Articles tagged with Stem Cells
Asymmetric cell division occurs perpendicular to the basal layer, resulting in one daughter cell naturally displaced out of the basal layer. This process controls skin differentiation and has implications for understanding skin diseases and cancer.
University of Utah researchers found that splicing, a process that codes for inflammatory protein Interleukin 1â (IL-1â), takes place in the cytoplasm of circulating platelets. This finding has potential implications for understanding gene expression and disease mechanisms.
Researchers discovered that the protein CrebA single-handedly controls the entire set of events leading to secretion in the fruit fly's salivary gland, improving understanding of how cells become specialized for secretion. This finding could potentially help fix problems with pancreatic cells in juvenile (type I) diabetes.
The American Academy of Neurology has supported a bill that would expand funding scope for National Institutes of Health support of embryonic stem-cell research. This move is expected to significantly advance the field while ensuring strong ethical safeguards.
Researchers discovered that induction of the HIF-1 pathway can act as a 'super-antibiotic', increasing bacterial killing in low-oxygen environments. Additionally, studies on skeletal muscle and kidney regeneration found that these organs' natural repair mechanisms play a crucial role in maintaining function and tissue health.
The Howard Hughes Medical Institute (HHMI) has awarded six fellowship grants to outstanding minority and disadvantaged PhD students pursuing research in life sciences at Yale University. The recipients, Imran Babar and Meisha Bynoe, conducted research projects on lung cancer and HIV, respectively.
A new study by the University of Pittsburgh Medical Center has found that muscle-derived stem cell cultures can improve leak point pressure and regenerate deficient urethral muscle, even when contaminated with fibroblasts. The research paves the way for a more efficient and effective treatment for urinary incontinence.
Researchers used disabled retroviruses to discover genes that increase the multiplication rate of stem cells, which could improve regenerative medicine. The study found that these genes can be used to enhance the fitness of stem cells, potentially leading to new treatments for inherited blood disorders.
Arteriocyte, a startup company spun out from Case Western Reserve University, is developing a novel stem cell therapy to generate new blood vessels and replace damaged ones in patients with heart disease. The therapy has shown encouraging results in animal studies and plans for patient testing are pending NIH and FDA approval.
Researchers discover CML's unique cell death protein, lipocalin 24p3, that destroys healthy bone marrow cells, allowing leukemia to grow and spread. Blocking this protein with an antibody may prove useful in treating CML patients when combined with traditional treatment.
Georgia Tech researchers reveal that biomaterial surface chemistry influences cell behavior by altering adhesion proteins. This discovery can lead to the development of novel, rationally-designed biomaterials that control interactions between cells and materials.
Researchers are exploring new technologies to regenerate bone, enhance ligament healing, produce tissue-engineered cartilage and improve bone healing with stem cells derived from muscle. These advances hold promise for treating devastating congenital or traumatic problems and preventing degenerative processes in the aging population.
Researchers at UT Southwestern Medical Center have developed a new gene therapy technique that uses homologous recombination to replace mutated genes in human immune cells, restoring both gene function and protein production. This approach has shown promising results in treating severe combined immunodeficiency disease (SCID) and may a...
Scientists have successfully grown functional fat cells in a laboratory using a new microscopic three-dimensional scaffolding. The discovery may lead to breakthroughs in treating type II diabetes and could provide a source of transplantable organs.
The American Physiological Society has awarded young investigators in various fields of physiological research, including respiratory physiology and epithelial renal physiology. These awards recognize outstanding promise in the field and support research that could lead to advances in stem cell therapy and gene treatment.
A minimally invasive procedure involving stem cells has shown improvement in heart function for patients with severe heart failure and no coronary blockages. All 15 patients who received stem cell injections experienced some degree of improvement, while the control group saw little change.
A new reduced-intensity stem cell transplant regimen has shown superior results in pediatric patients, allowing early recovery of immune function and nearly eliminating transplant rejection. The procedure, which uses a shorter and lower-dose treatment of Campath-1H, also reduces the incidence and severity of graft vs. host disease.
Researchers discovered human islet-derived precursor cells that reproduce easily and can differentiate into hormone-producing cells. The findings may eventually have implications for islet transplantation, an experimental treatment for type 1 diabetes.
Researchers have found that stem cells can preserve vision in mice with damaged retinas, holding hope for treatments of macular degeneration and other retinal diseases. The transplanted cells were found to migrate to the damaged area and regain or retain function in cone cells.
Researchers at Tufts University's Friedman School of Nutrition Science and Policy found that poor ubiquitin function contributes to eye diseases like cataracts. Adolescents who read nutrition labels often don't translate the information into healthier diets, with boys consuming more calories from fat.
Researchers at UNC Lineberger identified two proteins, p16INK4a and ARF, that increase dramatically as cells age, suggesting a link between cellular aging and their upregulation. This discovery may lead to new biomarkers for determining the molecular age of people and potentially slow aging.
Dr. von Andrian will focus on setting up a new microscopy model at Joslin to study the interaction between islet cells and immune cells, aiming to develop a simple model for studying islet cells in living animals. He will also collaborate with Joslin researchers on stem cell projects and vascular complications in people with diabetes.
A team of biomedical engineers is using $11.5 million grant from the National Institutes of Health to understand how mechanical forces govern white blood cells' behavior. The research aims to develop new treatments for diseases caused by inappropriate immune responses, such as diabetes and heart disease.
Scientists found that people with psoriasis have transit amplifying cells divide without signal, leading to rapid skin renewal and increased cell layers. This discovery may lead to new treatments for the disease, which affects 300,000 people in the Netherlands.
A U-M team, led by Dr. Stephen Feinberg, is engineering tissue grafts to treat mouth wounds in patients with diabetes or undergoing chemotherapy. The grafts, made from a combination of mucosal cells and AlloDerm, show promise for smaller donor sites and faster healing times.
A team of European researchers, led by Prof. Rosenthal, will collaborate with American scientists to develop and study human cells with an enhanced potential for cardiac regeneration. They aim to apply their collective understanding of adult progenitor cell biology to effective human cardiac repair.
Researchers found that bone marrow-derived cells cluster within the healing area of a wound, producing collagen type III, a key component of skin. This discovery suggests new ways to treat serious wounds, as these cells also maintain the matrix environment and integrity of the skin.
Researchers discovered that donor-derived bone marrow cells can differentiate into human endometrial tissue, contributing to endometrial regeneration. This finding may lead to new treatments for uterine disorders like infertility, abnormal bleeding, and cancer.
Researchers found that bone marrow cells can differentiate into epithelial cells under normal circumstances, suggesting a new mechanism of transformation. However, the exact mechanisms behind this process are still unclear and require further investigation.
Researchers at Johns Hopkins Medicine discovered that adding a single protein, BMP4, induced mouse stem cells to become fat cells. The study suggests that a similar signal is likely involved in humans, too, paving the way for new treatments for obesity and related diseases.
Researchers have made significant breakthroughs in understanding a natural mechanism cells use to protect themselves from stress, with potential applications for preventing motor nerve cell death. Up to 50% of nerve cell death could be prevented in mice with sciatic nerve injury using this approach.
Researchers found that younger children and smaller children have a lower risk of infection due to higher T lymphocyte counts, while low dendritic cell numbers correlate with increased risk. A closer cord blood match also reduces the risk of infection.
A study suggests that genetic enhancement can increase muscle mass and strength in rats, which could benefit elite athletes, patients with muscle wasting, and elderly individuals. The research also highlights the need for regulatory bodies to distinguish between allowed and banned endurance enhancement practices.
Researchers discovered that a growth factor, granulocyte colony stimulating factor (G-CSF), can increase the number of stem cells in the heart, which may help repair damaged heart tissue. After six weeks, patients showed significant improvements in heart function and metabolic recovery.
Researchers used endothelial progenitor cells from bone marrow to repair damaged blood vessels in rats with pulmonary arterial hypertension (PAH), reducing systolic pressure and improving microcirculation. The study suggests a regenerative approach that could lead to a new clinical therapy for this devastating disease.
Researchers have successfully treated heart attack patients with stem cells harvested from their own bone marrow, resulting in improved cardiac function and increased blood flow to the damaged area. This breakthrough therapy could potentially lead to a new treatment for heart attacks.
Scientists at Duke University Medical Center discovered that age-related stem cell loss prevents artery repair and leads to atherosclerosis. The researchers found that bone marrow-derived vascular progenitor cells play a critical role in determining the onset and progression of atherosclerosis.
Researchers have found that stem cells from blood vessels can regenerate wasting muscle in mice with muscular dystrophy-like symptoms. The study's results provide a possible new approach for treating the disease, which currently has no cure.
Researchers found that patients with a negative pretransplantation scan had a favorable outcome, with 25 still in complete remission after a median follow-up of 1,510 days. In contrast, patients with a positive scan relapsed more frequently, highlighting the potential for [F]FDG-PET to identify nonresponders.
Researchers have found that green tea polyphenol EGCG can reactivate dying skin cells, accelerating their growth and differentiation. This could lead to new treatments for skin diseases and wounds, such as aphthous ulcers and psoriasis.
A new Composite Physiologic Index (CPI) effectively tracks pulmonary fibrosis in patients and provides a more accurate prognostic indicator for interstitial pneumonia. Additionally, researchers explore the potential of stem cells to treat acute lung injury and its severe form, ARDS.
Experimental evidence suggests that stem cell implantation can trigger angiogenesis in damaged heart tissue, leading to improved blood flow and potentially safe treatment outcomes. However, further controlled studies are needed to fully understand the role of cell transplantation in myocardial regeneration.
Researchers found that bone marrow cells can repair damaged vessels to reduce atherosclerosis in mice. The study suggests a potential new approach to treating coronary artery disease and could lead to the development of stem cell-based therapies.
Scientists at Stanford University have created synthetic DNA nanocircles that can lengthen telomeres in test tube cells, a key factor in determining cell lifespan. This breakthrough could lead to the development of new methods for studying aging and cancer, as well as alternative approaches to transplantation medicine.
A recent study has provided the first direct evidence that transplanted muscle cells can form muscle fibers and blood vessels in damaged hearts. Satellite cells from patients' thigh muscles were injected into their heart tissue, surviving and differentiating into mature muscle fibers without triggering an immune reaction.
The study found that older men are more likely to have sperm with genetic mutations causing Apert syndrome, which increases the risk of having a child with the disease. The scientists suggest that the number of cell divisions in making sperm plays a role in this link.
Researchers have made significant progress in developing tolerance to transplanted organs through innovative approaches. Studies show that patients can be weaned off immunosuppressive drugs within months after receiving living donor kidney or small bowel transplants, with some patients achieving complete drug-free status.
Muscle stem cells have shown potential in treating muscular dystrophy by differentiating into other cell types and resisting rejection, overcoming major obstacles such as low survival rates and immune system rejection. The study's findings could lead to more effective treatments for MD and other muscle-related diseases.
A new gene therapy protocol has successfully treated a child born without an immune system, reversing severe combined immunodeficiency. The procedure improved genetically altered stem cells, giving them a biological advantage and allowing them to prevail over the abnormal cells.
Scientists have identified a crucial protein called DE-cadherin-mediated cell adhesion, or 'cell glue', which enables stem cells to locate their niche and receive essential instructions for survival. The discovery sheds light on the importance of microenvironment in determining stem cell fate.
Researchers at Ohio State University have discovered a gene that controls the growth of stomatal cells in plants, which could lead to enhanced crop plant development. The TMM gene is involved in the formation and distribution of stomatal cells on leaf surfaces, and its discovery may provide new insights into stem cell biology.
Dr. Stephen B. Trippel's research involves articular cartilage repair through the use of a naturally occurring growth factor, with laboratory results encouraging for repairing musculo-skeletal tissue. The technique combines gene therapy and tissue engineering to stimulate cartilage-cell growth.
A groundbreaking study by Stanford University Medical Center has discovered a way to transplant kidneys without lifelong use of immune-suppressing drugs, improving patient quality of life. The innovative approach uses radiation and stem cells to create a hybrid immune system that recognizes the donor organ as 'friend' rather than foe.
A team of researchers at UC Davis has developed a method to freeze-dry platelets, which can be stored for at least a year without refrigeration. The innovation uses trehalose, a natural protectant found in certain animals and plants, to preserve the structure of proteins and other large molecules.
Researchers at Harvard Medical School have identified nearly all the genes responsible for vision in mice, which could lead to new methods for preserving and restoring vision. The discovery provides a genetic data base that can help identify genes mutated in inherited diseases such as retinitis pigmentosa and cone-rod dystrophy.
Researchers at University of Pennsylvania successfully inserted a foreign gene into male mouse spermatogonial stem cells, achieving high efficiency and expression. The breakthrough enables the creation of transgenic individuals in various species, paving the way for studying human diseases.