Articles tagged with Stem Cells
Researchers have engineered silkworms to produce different variants of E-selectin, a critical adhesion molecule involved in inflammation, cancer, and disease processes. The study found that the connecting arm of E-selectin is crucial for binding, while longer armed proteins are better at tethering blood stem cells.
A bacterial superbug can prevent stem cells in the gut from regenerating the inner lining of the intestine, causing potentially severe disease. This damage impairs tissue repair and recovery from disease, particularly in older adults.
Researchers discovered that keratohyalin granules, which form through phase separation, carry molecular messages that prompt skin cells to flatten and die. This process is crucial for maintaining the skin barrier against pathogens.
Researchers at Stanford University have discovered the invisible pattern that growing neurons follow to form a brain using microscopy and mathematics. The technique could be used to coax stem cells to grow into replacement body parts, such as artificial organs.
A team of Cornell researchers compiled a 'cell atlas' of muscle regeneration, cataloging the activity of almost every type of cell involved in muscle repair. The dataset provides a comprehensive picture of cellular interactions and may lead to improved rehabilitation strategies for patients recovering from muscle injuries.
Researchers have discovered that T follicular helper cells can persist for at least 400 days after infection, supporting antibody production even in late stages. This finding opens up new prospects for creating long-term acquired immunity through vaccination strategies.
Researchers at UConn School of Dental Medicine have discovered a population of stem cells residing along vascular channels in bone that can generate new bone-forming cells. These perivascular cells may regulate bone formation and participate in bone mass maintenance.
Researchers developed a new single-cell sequencing technique to study the regulation of gene transcripts. They found that cells use distinct strategies to control transcript copies, involving both transcription and degradation processes.
Researchers at Karolinska Institutet found that so-called egg stem cells do not exist in the human ovary, contrary to previous reports. The study's comprehensive map of ovarian cells will contribute to the development of new methods for treating female infertility.
A new study by KU Leuven and Harvard University found that specific nutrients can inform stem cells which type of cell they should become. Fatty acids signal to stem cells to develop into bone-forming cells when blood vessels are present, while cartilage is formed without them.
Researchers found that intestinal stem cells (ISCs) regenerate through the process of de-differentiation, eliminating the need for a reserve stockpile. Under normal conditions, ISCs differentiate into daughter cells, which can then reverse their differentiation to become ISCs.
Scientists have successfully used CRISPR/Cas9 base-editing to cure cystic fibrosis in human stem cells, providing a promising new approach for treating genetic diseases. The technique, which repairs mutations without cutting DNA, shows great promise for the future treatment of various genetic disorders.
Researchers at Stanford University have developed a CRISPR-Cas tool that can detect and debug faulty genetic circuits, facilitating more precise treatments for diseases like cancer. The technology allows for greater precision in identifying and eliminating diseased cells, with potential applications beyond cancer treatment.
Researchers created 3D human gut organoids from patient cells to simulate leaky gut conditions, revealing new biomarkers and a potential pathway for tightening the gut lining. The study found that the diabetes drug metformin strengthens the junctions of mini-guts, increasing occludin levels up to six-fold.
The bioprinting research roadmap identifies key areas of progress and development, including advancements in bioinks, 3D printing processes, and crosslinking techniques. The report also highlights the potential for bioprinting to create complex biological models and therapeutic products.
Researchers at Texas A&M University have developed biodegradable hydrogels that create a fertile environment for bone stem cells to grow and proliferate. The study found that the space created by degrading hydrogels enables stem cells to thrive, remodel their local environment, and form intricate cellular networks.
Researchers discover that mature bone marrow stromal cells can transform into regenerative cells after an injury, providing an alternative source for bone healing. This breakthrough suggests that these cells could be generated through transformation of readily available mature stromal cells.
A study published in Circulation reveals that an imbalance in the ratio of active and inactive myosin protein disrupts heart muscle contraction and relaxation, leading to hypertrophic cardiomyopathy. Treatment with a small-molecule drug restores proper contraction and energy consumption in human and rodent heart cells.
Researchers developed a novel cryogel vaccine that primes the immune system to attack and eliminate acute myeloid leukemia cells in mice. The vaccine successfully protected against disease recurrence when combined with chemotherapy.
Susan Solomon, CEO of The New York Stem Cell Foundation (NYSCF) Research Institute, receives the 2020 ISSCR Public Service Award for her tireless efforts to support stem cell science and researchers. NYSCF has raised over $350 million for stem cell research projects.
Researchers have developed a new method to transform stem cells into bone cells using an artificial muscle sheet with shape-memory function. This technology has potential applications in treating complex bone fractures by culturing stem cells on the sheet and adapting them to directly strengthen bones.
Researchers at UConn have discovered that transplanting healthy donor bone marrow cells into mice with OI can improve bone strength and structure. The study found that these cells can replace mutant collagen and increase bone mass, offering potential for new therapies to correct the disorder.
Researchers have identified a new subtype of satellite cells that can regenerate muscle tissue without the transcription factor PAX7. This discovery could lead to new gene therapies for people with muscular dystrophy, such as Lavin, who has a rare genetic mutation preventing her from producing this protein.
Researchers have developed a combined experimental and computational pipeline to understand the role of genes in IBD. The study uses organoids to analyze gene expression and identifies 'master regulators' that overlap with IBD-related processes. This breakthrough enables design of new experiments to explore IBD-related processes further.
Scientists from Institut Pasteur have identified a key protein associated with ageing, which is progressively depleted in cells leading to senescence. The discovery sheds light on the mechanisms of senescence and its link to cellular ageing, paving the way for potential therapeutic targets.
A new analysis reveals that donor stem cell transplantation following PD-1 treatment is generally safe and produces good outcomes for patients with Hodgkin lymphoma. Post-transplant treatment with cyclophosphamide may also lead to improved results, reducing rates of acute GVHD and relapse.
A new study finds the 'conductor' gene TCX2 in plant root stem cells coordinates division of different types, ensuring harmonic communication for plant growth. The researchers used mathematical modeling and machine learning to identify TCX2's role in regulating stem cell networks.
Researchers have identified a complex molecular interaction between reactive oxygen species and protein RITF1 that regulates root growth in the small flowering plant Arabidopsis thaliana. This discovery could lead to more efficient crop development for different soil types, optimizing productivity.
Researchers have found that Saussurea extract has antimicrobial properties and can speed up bone tissue regeneration. The study suggests using Saussurea to treat bacterial bone infections, which are resistant to antibiotics.
A recent study in Nature sheds new light on heart treatment controversy by showing that stem cell therapy triggers an acute inflammatory response to enhance mechanical properties of injured areas. Injecting living or dead stem cells into the heart's infarct region provides a modest benefit to heart function after a heart attack.
A clinical trial enrolled 10 adults with traumatic spinal cord injuries to receive stem cell injections, with the first patient demonstrating significant improvement in motor and sensory functions. The study's early findings suggest that patient response varies, but the treatment may offer a new option for improving physical function a...
Researchers discovered tendon stem cells that can improve tendon healing and potentially avoid surgery. These stem cells compete with scar tissue precursors, suggesting a therapeutic approach to prevent fibrous scarring.
A study by Stanford University researchers found that omega-3 fatty acids influence stem cell division and fat cell formation. The findings suggest that consuming healthy fats can help regulate body weight and insulin sensitivity.
Researchers at Osaka University have discovered a previously unknown type of RA-causing cell within arthritic joints that could be a target for new treatments. The newly discovered cells, dubbed 'AtoMs', have properties that make them amenable to therapeutic targeting.
By adding amniotic epithelial cells to pancreatic islet clusters, researchers created more robust
Researchers have discovered a new mechanism of antitumor response of Natural Killer (NK) cells in myeloma, utilizing histones. Histones bind to CD138 receptors on myeloma cells, promoting tumor cell aggregation and enhancing the recruitment of T lymphocytes, thereby increasing antitumor activity.
Researchers at EMBL developed a new variant of the Sleeping Beauty transposase with improved biochemical properties, allowing for direct protein delivery and autonomous cell penetration. This breakthrough enables efficient and stable genome modifications in target cells on demand.
Scientists discover molecular coordination tool and specialized lymphatic capillaries that transport immune cells and drain excess fluids from tissues, controlling fluid composition and cell synchronization during hair follicle stem cell activity.
Researchers developed a nondestructive TFM platform allowing for high-throughput cell measurements. The new platform uses a regular array of fluorescent markers to enable zero-stress state measurements, reducing the need for cell removal or relaxation.
Researchers discovered a way to stop the process that allows TB bacillus to infect and hijack blood stem cells using an anti-arthritis drug, Tocilizumab. The study found that this transformation can be halted by administering the drug.
Researchers at TU Wien have developed a new bioprinting process that integrates living cells into fine structures created in a 3D printer, achieving high resolution and speed. This technique allows for the control of cell behavior and growth, enabling studies on tissue development and disease spread.
Researchers discover a new drug that reduces inflammation and improves heart function in genetically inherited heart disease, ACM. The treatment targets the immune system's role in disease progression.
The Southwest Research Institute (SwRI) has received additional funding to develop a novel bioreactor for stem cell and CAR T-cell manufacturing, which could revolutionize personalized regenerative medicine.
Biomedical engineer Tara Deans receives $1.5 million grant to develop alternative platelets that can help stop tumor cells from spreading in the bloodstream. Her lab will engineer platelets with proteins that kill cancer cells, inspired by her friend's diagnosis with blood cancer.
Researchers warn that stem cell therapies for shoulder and elbow injuries have far outpaced supporting scientific data, with many treatments still unproven. The clinical data for these treatments are currently limited, and a greater understanding of optimal formulations and dosing schedules is needed to determine their effectiveness.
Researchers found that protein GAS1 suppresses muscle stem cells' ability to build new muscles and regenerate after injury. Reversing GAS1's effect by using GDNF restores muscle stem cell function and regeneration.
A recent study published in eLife reveals that tapeworm regeneration is dependent on stem cells located near the head. Researchers found that severing the head did not prevent regrowth, but signals from the neck are necessary to activate stem cells.
A study published in JCI Insight found that Apolipoprotein E interferes with bone healing in older individuals, leading to weaker bones and increased risk of re-fracture. Researchers discovered that reducing ApoE levels can reverse aging effects on the bones, promoting faster and more effective healing.
A months-old infant with rare childhood leukemia was treated with sorafenib, a targeted therapy approved for adults with inoperable liver cancer. The patient's unique genetic mutation led to a significant response to the treatment, highlighting the importance of identifying genetic mutations in cancer treatment.
A study of institutional 'report cards' found that although a growing number of women are training in the sciences, they are underrepresented in senior roles and face inadequate policies. The researchers suggest that retaining and promoting women scientists is key to achieving gender parity in STEM.
Researchers have developed an 'Islet-on-a-Chip' device that integrates organ-on-a-chip and stem-cell technologies to screen insulin-producing cells, test insulin-stimulating compounds, and study the fundamental biology of diabetes. The device makes it easier to monitor islet function and study cell therapies for diabetes.
Researchers found that non-cancerous cells in tumor microenvironment regress into stem cell-like state, supporting cancer growth. This 'corruption' of neighboring cells enables cancer to thrive and spread.
Researchers from UCLA School of Dentistry developed a new hydrogel that promotes tissue repair and regeneration, inducing stem cell migration to enhance bone healing. The clay-enhanced hydrogel has a more porous structure, improving its ability to deliver cells to defective areas.
The relaxation of international regenerative medicine regulations can lead to a downward spiral in standards, warns Professor Margaret Sleeboom-Faulkner from the University of Sussex. As countries compete for innovative treatments, efficacy is compromised, and risks increase, making it harder to ensure patient safety.
Researchers have developed a novel method to precisely detect and characterize genes in individual cells, enabling selective enrichment of selected molecules. This approach, called BART-Seq, addresses the challenge of detecting low-abundance gene transcripts and has potential applications in disease diagnosis and precision gene-editing.
Researchers at Harvard have grown simplified organs with fully integrated sensors, offering a rare view into early stages of organ development. The cyborg organoids can monitor the electrophysiological activity of cells for up to 90 days, providing insights into how individual cells interact and synchronize during development.
As people age, the prostate grows, leading to an increased risk for prostate cancer and benign prostatic hyperplasia. A new UCLA study found that older mice have more luminal progenitor cells, which can generate new prostate tissue, helping explain why the prostate tends to grow with age.
Researchers have developed a novel culture method for 3D multicellular spheroids, utilizing a durable superamphiphobic surface. This method enables efficient, safe, and in-situ observation of cell growth, with potential applications in drug screening, stem cell differentiation, and regenerative medicine.
Researchers have found that a combination of heart muscle cells and supportive epicardial cells can improve heart function, allowing transplanted cells to survive longer and restore lost heart tissue. The study offers new hope for treating heart failure with an alternative therapy.
The study found that orthopedic, inflammatory, and pain conditions are the main types of medical conditions treated with stem cells at direct-to-consumer stem cell clinics in the Southwest. The researchers also identified differences in the degree to which listed expertise matches the medical conditions treated with stem cells.