Articles tagged with Stem Cells
Researchers found that MyoD activates CDC6 expression to promote rapid proliferation of muscle stem cells. The study suggests a new mechanism for muscle regeneration and highlights the importance of transcription factors in controlling cell cycle progression.
The University of Maryland School of Medicine will coordinate a consortium of national experts in stem cell research, with a focus on regenerative therapy and new clinical therapies. The seven-year grant aims to advance the field at a faster pace and realize potential for new treatments sooner.
Researchers investigated over 300 proteins in axolotl limbs, discovering key proteins involved in cell reprogramming and avoiding cell death. These findings may contribute to a better understanding of limb regeneration and potentially lead to new treatments for human amputations.
Researchers at Johns Hopkins have developed therapies using gene therapy and stem cells to increase blood flow, improve movement, and decrease tissue death. The findings hold promise for developing clinical therapies to save limbs from amputation.
Scientists at Weizmann Institute of Science have developed a new method for transplanting bone marrow-based stem cells from mismatched donors, restoring the immune system faster and improving cure rates for leukemia patients. The procedure involves infusing regulatory T cells into cancer patients before receiving donor stem cells, lead...
Researchers from UCLA demonstrate that human blood stem cells can be engineered into cells that target and kill HIV-infected cells. This approach, similar to a genetic vaccine, could be effective against other chronic viral diseases. The study provides proof-of-principle for using this strategy in the human body.
Scientists at the University of Bonn have discovered a way to turn on the 'natural heating system' in brown fat cells, which can lead to increased energy expenditure and reduced body weight. By activating this mechanism, it may be possible to fight obesity with fat.
A synthetic bone matrix offers hope for babies born with craniosynostosis by replacing fused bones and encouraging natural bone healing. The biodegradable implant could eliminate the need for multiple surgeries, resulting in improved developmental outcomes.
Research by Nick Fulcher and Robert Sablowski found that plant stem cells are sensitive to DNA damage and can detect defects, triggering cell death to prevent them from being passed on. This mechanism helps protect plants against genetic damage caused by environmental stresses such as drought, high salinity, and hazardous chemicals.
Researchers from the University of Granada and University of León found that human mononuclear cells isolated from umbilical cord blood exerted a deleterious effect on rats with liver cirrhosis, inducing hepatorenal syndrome instead of improving health. The study highlights the need for further research in hepatic regenerative medicine.
Researchers at Harvard's Wyss Institute have developed a method to grow cells in three dimensions using paper stacks, mimicking real tissues. This technique allows for uniform oxygen and nutrient delivery, making it easier to study cancer and other diseases.
Research supports potential for new anti-cancer agent as loss of p53 and ATR severely disrupts tissue maintenance in mice, leading to rapid deterioration and fatal outcomes. Cells without ATR persisting in tissues cause blockage of regeneration, while absence of p53 worsens tissue degeneration.
Researchers at Virginia Tech's Marion duPont Scott Equine Medical Center are studying the best ways to treat lameness in horses through tendon and ligament repair. Dr. Jennifer Barrett is investigating regenerative medicine techniques, including stem cell therapy, to regenerate damaged tendons and cartilage.
Research found that elevated levels of reactive oxygen in fruit fly blood stem cells signal differentiation into immune-bolstering cells. This raises concerns about the potential impact of excessive antioxidant use on human immunity.
A new study reveals that telomeres, which regulate cell division, replicate at various times during DNA replication, leading to uncontrolled cell growth. The research also found that telomerase enables unlimited growth in cancer cells by rebuilding most or all of the telomeres.
Researchers have developed acoustic tweezers that can position single cells or nanosized beads using sound waves, allowing for efficient manipulation without damaging live cells. The technology has significant advantages over existing methods in terms of versatility, miniaturization, and power consumption.
Researchers engineered a chimeric protein that increases cell survival, migration and proliferation to improve liver stem cell engraftment. The protein, TAT-Tpr-Met, was shown to increase the number of hepatic stem cells integrated into the liver of mice.
A new technique uses microscopic magnetic particles to target stem cells to sites of cardiovascular injury, resulting in a five-fold increase in cell localization and six-fold increase in cell capture. The method is directly applicable to clinical practice and could lead to the treatment of heart attacks and other vascular injuries usi...
Researchers at UCF have developed a method to optically steer cells using low-intensity polarized light, guiding them towards desired locations. This technology has the potential to improve stem cell therapies for wound healing and cancer treatment.
Researchers created airway spheres using animal and human cells, providing a new model to study dynamic processes in lung diseases. The 3-D spheres lined with ciliary and secretory cells can be used to investigate mechanisms underlying cancer and chronic asthma.
Researchers have found that placenta-derived stem cells can reduce lung fibrosis and inflammation in mice with bleomycin-induced injury. The study's findings suggest these cells may be useful for cell therapy of fibrotic diseases in the future.
A new study reveals that specialized blood cells have bone-forming potential and can contribute to abnormal bone growth in rare genetic disorders like fibrodysplasia ossificans progressiva. This discovery has significant implications for understanding FOP and other conditions where bone forms outside the skeleton.
Researchers explore two bone marrow cell delivery methods to treat heart attacks and limb ischemia. Studies show that anterograde intra-coronary delivery improves left ventricle function, while bone marrow stem cell transplants increase blood flow in severely ischemic limbs.
Researchers at the University of New South Wales used a simple contact lens to rehabilitate damaged eye surfaces by cultivating patients' own stem cells. The procedure significantly improved sight within weeks and has potential applications in other organs.
The BioInterfaces program aims to develop new tools to control cells, leading to therapies for muscle, retina, and central nervous system diseases. The program also focuses on controlling bacterial cells that form biofilms on man-made surfaces.
Researchers at Thomas Jefferson University are exploring the role of notch signaling pathway proteins in regulating stem cell activities. They plan to develop a genetically engineered mouse model to gain insights into this process and potentially harness the body's own regenerative potential to treat degenerative disc disease.
A £4M funding award will support a multidisciplinary study combining stem cell science and tissue engineering to develop new treatments for bone fractures and orthopaedic problems. The research aims to improve our understanding of skeletal cell activity, scaffold development, and environmental factors that affect tissue regeneration.
Researchers have identified three genetic factors that can turn non-muscle cells into beating heart cells, providing a significant breakthrough in understanding how to repair damaged hearts. The discovery could lead to the development of new therapeutic approaches using stem cells.
Researchers at UBC's Biomedical Research Centre have identified S1P as a molecule that can open the thymic gate for migrating stem cells. This discovery holds promise for increasing the success of blood stem cell transplants, which are currently used to treat diseases such as leukemia and aplastic anemia.
A major international study by the FANTOM consortium has found that genes are not controlled by 'master regulators' as previously thought. Instead, a more subtle and coordinated approach is needed for cellular differentiation and cancer development.
Researchers at Emory University discover a process required for epigenetic reprogramming between generations, shedding light on fertilization, stem-cell formation, and cloning. The study found that histone protein modification can be inherited through cell-to-cell transmission.
Researchers have developed a new culture system to isolate and proliferate liver stem cells from bone marrow cells, achieving six passages of the stem cells. The method uses a selecting culture system containing cholestatic serum to purify the stem cells, providing an easy and efficient way to separate them.
Researchers at UT Houston are conducting a Phase I safety trial using patient's own stem cells to treat strokes. The study aims to reduce disability in patients and could be an exciting new therapeutic approach.
Scientists have developed a device that protects transplanted pancreatic precursor cells from the immune system, allowing them to mature into functional beta cells. This breakthrough approach could alleviate the need for long-term immunosuppression in cell transplantation therapy.
Research led by David Hess identified how to use bone marrow stem cells to grow new blood vessels in mice with ligated leg arteries. These pro-angiogenic stem cells have a natural ability to induce blood vessel repair and improve blood flow in ischemic limbs.
The University of Nottingham's studies found that improved collaboration with clinicians, better funding, and regulatory certainty are crucial for stem cell therapy success. The industry is at risk of market failure due to structural barriers within the NHS.
A new dual therapy approach generates new blood vessels and improves cardiac function following a heart attack, overcoming current stem-cell-mobilizing therapies' ineffectiveness in humans. This strategy stabilizes SDF-1 and enhances the recruitment of EPCs to damaged heart tissue.
Researchers found that treating patients with their own bone marrow stem cells after a heart attack increased circulation within the heart. The study showed that higher doses of cells led to greater improvement in blood flow, but results for cardiac function were not significant.
Research at University of Gothenburg reveals that egg cells can rejuvenate sperm by extending telomeres, reducing the risk of chromosomal abnormalities. This breakthrough has significant implications for future stem cell therapy, which aims to replace diseased or dying cells.
Researchers found significant benefits in glycemic control and reduced insulin requirements in patients with type 2 diabetes who received stem cell infusion and hyperbaric oxygen treatment. The combination therapy showed promising results in decreasing type 2 diabetes morbidity and mortality.
A new study using a seaweed-based capsule and firefly-inspired bioluminescent agents successfully delivered therapeutic stem cells to treat peripheral arterial disease (PAD) in rabbits. The breakthrough could pave the way for targeted stem cell treatments for patients with PAD, which affects millions of Americans.
A CU-Boulder research team has identified a type of skeletal muscle stem cell that contributes to the repair of damaged muscles in mice. The newly identified stem cells, dubbed satellite-SP cells, renew the satellite cell population after injection into injured muscle cells, contributing to recovery of muscle tissue.
Scientists have created synthetic microtissues that can perform functions like secreting hormones and responding to stimuli, surpassing individual cell capabilities. The technique uses DNA hybridization as a programmable glue to link cells together in 3D arrangements.
Researchers have discovered that two noncoding RNAs, MENε and MENβ, play a critical role in maintaining the structure of paraspeckles, a compartment within the cell nucleus. This discovery sheds light on the functional roles of noncoding RNAs in regulating gene activity and responding to stress signals.
A recent study at the University of Pennsylvania School of Medicine reveals that immature cells in blood vessels deep within skeletal muscle orchestrate aberrant bone formation. Cells from the inflammatory response to injury trigger skeleton-stimulating proteins to transform muscle tissue into bone.
Researchers have successfully used stem cells to grow on a scaffold made from tissue extract, overcoming two key challenges for organ transplantation. This breakthrough enables the creation of bioengineered organs that can be transplanted without rejection.
Researchers at UCR identified all the genes expressed in plant stem cells, providing a global view of which genes are expressed and where within the shoot apical meristem. This discovery can help scientists develop better varieties of crops and understand why stem cells give rise to specialized cells.
Plant cells use microscopic channels called plasmodesmata to communicate and transport nutrients; the GAT1 gene encodes an enzyme that acts as an antioxidant, relieving cellular stress and maintaining flow through these channels. Turning on this gene helps plants prevent excessive callose accumulation and keeps channels open.
A new study reveals that the chemical mediator sphingosine-1-phosphate plays a crucial role in maintaining bone balance. Researchers found that mice with functional S1P receptors had denser bones than those without, suggesting a potential target for treating bone-resorptive disorders.
The University of California, Irvine has received a $3.3 million grant to expand its stem cell training program, which will attract top talent and develop more physician-scientists engaged in stem cell research. The program will train researchers to cross disciplines and develop new disease treatments.
Researchers found that ordinary plant cells can replace lost organs and tissue without the need for stem cells, a function previously thought to be exclusive to stem cells. The study suggests that plants can regenerate without stem cells through a process of reprogramming.
Researchers developed intelligent materials that stimulate cell growth and development, eliminating pharmaceutical side-effects. The technology has the potential to revolutionize orthopedic, dental, and cardiovascular prostheses.
Researchers have identified a new subtype of childhood T-lymphoblastic leukemia, also known as ETP-ALL, which is characterized by poor response to standard intensive chemotherapy. The disease has a dire prognosis, with high rates of remission failure and relapse compared to typical T-ALL patients.
Phase II trials demonstrate significant activity of pomalidomide in MM and myelofibrosis, with disease improvement or stabilization in 76% of patients. Pomalidomide also shows promise in patients who previously did not respond to REVLIMID therapy.
A study published by researchers at M.D. Anderson Cancer Center revealed that intense chemotherapy significantly reduces the risk of recurrence in young mantle cell lymphoma patients. In a median follow-up of seven years, 52% of patients aged 65 or younger achieved disease-free survival.
A UCSF study found that maternal cells enter the fetus during pregnancy, inducing regulatory T cells that enforce a state of tolerance between the fetus and mother. This discovery defines a previously-unrecognized pathway for human tolerance development.
A study by USC biologists found that older female flies can live 5-30% longer and produce more offspring when altered to over-express specific genes. This challenges the long-held idea of a tradeoff between reproduction and longevity.
Researchers at Stanford University School of Medicine have devised a new way to track the location and survival of specially modified cancer-killing cells in living patients for months and years. The technique uses a reporter gene that is expressed throughout a cell's lifetime, providing repeated snapshots of the cells' status.
A 30-year-old Colombian woman has undergone successful transplantation of a tissue-engineered airway, showing improved quality of life with normal functioning and no rejection. The graft developed its own blood supply and the patient was discharged without complications.
Researchers at the University of Utah are enrolling patients in a clinical trial using their own bone marrow cells to regenerate heart muscle and improve blood flow. The study aims to improve heart function and quality of life for those with congestive heart failure.