Articles tagged with Stem Cells
Researchers found that wounded plants produce jasmonates, which inhibit cell division and stunt plant growth. This discovery opens the possibility of improving crop growth through the manipulation of the jasmonate signal pathway.
Researchers have successfully grown human-like tissue in the lab using umbilical cord blood stem cells to create functional heart valves. The tissue-engineered valves exhibited properties similar to those of natural human valves, including collagen and elastin production.
Researchers at University of Bristol discover how bodies respond to internal distress signals, revealing potential for targeted stem cell therapy in heart patients. Kinin-sensitive EPCs identified as key to repairing blood supply and improving outcomes.
Researchers identified a peptide sequence that acts like a drug to break apart the MLL molecular switch, potentially slowing or stopping abnormal white blood cell production. The discovery may lead to more effective treatments with fewer side effects for some types of leukemia.
Researchers at VIB have discovered a protein called ACR4 that triggers the formation of root offshoots in plants. This discovery can lead to more efficient agricultural practices, such as promoting or retarding root offshoot growth for better nutrient absorption and crop yields.
Researchers discovered a molecule called ACF7 that helps regulate and power cell movement along the extracellular matrix. Without ACF7, cellular movement slows down, suggesting its importance in preventing cancer cell migration and metastasis.
Researchers at Singapore's Institute of Bioengineering and Nanotechnology have invented a thixotropic nanocomposite gel that can liquefy on demand, facilitating safe and convenient 3D cell culture. The novel material supports the extracellular matrix secretions of cells and enables controlled differentiation of stem cells.
Two UC San Diego faculty members, Karen Christman and Seth J. Field, received $1.5 million grants from the NIH to support their cutting-edge research in tissue engineering and lipid signaling molecules. Their projects aim to improve human health through regenerative medicine approaches.
Researchers at Stanford University School of Medicine confirmed that satellite cells harbor an elusive muscle stem cell, which can self-renew and give rise to specialized progeny. This discovery has profound therapeutic implications for disorders like muscular dystrophy and muscle wasting due to aging.
Reinnervate has developed a polystyrene foam scaffold to grow cells in 3D, revolutionizing drug testing and saving companies money. The company is now poised for commercial manufacture and global sales after securing significant funding.
The REGENT trial found that intracoronary infusion of CD34+CXCR4+ stem cells improved LVEF in patients with severely depressed baseline LVEF. While the treatment showed no significant improvement in overall patient groups, it was safe and feasible.
A retrospective cohort study found complex gender interactions in kidney transplantation outcomes, with female donors having a higher rate of graft loss and female recipients experiencing a lower rate of graft failure. The study suggests considering sex in future studies and decisions on organ allocation to optimize transplant success.
Scientists at Cincinnati Children's Hospital Medical Center have discovered that the microenvironment of blood-forming tissues plays a critical role in promoting leukemia progression and determining disease type in mixed lineage leukemias (MLL). The study, which used human-based MLL models in mice, suggests that disrupting the protein ...
Researchers at Children's Hospital Boston have identified the cells responsible for infantile hemangiomas, a common benign tumor. By using these cells to develop a new mouse model, scientists hope to identify potential therapeutic targets for this disease.
Researchers found that stem cells differentiate through the collective behavior of multiple genes in a network, leading to just a few endpoints. The findings also suggest that cell populations maintain built-in variability that nature can harness for change under the right conditions.
Researchers from Germany and Austria used muscle-derived stem cells to repair damaged sphincters. Patients showed significant improvements in continence, with some being completely continent after treatment.
Researchers have discovered a unique genetic profile associated with alcohol-induced heart failure, which could enable earlier diagnoses and monitor clinical outcomes. The study's findings offer new hope for addressing this condition, particularly when caught early through aggressive intervention.
Researchers at UT Southwestern Medical Center used a drug-treated blood stem cell compound to transform human blood stem cells into immature heart cells. This helped improve the function of injured rodent hearts and may lead to new treatments for heart attacks.
A new surgical technique, osteoprogenitor cellular grafting, has been used to treat steroid-induced osteonecrosis of the knee in three young patients. The procedure involves transplanting cellular material from the pelvic area into the knee, resulting in nearly normal activity and knee function with no complications.
Researchers at Schepens Eye Research Institute have identified a chemical compound that can awaken dormant Müller cells in the eye, transforming them into progenitor cells capable of generating new retinal cells. This breakthrough discovery offers new potential for treating diseases such as macular degeneration and retinitis pigmentosa.
Researchers identified a key mechanism by which macrophages recognize friendly cells, preventing them from being eaten. This discovery could lead to new treatments for inflammatory diseases such as arthritis and atherosclerosis.
Researchers at MIT have devised a simple and inexpensive method for sorting different types of cells, which could lead to low-cost tools for diagnosing diseases like cancer. The new device relies on the way cells interact with a surface by rolling along it, allowing specific types of cells to be separated.
Scientists at the University of Minnesota Center for Cardiovascular Repair successfully grew a functioning beating heart by reseeding dead rat and pig hearts with live cells. The decellularization process shows promise for creating transplantable blood vessels or whole organs made from a patient's own cells.
A new study published in PLOS Computational Biology suggests that the inefficient process of replacing worn-out cells is a defense against cancer. The researchers found that multicellular organisms use a complex system to replace lost cells, which suppresses mutations that could lead to uncontrolled cell growth.
Researchers at Stanford University School of Medicine have isolated a human blood cell called the multipotent progenitor, which is thought to be the great-grandparent of all cells in the blood. This finding could lead to new treatments for blood cancers and other blood diseases.
Scientists at UC Berkeley have discovered a technique that enables the detection of biomolecules' dynamic reactions in a single living cell, providing unprecedented resolution. By using gold nanoparticles, researchers can determine enzyme activation and gene expression in real-time without killing the cells.
Researchers discovered a novel type of stem cell in menstrual blood that can rapidly replicate and develop into various cell types, including heart, liver, and lung cells. This breakthrough could lead to innovative treatments for damaged tissues and diseases such as diabetes and liver failure.
Scientists have developed a novel 3D cell culture technology that more accurately reflects human tissue structure and behavior. This technology can lead to reduced animal testing and improved drug discovery efficiency.
A UCR plant cell biologist is studying how plant stem cells maintain their identity and specialize into different cell types. He will use two powerful methods, microgenomics and live imaging, to understand the molecular and cellular mechanisms behind stem-cell regulation.
University of Minnesota researchers have initiated a groundbreaking clinical trial to determine the optimal dose and safety of T regulatory cells from umbilical cord blood in decreasing the risk of immune reactions common in patients undergoing blood and marrow transplantation. The study aims to enhance blood and marrow recovery, reduc...
Scientists at GIS found that DNA replication efficiency increases later in the S-phase, suggesting a novel approach for studying human biology and stem cell research. The discovery could lead to more efficient analyses and tests related to cellular replication.
Researchers found that Wnt protein impairs communication between stem cells and damaged muscles in older adults. This impairment leads to slower healing times and poorer tissue repair. The discovery opens doors to potential treatments for various tissues, including skin, gut, bone marrow, and even brain.
Scientists at University of Pennsylvania discover technique to apply physical stress to cells, unfolding proteins and revealing novel targets for treating diseases. This breakthrough has potential applications in various fields, including cancer research and regenerative medicine.
Researchers have found that ethylene regulates cell division in root stem cells, allowing plants to detect favorable soil conditions. This breakthrough has significant implications for tackling soil compaction issues in tropical agriculture.
A study published in The Lancet found that injecting autologous myoblasts and fibroblasts into the urethra improved continence rates for women with stress urinary incontinence. After 12 months, 38 out of 42 women treated with autologous cells were completely continent, compared to only two out of 21 women treated with collagen.
Researchers explored the use of autologous cells derived from bone marrow cells (BMC) to strengthen cardiac function and prevent heart attacks. The study found a significant reduction in clinical events, including death, heart attack, or revascularization, in patients who received BMC infusion compared to placebo.
Researchers found that unrelated umbilical cord blood transplants can provide similar five-year survival rates to allele-matched bone marrow transplants for children with acute leukemia. However, matched cord blood transplants showed greater survival rates but required further study to confirm.
Researchers have discovered two types of satellite cells in muscle that behave like stem cells, allowing them to regrow and repair muscle tissue. These findings could lead to new treatments for muscle-wasting diseases and potentially even help maintain muscle mass with age.
A study led by researchers at the University of Pittsburgh School of Medicine found that muscle-derived stem cell injections strengthened sphincter muscles, improving bladder control and quality of life for women with stress urinary incontinence. The treatment was safe and effective, with long-term improvements observed.
A study by USF researchers debunks the theory that older women can generate new eggs, challenging a controversial finding made by Harvard scientist Jonathan Tilly. The researchers found no evidence of egg stem cells in ovarian cells biopsied from 12 women between 28 and 53 years old.
Researchers developed an agent that shields rapidly dividing cells from radiation-induced death, regardless of timing of administration. The treatment prevents apoptosis in immune system cells, providing proof-in-principle for a new approach to fending off radiation damage.
Researchers are developing nanotechnology to stimulate the body's healing abilities, enabling damaged organs to repair themselves. Early results show paralyzed lab mice regaining mobility after receiving a nanomaterial injection, offering hope for treating intractable diseases.
A team of scientists has discovered a key mechanism by which plant proteins, Scarecrow and Short-root, regulate water and nutrient uptake in plants. This complex system ensures that plants can control the amount of water and nutrients they take in through their roots, enabling them to thrive in various environments.
Researchers provide new insights into how a key protein used to fight viruses works, raising hopes for improved treatments against viral infection. Additionally, heart stem cells are shown to be unaffected by acute heart failure, making them available for cardiac recovery. A chemical called thioredoxin also helps prevent loss of neuron...
A study by Pittsburgh scientists found that female stem cells have a greater ability to regenerate skeletal muscle tissue than male cells. The researchers isolated female and male muscle-derived stem cells and tested their regenerative capabilities in dystrophic mice. Female stem cells were more efficient at regenerating skeletal muscl...
A new study presents the first US controlled clinical trial using muscle stem cells to treat congestive heart failure. The procedure involves injecting autologous skeletal myoblasts into scarred tissue via a minimally invasive catheter, showing improved quality of life and potential cardiac function.
Researchers found that cellular noise can amplify cell transformation and differentiation in bacteria cells. This discovery provides a systems-level view of gene circuits, revealing a potential role for noise in driving biological processes.
Scientists have discovered how immune cells decide to respond to infections by either fighting to the death or becoming the body's memory for future infections. The research reveals that immune cells can take divergent paths, leading to a more targeted approach to developing vaccines.
Researchers transplanted bone marrow stem cells into testes of infertile mice, showing potential for treating male infertility. The stem cells differentiated into germ cells and supporting cells, suggesting a new approach to replacing nonfunctioning cells involved in sperm production.
Scientists discovered that cells passed from mother to child during pregnancy can differentiate into functioning islet beta cells producing insulin. Higher levels of maternal DNA were found in the blood of children and young adults with Type 1 diabetes, suggesting a beneficial role for microchimerism.
Researchers at UC Berkeley discovered a synthetic peptide that prevents the genital warts virus from infecting cells. The peptide targets the viral E2 protein, which binds to chromosomal proteins, and blocks its action, potentially stopping the spread of the virus and preventing cancer.
Scientists at the Max Planck Institute discovered that newt heart cells can re-differentiate after damage, allowing for complete repair and restoration of function. The researchers found that Phospho-H3 protein marks the G2 phase of cell cycle and indicates regeneration without stem cells.
A simpler, cheaper method for cell fusion has been developed by Chang Lu at Purdue University, enabling researchers to fuse cells with greater control and precision. The new technology uses constant DC voltage and could lead to breakthroughs in stem cell research, disease antibody production, and cloning.
A study published in Proceedings of the National Academy of Sciences reveals that SOX9 and RUNX2 are two master transcription factors involved in differentiating skeletal progenitor cells into bone or cartilage. The researchers found that SOX9 appears to be the dominant player, suppressing RUNX2 activity to promote cartilage formation.
Researchers discovered a new 'helper' compound, dasatinib, that effectively treats some leukemias by targeting both BCR-ABL and SRC kinases. The findings suggest addressing both pathways is crucial for optimal treatment outcomes.
A new technique called multi-isotope imaging mass spectrometry (MIMS) allows researchers to image and quantify molecules at a subcellular level. This enables the tracking of individual donor cells after transplantation and the measurement of cancer treatment drug efficacy within cells.
Research at Karolinska Institutet reveals that human neocortical nerve cells do not regenerate, contradicting previous studies on apes and rodents. The new method uses atmospheric C14 levels to pinpoint cell birth times, showing no cell division took place in the neocortex from infancy to adulthood.
Researchers discovered that Bruli protein plays a crucial role in maintaining stem cells in planarians, enabling their remarkable ability to regenerate lost body parts. The study provides new insights into the fundamental mechanisms of stem cell self-renewal and its potential applications in human therapy.
Using minimally invasive robotic surgery, researchers successfully transplanted stem cells into damaged pig hearts, showing improved function and cell engraftment. The technique offers several benefits for patients with heart failure, including reduced risk and less time under anesthesia.
University of Illinois researchers found unexpected two-way communication between blood stem cells and T cells, changing their fate. This loop may lead to a strong immune response, increasing the risk of graft-versus-host disease or rejection.