Articles tagged with Stem Cells
Researchers at the University of Delaware have identified a protein called endoglin that regulates the creation of fat cells. By decreasing the amount of this protein on the surface of cells, it may be possible to force fat cells to transform into other cell types, potentially leading to new treatments for osteoporosis and obesity.
Researchers suggest that stem cells have intrinsic capacities for self-maintenance and evasion of differentiation. By analyzing current properties and characteristics of stem cells, the 'by default' hypothesis proposes that stem cells exist due to factors that repress cellular signals for specialization.
Researchers have discovered a hormone that can be produced by fat stem cells to lower blood sugar levels and improve metabolism. The hormone appears to bypass the need for insulin, sending glucose out of the bloodstream and into muscle cells.
New cell printing technology enables precise pattern formation of human cells, paving the way for advancement in tissue engineering and regeneration. Researchers demonstrated the use of acoustic droplet ejection followed by aqueous two-phase exclusion patterning to control cell placement.
The FOCUS trial found that patients with chronic ischemic heart disease who received stem cell therapy had a significant increase in left ventricular ejection fraction, with improvements correlated to the number of progenitor cells in their bone marrow. This study provides valuable insights for future therapies and trials.
A study led by Mayo Clinic researchers found that bone marrow-derived stem cells improved ejection fraction, a measure of the left ventricle's pumping ability, by 2.7% in patients with chronic heart failure. The most significant improvements were seen in younger patients and those with enriched CD34+ and CD133+ type of stem cells.
A new study found that using a patient's own bone marrow cells can help repair damaged areas of the heart caused by heart failure. The treatment increased left ventricular ejection fraction by a small but significant amount, and improved perfusion defects in patients with chronic ischemic heart disease.
Researchers develop a new approach to regenerating and transplanting organs using artificial scaffolds with patient stem cells, promising a potential solution to the organ donor shortage crisis. The technique requires no human donors, has no rejection issues, and eliminates the need for immunosuppressive drugs.
Researchers from the University of Victoria have developed a new 3D stem cell culture method, enabling scientists to study cell behavior in conditions similar to those in the body. This breakthrough has significant implications for regenerative medicine and other fields.
Scientists have developed a method to imbue yeast with magnetic properties, enabling potential applications in medical, industrial, and research settings. The technology could be used to target and isolate specific cells, guiding them toward certain manufacturing processes or interacting with non-living machinery.
A new microfluidic device can isolate target cells much faster than existing devices, using a soft membrane with nanoscale pores to guide fluid and bring cells in contact with antibodies. This technology could be used for point-of-care diagnostics and personalized medicine applications, such as cancer diagnosis.
A UCLA study reveals that migrating cells exhibit a tendency to turn right in response to environmental changes, leading to the formation of diagonal stripes resembling tissue architecture. The researchers believe this phenomenon holds promise for developing new methods for tissue engineering and organ regeneration.
Researchers at Yale University have identified a new regulator that controls p53's activity in sperm production, which could lead to breakthroughs in fertility treatments and cancer therapy. The study found that a molecule called Pumilo 1 plays a crucial role in this process.
A UCSF stem cell study conducted in mice suggests a novel strategy for treating damaged cardiac tissue after a heart attack. The approach potentially improves cardiac function, minimizes scar size, and avoids tissue rejection.
A Cedars-Sinai Heart Institute clinical trial has demonstrated that treating heart attack patients with their own heart-derived cells can help damaged hearts regrow healthy muscle. The study found a significant reduction in scar size and an increase in healthy heart muscle following the stem cell treatments.
A study published in The Lancet found that infusing patients' own cardiac stem cells into the heart after a heart attack reduces scar tissue by 50%. This breakthrough suggests that healthy heart muscle can be restored after previously thought-to-be irreparable damage.
Researchers have discovered that dynein, a motor protein, plays a crucial role in spindle alignment during mitosis. A signal from the chromosomes involving the ras-related nuclear protein (Ran) blocks LGN and dynein from attaching to the cell cortex closest to the chromosomes.
The Broad Institute has received a $32.5 million grant to launch the Klarman Cell Observatory, which will decipher how biological decisions are made in health and disease. The Observatory aims to shed light on the inner workings of cells, leading to major treatment breakthroughs.
Researchers at Kyoto University and the University of Oxford have successfully constructed a DNA motor capable of navigating a programmable network of tracks with multiple switches. The breakthrough uses DNA origami technology, allowing for autonomous nanoscale devices to produce predictable outputs based on different starting conditions.
A study in Cell Metabolism identifies serum response factor (Srf) as a crucial signal that tells surrounding muscle stem cells to multiply and join muscle fibers, controlling muscle growth. SRF's role in regulating muscle atrophy is also confirmed, with potential applications for therapies targeting its targets.
Scientists developed a way to deliver therapeutic human cells to diseased areas using superparamagnetic iron oxide nanoparticles. The new process, reported in ACS' journal Langmuir, successfully attaches these nanoparticles to the outside of human cells without causing damage.
Researchers at Kyoto University have discovered a way to create ultra-high-speed transistors and high-efficiency photovoltaic cells using terahertz pulses. The study found that exposing gallium arsenide to a single-cycle terahertz pulse increased electron density by an astonishing 1,000-fold.
Researchers at the University of Illinois have developed spiral-shaped proteins that can efficiently deliver DNA segments to cells. The polypeptides outperform commercial agents in terms of efficiency and control toxicity, offering a promising new approach for clinical gene therapy.
A rare genetic disorder has provided insight into pancreatic development, suggesting that GATA6 plays a crucial role in programming stem cells to become pancreatic cells. The study sheds light on the underlying causes of most cases of pancreatic agenesis and may help develop new treatments for type 1 diabetes.
Scientists have identified a gene mutation that underlies the vast majority of cases of Waldenstrom's macroglobulinemia. The mutation causes tumor cells to produce a distorted protein, leading to activation of NF-kB and growth of Waldenstrom's tumor cells.
A new device, designed to mimic the periosteum, has shown promising results in healing critical-sized bone defects in sheep. The device delivers stem cells, growth factors, and natural components of the periosteum to promote bone growth, and can be used for a range of applications beyond bone healing.
Researchers at Penn School of Medicine have developed a technique to expand immune cells in umbilical cord blood prior to transplants, leading to quicker immune system rebuilding and lower risk of infections. The method paves the way for future salvage therapy options and increased use of public cord blood banks.
Researchers discovered a mutation in the GATA6 gene linked to pancreatic agenesis, a rare condition where the pancreas fails to develop. This finding provides insight into how stem cells can be programmed to become pancreatic cells, potentially leading to new treatments for type 1 diabetes.
A new cellular automaton model has successfully predicted how hair follicle stem cells regenerate, shedding light on the mechanisms behind alopecia. The study suggests that improving the environment around hair follicles may be a more effective approach to regrowing hair than implanting stem cells.
Researchers at Joslin Diabetes Center have identified two major molecular signaling pathways that regulate cell growth and division, hallmarks of cancer biology. The study provides new candidate targets for treating soft-tissue sarcomas, which can be controlled but not cured by current treatments.
A 36-year-old Eritrean patient received a pioneering trachea transplant using an artificial scaffold seeded with stem cells, allowing him to live a normal life. The procedure has shown promising results and may pave the way for future treatments of airway diseases.
Researchers have discovered a new muscle repair gene, MEGF10, which plays a crucial role in the fusion process of satellite cells. The findings provide accurate genetic testing and diagnosis for devastating conditions affecting muscle function, enabling hope for families affected by progressive muscle disease.
Researchers at the University at Buffalo have developed a new approach to regenerating heart muscle cells. By infusing cardiosphere-derived cells into coronary arteries, they were able to increase healthy heart muscle cells by 30% within a month.
Researchers found that scarring after a heart attack can help prevent further damage, but interrupting the process weakens heart function. The study suggests that timing is essential in manipulating cells to decrease scarring and enhance regeneration.
A new clinical trial funded by NIH found that delayed stem cell therapy after a heart attack is safe, but it does not improve heart function six months later. The study suggests future clinical benefits may still be possible.
Researchers found that boosting a gene in fruit flies' intestinal stem cells extended their lifespan by up to 50% and delayed the aging of their intestine. The study suggests that the gene, PGC-1, can act as a biological dial for slowing the aging process and may serve as a target for new therapies.
Researchers at Boston University have discovered how Wolbachia bacteria alter insect reproduction, leading to increased egg production and reduced death rates. The study provides insights into the cellular mechanisms behind this relationship, which could inform novel approaches to disease control.
Researchers identified cells and signaling molecules that trigger lung repair in mice. Fibroblast growth factor 10 (FGF10) induces epithelial cells to revert to a stem-cell state, proliferate, and repopulate the lung lining.
Researchers at UCSF found that bone marrow cells used to treat human hearts after a heart attack are impaired due to inflammation caused by the attack. This discovery may lead to new therapeutic approaches to improve treatment outcomes for heart attack patients.
Scientists at Norwich BioScience Institutes discovered that plant pores, essential for life and carbon cycles, are evenly spaced due to a specific protein called SPEECHLESS. This protein's activity helps create an even spatial pattern during plant growth, allowing plants to breathe efficiently in different environments.
Researchers at Kyoto University have designed an inexpensive new material capable of quick and accurate detection of carbon dioxide gas. The compound gives off variable degrees of visible light in correspondence with different gas concentrations, enabling the development of easy-to-use monitoring devices.
Yale scientists identify adipose precursor cells as key players in triggering hair growth. These cells produce PDGF molecules necessary for producing hair growth in mice. The study offers a promising avenue for developing new treatments for male pattern baldness by targeting these stem cells and signals.
Researchers discovered that chaperonins are necessary for KN1 protein trafficking between plant cells via plasmodesmata, which helps establish and maintain stem cell populations. This signaling pathway is vital for plant development and growth, allowing cells to communicate and influence each other.
The study discovered that pericytes can stimulate new blood vessels and aid in the recovery of a heart attack by transferring microRNAs to endothelial cells. This novel mechanism could lead to the development of new treatments for cardiovascular disease.
Researchers discovered the expression of cancer-killer SAC-GFP activity in bone marrow cells after transplantation, suggesting successful transfer and colonization of anti-cancer tissue. The study shows promise for treating primary and metastatic tumors with genetically modified stem cells that secrete potent Par-4/SAC killer proteins.
A new treatment developed at Tel Aviv University uses laser-treated bone marrow stem cells to help restore heart function and health. The procedure significantly reduces heart scarring after an ischemic event by up to 80 percent, offering a safer and quicker alternative to existing options.
Researchers have identified a crucial role for TCF-1 in regulating T-cell development, which could lead to improved treatments for immune-suppressed patients. Notch triggers the process of T-cell development and turns on expression of TCF-1, but not itself.
A recent study published in Cell Stem Cell found that low doses of erythropoietin (EPO) may reduce the risk of heart failure associated with some anticancer therapies. EPO was shown to bind to cardiac stem cells and restore their ability to form new blood vessels, preserving cardiac function.
The study reveals that EphB-ephrin bindings activate metaloprotease ADAM10, destroying binding between distinct cell types and preventing cell mixing. This mechanism is crucial for maintaining tissue organization in the intestinal epithelium.
The UBC device allows scientists to analyze individual cells rapidly and cost-effectively, accelerating genetic research and cancer diagnosis. By analyzing isolated cells, researchers can distinguish between normal and cancer cells, leading to more accurate treatments.
Researchers have developed a platform technology for monitoring single-cell interactions in real-time using nanotechnology, allowing for unprecedented spatial and temporal resolution. This innovation has broad implications for basic science, drug discovery, and personalized medicine.
Researchers at Boston University School of Medicine have identified a possible new approach to treating myelofibrosis by inhibiting an enzyme that forms scar tissue in the bone marrow. The study found that inhibiting this enzyme resulted in a significant decrease in the burden of myelofibrosis, offering a potential new avenue for treat...
Scientists have discovered a protein marker on the surface of adipose stromal cells (ASCs), which drive fat expansion in the body. The finding may lead to developing a method to inactivate these cells, potentially treating obesity and improving regenerative therapies.
Scientists use new technique to demonstrate that cell membrane and cytoplasm structure can guide asymmetric cell division. Model cells show that simple chemical interactions can result in complex behaviors like asymmetric division even without genetic signals.
Researchers at Brigham and Women's Hospital have identified a human lung stem cell capable of regenerating damaged lung tissue. The discovery has the potential to offer a new treatment option for those suffering from chronic lung diseases.
Researchers have identified genetic mutations that predict risk of sudden cardiac death and cardiac events in patients with Long QT syndrome. The findings could lead to personalized treatment approaches for individuals with the condition, who are often at risk but may not exhibit typical clinical symptoms.
Researchers deciphered how hair stem cells communicate with each other to encourage mutually coordinated regeneration, holding potential for finding a cure for alopecia. The study's findings provide insight into potential stem cell behavior in other organs, which holds ramifications for regenerative medicine research.
Biophysicists at Penn have developed a new technique to study how proteins respond to physical stress, particularly in red blood cells. The technique, which measures the degree of exposed cysteine in proteins, reveals that stressed cells are more fluorescent under microscopy.
Researchers at the University of Alberta have discovered a critical molecule that, when absent in T-cells, can cause autoimmunity. This finding has significant implications for stem-cell transplantation treatments used for autoimmune diseases and cancer.
A team of researchers has identified a key role for the protein fibulin-5 in preventing pelvic organ prolapse (POP) in mice. Fibulin-5 prevents POP by facilitating the assembly of normal elastic fibers and inhibiting the activity of MMP9, a protein that degrades these fibers. Increased levels of MMP-9 were found in vaginal tissue sampl...