Articles tagged with Stem Cells
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
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Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers at Kyoto University have discovered a way to create ultra-high-speed transistors and high-efficiency photovoltaic cells using terahertz pulses. The study found that exposing gallium arsenide to a single-cycle terahertz pulse increased electron density by an astonishing 1,000-fold.
Researchers at the University of Illinois have developed spiral-shaped proteins that can efficiently deliver DNA segments to cells. The polypeptides outperform commercial agents in terms of efficiency and control toxicity, offering a promising new approach for clinical gene therapy.
Scientists have identified a gene mutation that underlies the vast majority of cases of Waldenstrom's macroglobulinemia. The mutation causes tumor cells to produce a distorted protein, leading to activation of NF-kB and growth of Waldenstrom's tumor cells.
A new device, designed to mimic the periosteum, has shown promising results in healing critical-sized bone defects in sheep. The device delivers stem cells, growth factors, and natural components of the periosteum to promote bone growth, and can be used for a range of applications beyond bone healing.
A rare genetic disorder has provided insight into pancreatic development, suggesting that GATA6 plays a crucial role in programming stem cells to become pancreatic cells. The study sheds light on the underlying causes of most cases of pancreatic agenesis and may help develop new treatments for type 1 diabetes.
Researchers discovered a mutation in the GATA6 gene linked to pancreatic agenesis, a rare condition where the pancreas fails to develop. This finding provides insight into how stem cells can be programmed to become pancreatic cells, potentially leading to new treatments for type 1 diabetes.
Researchers at Penn School of Medicine have developed a technique to expand immune cells in umbilical cord blood prior to transplants, leading to quicker immune system rebuilding and lower risk of infections. The method paves the way for future salvage therapy options and increased use of public cord blood banks.
A new cellular automaton model has successfully predicted how hair follicle stem cells regenerate, shedding light on the mechanisms behind alopecia. The study suggests that improving the environment around hair follicles may be a more effective approach to regrowing hair than implanting stem cells.
Researchers at Joslin Diabetes Center have identified two major molecular signaling pathways that regulate cell growth and division, hallmarks of cancer biology. The study provides new candidate targets for treating soft-tissue sarcomas, which can be controlled but not cured by current treatments.
A 36-year-old Eritrean patient received a pioneering trachea transplant using an artificial scaffold seeded with stem cells, allowing him to live a normal life. The procedure has shown promising results and may pave the way for future treatments of airway diseases.
Researchers have discovered a new muscle repair gene, MEGF10, which plays a crucial role in the fusion process of satellite cells. The findings provide accurate genetic testing and diagnosis for devastating conditions affecting muscle function, enabling hope for families affected by progressive muscle disease.
Researchers found that scarring after a heart attack can help prevent further damage, but interrupting the process weakens heart function. The study suggests that timing is essential in manipulating cells to decrease scarring and enhance regeneration.
Researchers at the University at Buffalo have developed a new approach to regenerating heart muscle cells. By infusing cardiosphere-derived cells into coronary arteries, they were able to increase healthy heart muscle cells by 30% within a month.
A new clinical trial funded by NIH found that delayed stem cell therapy after a heart attack is safe, but it does not improve heart function six months later. The study suggests future clinical benefits may still be possible.
Researchers found that boosting a gene in fruit flies' intestinal stem cells extended their lifespan by up to 50% and delayed the aging of their intestine. The study suggests that the gene, PGC-1, can act as a biological dial for slowing the aging process and may serve as a target for new therapies.
Researchers at Boston University have discovered how Wolbachia bacteria alter insect reproduction, leading to increased egg production and reduced death rates. The study provides insights into the cellular mechanisms behind this relationship, which could inform novel approaches to disease control.
Researchers identified cells and signaling molecules that trigger lung repair in mice. Fibroblast growth factor 10 (FGF10) induces epithelial cells to revert to a stem-cell state, proliferate, and repopulate the lung lining.
Researchers at UCSF found that bone marrow cells used to treat human hearts after a heart attack are impaired due to inflammation caused by the attack. This discovery may lead to new therapeutic approaches to improve treatment outcomes for heart attack patients.
Scientists at Norwich BioScience Institutes discovered that plant pores, essential for life and carbon cycles, are evenly spaced due to a specific protein called SPEECHLESS. This protein's activity helps create an even spatial pattern during plant growth, allowing plants to breathe efficiently in different environments.
Researchers at Kyoto University have designed an inexpensive new material capable of quick and accurate detection of carbon dioxide gas. The compound gives off variable degrees of visible light in correspondence with different gas concentrations, enabling the development of easy-to-use monitoring devices.
Yale scientists identify adipose precursor cells as key players in triggering hair growth. These cells produce PDGF molecules necessary for producing hair growth in mice. The study offers a promising avenue for developing new treatments for male pattern baldness by targeting these stem cells and signals.
The study discovered that pericytes can stimulate new blood vessels and aid in the recovery of a heart attack by transferring microRNAs to endothelial cells. This novel mechanism could lead to the development of new treatments for cardiovascular disease.
Researchers discovered that chaperonins are necessary for KN1 protein trafficking between plant cells via plasmodesmata, which helps establish and maintain stem cell populations. This signaling pathway is vital for plant development and growth, allowing cells to communicate and influence each other.
Researchers discovered the expression of cancer-killer SAC-GFP activity in bone marrow cells after transplantation, suggesting successful transfer and colonization of anti-cancer tissue. The study shows promise for treating primary and metastatic tumors with genetically modified stem cells that secrete potent Par-4/SAC killer proteins.
A new treatment developed at Tel Aviv University uses laser-treated bone marrow stem cells to help restore heart function and health. The procedure significantly reduces heart scarring after an ischemic event by up to 80 percent, offering a safer and quicker alternative to existing options.
Researchers have identified a crucial role for TCF-1 in regulating T-cell development, which could lead to improved treatments for immune-suppressed patients. Notch triggers the process of T-cell development and turns on expression of TCF-1, but not itself.
A recent study published in Cell Stem Cell found that low doses of erythropoietin (EPO) may reduce the risk of heart failure associated with some anticancer therapies. EPO was shown to bind to cardiac stem cells and restore their ability to form new blood vessels, preserving cardiac function.
The study reveals that EphB-ephrin bindings activate metaloprotease ADAM10, destroying binding between distinct cell types and preventing cell mixing. This mechanism is crucial for maintaining tissue organization in the intestinal epithelium.
The UBC device allows scientists to analyze individual cells rapidly and cost-effectively, accelerating genetic research and cancer diagnosis. By analyzing isolated cells, researchers can distinguish between normal and cancer cells, leading to more accurate treatments.
Researchers have developed a platform technology for monitoring single-cell interactions in real-time using nanotechnology, allowing for unprecedented spatial and temporal resolution. This innovation has broad implications for basic science, drug discovery, and personalized medicine.
Researchers at Boston University School of Medicine have identified a possible new approach to treating myelofibrosis by inhibiting an enzyme that forms scar tissue in the bone marrow. The study found that inhibiting this enzyme resulted in a significant decrease in the burden of myelofibrosis, offering a potential new avenue for treat...
Scientists have discovered a protein marker on the surface of adipose stromal cells (ASCs), which drive fat expansion in the body. The finding may lead to developing a method to inactivate these cells, potentially treating obesity and improving regenerative therapies.
Scientists use new technique to demonstrate that cell membrane and cytoplasm structure can guide asymmetric cell division. Model cells show that simple chemical interactions can result in complex behaviors like asymmetric division even without genetic signals.
Researchers at Brigham and Women's Hospital have identified a human lung stem cell capable of regenerating damaged lung tissue. The discovery has the potential to offer a new treatment option for those suffering from chronic lung diseases.
Researchers have identified genetic mutations that predict risk of sudden cardiac death and cardiac events in patients with Long QT syndrome. The findings could lead to personalized treatment approaches for individuals with the condition, who are often at risk but may not exhibit typical clinical symptoms.
Researchers deciphered how hair stem cells communicate with each other to encourage mutually coordinated regeneration, holding potential for finding a cure for alopecia. The study's findings provide insight into potential stem cell behavior in other organs, which holds ramifications for regenerative medicine research.
Biophysicists at Penn have developed a new technique to study how proteins respond to physical stress, particularly in red blood cells. The technique, which measures the degree of exposed cysteine in proteins, reveals that stressed cells are more fluorescent under microscopy.
Researchers at the University of Alberta have discovered a critical molecule that, when absent in T-cells, can cause autoimmunity. This finding has significant implications for stem-cell transplantation treatments used for autoimmune diseases and cancer.
A team of researchers has identified a key role for the protein fibulin-5 in preventing pelvic organ prolapse (POP) in mice. Fibulin-5 prevents POP by facilitating the assembly of normal elastic fibers and inhibiting the activity of MMP9, a protein that degrades these fibers. Increased levels of MMP-9 were found in vaginal tissue sampl...
A team of bioengineers at Rice University is developing new materials to grow replacement heart valves using gel-like scaffolds that mimic the complex structure and physical properties of heart-valve tissues. The goal is to create living valves that use a patient's own cells, eliminating tissue rejection.
Experts recommend collecting peripheral blood stem cells from Fukushima radiation workers to prepare for potential future stem cell transplants. This technique has several advantages over allogeneic transplantation, including reducing the risk of graft-versus-host disease and immunosuppression.
Cardiac stem cell treatment is being explored as an option for treating heart failure. Dr. Bolli's study, SCIPIO, aims to perfect a technique using a patient's own cardiac stem cells to regenerate dead heart muscle after a heart attack. Results show promising improvements in patients' physical capabilities and ejection fraction.
Researchers have successfully treated severe Crohn's disease with a new cell therapy approach using Type 1 regulatory lymphocytes. The preliminary results indicate improved condition and good tolerability, paving the way for further phase 2b clinical trials.
A long-term study reports the effectiveness of stem cell transplants in replacing bone marrow and reducing disease activity in people with rapidly progressive MS. The treatment showed promising results, with an average improvement in symptoms lasting two years.
A study published in Blood reveals a close relationship between pulmonary arterial hypertension and myeloid abnormalities in the bone marrow. The researchers found that blood progenitor cells are increased in patients with PAH, suggesting an abnormal feedback loop connecting blood and lung cell behavior.
Researchers describe the mechanism of blockade and reactivation in molecular detail, revealing TFIIS's role in facilitating mRNA excision. This process is essential for cell survival and regulates gene activity in stem and tumor cells.
Researchers have created a bioengineered protein called CD19-L that selectively targets and destroys leukemia cells, including those resistant to chemotherapy. This breakthrough discovery offers new hope for treating childhood leukemia.
Two studies investigate the role of bone marrow stem cells in diabetic therapy and islet cell regeneration, offering new therapeutic possibilities. Researchers also focus on improving pancreatic islet culture and preservation techniques to prolong the survival and functionality of islet cells in vitro.
The research team used single-molecule imaging to study G protein-coupled receptors (GPCRs) and found that they can interconvert between monomers and dimers. This understanding is crucial for predicting GPCR numbers in cells and blocking signal amplification by these molecules.
A team of scientists created a programable molecular transport system, observed in real time using atomic force microscopy. The system consists of a DNA origami track with a motor and fuel, allowing for adjustable speed and potential applications in drug delivery and synthetic ribosome creation.
Researchers at Kyoto University have developed a porous framework that can capture common air pollutants and emit glowing colors when exposed to ultraviolet light. This breakthrough enables the creation of portable, solid-state pollution detectors with potential applications in medicine, pharmaceuticals, and industry.
UCSF researchers developed a new approach to examine how cells convert DNA into RNA, bridging a gap in understanding gene expression. The technique enables direct observation of the transcription process at unprecedented resolution, providing insights into gene regulation and function.
A team of researchers from University of Missouri and Columbia University successfully regenerates complete shoulder joint surfaces in animals using the patient's own cells. The new technique eliminates the need for multiple surgeries to harvest and implant cells, making it a promising alternative to metal and plastic joints.
Researchers at UCLA's Jonsson Comprehensive Cancer Center have found a new mechanism that regulates protein stability in cells, triggered by the GSK3 enzyme. This discovery could lead to potential new treatments for cancer, particularly colorectal cancers and other forms of cancer.
Researchers found that human CML stem cells do not rely on BCR-ABL activity for survival, rendering traditional treatments ineffective. This breakthrough highlights the need for new therapeutic strategies to target these resilient cancer cells.
A new mouse model of Duchenne muscular dystrophy suggests that muscle stem cells are key to understanding the disease's progression. The research found that mice with a similar mutation to humans experience severe muscle weakness and shortened life spans due to the inability of their muscle stem cells to keep up with ongoing damage.
Researchers found that Duchenne muscular dystrophy symptoms emerge when skeletal muscle stem cells can no longer keep up with repairs, leading to progressive muscle weakening and respiratory failure. Successful treatments targeting muscle stem cells may alleviate symptoms and offer new hope for managing the disease.
Researchers discovered a protein necessary for normal cell division in blood-forming stem cells, which resulted in abnormal numbers of chromosomes and high rates of cell death. This finding highlights the metabolic differences between stem cells and other blood-forming cells.
Tel Aviv University researchers discovered that endurance exercises increase muscle stem cells and enhance their ability to rejuvenate old muscles. This finding could lead to a new drug to help the elderly and immobilized heal their muscles faster.
Researchers at Rockefeller University Press have successfully reprogrammed human skin cells to produce platelets that can be used in patients with thrombocytopenia. The breakthrough method involves culturing these cells in a cocktail of platelet-promoting factors, resulting in platelets that function like normal healthy platelets.