a cell-like structure that harnesses photosynthesis to perform metabolic reactions, including energy harvesting and cytoskeleton formation. This innovation opens up new possibilities for building artificial cells that can mimic complex biological behaviors.
Scientists at Newcastle University successfully printed the first human corneas using a unique gel-like substance and 3D printing technology. The breakthrough could provide an unlimited supply of corneas for transplantation, addressing a significant shortage that affects millions worldwide.
A special section in Perspectives in Biology and Medicine examines the newest and most complex issues surrounding stem cells. The issue includes essays on the potential impacts of using a person's own stem cells on patients, health-care systems, and the public trust in science and medicine.
Recent studies suggest tRNAs and tRNA fragments are involved in cellular processes associated with diseases such as cancer, viral infections, and neurodegenerative disorders. Dr. Todd Lowe's lab is characterizing all 500 human tRNA genes to determine their roles in the cell.
Crowdfunding campaigns for unproven stem cell interventions often convey misleading information about treatment efficacy and risks. The study analyzed 408 campaigns, finding that 44% made definitive claims, while 36 mentions of low-risk interventions were reported.
Researchers discovered a connection between genes controlling hair color and innate immune response in mice. Gray hair is associated with activation of the innate immune system, which produces signaling molecules to fight off viruses and bacteria.
Researchers tracked 27 patients for five years after receiving purified CD34+ cell therapy, showing improved pain management and limb salvage. The study suggests a potential new cell therapy for debilitating disease.
Researchers have developed a new way to introduce molecules and therapeutic genes into human cells using ultrafast compression, which can improve cell transfection efficiency. The technique involves compressing cells in microfluidic devices, causing them to take up surrounding fluid and macromolecules.
Salk Institute researchers have generated aggressive glioblastoma multiforme tumors in human cerebral organoids using CRISPR-Cas9 tool. The new model could be used to study tumor progression, investigate new drugs or personalize treatments for patients.
Gene editing of bone marrow stem cells has shown promise against HIV in non-human primates. The technique successfully reduced the size of dormant 'viral reservoirs' that pose a risk of reactivation, giving rise to white blood cells resistant to SHIV.
Researchers at Stockholm University discovered a new mechanism regulating stem cells in the fruit fly's intestine and found that a specific protein can slow tumour growth. The study sheds light on how intestinal diseases occur and may contribute to the development of new medicine to prevent and cure them.
Researchers have identified tuft cells as the primary target of norovirus infection, a discovery that could pave the way for new treatments. The study found that administering immune signaling proteins IL-4 and IL-25 increased viral transmission and abundance in mice.
Researchers at the University of Iowa have discovered glandular myoepithelial cells that can regenerate airways after severe injury. These reserve stem cells can develop into new replacement cells in both submucosal glands and the lining of the airway, offering a potential therapeutic target for lung diseases.
Researchers at University of Sydney establish method to identify individual extracellular vesicles (EVs) using resonance-enhanced atomic force microscope infrared spectroscopy. This allows for biomarkers for diverse diseases such as cancers, cardiovascular, kidney and liver disease, dementia, and multiple sclerosis.
Researchers at UCLA have identified four distinct subtypes of melanoma with varying levels of sensitivity to ferroptosis, a type of self-inflicted cell death. These findings suggest new treatment approaches for dedifferentiated melanomas by combining ferroptosis-inducing drugs with multiple cancer therapies.
A team of computational biologists developed an algorithm to integrate multiple sequencing datasets at single-cell resolution. This approach enables the comparison of single-cell datasets and dissects differences between them.
Researchers from Moscow State University discovered the structure of a key region of the telomerase enzyme, which plays a crucial role in cellular aging and DNA replication. The study's findings have significant implications for developing potential anticancer drugs and understanding the regulation of telomerase activity.
A team of plant geneticists at Cold Spring Harbor Laboratory identified a protein receptor on stem cells that issues different instructions depending on the peptide fragment activating it. This multi-functional receptor has important implications for boosting crop yields, particularly in crops like corn and rice.
Researchers created a 3D bioengineered tooth bud model using Gelatin Methacrylate (GelMA) hydrogel and postnatal dental stem cells. Decellularized tooth bud extracellular matrix (dTB ECM) was introduced to enhance dental stem cell differentiation, resulting in whole tooth structures upon in vivo implantation
A new study suggests that low-calorie sweeteners can promote metabolic syndrome and increase the risk of prediabetes and diabetes in overweight individuals. The research found that these substances can lead to increased glucose entry into cells through enhanced activity of genes called glucose transporters.
Researchers at University of Illinois Chicago developed chimeric cells that can restore the structural muscle protein dystrophin in people with Duchenne muscular dystrophy, potentially avoiding the need for immunosuppressive drugs.
Researchers at BWH discovered that cell sex influences nanoparticle uptake, response to reprogramming techniques, and paracrine factors. These findings may help develop sex-specific nanomedicines for targeted drug delivery applications.
Researchers at UCLA have created a new method for targeted gene delivery using 'nanospears,' which can enable safer, faster and more cost-effective gene therapies. The nanostructures are biodegradable and can be mass-produced inexpensively, delivering genetic information with minimal impact on cell viability and metabolism.
Researchers have developed a method to create large amounts of fillable and targeted nanovesicles using immune cells. These nanovesicles can be customized with specific ligands to target different types of tumors, enabling more effective cancer treatment.
Researchers have identified a lung stem cell that repairs the organ's gas exchange compartment and restores respiratory function after severe influenza and other respiratory ailments. The discovery provides new insights into lung regeneration and identifies novel genetic and epigenetic pathways important for lung regeneration.
Researchers found that S597 slows progression of atherosclerosis in mice with metabolic syndrome by reducing inflammation and immune cell activity. The peptide lowers blood sugar levels without preventing atherosclerosis, offering a novel treatment strategy for protecting against advanced cardiovascular disease.
A University of Guelph study found that cardiolipin helps prevent protein misfolding in Parkinson's disease, leading to nerve cell death. Researchers believe cardiolipin may represent a new target for developing therapies to slow the progression of the disease.
A new study examines the evolutionary dynamics of cancer development in Barrett's Esophagus patients, revealing influences that lead some cells to remain stable while others become cancerous. The research provides insights into the genetic and chromosomal variations that predict progression to esophageal adenocarcinoma.
Researchers at Karolinska Institutet discover high number of mutations in muscle stem cells impairing cell regeneration, which may result in new medication for building stronger muscles. The study found that physical exercise could clear out cells with many mutations.
A new study shows that injecting cardiac progenitor cells can reverse fatal heart disease caused by Duchenne muscular dystrophy, while also improving limb strength and movement ability. Exosomes secreted by the injected cells unexpectedly restore muscle function in a mouse model of muscular dystrophy.
Researchers found that mature cells in different organs activate the same genes and undergo similar processes when dividing again, leading to potential new targets for cancer treatment. This discovery could support using universal strategies to treat or prevent cancer in various organs.
Scientists at Rice University have successfully used CRISPR/Cas9-based gene editing to repair 20-40% of stem and progenitor cells from patients with sickle cell disease. The study, led by bioengineer Gang Bao, aims to find a cure for the hereditary disease.
Researchers at the University of York have identified a potential link between altered sugar chains and enhanced bone formation in stem cells. By treating cells with a chemical that modifies sugar chains, they found improved bone growth processes, which could pave the way for new osteoporosis treatments.
Researchers at Queen Mary University of London have discovered that cells can 'walk' on liquids using protein nanosheets with strong mechanical properties. This breakthrough could lead to the design of new cell technologies for regenerative medicine and tissue engineering.
PanTHERA CryoSolutions has discovered a small molecule inhibitor that prevents ice recrystallization, a process causing cell death and damage when freezing cells and tissues. This technology results in faster engraftment and increased incidence of engraftment for clinical settings.
Scientists at CRAG have found that plant cells know when to stop growing by detecting their size, allowing for coordinated division, elongation, and differentiation. This process is also linked to the effect of steroid hormones, such as brassinosteroids, on root growth.
Scientists have discovered a protein called Setd7 that regulates stem cell growth and differentiation. Inhibiting this protein allows stem cells to remain undifferentiated, facilitating tissue regeneration and improved muscle function.
Researchers at Howard Hughes Medical Institute have developed a synthetic version of the plant hormone auxin and an engineered receptor to recognize it, enabling precise control over plant growth and development. This breakthrough system, called
A novel hypothesis proposes that animal diversification resulted from a revolution within the animals' own biology, rather than in surrounding chemistry. Cells with stem cell properties are vital for multicellular life, and tumor cells have developed mechanisms to maintain these properties despite high oxygen levels.
Scientists have created new tiny tubes that can help with water filtration and tissue engineering studies. The tubes are inspired by protein structures called microtubules found in cells and are thousands of times smaller than a human hair.
Researchers suggest a biological innovation fueled animal diversification during the Cambrian explosion, rather than atmospheric oxygen changes. Tumor biology insights reveal how stem cells maintain properties in high-oxygen environments, sparking new perspective on tissue renewal.
Researchers at Radboud University Medical Center discovered that mevalonate, a byproduct of cholesterol production, trains the immune system. A Western diet rich in cholesterol can also induce trained immune cells, leading to long-lasting inflammation. Statins may inhibit this training, while boosting it could help weakened immune systems
A team of Canadian researchers has discovered a way to re-program innate immune cells to kill tuberculosis. The innovative work aims to make vaccines more effective against TB and other infectious diseases like the flu. By targeting stem cells in the bone marrow, scientists were able to boost the killing efficiency of macrophages.
Researchers have identified a key gene, Ufbp1, that helps maintain healthy Paneth cells in the small intestine, which are essential for a balanced gut microbiome. The study found that when this gene is knocked out, Paneth cells die and good bacteria levels decrease, leading to inflammatory bowel disease.
A gene therapy approach using AAV vectors reprograms alpha cells into functional insulin-producing beta cells, restoring normal blood glucose levels for an extended period. The strategy shows promise for treating autoimmune diabetes without immunosuppression.
A new removable implant has been developed to control type 1 diabetes, with hundreds of thousands of islet cells protected by a thin hydrogel coating and attached to a polymer thread. This therapy could replace daily insulin injections and offer a more effective management solution for the disease.