Articles tagged with Stem Cells
Researchers at RIKEN have discovered a method to maintain immune cells in a stem cell-like state by inhibiting differentiation, allowing them to proliferate extensively. This breakthrough could lead to the development of new treatments for regenerative medicine and immune therapy.
Researchers have discovered a gene called Sox9 that enables kidney cells to switch on and repair damaged tissue after acute injury, offering new hope for treating this serious condition. The study found that the Sox9 gene promotes timely repair of the nephron's cellular lining and repairs the kidney after AKI.
A Johns Hopkins University biologist has made significant progress in understanding the mysterious shape-shifting ways of stem cells. The study found that an enzyme in the niche where stem cells are found can help sustain them and promote other cells to become like stem cells, which has medical implications for diseases such as cancer.
Researchers from Johns Hopkins Medicine have successfully grown a healthy intestine in a lab using stem cells and a 3-D scaffold. The lab-grown intestine regenerated gut tissue in dogs with missing gut lining, offering hope for the development of an implantable replacement intestine.
Research at Boston Children's Hospital identifies IGFBP3 as the hormone destroying intestinal stem cells in type 1 diabetes, leading to a potential treatment strategy with TMEM219. The study also suggests a new approach to cell therapy by exploiting hormones controlling stem cell production.
Researchers have created a new investigational drug that traps IGFBP3, preventing gastrointestinal symptoms and restoring the intestine's mucosal lining structure. The drug may hold promise as a potential treatment for diabetic enteropathy, a common complication of type 1 diabetes.
Researchers discovered that excess IGFBP3 damages colonic stem cells, leading to intestinal lining damage and chronic gastrointestinal symptoms. A biopharmaceutical blocking circulating levels of the protein has shown promising results in reversing colon damage in diabetic mice.
Researchers at Baylor College of Medicine found that infancy's gut development can have lifelong implications on intestinal health. The study discovered that epigenetic changes and the gut microbiome play a crucial role in shaping intestinal stem cells, which control gut physiology throughout life.
Scientists have identified 500 novel membrane proteins that play a critical role in normal heart function and may help uncover new information about heart failure and arrhythmias. The research focuses on protein Tmem65, which regulates communication between cardiac contractile cells.
A new strategy using porous, transplantable hydrogels has experimentally improved bone repair by boosting the survival rate of transplanted stem cells and influencing their cell differentiation. This breakthrough could lead to enhanced regenerative therapies for various tissues and organs.
Researchers at Penn State College of Medicine have discovered a potential target for treating acute myeloid leukemia (AML) relapse after stem cell transplant. They found that exhausted T cells, specifically PD-1hiTIM-3+ cells, play a key role in AML relapse.
Researchers discovered a way to create cell immunity to the E. histolytica parasite by silencing specific genes involved in potassium transport. This approach could lead to the development of new drugs targeting the parasite and preventing deadly diseases.
A team of scientists is using an optical interferometer to monitor the growth of stem cells on tiny polymer spheres, enabling large-scale production and quality control. The device takes images as the tank is stirred, allowing researchers to track cell confluence and morphology.
Research suggests that fetal microchimerism can have both cooperative and competitive effects on maternal health, depending on the context. Fetal cells may provide benefits by migrating to damaged tissue and repairing it, while also contributing to inflammatory responses and autoimmunity in some cases.
Researchers at UC Berkeley created an implant containing stem cells that form functional brown-fat-like tissue, reducing weight gain and lowering blood glucose levels in mice. The study's results suggest the technique could lead to new therapeutic approaches for metabolic disorders.
Participants with late-stage retinitis pigmentosa are being enrolled in the clinical trial to test the safety of retinal progenitor cells. The open-label phase I/IIa trial aims to evaluate the treatment's efficacy in preserving vision by protecting and potentially reactivating degenerating photoreceptors.
A new method called Time-lapse Imaging Microscopy in Nanowell Grids (TIMING) allows researchers to study immune cells and cancer cells in isolation, enabling the identification of high-performing outliers. This technology has the potential to expand cancer immunotherapy treatment options for more patients.
HHMI scientists have discovered functional liver stem cells that proliferate and give rise to mature hepatocytes, even in healthy livers. The newly found stem cells require Wnt signals to maintain their identity and are responsible for replenishing the liver's population.
Researchers discovered that CA125-negative tumor cells have an enhanced ability to repair their DNA and resist programmed cell death, making them dangerous. Combining chemotherapy with birinapant significantly improved disease-free survival in laboratory models of human ovarian cancer.
A new microfluidic technique allows for efficient epigenomic analysis using minimal cells, paving the way for personalized treatment strategies. The technology reduces testing requirements from 10 million cells to just 100 cells, enabling studies of diseases such as stem cell differentiation, inflammation, and cancer.
Scientists have developed a novel process to regenerate salivary cells using silk fibers as a framework, which could help millions in the US with dry mouth due to Sjögren's syndrome. The process has been shown to retain salivary gland cell properties and is a significant step towards developing new cell-based therapeutics.
Researchers found that genetically distinct cells in pregnant mothers, known as microchimeric cells, promote reproductive health and prevent pregnancy complications like prematurity and stillbirth. These cells help the immune system recognize and accept non-inherited maternal antigens, suppressing an immune system attack on the fetus.
Researchers at University of Birmingham discovered how mutated FLT3 genes reprogram blood stem cells, leading to abnormal cell production. The findings provide hope for developing new treatments for acute myeloid leukaemia.
Researchers at the University of Pennsylvania discovered that a ring of protein actin forms between daughter cells to block cytokinesis, controlling when and how this process coordinates all cell players in sperm maturation. The study sheds light on the coordination of stem cell types in niche environments.
A lab-produced hamburger has gained significant interest with over 60% of consumers supporting its purchase and consumption. The $300,000 cultured burger recipe is being refined to increase taste, texture, and color consistency.
A team of Canadian and British researchers has made a breakthrough discovery about the cell division mechanism, finding that chromosomes emit signals to influence microtubule action. This signaling pathway is crucial for the segregation of chromosomes during cytokinesis, a critical step in cell division.
A new study reveals that smooth muscle cells play a more complex role in the formation and stability of atherosclerotic plaques than previously thought. The researchers found that 82% of smooth muscle cells within advanced lesions cannot be identified using traditional methods, leading to confusion about cell identity.
Researchers at the University of Washington have engineered yeast cells to communicate with each other using auxin, a plant hormone that can induce specific genes to be expressed. This breakthrough could lead to the development of synthetic stem cells and artificial organs that require different types of cells to work together.
Researchers at NYU Polytechnic School of Engineering and NYU School of Medicine are exploring a new method to amplify the body's signaling system for recruiting bone-forming stem cells to injured areas. They plan to focus on a single recruitment factor, CXCL12, which they hypothesize plays key roles in promoting osteogenesis.
Researchers have created a way to combine cells with a special scaffold to produce living tissue in the laboratory, overcame oxygen limitation problems for larger dimensions. The technology has potential applications in replacing diseased parts of the body and repairing severe joint damage.
Scientists at Baylor College of Medicine have created a new disease model that closely resembles the human mechanisms and effectively studies hypercholesterolemia. The study successfully cured the disorder using gene therapy, offering a promising approach for treating metabolic diseases.
A study found that umbilical cord stem cells from children born to obese mothers have a 30% higher fat content compared to those from normal-weight mothers. This suggests an inherent propensity towards more fat accumulation in the offspring's cells, potentially leading to insulin resistance and metabolic disease.
A new study from Australian and Singaporean scientists has discovered that each subtype of dendritic cell has its own unique parent cell. This discovery could lead to more efficient treatments for autoimmune diseases like lupus and rheumatoid arthritis by targeting the progenitor cells that produce these immune cells.
A study led by Ellen Heber-Katz demonstrates that a primordial form of energy production can trigger healthy regrowth of lost or damaged tissue in mice. The researchers found that stabilizing the HIF-1a pathway opens up new possibilities for mammalian tissue regeneration, potentially leading to new therapies for human tissue repair.
Researchers at Wake Forest Baptist Medical Center have made progress in recycling human kidneys for transplantation. The team successfully preserved the micro-vessels and growth factors within discarded kidneys, paving the way for tailor-made replacement kidneys.
Researchers developed an algorithm called KeyGenes that uses gene expression to predict the future identity of human fetal stem cells. The platform integrates data from both human fetal and adult tissue, allowing for more accurate differentiation protocols.
A renowned researcher has been awarded a $4.9 million grant to advance her work on retinitis pigmentosa, a degenerative retinal disease affecting 150,000 individuals nationally. The grant will support stem cell therapy aiming to delay the progression of the disease and preserve vision.
Researchers at Cold Spring Harbor Laboratory found that the mammary gland forms a long-term memory of pregnancy, allowing it to respond more efficiently to hormonal changes during subsequent pregnancies. This epigenetic memory is thought to explain why breastfeeding is easier in second and subsequent pregnancies.
Clinics across the US are advertising stem cell treatments with claims of regulatory compliance, despite lacking proper oversight from the FDA. Proponents charge thousands for cosmetic and disease treatments, despite little evidence of safety and efficacy.
Researchers found that differences in reactivity to retinoic acid in spermatogonial stem cells are controlled by the Rarγ gene. This discovery explains how mammalian testis maintain a delicate balance between stem cell numbers and differentiation into sperm. The study suggests that other tissues may also be maintained through similar m...
Researchers have discovered that telomeres are essential for the renewal of plant stem cells and growth. The study uses innovative technology to measure telomeres at the cellular level in plants, revealing a vital relationship between telomere length, stem cells, and longevity. This breakthrough has implications for developing novel th...
Researchers at Toyohashi University of Technology developed a novel cell-manipulation tool that can trap and release single cells in a parallel arrangement. The tool, consisting of hollow microprobes, works like micro fingers to pick up human cells.
A new study successfully grew stem cells with dead feeder cells, challenging the theory that feeder cells provide nutrients. The discovery suggests that stem cells may only like the topology of feeder cells, enabling a simpler approach to growth using nanomanufacturing techniques.
A new study uses fossil data to predict that most rodent species will evolve continuously growing molar teeth over the next 50 million years. The researchers found evidence that many species possess the potential for acquiring dental stem cells, which are required for continuous tooth growth.
Researchers have identified a key role for Gli1+ stem cells in skull development and facial bone repair. Transplanting these stem cells into injured areas may help restore normal anatomy and facilitate brain growth, offering potential treatment options for infants with craniosynostosis and patients with facial disfigurement.
A USC research team led by Cheng-Ming Chuong has discovered that plucking hair in a specific pattern can trigger the growth of new hairs in mice. The study used quorum sensing to understand how the hair follicle system responds to injury and found that it recruits immune cells to secrete signaling molecules that promote hair growth.
Researchers from Carnegie Institution for Science discovered that brassinosteroids and auxin hormones work antagonistically to regulate root cell elongation, affecting the rate of root growth. This finding could lead to engineering more-efficient crops with idealized root growth and water uptake.
Researchers found that stem cells discard old mitochondria in daughter cells that differentiate, while new stem cells receive young ones. This mechanism may help reduce cellular damage and aging.
Scientists discovered that stem cells distinguish between old and young mitochondria, allocating them disproportionately to daughter cells. This mechanism prevents damage accumulation in the lineage over time.
Researchers compared two fat grafting techniques for facial rejuvenation and found that both methods produce similar results. The simpler approach using fat cells plus stromal vascular fraction has advantages over stem cell injection due to its faster processing time.
Researchers at Rockefeller University identified Sox9 as a key molecule controlling stem cell plasticity in hair follicles. Sox9 enables hair follicle stem cells to regain their ability to produce new tissue and heal wounds by amplifying genes associated with stemness.
Researchers at Scripps Research and Mayo Clinic have identified a new class of senolytic drugs that can slow the aging process. These compounds, dasatinib and quercetin, selectively induce death in senescent cells, leading to improved cardiovascular function, exercise endurance, and extended healthspan.
The Initiative on Women in Science and Engineering Working Group presents seven strategies to address gender imbalances in STEM fields, including financial support and education initiatives. The working group aims to elevate the entire field and ensure women have equal opportunities for career advancement.
Lene Oddershede's work focuses on merging physics, biology, and medicine to develop new treatments for diseases. Her award-winning research includes the creation of Scandinavia's first optical tweezers, which enable the study of individual cells and molecules without damaging surrounding tissues.
Researchers estimate that up to 20% of people aged 50-60 and more than 70% of people over 90 have blood cells with the same gene changes as found in leukemia. Genetic mutations associated with leukaemia become inevitable with age, increasing dramatically with age.
Recent studies by UC San Diego researchers have uncovered widespread differences in gene regulation between chromosome pairs, influenced by inherited sequence variations. Chromosome folding structures, known as topologically associating domains (TADs), were also found to play a crucial role in gene expression and epigenome organization.
A Massachusetts General Hospital team has developed a method to protect insulin-producing islets from the immune system, enabling long-term blood sugar control without immunosuppression. The approach involves coating or encapsulating islets with CXCL12, a protein that repels immune cells and attracts regulatory T cells.
The FANTOM5 project has discovered that the activation of enhancers triggers coordinated changes in gene expression, leading to dramatic cellular phenotypic changes. This understanding is crucial for understanding cell differentiation and human biology.
A study published in the Journal of Immunology found that infusing memory cells can produce and repeatedly replenish all of the T-effector cells needed to fight CMV infection. This approach may improve on current therapeutic options for controlling CMV infection, which affects up to 80% of adults in the US.
Researchers have developed a treatment that extends telomeres in human cells, which could lead to longer and healthier lives. The treatment uses modified mRNA encoding TERT, resulting in rapid lengthening of telomeres and increased cell division capacity.