Articles tagged with Stem Cells
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A new study suggests that fat-derived stem cells can safely improve heart function after a heart attack by reducing damaged tissue, increasing blood flow, and boosting the heart's pumping ability. The treatment was found to be effective in patients with severe heart attacks, but further research is needed to confirm its efficacy.
A mathematical model developed by researchers at Massachusetts General Hospital and Harvard University can predict the risk of anemia in individuals. The model reflects how red blood cells change in size and hemoglobin content during their four-month lifespan, allowing for early detection of iron-deficiency anemia.
A University of Colorado at Boulder-led study found that specific stem cells can prevent the loss of muscle function and mass with aging. The transplanted stem cells doubled in mass and sustained themselves for two years, suggesting a potential treatment for humans with chronic degenerative muscle diseases.
A phase I clinical trial at University of Texas M. D. Anderson Cancer Center found an antibody loaded with an anti-cancer agent produced complete or partial remissions in 38 percent of patients with relapsed or therapy-resistant Hodgkin lymphoma.
Researchers found daily whole body vibration improves bone density around the hip joint and femur, reducing a biomarker of bone breakdown. The technique also stimulates stem cells to differentiate into bone cells, potentially aiding fracture healing. Vibration has shown promise in improving glucose uptake and reducing fatty liver disease.
A new method for molecular imaging in cells using CARS technique reduces power levels while increasing speed, enabling detailed molecular maps without damaging cells. This breakthrough opens the door for widespread use of vibrational spectroscopy in biology and clinical diagnosis.
Engineered 'firefly' stem cells can help repair damaged hearts without cutting into patients' chests. Researchers can now track the cells' progress using a special camera lens that picks up the glow under a microscope.
The annual Stem Cells Young Investigator Award is presented to a young scientist who published an important paper in the journal. The award recognizes innovative young investigators making significant contributions to stem cell biology and applications.
Researchers have developed an in vitro system to investigate hair-cell regeneration techniques, while studies also examine the presence of biofilms in chronic rhinosinusitis with nasal polyps. Disparities in healthcare access and utilization among children with ear infections were also found, highlighting the need for targeted interven...
Research at OHSU's Vaccine and Gene Therapy Institute suggests that G-CSF, a hormone stimulating stem cell growth, can reactivate human cytomegalovirus in bone marrow recipients, increasing their risk of infection. The study highlights the need for factoring in the risks associated with G-CSF use during transplants.
Researchers at IRCM discover a protein called Gfi1b that regulates blood stem cell activity and mobilization, potentially accelerating the production of new blood cells. This breakthrough could lead to more efficient and safer stem cell therapy for leukemia patients.
A study published in Cell Stem Cell reveals that NURF, an enzyme that regulates DNA packaging, allows specific genes to be turned on and off in stem cells. This dynamic structure enables stem cells to maintain their potency and prevent differentiation into other cell types.
The University of South Florida researchers warn that the growing number of stem cell journals may compromise the quality of research in the field. They recommend authors to follow Good Publications Practices when choosing a publication outlet.
Scientists have identified a population of cells enriched with the capacity to regenerate blood vessels, which show promise in treating cardiovascular disease. These cells, isolated from human blood or bone marrow, can support the growth of nearby blood vessels and enhance blood flow.
Researchers at Duke University have developed a method for injecting substances into single cells using sharp fluid jets, which may revolutionize stem cell research and cellular-level studies. The technique allows for the introduction of live cells to nontoxic substances without significantly damaging them.
The researchers created a library of micromolded, hexagonally spaced elastomeric micropost arrays to study the effects of substrate flexibility on stem cell development and adhesion. The system allowed them to modulate the rigidity and flexibility of the substrate surface without changing its adhesive properties.
Researchers at UT Southwestern Medical Center discovered a tiny RNA fragment, miR-451, that regulates red blood cell production. By inhibiting this process, they hope to develop new treatments for cancers and anemia.
A pioneering study has shown that joints can be regrown using a host's own stem cells, potentially leading to longer-lasting artificial joint replacements. The work provides a proof-of-concept for naturally grown joints and may lead to clinical applications in the future.
Researchers implanted genetically engineered stem cells with cytokines HGF, SDF-1, and VEGF to reduce organ damage and improve cardiac function after a heart attack. The results showed that two therapies - SDF-1 and Akt1 overproduction - limited cardiac damage.
Italian scientists have successfully completed preclinical trials for a gene transfer treatment that can correct the lack of beta-globin in patients' blood cells, a major step towards treating beta-thalassemia. The treatment uses genetically corrected stem cells to restore haemoglobin production and overcome the disorder.
A new generation of biological scaffolds enables the development of off-the-shelf tissue transplants that can be repaired and renewed like normal tissue. The technique removes cells from natural tissues to leave a biocompatible scaffold made of collagen, allowing patients' own cells to populate and bind to it.
A multicentric clinical phase II study led by Professor Dr. Peter Dreger found that allogeneic stem cell transplantation significantly improved tolerance and cured nearly half of patients with therapy-resistant chronic leukemia, regardless of genetic risk profile or prior treatment outcomes.
A new DNA delivery method has been discovered by Virginia Tech chemical engineers, which enhances the delivery of genetic material into cells. The method uses hydrodynamic effects to uniformly deliver DNA over the entire cell surface, resulting in a greatly enhanced transfer of genetic material.
A study found that more than 40% of patients with treatment-resistant CLL enjoyed long-term freedom from relapse after receiving allogeneic stem cell transplants. The transplants were associated with significant risks but offered a potential cure for this patient population.
Researchers discovered a key regulator of spermatogonial stem cell self-renewal by manipulating the STAT3 protein. This process may be linked to degenerative diseases in humans, highlighting the importance of understanding stem-cell activity in disease prevention and treatment.
A recent study published in Nature found that auxin and cytokinin, two previously thought-to-be antagonistic plant growth hormones, actually cooperate to regulate plant growth. The international team of researchers discovered that auxin boosts the effect of cytokinin by suppressing genes that limit its activity.
Researchers have successfully extracted stem cells from sections of vein removed for heart bypass surgery, which can stimulate new blood vessels to grow and potentially help repair damaged heart muscle after a heart attack. The discovery brings the possibility of 'cell therapy' for damaged hearts one step closer.
A new clinical trial, IMPACT-CABG, evaluates the safety and efficacy of injecting stem cells into the hearts of patients undergoing coronary bypass surgery. The study aims to promote healing and regeneration of damaged heart muscle, offering a less invasive alternative to heart transplant.
Researchers at Cedars-Sinai Heart Institute have developed a method to guide cardiac stem cells using micro-size iron particles and a magnet, increasing retention in the injured area and enhancing heart function. This innovative technique shows great promise for improving the effectiveness of stem cell therapies for heart disease.
A novel stem cell therapy has been developed to arm the immune system against HIV, potentially improving quality of life and life expectancy for those who have failed antiviral drugs. The therapy involves delivering antiviral DNA to patient immune cells, which can block viral gene production using RNA interference.
Researchers have discovered that infantile hemangiomas originate from stem cells. Steroids target these stem cells specifically, inhibiting their ability to stimulate blood vessel growth. This finding opens the way for more specific and safer therapies for hemangioma.
Researchers at Northwestern University characterized a special type of stem cell, endothelial progenitor cells (EPCs), to see if they can behave as endothelial cells in the body when cultured on a bioengineered surface. The study shows promise for improving surgery success rates for peripheral arterial disease.
Researchers identify a new reservoir for hidden HIV-infected cells in bone marrow, which can serve as a factory for new infections. The discovery opens up new possibilities for treating HIV, particularly for individuals who have been taking anti-viral drugs for their entire life.
Researchers at Rensselaer Polytechnic Institute have developed a new method to predict the fate of stem cells using advanced computer vision technology. With up to 99 percent accuracy, this method can forecast how cells will divide and what characteristics their daughter cells will exhibit.
Scientists at Rhode Island Hospital have discovered a novel mechanism of cell-to-cell communication using microvesicles, which can reprogram stem cells to behave like healthy cells. This finding offers hope for tissue regeneration and potential treatments for diseases such as cancer.
Researchers at UCLA successfully removed CCR5 receptor, which HIV binds to, from human immune cells using a gene-based approach. This strategy shows promise for treating HIV-infected individuals by reducing the virus's ability to infect cells.
Researchers evaluated cord blood-derived CD133+ cells for treating myocardial infarction. The cells showed promising results, improving left ventricular ejection fraction and forming tubule-like structures. Further pre-clinical testing is needed to determine their clinical advantages.
Scientists have discovered a mechanism by which yeast cells transport damaged proteins to mother cells using conveyor-like structures called actin cables. This process ensures that newly formed daughter cells are born without age-related damage, paving the way for potential treatments of age-related diseases.
Researchers at the University of Melbourne discovered a type of cell that causes T cell Acute Lymphoblastic Leukaemia in children. Targeting these cells could reduce treatment length and toxicity, leading to better patient outcomes.
Researchers found that MyoD activates CDC6 expression to promote rapid proliferation of muscle stem cells. The study suggests a new mechanism for muscle regeneration and highlights the importance of transcription factors in controlling cell cycle progression.
The University of Maryland School of Medicine will coordinate a consortium of national experts in stem cell research, with a focus on regenerative therapy and new clinical therapies. The seven-year grant aims to advance the field at a faster pace and realize potential for new treatments sooner.
Researchers investigated over 300 proteins in axolotl limbs, discovering key proteins involved in cell reprogramming and avoiding cell death. These findings may contribute to a better understanding of limb regeneration and potentially lead to new treatments for human amputations.
Researchers at Johns Hopkins have developed therapies using gene therapy and stem cells to increase blood flow, improve movement, and decrease tissue death. The findings hold promise for developing clinical therapies to save limbs from amputation.
Scientists at Weizmann Institute of Science have developed a new method for transplanting bone marrow-based stem cells from mismatched donors, restoring the immune system faster and improving cure rates for leukemia patients. The procedure involves infusing regulatory T cells into cancer patients before receiving donor stem cells, lead...
Researchers from UCLA demonstrate that human blood stem cells can be engineered into cells that target and kill HIV-infected cells. This approach, similar to a genetic vaccine, could be effective against other chronic viral diseases. The study provides proof-of-principle for using this strategy in the human body.
Scientists at the University of Bonn have discovered a way to turn on the 'natural heating system' in brown fat cells, which can lead to increased energy expenditure and reduced body weight. By activating this mechanism, it may be possible to fight obesity with fat.
A synthetic bone matrix offers hope for babies born with craniosynostosis by replacing fused bones and encouraging natural bone healing. The biodegradable implant could eliminate the need for multiple surgeries, resulting in improved developmental outcomes.
Research by Nick Fulcher and Robert Sablowski found that plant stem cells are sensitive to DNA damage and can detect defects, triggering cell death to prevent them from being passed on. This mechanism helps protect plants against genetic damage caused by environmental stresses such as drought, high salinity, and hazardous chemicals.
Researchers from the University of Granada and University of León found that human mononuclear cells isolated from umbilical cord blood exerted a deleterious effect on rats with liver cirrhosis, inducing hepatorenal syndrome instead of improving health. The study highlights the need for further research in hepatic regenerative medicine.
Researchers at Harvard's Wyss Institute have developed a method to grow cells in three dimensions using paper stacks, mimicking real tissues. This technique allows for uniform oxygen and nutrient delivery, making it easier to study cancer and other diseases.
Research supports potential for new anti-cancer agent as loss of p53 and ATR severely disrupts tissue maintenance in mice, leading to rapid deterioration and fatal outcomes. Cells without ATR persisting in tissues cause blockage of regeneration, while absence of p53 worsens tissue degeneration.
Researchers at Virginia Tech's Marion duPont Scott Equine Medical Center are studying the best ways to treat lameness in horses through tendon and ligament repair. Dr. Jennifer Barrett is investigating regenerative medicine techniques, including stem cell therapy, to regenerate damaged tendons and cartilage.
Research found that elevated levels of reactive oxygen in fruit fly blood stem cells signal differentiation into immune-bolstering cells. This raises concerns about the potential impact of excessive antioxidant use on human immunity.
A new study reveals that telomeres, which regulate cell division, replicate at various times during DNA replication, leading to uncontrolled cell growth. The research also found that telomerase enables unlimited growth in cancer cells by rebuilding most or all of the telomeres.
Researchers have developed acoustic tweezers that can position single cells or nanosized beads using sound waves, allowing for efficient manipulation without damaging live cells. The technology has significant advantages over existing methods in terms of versatility, miniaturization, and power consumption.
Researchers engineered a chimeric protein that increases cell survival, migration and proliferation to improve liver stem cell engraftment. The protein, TAT-Tpr-Met, was shown to increase the number of hepatic stem cells integrated into the liver of mice.
A new technique uses microscopic magnetic particles to target stem cells to sites of cardiovascular injury, resulting in a five-fold increase in cell localization and six-fold increase in cell capture. The method is directly applicable to clinical practice and could lead to the treatment of heart attacks and other vascular injuries usi...
Researchers at UCF have developed a method to optically steer cells using low-intensity polarized light, guiding them towards desired locations. This technology has the potential to improve stem cell therapies for wound healing and cancer treatment.
Researchers created airway spheres using animal and human cells, providing a new model to study dynamic processes in lung diseases. The 3-D spheres lined with ciliary and secretory cells can be used to investigate mechanisms underlying cancer and chronic asthma.
Researchers have found that placenta-derived stem cells can reduce lung fibrosis and inflammation in mice with bleomycin-induced injury. The study's findings suggest these cells may be useful for cell therapy of fibrotic diseases in the future.