Articles tagged with Stem Cells
Researchers at Brigham and Women's Hospital have discovered that NAD+, a natural molecule found in living cells, can regulate autoimmune diseases by altering the immune response and turning destructive cells into protective ones. The study showed significant delayed onset of disease and reduced severity in mice receiving NAD+ treatment.
Researchers create a fluorescent tag that identifies bone-producing cells in human fat, yielding more than twice the yield of potential bone-makers compared to another method. The extracted cells produce significant amounts of bone matrix and show promise for regenerative therapies.
Researchers at UC San Diego aim to bioengineer the irregularly shaped patches of the pancreas called Islets of Langerhans in a dish. This could lead to studying the events that trigger beta cell destruction and developing new drug therapies, as well as understanding the genetic component of the disease.
Researchers have identified a novel source of stem cells in the corneal limbus that can be directed to behave like photoreceptor cells, potentially treating conditions like age-related macular degeneration. These cells can also be cultured from older eyes and may offer a promising approach for new treatments.
Researchers at Tel Aviv University developed a hybrid cardiac patch using biomaterial from patients and gold nanoparticles. The patch can improve heart function after heart attacks without triggering an immune response.
A new technique uses perfluorocarbon tracers in combination with MRI to track therapeutic immune cells injected into patients with colorectal cancer. The study found that only half of the delivered cell vaccine remained at the inoculation site after 24 hours, but the technology shows promise for tracking other cell types and diseases.
Researchers discovered a mutated regulator that disrupts blood cell production, leading to leukemia. Removing this regulator restored normal function and offers hope for new treatments.
A new protocol converts stem cells into reliable, insulin-producing cells in about six weeks, a significant improvement over previous methods. The breakthrough could lead to an unlimited supply of insulin-producing cells to treat patients with Type 1 diabetes.
In a breakthrough study published in Nature Communications, Cedars-Sinai researchers successfully targeted stem cells to injured heart muscle using antibody-studded iron nanoparticles. This innovative approach enables precise localization of the body's own stem cells to the site of injury, promoting regeneration and repair.
A study of 282 patients with chronic graft-vs-host disease found a link between female donors and the development of vitiligo and alopecia areata. The study identified risk factors, including sex mismatch and certain antibodies, which may lead to better understanding of autoimmune manifestations in this condition.
Researchers at Children's Hospital Los Angeles discovered a protein in breast milk called neuregulin-4 (NRG4) that appears to protect against necrotizing enterocolitis (NEC), a potentially lethal intestinal disorder. Formula feeding is a known risk factor for NEC, highlighting the importance of breastfeeding.
Researchers discover how stem cells combat lung disease by targeting macrophages, reducing inflammation and improving bacterial clearance. This breakthrough brings hope for new treatments for acute respiratory distress syndrome (ARDS) patients.
Researchers at Wake Forest Baptist Medical Center have successfully mobilized stem cells to form muscle tissue within a biomaterial scaffold. The study, published in Acta Biomaterialia, demonstrates the potential for harnessing the body's natural healing powers to regenerate damaged muscle tissue.
Researchers at the University of Miami found that small dosages of nicotine in cigarette substitutes can harm the musculoskeletal system due to overuse. The study suggests that more information is needed on the potential effects of these alternatives, which are not yet regulated by the FDA.
Researchers found that auxin and PLETHORA transcription factors regulate root growth by controlling cell division, elongation, and differentiation. The study reveals a graded distribution of these factors near the root tip, enabling plants to adapt to environmental conditions.
Researchers at Vanderbilt University have found that endothelial cells in the coronary arteries can function as cardiac stem cells to produce new heart muscle tissue. This discovery could lead to new treatments for heart failure and repair after a heart attack, particularly in cases of coronary artery disease.
Researchers at Caltech have developed a new technique called PARS that allows for whole-body clearing of tissue, enabling the study of individual cells and fine structures. This breakthrough has significant implications for disease diagnosis and development research.
Researchers at MIT have developed a new technique for studying the hepatitis B virus lifecycle, allowing them to investigate immune responses and drug treatments. The model could help find a cure for the disease by understanding how the virus interacts with liver cells.
A team of Cold Spring Harbor Laboratory scientists describe how Dis3l2 uses recognition sites to capture and degrade specific RNAs that are marked for decay. This mechanism helps preserve the character of stem cells and maintain their identity.
A review in Plastic and Reconstructive Surgery warns of the dangers of unsubstantiated claims surrounding cosmetic stem cell procedures. The authors cite potential risks to patients and highlight the need for rigorous scientific evaluation before these treatments are advertised.
Researchers used DNA origami to test theories about cell signaling, finding that distance between ephrin molecules affects EphA2 receptor activity in breast cancer cells. This study developed a method for controlled environment cell communication research, which may lead to new approaches to pharmaceuticals.
A new study reveals that adipose-derived human stem cells can withstand high doses of the chemotherapy drug methotrexate, unlike other cell types. This finding has significant implications for developing an ASC-based therapy to promote bone growth and regeneration in cancer patients.
A recent study shows that half of patients with severe sickle cell disease have safely stopped immunosuppressant medication after a modified blood stem-cell transplant. The trial reversed the condition in nearly all patients and allowed them to achieve stable mixed donor chimerism.
Researchers at Kiel University discovered primordial cancer in a primitive animal, Hydra, which provides crucial information to understand complex problems like cancer. The study confirms that tumours exist in evolutionary old animals and affect only female Hydra polyps, resembling ovarian cancers in humans.
Researchers at Tel Aviv University and Stanford University discovered the multi-layered nature of kidney growth using a rainbow mouse model. The WNT signal was found to be responsible for renal cellular growth, allowing for potential therapeutic applications in human kidney regeneration.
Scientists from the University of Leeds have found a way to restore the function of damaged blood vessel repair cells. A protein called Akt was identified as the reason for reduced effectiveness in South Asian men's cells, which were able to be restored through the addition of active Akt.
Researchers from Queen Mary University of London have developed nanopatches to alter surface properties, enabling stem cells to differentiate and behave like those grown on soft surfaces. This breakthrough enhances the potential of regenerative medicine and tissue engineering.
A University of Rochester research team has created a technique that keeps stem cells in place, resulting in faster and better tissue regeneration. The key is encasing the stem cells in polymers that attract water and disappear when their work is done.
Researchers will analyze fat stem cells from obese patients to understand the mechanism underlying excess fat storage and insulin response. The study aims to identify potential therapeutic strategies for treating different groups of obese individuals at varying risk of developing diabetes and other health issues.
Researchers discovered that an enzyme called IDO plays a crucial role in regulating inflammation during reperfusion injury. By boosting stem cell efficacy, IDO reduces inflammation and cell death, leading to improved recovery rates.
Researchers at Harvard University have developed a new model of heart tissue carrying an inherited cardiovascular disease, a major step forward for personalized medicine. The study used patient-derived cardiac cells and 'organs-on-chips' technology to create a functional human heart tissue that can be replicated in the laboratory.
Researchers found that heart muscle cells in mice undergo a brief proliferative burst prior to adolescence, increasing in number by about 40% to meet the body's growing needs. This discovery suggests that thyroid hormone therapy could stimulate this process, enhancing the heart's ability to regenerate in patients with heart disease.
Researchers at Albert Einstein College of Medicine will study how aging and poor nutrition interact to cause colon cancer mutations. They will use novel techniques, including single-cell whole-genome sequencing, to understand the development of tumors and identify new approaches for preventing and detecting colon cancer.
Researchers have recreated the 3D architecture of the cornea to facilitate the transplant of healthy corneal stem cells. This innovation restores sight by replacing damaged cell layers with functional ones.
Melbourne researchers solved a puzzle on how an essential hormone stimulates platelet production. They found that bone marrow cells can become overstimulated and produce too many platelets, leading to blood diseases such as essential thrombocythemia.
Researchers at Duke University have successfully grown lab-grown muscle that demonstrates self-healing properties, integrating into mice quickly and contracting powerfully. The breakthrough, led by Nenad Bursac, uses well-developed contractile muscle fibers and satellite cells to create a microenvironment for regeneration.
A comprehensive 'roadmap' of blood cells has been presented by researchers, pinpointing the location of key genetic regulators that determine cell development and function. This robust genetic catalog will enable hematologists to trace the development of blood cells and identify potential triggers for malignancies.
A comprehensive atlas of human gene activity has been released, revealing complex networks that govern gene expression. The new findings could lead to a better understanding of the genetic causes of diseases and improve disease diagnosis.
Researchers have successfully reprogrammed rat astrocytes into neurons using Mash1, a transcription factor. This method avoids malignant transformation and offers a promising therapeutic strategy for neural regeneration.
Researchers discovered that cells respond to rhythmic biological signals by counting the number of cycles, not their strength or duration. This mechanism, found in single-celled organisms, synchronizes changes in cell fate and may explain patterns in developing embryos and snail learning.
Scientists have made a breakthrough in treating type 1 and type 2 diabetes by successfully converting gut cells into functional insulin-producing cells. The new method involves introducing specific transcription factors into intestinal crypt cells, which can then produce insulin and improve hyperglycemia in diabetic mice.
Researchers have developed novel techniques for engineering lungs using 3D scaffolds, enabling high-throughput studies of human lungs and accelerating progress towards lung tissue regeneration. The new methods allow for selective injection of stem cells into decellularized lung segments while preserving vascular and airway channels.
Researchers found that a common mutation activates the Akt pathway, rendering cells resistant to chemotherapy and increasing growth. Inhibition of this pathway restored leukemic cell responses to front-line therapy.
Scientists have discovered a molecular 'switch' that regulates heart cell division and could potentially be used to regenerate damaged heart tissue. The discovery was made by studying infant siblings with a rare heart defect, who exhibited unusual heart cell proliferation.
Scientists at UC San Diego School of Medicine have made a breakthrough discovery on the fate determination of T lymphocytes during an infection. They found that individual cells can make decisions about whether to become effector or memory cells almost immediately after exposure to a pathogen, suggesting that this process could be cruc...
Researchers have created a highly aligned nanofibrous scaffold derived from decellularized human fibroblasts, allowing cells to thrive and mimic the natural extracellular matrix. The scaffold's uniform composition and low immune response make it suitable for engineering softer tissues like skin, blood vessels, and muscle.
Researchers at Caltech have shown that bone marrow cells are sensitive to infection-related molecules and respond rapidly. They detect invasion and mount an inflammatory response, producing cytokines that stimulate the differentiation of immune cells.
Researchers have discovered a method for restoring strength to damaged skeletal muscles in the elderly using stem cell therapy. The treatment involves treating cells outside the body with a drug that prevents protein modification and culturing them on soft biomaterials, allowing aged cells to grow and self-renew.
Researchers analyzed T cell receptor sequences to understand immune system reconstitution following high-dose immunosuppression. CD4+ and CD8+ lymphocytes exhibit different reconstitution patterns, with dominant clones expanded or undetectable at 12 months post-transplant.
Researchers have found that aging muscle stem cells become less able to regenerate new fibers and self-renew. However, they discovered a process to rejuvenate old muscle stem cells using a drug and soft hydrogel substrate, enabling them to repair muscle damage in mice.
A recent study published in Biology of Blood and Marrow Transplantation found that parents of children undergoing stem cell transplant experience increased distress during the procedure but recover to normal levels of adjustment. Parents demonstrate remarkable recovery despite facing significant life challenges.
Researchers at NIST have developed a way to measure and classify the shapes cells take in different environments. By analyzing these shapes, they can compare and differentiate various scaffolds used in tissue engineering, enabling more effective cell growth and development into viable tissues.
A new nanoparticle system will recruit stem cells to regenerate arterial walls, reducing complications and extending patient lives. Researchers have discovered a way to use nanoparticles to help arteries heal more effectively following surgical procedures.
Researchers at UT Southwestern Medical Center found that estrogen increases proliferation of blood-forming stem cells in females, leading to increased red blood cell production. This discovery raises possibilities for treating blood cancers and reducing chemotherapy toxicity by considering estrogen levels.
A new imaging technique called white-light diffraction tomography (WDT) provides high-resolution, three-dimensional images of living cells without the need for dyes or chemicals. This allows researchers to study cellular processes and dynamics in a non-invasive manner, enabling unprecedented insights into cell function and behavior.
A study published in Cell found that altering the symbiotic relationship between bacteria and intestinal cells can promote health and increase lifespan in flies. The research highlights the importance of maintaining a balanced gut microbiome and suggests that this may be key to enjoying a long healthy life.
Researchers discovered a targeted treatment's mechanism of action, which involves the PML/p53 pathway and senescence. The treatment's effectiveness relies on reorganizing nuclear bodies and triggering p53 activation, leading to the elimination of cancer cells and patient recovery.
Azim Surani receives the McEwen Award for Innovation for pioneering epigenetics research; Valentina Greco wins the ISSCR-BD Biosciences Outstanding Young Investigator Award for her noninvasive method to visualize skin stem cell division. Paolo Bianco, Elena Cattaneo, and Michele De Luca receive the ISSCR Public Service Award for their ...
Researchers discover a subgroup of memory T-cells that are resistant to HIV killing and can survive for years, making them a key target for developing a true 'cure' for HIV infection. This finding could also lead to the development of new cancer therapies targeting stem-cell metabolic pathways.
A research team at the University of California, San Diego has discovered how calcium phosphate-based materials encourage stem cells to differentiate into bone-forming cells. The findings could lead to the development of new biomaterials that can be used to treat bone defects and diseases.