Articles tagged with Stem Cells
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A new study reveals that specialized blood cells have bone-forming potential and can contribute to abnormal bone growth in rare genetic disorders like fibrodysplasia ossificans progressiva. This discovery has significant implications for understanding FOP and other conditions where bone forms outside the skeleton.
Researchers explore two bone marrow cell delivery methods to treat heart attacks and limb ischemia. Studies show that anterograde intra-coronary delivery improves left ventricle function, while bone marrow stem cell transplants increase blood flow in severely ischemic limbs.
Researchers at the University of New South Wales used a simple contact lens to rehabilitate damaged eye surfaces by cultivating patients' own stem cells. The procedure significantly improved sight within weeks and has potential applications in other organs.
The BioInterfaces program aims to develop new tools to control cells, leading to therapies for muscle, retina, and central nervous system diseases. The program also focuses on controlling bacterial cells that form biofilms on man-made surfaces.
Researchers at Thomas Jefferson University are exploring the role of notch signaling pathway proteins in regulating stem cell activities. They plan to develop a genetically engineered mouse model to gain insights into this process and potentially harness the body's own regenerative potential to treat degenerative disc disease.
A £4M funding award will support a multidisciplinary study combining stem cell science and tissue engineering to develop new treatments for bone fractures and orthopaedic problems. The research aims to improve our understanding of skeletal cell activity, scaffold development, and environmental factors that affect tissue regeneration.
Researchers have identified three genetic factors that can turn non-muscle cells into beating heart cells, providing a significant breakthrough in understanding how to repair damaged hearts. The discovery could lead to the development of new therapeutic approaches using stem cells.
Researchers at UBC's Biomedical Research Centre have identified S1P as a molecule that can open the thymic gate for migrating stem cells. This discovery holds promise for increasing the success of blood stem cell transplants, which are currently used to treat diseases such as leukemia and aplastic anemia.
A major international study by the FANTOM consortium has found that genes are not controlled by 'master regulators' as previously thought. Instead, a more subtle and coordinated approach is needed for cellular differentiation and cancer development.
Researchers at Emory University discover a process required for epigenetic reprogramming between generations, shedding light on fertilization, stem-cell formation, and cloning. The study found that histone protein modification can be inherited through cell-to-cell transmission.
Researchers have developed a new culture system to isolate and proliferate liver stem cells from bone marrow cells, achieving six passages of the stem cells. The method uses a selecting culture system containing cholestatic serum to purify the stem cells, providing an easy and efficient way to separate them.
Researchers at UT Houston are conducting a Phase I safety trial using patient's own stem cells to treat strokes. The study aims to reduce disability in patients and could be an exciting new therapeutic approach.
Scientists have developed a device that protects transplanted pancreatic precursor cells from the immune system, allowing them to mature into functional beta cells. This breakthrough approach could alleviate the need for long-term immunosuppression in cell transplantation therapy.
Research led by David Hess identified how to use bone marrow stem cells to grow new blood vessels in mice with ligated leg arteries. These pro-angiogenic stem cells have a natural ability to induce blood vessel repair and improve blood flow in ischemic limbs.
The University of Nottingham's studies found that improved collaboration with clinicians, better funding, and regulatory certainty are crucial for stem cell therapy success. The industry is at risk of market failure due to structural barriers within the NHS.
A new dual therapy approach generates new blood vessels and improves cardiac function following a heart attack, overcoming current stem-cell-mobilizing therapies' ineffectiveness in humans. This strategy stabilizes SDF-1 and enhances the recruitment of EPCs to damaged heart tissue.
Researchers found that treating patients with their own bone marrow stem cells after a heart attack increased circulation within the heart. The study showed that higher doses of cells led to greater improvement in blood flow, but results for cardiac function were not significant.
Research at University of Gothenburg reveals that egg cells can rejuvenate sperm by extending telomeres, reducing the risk of chromosomal abnormalities. This breakthrough has significant implications for future stem cell therapy, which aims to replace diseased or dying cells.
Researchers found significant benefits in glycemic control and reduced insulin requirements in patients with type 2 diabetes who received stem cell infusion and hyperbaric oxygen treatment. The combination therapy showed promising results in decreasing type 2 diabetes morbidity and mortality.
A new study using a seaweed-based capsule and firefly-inspired bioluminescent agents successfully delivered therapeutic stem cells to treat peripheral arterial disease (PAD) in rabbits. The breakthrough could pave the way for targeted stem cell treatments for patients with PAD, which affects millions of Americans.
A CU-Boulder research team has identified a type of skeletal muscle stem cell that contributes to the repair of damaged muscles in mice. The newly identified stem cells, dubbed satellite-SP cells, renew the satellite cell population after injection into injured muscle cells, contributing to recovery of muscle tissue.
Scientists have created synthetic microtissues that can perform functions like secreting hormones and responding to stimuli, surpassing individual cell capabilities. The technique uses DNA hybridization as a programmable glue to link cells together in 3D arrangements.
A recent study at the University of Pennsylvania School of Medicine reveals that immature cells in blood vessels deep within skeletal muscle orchestrate aberrant bone formation. Cells from the inflammatory response to injury trigger skeleton-stimulating proteins to transform muscle tissue into bone.
Researchers have discovered that two noncoding RNAs, MENε and MENβ, play a critical role in maintaining the structure of paraspeckles, a compartment within the cell nucleus. This discovery sheds light on the functional roles of noncoding RNAs in regulating gene activity and responding to stress signals.
Researchers have successfully used stem cells to grow on a scaffold made from tissue extract, overcoming two key challenges for organ transplantation. This breakthrough enables the creation of bioengineered organs that can be transplanted without rejection.
Researchers at UCR identified all the genes expressed in plant stem cells, providing a global view of which genes are expressed and where within the shoot apical meristem. This discovery can help scientists develop better varieties of crops and understand why stem cells give rise to specialized cells.
Plant cells use microscopic channels called plasmodesmata to communicate and transport nutrients; the GAT1 gene encodes an enzyme that acts as an antioxidant, relieving cellular stress and maintaining flow through these channels. Turning on this gene helps plants prevent excessive callose accumulation and keeps channels open.
A new study reveals that the chemical mediator sphingosine-1-phosphate plays a crucial role in maintaining bone balance. Researchers found that mice with functional S1P receptors had denser bones than those without, suggesting a potential target for treating bone-resorptive disorders.
The University of California, Irvine has received a $3.3 million grant to expand its stem cell training program, which will attract top talent and develop more physician-scientists engaged in stem cell research. The program will train researchers to cross disciplines and develop new disease treatments.
Researchers found that ordinary plant cells can replace lost organs and tissue without the need for stem cells, a function previously thought to be exclusive to stem cells. The study suggests that plants can regenerate without stem cells through a process of reprogramming.
Researchers developed intelligent materials that stimulate cell growth and development, eliminating pharmaceutical side-effects. The technology has the potential to revolutionize orthopedic, dental, and cardiovascular prostheses.
Researchers have identified a new subtype of childhood T-lymphoblastic leukemia, also known as ETP-ALL, which is characterized by poor response to standard intensive chemotherapy. The disease has a dire prognosis, with high rates of remission failure and relapse compared to typical T-ALL patients.
Phase II trials demonstrate significant activity of pomalidomide in MM and myelofibrosis, with disease improvement or stabilization in 76% of patients. Pomalidomide also shows promise in patients who previously did not respond to REVLIMID therapy.
A study published by researchers at M.D. Anderson Cancer Center revealed that intense chemotherapy significantly reduces the risk of recurrence in young mantle cell lymphoma patients. In a median follow-up of seven years, 52% of patients aged 65 or younger achieved disease-free survival.
A UCSF study found that maternal cells enter the fetus during pregnancy, inducing regulatory T cells that enforce a state of tolerance between the fetus and mother. This discovery defines a previously-unrecognized pathway for human tolerance development.
A study by USC biologists found that older female flies can live 5-30% longer and produce more offspring when altered to over-express specific genes. This challenges the long-held idea of a tradeoff between reproduction and longevity.
Researchers at Stanford University School of Medicine have devised a new way to track the location and survival of specially modified cancer-killing cells in living patients for months and years. The technique uses a reporter gene that is expressed throughout a cell's lifetime, providing repeated snapshots of the cells' status.
A 30-year-old Colombian woman has undergone successful transplantation of a tissue-engineered airway, showing improved quality of life with normal functioning and no rejection. The graft developed its own blood supply and the patient was discharged without complications.
Researchers at the University of Utah are enrolling patients in a clinical trial using their own bone marrow cells to regenerate heart muscle and improve blood flow. The study aims to improve heart function and quality of life for those with congestive heart failure.
Researchers found that wounded plants produce jasmonates, which inhibit cell division and stunt plant growth. This discovery opens the possibility of improving crop growth through the manipulation of the jasmonate signal pathway.
Researchers have successfully grown human-like tissue in the lab using umbilical cord blood stem cells to create functional heart valves. The tissue-engineered valves exhibited properties similar to those of natural human valves, including collagen and elastin production.
Researchers at University of Bristol discover how bodies respond to internal distress signals, revealing potential for targeted stem cell therapy in heart patients. Kinin-sensitive EPCs identified as key to repairing blood supply and improving outcomes.
Researchers identified a peptide sequence that acts like a drug to break apart the MLL molecular switch, potentially slowing or stopping abnormal white blood cell production. The discovery may lead to more effective treatments with fewer side effects for some types of leukemia.
Researchers at VIB have discovered a protein called ACR4 that triggers the formation of root offshoots in plants. This discovery can lead to more efficient agricultural practices, such as promoting or retarding root offshoot growth for better nutrient absorption and crop yields.
Researchers discovered a molecule called ACF7 that helps regulate and power cell movement along the extracellular matrix. Without ACF7, cellular movement slows down, suggesting its importance in preventing cancer cell migration and metastasis.
Researchers at Singapore's Institute of Bioengineering and Nanotechnology have invented a thixotropic nanocomposite gel that can liquefy on demand, facilitating safe and convenient 3D cell culture. The novel material supports the extracellular matrix secretions of cells and enables controlled differentiation of stem cells.
Two UC San Diego faculty members, Karen Christman and Seth J. Field, received $1.5 million grants from the NIH to support their cutting-edge research in tissue engineering and lipid signaling molecules. Their projects aim to improve human health through regenerative medicine approaches.
Researchers at Stanford University School of Medicine confirmed that satellite cells harbor an elusive muscle stem cell, which can self-renew and give rise to specialized progeny. This discovery has profound therapeutic implications for disorders like muscular dystrophy and muscle wasting due to aging.
Reinnervate has developed a polystyrene foam scaffold to grow cells in 3D, revolutionizing drug testing and saving companies money. The company is now poised for commercial manufacture and global sales after securing significant funding.
The REGENT trial found that intracoronary infusion of CD34+CXCR4+ stem cells improved LVEF in patients with severely depressed baseline LVEF. While the treatment showed no significant improvement in overall patient groups, it was safe and feasible.
A retrospective cohort study found complex gender interactions in kidney transplantation outcomes, with female donors having a higher rate of graft loss and female recipients experiencing a lower rate of graft failure. The study suggests considering sex in future studies and decisions on organ allocation to optimize transplant success.
Scientists at Cincinnati Children's Hospital Medical Center have discovered that the microenvironment of blood-forming tissues plays a critical role in promoting leukemia progression and determining disease type in mixed lineage leukemias (MLL). The study, which used human-based MLL models in mice, suggests that disrupting the protein ...
Researchers at Children's Hospital Boston have identified the cells responsible for infantile hemangiomas, a common benign tumor. By using these cells to develop a new mouse model, scientists hope to identify potential therapeutic targets for this disease.
Researchers found that stem cells differentiate through the collective behavior of multiple genes in a network, leading to just a few endpoints. The findings also suggest that cell populations maintain built-in variability that nature can harness for change under the right conditions.
Researchers from Germany and Austria used muscle-derived stem cells to repair damaged sphincters. Patients showed significant improvements in continence, with some being completely continent after treatment.
Researchers have discovered a unique genetic profile associated with alcohol-induced heart failure, which could enable earlier diagnoses and monitor clinical outcomes. The study's findings offer new hope for addressing this condition, particularly when caught early through aggressive intervention.
Researchers at UT Southwestern Medical Center used a drug-treated blood stem cell compound to transform human blood stem cells into immature heart cells. This helped improve the function of injured rodent hearts and may lead to new treatments for heart attacks.
A new surgical technique, osteoprogenitor cellular grafting, has been used to treat steroid-induced osteonecrosis of the knee in three young patients. The procedure involves transplanting cellular material from the pelvic area into the knee, resulting in nearly normal activity and knee function with no complications.
Researchers at Schepens Eye Research Institute have identified a chemical compound that can awaken dormant Müller cells in the eye, transforming them into progenitor cells capable of generating new retinal cells. This breakthrough discovery offers new potential for treating diseases such as macular degeneration and retinitis pigmentosa.
Researchers identified a key mechanism by which macrophages recognize friendly cells, preventing them from being eaten. This discovery could lead to new treatments for inflammatory diseases such as arthritis and atherosclerosis.