Articles tagged with Stem Cells
A USC research team led by Cheng-Ming Chuong has discovered that plucking hair in a specific pattern can trigger the growth of new hairs in mice. The study used quorum sensing to understand how the hair follicle system responds to injury and found that it recruits immune cells to secrete signaling molecules that promote hair growth.
Researchers from Carnegie Institution for Science discovered that brassinosteroids and auxin hormones work antagonistically to regulate root cell elongation, affecting the rate of root growth. This finding could lead to engineering more-efficient crops with idealized root growth and water uptake.
Researchers found that stem cells discard old mitochondria in daughter cells that differentiate, while new stem cells receive young ones. This mechanism may help reduce cellular damage and aging.
Scientists discovered that stem cells distinguish between old and young mitochondria, allocating them disproportionately to daughter cells. This mechanism prevents damage accumulation in the lineage over time.
Researchers compared two fat grafting techniques for facial rejuvenation and found that both methods produce similar results. The simpler approach using fat cells plus stromal vascular fraction has advantages over stem cell injection due to its faster processing time.
Researchers at Rockefeller University identified Sox9 as a key molecule controlling stem cell plasticity in hair follicles. Sox9 enables hair follicle stem cells to regain their ability to produce new tissue and heal wounds by amplifying genes associated with stemness.
Researchers at Scripps Research and Mayo Clinic have identified a new class of senolytic drugs that can slow the aging process. These compounds, dasatinib and quercetin, selectively induce death in senescent cells, leading to improved cardiovascular function, exercise endurance, and extended healthspan.
The Initiative on Women in Science and Engineering Working Group presents seven strategies to address gender imbalances in STEM fields, including financial support and education initiatives. The working group aims to elevate the entire field and ensure women have equal opportunities for career advancement.
Researchers estimate that up to 20% of people aged 50-60 and more than 70% of people over 90 have blood cells with the same gene changes as found in leukemia. Genetic mutations associated with leukaemia become inevitable with age, increasing dramatically with age.
Lene Oddershede's work focuses on merging physics, biology, and medicine to develop new treatments for diseases. Her award-winning research includes the creation of Scandinavia's first optical tweezers, which enable the study of individual cells and molecules without damaging surrounding tissues.
A Massachusetts General Hospital team has developed a method to protect insulin-producing islets from the immune system, enabling long-term blood sugar control without immunosuppression. The approach involves coating or encapsulating islets with CXCL12, a protein that repels immune cells and attracts regulatory T cells.
Recent studies by UC San Diego researchers have uncovered widespread differences in gene regulation between chromosome pairs, influenced by inherited sequence variations. Chromosome folding structures, known as topologically associating domains (TADs), were also found to play a crucial role in gene expression and epigenome organization.
The FANTOM5 project has discovered that the activation of enhancers triggers coordinated changes in gene expression, leading to dramatic cellular phenotypic changes. This understanding is crucial for understanding cell differentiation and human biology.
A study published in the Journal of Immunology found that infusing memory cells can produce and repeatedly replenish all of the T-effector cells needed to fight CMV infection. This approach may improve on current therapeutic options for controlling CMV infection, which affects up to 80% of adults in the US.
Researchers have developed a treatment that extends telomeres in human cells, which could lead to longer and healthier lives. The treatment uses modified mRNA encoding TERT, resulting in rapid lengthening of telomeres and increased cell division capacity.
A new procedure can increase the length of human telomeres by up to 1,000 nucleotides, allowing researchers to generate large numbers of cells for study or drug development. This breakthrough may lead to new ways to treat diseases caused by shortened telomeres.
A new study by researchers at Children's Hospital Los Angeles has shown that tissue-engineered small intestine grown from human cells replicates key aspects of a functioning human intestine. The tissue-engineered small intestine offers a promising treatment for short bowel syndrome, a major cause of intestinal failure.
Researchers found that circadian rhythms play a key role in coordinating daily metabolic cycles and cell division in skin stem cells. This regulation helps avoid DNA damage caused by metabolism-generated oxygen radicals.
Scientists at the University of Pittsburgh School of Medicine have made a groundbreaking discovery in treating corneal injuries by using stem cells from a patient's own eye. The study found that these cells can regenerate healthy corneal tissue, clearing the cloudy surface and restoring vision.
Researchers at Harvard University have developed a system using human stem cells to screen for compounds that can turn white, or 'bad', fat cells into brown, or 'good' fat cells. They have identified two compounds that can accomplish this in human cells, taking the first step towards a potential pill for obesity treatment.
A new study from Rice University's Baker Institute finds that NFL players are seeking out unproven stem cell therapies to accelerate recoveries, despite potential risks. The authors suggest the NFL should establish guidelines and regulate these treatments to protect player health.
Researchers at Mount Sinai aim to re-create patients' ocular stem cells to restore vision, eliminating the need for immunosuppressive drugs. The grant will support efforts to discover new stem cell therapies and develop biomaterials for engrafting patient-owned stem cells.
Researchers at USC Health Sciences identified a new population of nail stem cells that can self-renew or differentiate into multiple tissues, including nail and skin. These stem cells play a crucial role in nail repair, but their potential to generate additional types of tissue is still unknown.
A UTA researcher has made a breakthrough in regenerating cartilage tissue using microscaffolding injections, aiming to reduce posttraumatic osteoarthritis symptoms. The treatment utilizes patients' own stem cells to form new cartilage tissue, potentially curing the disease.
Researchers at University of Gothenburg have successfully grown a functional blood vessel in just one week using autologous peripheral whole blood. The breakthrough procedure involves extracting stem cells from a patient's blood, which accelerates growth and enables the creation of a new vein. This technology has the potential to benef...
Researchers found that 90% of misfolded protein aggregates form on the ER surface, dependent on active protein synthesis and ribosome activity. The aggregation is regulated by mitochondria, which play a key role in confining the aggregates to the mother cell during asymmetric cell division.
Researchers found that autophagy, a cellular recycling mechanism, helps activate muscle stem cells by inducing metabolic shifts and coping with increased biosynthesis demands. Inhibited autophagy delayed stem cell activation, highlighting SIRT1's regulatory role in this process.
Researchers at Brigham and Women's Hospital have discovered that NAD+, a natural molecule found in living cells, can regulate autoimmune diseases by altering the immune response and turning destructive cells into protective ones. The study showed significant delayed onset of disease and reduced severity in mice receiving NAD+ treatment.
Researchers create a fluorescent tag that identifies bone-producing cells in human fat, yielding more than twice the yield of potential bone-makers compared to another method. The extracted cells produce significant amounts of bone matrix and show promise for regenerative therapies.
Researchers have identified a novel source of stem cells in the corneal limbus that can be directed to behave like photoreceptor cells, potentially treating conditions like age-related macular degeneration. These cells can also be cultured from older eyes and may offer a promising approach for new treatments.
Researchers at UC San Diego aim to bioengineer the irregularly shaped patches of the pancreas called Islets of Langerhans in a dish. This could lead to studying the events that trigger beta cell destruction and developing new drug therapies, as well as understanding the genetic component of the disease.
Researchers at Tel Aviv University developed a hybrid cardiac patch using biomaterial from patients and gold nanoparticles. The patch can improve heart function after heart attacks without triggering an immune response.
A new technique uses perfluorocarbon tracers in combination with MRI to track therapeutic immune cells injected into patients with colorectal cancer. The study found that only half of the delivered cell vaccine remained at the inoculation site after 24 hours, but the technology shows promise for tracking other cell types and diseases.
Researchers discovered a mutated regulator that disrupts blood cell production, leading to leukemia. Removing this regulator restored normal function and offers hope for new treatments.
A new protocol converts stem cells into reliable, insulin-producing cells in about six weeks, a significant improvement over previous methods. The breakthrough could lead to an unlimited supply of insulin-producing cells to treat patients with Type 1 diabetes.
A study of 282 patients with chronic graft-vs-host disease found a link between female donors and the development of vitiligo and alopecia areata. The study identified risk factors, including sex mismatch and certain antibodies, which may lead to better understanding of autoimmune manifestations in this condition.
In a breakthrough study published in Nature Communications, Cedars-Sinai researchers successfully targeted stem cells to injured heart muscle using antibody-studded iron nanoparticles. This innovative approach enables precise localization of the body's own stem cells to the site of injury, promoting regeneration and repair.
Researchers discover how stem cells combat lung disease by targeting macrophages, reducing inflammation and improving bacterial clearance. This breakthrough brings hope for new treatments for acute respiratory distress syndrome (ARDS) patients.
Researchers at Children's Hospital Los Angeles discovered a protein in breast milk called neuregulin-4 (NRG4) that appears to protect against necrotizing enterocolitis (NEC), a potentially lethal intestinal disorder. Formula feeding is a known risk factor for NEC, highlighting the importance of breastfeeding.
Researchers at Wake Forest Baptist Medical Center have successfully mobilized stem cells to form muscle tissue within a biomaterial scaffold. The study, published in Acta Biomaterialia, demonstrates the potential for harnessing the body's natural healing powers to regenerate damaged muscle tissue.
Researchers at the University of Miami found that small dosages of nicotine in cigarette substitutes can harm the musculoskeletal system due to overuse. The study suggests that more information is needed on the potential effects of these alternatives, which are not yet regulated by the FDA.
Researchers found that auxin and PLETHORA transcription factors regulate root growth by controlling cell division, elongation, and differentiation. The study reveals a graded distribution of these factors near the root tip, enabling plants to adapt to environmental conditions.
Researchers at Vanderbilt University have found that endothelial cells in the coronary arteries can function as cardiac stem cells to produce new heart muscle tissue. This discovery could lead to new treatments for heart failure and repair after a heart attack, particularly in cases of coronary artery disease.
Researchers at Caltech have developed a new technique called PARS that allows for whole-body clearing of tissue, enabling the study of individual cells and fine structures. This breakthrough has significant implications for disease diagnosis and development research.
Researchers at MIT have developed a new technique for studying the hepatitis B virus lifecycle, allowing them to investigate immune responses and drug treatments. The model could help find a cure for the disease by understanding how the virus interacts with liver cells.
A team of Cold Spring Harbor Laboratory scientists describe how Dis3l2 uses recognition sites to capture and degrade specific RNAs that are marked for decay. This mechanism helps preserve the character of stem cells and maintain their identity.
A review in Plastic and Reconstructive Surgery warns of the dangers of unsubstantiated claims surrounding cosmetic stem cell procedures. The authors cite potential risks to patients and highlight the need for rigorous scientific evaluation before these treatments are advertised.
Researchers used DNA origami to test theories about cell signaling, finding that distance between ephrin molecules affects EphA2 receptor activity in breast cancer cells. This study developed a method for controlled environment cell communication research, which may lead to new approaches to pharmaceuticals.
A new study reveals that adipose-derived human stem cells can withstand high doses of the chemotherapy drug methotrexate, unlike other cell types. This finding has significant implications for developing an ASC-based therapy to promote bone growth and regeneration in cancer patients.
A recent study shows that half of patients with severe sickle cell disease have safely stopped immunosuppressant medication after a modified blood stem-cell transplant. The trial reversed the condition in nearly all patients and allowed them to achieve stable mixed donor chimerism.
Researchers at Kiel University discovered primordial cancer in a primitive animal, Hydra, which provides crucial information to understand complex problems like cancer. The study confirms that tumours exist in evolutionary old animals and affect only female Hydra polyps, resembling ovarian cancers in humans.
Researchers at Tel Aviv University and Stanford University discovered the multi-layered nature of kidney growth using a rainbow mouse model. The WNT signal was found to be responsible for renal cellular growth, allowing for potential therapeutic applications in human kidney regeneration.
Scientists from the University of Leeds have found a way to restore the function of damaged blood vessel repair cells. A protein called Akt was identified as the reason for reduced effectiveness in South Asian men's cells, which were able to be restored through the addition of active Akt.
Researchers from Queen Mary University of London have developed nanopatches to alter surface properties, enabling stem cells to differentiate and behave like those grown on soft surfaces. This breakthrough enhances the potential of regenerative medicine and tissue engineering.
A University of Rochester research team has created a technique that keeps stem cells in place, resulting in faster and better tissue regeneration. The key is encasing the stem cells in polymers that attract water and disappear when their work is done.
Researchers will analyze fat stem cells from obese patients to understand the mechanism underlying excess fat storage and insulin response. The study aims to identify potential therapeutic strategies for treating different groups of obese individuals at varying risk of developing diabetes and other health issues.
Researchers discovered that an enzyme called IDO plays a crucial role in regulating inflammation during reperfusion injury. By boosting stem cell efficacy, IDO reduces inflammation and cell death, leading to improved recovery rates.
Researchers at Harvard University have developed a new model of heart tissue carrying an inherited cardiovascular disease, a major step forward for personalized medicine. The study used patient-derived cardiac cells and 'organs-on-chips' technology to create a functional human heart tissue that can be replicated in the laboratory.
Researchers at Albert Einstein College of Medicine will study how aging and poor nutrition interact to cause colon cancer mutations. They will use novel techniques, including single-cell whole-genome sequencing, to understand the development of tumors and identify new approaches for preventing and detecting colon cancer.
Researchers found that heart muscle cells in mice undergo a brief proliferative burst prior to adolescence, increasing in number by about 40% to meet the body's growing needs. This discovery suggests that thyroid hormone therapy could stimulate this process, enhancing the heart's ability to regenerate in patients with heart disease.