Articles tagged with Stem Cells
Scientists have developed a novel 3D cell culture technology that more accurately reflects human tissue structure and behavior. This technology can lead to reduced animal testing and improved drug discovery efficiency.
A UCR plant cell biologist is studying how plant stem cells maintain their identity and specialize into different cell types. He will use two powerful methods, microgenomics and live imaging, to understand the molecular and cellular mechanisms behind stem-cell regulation.
University of Minnesota researchers have initiated a groundbreaking clinical trial to determine the optimal dose and safety of T regulatory cells from umbilical cord blood in decreasing the risk of immune reactions common in patients undergoing blood and marrow transplantation. The study aims to enhance blood and marrow recovery, reduc...
Scientists at GIS found that DNA replication efficiency increases later in the S-phase, suggesting a novel approach for studying human biology and stem cell research. The discovery could lead to more efficient analyses and tests related to cellular replication.
Researchers found that Wnt protein impairs communication between stem cells and damaged muscles in older adults. This impairment leads to slower healing times and poorer tissue repair. The discovery opens doors to potential treatments for various tissues, including skin, gut, bone marrow, and even brain.
Scientists at University of Pennsylvania discover technique to apply physical stress to cells, unfolding proteins and revealing novel targets for treating diseases. This breakthrough has potential applications in various fields, including cancer research and regenerative medicine.
Researchers have found that ethylene regulates cell division in root stem cells, allowing plants to detect favorable soil conditions. This breakthrough has significant implications for tackling soil compaction issues in tropical agriculture.
Researchers explored the use of autologous cells derived from bone marrow cells (BMC) to strengthen cardiac function and prevent heart attacks. The study found a significant reduction in clinical events, including death, heart attack, or revascularization, in patients who received BMC infusion compared to placebo.
A study published in The Lancet found that injecting autologous myoblasts and fibroblasts into the urethra improved continence rates for women with stress urinary incontinence. After 12 months, 38 out of 42 women treated with autologous cells were completely continent, compared to only two out of 21 women treated with collagen.
Researchers found that unrelated umbilical cord blood transplants can provide similar five-year survival rates to allele-matched bone marrow transplants for children with acute leukemia. However, matched cord blood transplants showed greater survival rates but required further study to confirm.
Researchers have discovered two types of satellite cells in muscle that behave like stem cells, allowing them to regrow and repair muscle tissue. These findings could lead to new treatments for muscle-wasting diseases and potentially even help maintain muscle mass with age.
A study led by researchers at the University of Pittsburgh School of Medicine found that muscle-derived stem cell injections strengthened sphincter muscles, improving bladder control and quality of life for women with stress urinary incontinence. The treatment was safe and effective, with long-term improvements observed.
A study by USF researchers debunks the theory that older women can generate new eggs, challenging a controversial finding made by Harvard scientist Jonathan Tilly. The researchers found no evidence of egg stem cells in ovarian cells biopsied from 12 women between 28 and 53 years old.
Researchers developed an agent that shields rapidly dividing cells from radiation-induced death, regardless of timing of administration. The treatment prevents apoptosis in immune system cells, providing proof-in-principle for a new approach to fending off radiation damage.
Researchers are developing nanotechnology to stimulate the body's healing abilities, enabling damaged organs to repair themselves. Early results show paralyzed lab mice regaining mobility after receiving a nanomaterial injection, offering hope for treating intractable diseases.
A team of scientists has discovered a key mechanism by which plant proteins, Scarecrow and Short-root, regulate water and nutrient uptake in plants. This complex system ensures that plants can control the amount of water and nutrients they take in through their roots, enabling them to thrive in various environments.
Researchers provide new insights into how a key protein used to fight viruses works, raising hopes for improved treatments against viral infection. Additionally, heart stem cells are shown to be unaffected by acute heart failure, making them available for cardiac recovery. A chemical called thioredoxin also helps prevent loss of neuron...
A study by Pittsburgh scientists found that female stem cells have a greater ability to regenerate skeletal muscle tissue than male cells. The researchers isolated female and male muscle-derived stem cells and tested their regenerative capabilities in dystrophic mice. Female stem cells were more efficient at regenerating skeletal muscl...
A new study presents the first US controlled clinical trial using muscle stem cells to treat congestive heart failure. The procedure involves injecting autologous skeletal myoblasts into scarred tissue via a minimally invasive catheter, showing improved quality of life and potential cardiac function.
Researchers found that cellular noise can amplify cell transformation and differentiation in bacteria cells. This discovery provides a systems-level view of gene circuits, revealing a potential role for noise in driving biological processes.
Researchers transplanted bone marrow stem cells into testes of infertile mice, showing potential for treating male infertility. The stem cells differentiated into germ cells and supporting cells, suggesting a new approach to replacing nonfunctioning cells involved in sperm production.
Scientists have discovered how immune cells decide to respond to infections by either fighting to the death or becoming the body's memory for future infections. The research reveals that immune cells can take divergent paths, leading to a more targeted approach to developing vaccines.
Scientists discovered that cells passed from mother to child during pregnancy can differentiate into functioning islet beta cells producing insulin. Higher levels of maternal DNA were found in the blood of children and young adults with Type 1 diabetes, suggesting a beneficial role for microchimerism.
Researchers at UC Berkeley discovered a synthetic peptide that prevents the genital warts virus from infecting cells. The peptide targets the viral E2 protein, which binds to chromosomal proteins, and blocks its action, potentially stopping the spread of the virus and preventing cancer.
Scientists at the Max Planck Institute discovered that newt heart cells can re-differentiate after damage, allowing for complete repair and restoration of function. The researchers found that Phospho-H3 protein marks the G2 phase of cell cycle and indicates regeneration without stem cells.
A simpler, cheaper method for cell fusion has been developed by Chang Lu at Purdue University, enabling researchers to fuse cells with greater control and precision. The new technology uses constant DC voltage and could lead to breakthroughs in stem cell research, disease antibody production, and cloning.
A study published in Proceedings of the National Academy of Sciences reveals that SOX9 and RUNX2 are two master transcription factors involved in differentiating skeletal progenitor cells into bone or cartilage. The researchers found that SOX9 appears to be the dominant player, suppressing RUNX2 activity to promote cartilage formation.
Researchers discovered a new 'helper' compound, dasatinib, that effectively treats some leukemias by targeting both BCR-ABL and SRC kinases. The findings suggest addressing both pathways is crucial for optimal treatment outcomes.
A new technique called multi-isotope imaging mass spectrometry (MIMS) allows researchers to image and quantify molecules at a subcellular level. This enables the tracking of individual donor cells after transplantation and the measurement of cancer treatment drug efficacy within cells.
Research at Karolinska Institutet reveals that human neocortical nerve cells do not regenerate, contradicting previous studies on apes and rodents. The new method uses atmospheric C14 levels to pinpoint cell birth times, showing no cell division took place in the neocortex from infancy to adulthood.
Researchers discovered that Bruli protein plays a crucial role in maintaining stem cells in planarians, enabling their remarkable ability to regenerate lost body parts. The study provides new insights into the fundamental mechanisms of stem cell self-renewal and its potential applications in human therapy.
Using minimally invasive robotic surgery, researchers successfully transplanted stem cells into damaged pig hearts, showing improved function and cell engraftment. The technique offers several benefits for patients with heart failure, including reduced risk and less time under anesthesia.
University of Illinois researchers found unexpected two-way communication between blood stem cells and T cells, changing their fate. This loop may lead to a strong immune response, increasing the risk of graft-versus-host disease or rejection.
Researchers developed engineered tissue that can conduct electricity, potentially replacing pacemakers in children with heart block. The tissue was tested in rats and shown to integrate with surrounding heart tissue, establishing an electrical conduction pathway.
Researchers have identified a signal transduction process regulating stem-cell division, which could lead to drugs stimulating endogenous cell production. The discovery may help treat conditions such as stroke and Parkinson's by promoting the formation of new nerve cells.
A clinical trial found that injecting stem cells from a woman's own muscle may effectively treat urinary incontinence. Five of seven patients reported significant improvements in bladder control and quality of life with no serious adverse effects. A follow-up study is planned to determine the optimal dose for effective treatment.
The J. David Gladstone Institutes will develop and implement a three-year, stem cell-specific curriculum for 10 postdoctoral fellows using the first third of $2.4 million grant. The program aims to educate scholars from various scientific backgrounds in stem cell biology and disease.
A University of Calgary bioengineering team has successfully grown insulin-producing cells in a lab, which could lead to the production of human tissue for transplantation. The breakthrough brings the team one step closer to addressing the serious condition that requires multiple daily insulin injections.
In a double-blind, placebo-controlled study, administering bone marrow stem cells to patients with acute myocardial infarction resulted in a significant reduction of the infarct size and improved regional left ventricle function. The findings suggest potential benefits for targeted clinical and pre-clinical research.
Researchers found that mice with half the normal amount of telomerase can't maintain their stem cells' chromosome ends, leading to early demise. The study suggests that inherited disease may be caused by inherited telomere length, not the status of the telomerase gene.
Melbourne-based researchers Dr Anthony Hannan and Dr Stephen Nutt have won $1 million Pfizer Fellowships to investigate environmental factors affecting brain diseases and blood cell development. Their work aims to develop new therapeutic approaches for devastating conditions like Huntington's disease, schizophrenia, and leukaemia.
A new cell transplantation technique has successfully restored insulin production in diabetic patients by injecting donor islet cells into the portal vein. The procedure, which uses a steroid-free protocol and sandwich closure method, showed promising results with all 13 patients producing insulin without major complications.
Researchers at Johns Hopkins Medicine have successfully created a biological pacemaker using connective tissue cells from lungs and heart muscle cells, paving the way for an alternative to implanted electronic pacemakers. The biopacemaker uses tiny electroactive 'pacing cells' that can fire on their own and regulate the heart's rhythmi...
Researchers discover GRK5 plays a key role in preventing cell growth and proliferation in blood vessel damage, hinting at alternative therapeutic targets. The study suggests that other cell types, such as epithelial cells or bone marrow derived stem cells, may also contribute to restenosis.
Researchers at EPFL discover that stem cells within hair follicles can develop into various cell types needed for hair growth and follicle replacement. This breakthrough has significant implications for regenerative medicine and could potentially be used to regenerate hair on patients with severe burns.
Researchers at Southampton and Nottingham universities are developing a new method of gene delivery to promote bone tissue formation. The technique, if successful, could provide a new source of bone tissue for orthopaedic procedures, addressing healthcare needs associated with trauma, degenerative disease, and age-related bone loss.
The Keck School's grant will train graduate students and post-doctoral fellows across 27 departments, developing courses on bioethics and cutting-edge gene-transfer technology. The program aims to create a pipeline of highly trained researchers for CIRM-funded projects.
Asymmetric cell division occurs perpendicular to the basal layer, resulting in one daughter cell naturally displaced out of the basal layer. This process controls skin differentiation and has implications for understanding skin diseases and cancer.
University of Utah researchers found that splicing, a process that codes for inflammatory protein Interleukin 1â (IL-1â), takes place in the cytoplasm of circulating platelets. This finding has potential implications for understanding gene expression and disease mechanisms.
Researchers discovered that the protein CrebA single-handedly controls the entire set of events leading to secretion in the fruit fly's salivary gland, improving understanding of how cells become specialized for secretion. This finding could potentially help fix problems with pancreatic cells in juvenile (type I) diabetes.
The American Academy of Neurology has supported a bill that would expand funding scope for National Institutes of Health support of embryonic stem-cell research. This move is expected to significantly advance the field while ensuring strong ethical safeguards.
Researchers discovered that induction of the HIF-1 pathway can act as a 'super-antibiotic', increasing bacterial killing in low-oxygen environments. Additionally, studies on skeletal muscle and kidney regeneration found that these organs' natural repair mechanisms play a crucial role in maintaining function and tissue health.
A new study by the University of Pittsburgh Medical Center has found that muscle-derived stem cell cultures can improve leak point pressure and regenerate deficient urethral muscle, even when contaminated with fibroblasts. The research paves the way for a more efficient and effective treatment for urinary incontinence.
The Howard Hughes Medical Institute (HHMI) has awarded six fellowship grants to outstanding minority and disadvantaged PhD students pursuing research in life sciences at Yale University. The recipients, Imran Babar and Meisha Bynoe, conducted research projects on lung cancer and HIV, respectively.
Researchers used disabled retroviruses to discover genes that increase the multiplication rate of stem cells, which could improve regenerative medicine. The study found that these genes can be used to enhance the fitness of stem cells, potentially leading to new treatments for inherited blood disorders.
Arteriocyte, a startup company spun out from Case Western Reserve University, is developing a novel stem cell therapy to generate new blood vessels and replace damaged ones in patients with heart disease. The therapy has shown encouraging results in animal studies and plans for patient testing are pending NIH and FDA approval.
Researchers discover CML's unique cell death protein, lipocalin 24p3, that destroys healthy bone marrow cells, allowing leukemia to grow and spread. Blocking this protein with an antibody may prove useful in treating CML patients when combined with traditional treatment.
Georgia Tech researchers reveal that biomaterial surface chemistry influences cell behavior by altering adhesion proteins. This discovery can lead to the development of novel, rationally-designed biomaterials that control interactions between cells and materials.
Researchers are exploring new technologies to regenerate bone, enhance ligament healing, produce tissue-engineered cartilage and improve bone healing with stem cells derived from muscle. These advances hold promise for treating devastating congenital or traumatic problems and preventing degenerative processes in the aging population.
Researchers at UT Southwestern Medical Center have developed a new gene therapy technique that uses homologous recombination to replace mutated genes in human immune cells, restoring both gene function and protein production. This approach has shown promising results in treating severe combined immunodeficiency disease (SCID) and may a...