Articles tagged with Stem Cells
Researchers found that intestinal stem-cell regeneration in fruit flies varies with the time of day, with gut healing being more effective at certain times. This study sheds light on how circadian rhythms control daily functions and has potential applications for human health, including optimizing chemotherapy timing.
Researchers grew and analysed stem cells from patients with von Willebrand disease to identify the cause of the disease in individual patients, enabling more effective treatments. The technique may also be used to treat diseases of the heart, blood and circulation, including haemophilia.
Researchers envision cell-based therapeutics as a promising approach to treat critical diseases. Cells can adapt and respond better than small-molecule drugs, offering a more predictable treatment option.
A study led by University of Washington researchers shows that genetic engineering can increase dATP levels in heart cells, leading to improved heart muscle function and greater force of contraction. The findings suggest a potential therapeutic treatment for heart failure conditions.
A new technique allows researchers to create complex tissues with any spatial organization, mimicking the body's natural complexity. The 'lock-and-key' method uses tiny shapes that lock into templates, allowing for rapid assembly of large tissues and precise control over cell alignment.
Researchers at RIKEN Center for Developmental Biology successfully cloned mice multiple times using somatic cell nuclear transfer (SCNT) technique, overcoming previous limitations. The study published in Cell Stem Cell reveals no accumulation of genetic or epigenetic abnormalities after repeated cloning.
Researchers used a 'homing' signal to activate stem cells in heart failure patients, improving symptoms and heart function. The study found that 50% of patients showed positive effects one year after treatment, indicating potential for this therapy to widely treat heart failure patients.
Researchers at Case Western Reserve University discovered a missing RNA element that significantly improves the effectiveness of gene therapy. The element, called Genomic RNA Packaging Enhancer element (GRPE), coordinates the production and filling of genetic material in viral vectors.
A new study from Rensselaer Polytechnic Institute and UC Berkeley uses blue light to activate specific proteins into large clusters, controlling cell signaling. This technique has potential applications in understanding cellular function and optimizing energy production.
Researchers at MIT have designed new synthetic biology circuits that combine memory and logic, enabling the creation of long-term environmental sensors and efficient controls for biomanufacturing. These circuits can be used to program stem cells to differentiate into other cell types and provide precise long-term memory.
Research reveals diabetes disrupts bone marrow's ability to produce and repair stem cells, exacerbating cardiovascular disease. MicroRNAs play a crucial role in this process, and targeting them may offer new treatments for diabetic patients.
Scientists at Forsyth Institute have made a groundbreaking discovery about latent tuberculosis, finding that the bacteria can lay dormant in bone marrow stem cells. This understanding has significant clinical implications, explaining why patients with TB remain sensitive to tests and treatment is so challenging.
Researchers at Washington University School of Medicine reprogrammed eye cells to prevent degeneration and allowed mice with retinitis pigmentosa to see. The study aims to develop therapies that can alleviate many forms of visual impairment by modifying existing cells in the eye.
Researchers in Calgary have launched the world's first gene therapy clinical trial for Fabry disease, a rare inherited enzyme deficiency. The trial aims to transplant stem cells with a working copy of the GLA gene into patients, potentially curing the condition.
Scientists at UC Santa Cruz used a novel technique to study the structural and mechanical properties of telomeres, which could guide the development of new anti-cancer drugs. The research found that a small structural displacement causes the G-quadruplex structure to unfold, revealing its mechanical stability.
Stem-cell therapy has been shown to prevent the decline in heart function associated with Duchenne muscular dystrophy. The treatment involves transplanting stem cells derived from normal mouse blood vessels into the hearts of mice with DMD, where it prevents dilated cardiomyopathy and promotes angiogenesis.
A Phase 2 clinical trial of ibrutinib in relapsed or refractory mantle cell lymphoma reported a 68% overall response rate and 22% complete remission rate, with few side effects. The drug's efficacy was consistent across different patient populations, making it a promising treatment option for patients with this aggressive disease.
Researchers at the University of Sheffield recreated randomly distributed sticky spots in stem cells to maximize adhesion and act as internal scaffolding. The findings will help inform biomaterials development for optimal stem cell growth.
Researchers at the University of Sheffield have developed a new method for delivering stem cell therapy to treat corneal blindness. The technique uses biodegradable discs loaded with stem cells that can multiply and repair damaged eyes naturally. This approach has the potential to be more accessible and safer than current treatments.
Researchers at Rice University have developed a way to selectively kill some diseased cells while treating others in the same sample using tunable plasmonic nanobubbles. The process activates with a pulse of laser light and leaves neighboring healthy cells untouched.
A research team has uncovered the molecular structure of MITF, a master regulator central to melanoma and other diseases. The X-ray analysis revealed unexpected insertions that limit MITF's ability to bind to DNA, providing a rational basis for the development of tailor-made drugs targeting this protein.
A study by researchers at the Perelman School of Medicine reveals how T-cell exhaustion occurs in chronic viral infections, with implications for novel therapies. The team found that two distinct classes of virus-specific CD8+ T cells work together to keep the infection in check, but their long-term pressure depletes progenitor pools.
Scientists at the University of Toronto have discovered a method to transform aged stem cells into functioning-like younger ones, paving the way for growing cardiac patches from patient's own cells. This breakthrough could potentially avoid rejection and treat damaged or diseased hearts.
A study published in Genome Biology reveals a link between transposable elements and the expression of stem cell-specific long noncoding RNAs. ERV transposition may have given rise to these lincRNAs, which have important regulatory roles.
A genetically-engineered vaccine aims to prevent HIV infection by continually producing disease-fighting cells. The new approach could provide long-term protection and potentially be adapted for use against other infections.
Researchers are using bioprinting to grow cells in 3D scaffolds that can be used to regenerate tissue, with the potential to treat diseases such as cavity wounds. However, limitations include cell survival rates and guaranteeing consistent quality.
A NIST team developed a model to predict cell behavior and change, using a data-driven landscape approach. The method provides reliable numbers for the complex evolution of cell populations, crucial for biomanufacturing and stem cell therapies.
Planarians can regrow missing organs, including the intestine, after injury. Researchers identified genes that control intestinal growth and regeneration using RNA interference. The study provides insights into stem cell division, cellular events, and molecular signaling pathways involved in organ regeneration.
Researchers develop safe approach to produce stable vascular endothelial cells from human amniotic cells, opening door to treating diverse vascular disorders. The new cell-based strategy has promise in mice and may benefit millions of patients worldwide.
Researchers at Wake Forest Baptist Medical Center identify a unique rat model of bladder regeneration, which may help understand regenerative processes in mammals. The study found that cells in the bladder lining proliferate and transition into stem cells to repair damaged bladders.
Researchers found that a developmental protein called fibroblast growth factor-2 drives aging muscle stem cells out of dormancy, reducing their ability to regenerate. Blocking FGF signaling improved muscle tissue repair in aged animals.
A research team at New York University has determined how cells that cause inflammatory ailments differentiate from stem cells. The study found hundreds of new genes involved in the function and development of these cells, which can be used to design new therapies for diseases such as Crohn's disease, multiple sclerosis, and arthritis.
Researchers have elucidated how muscle stem cells colonize niches for efficient growth and repair. They found that these stem cells weaken when located outside their muscle fiber niches, leading to weakened muscles. The Notch signaling pathway plays a crucial role in preventing differentiation of stem cells into muscle cells.
Researchers designed molecular beacons that bind to mRNA of three genes expressed only when stem cells transform into bone cells, allowing for real-time monitoring of gene expression. The technology provides a tool for discovering optimal conditions for stem cell differentiation and identifying desired tissue cells.
Researchers at Cedars-Sinai Heart Institute will study the cellular mechanisms behind an experimental stem cell therapy that regenerates healthy muscle in damaged hearts. The treatment has shown promising results, with a 50% reduction in scar size and improved cardiac regeneration.
A CNIO team has created a transgenic mouse model that simulates aplastic anaemia in humans. The model shows the link between telomere impairment and bone marrow failure.
Researchers have found that plants exhibit a wide range of mechanical properties, from stiffness and strength. Fruits and vegetables are the least stiff, while densest palms can be 100,000 times stiffer. Plants' microstructures, such as cell wall composition and arrangement, contribute to this diversity.
Researchers found that cells grown on different types of scaffolds vary in their ability to repair damaged blood vessels and suppress inflammation. Cells grown on porous surfaces tend to be more effective at repairing damage.
A new study found that inhibiting myostatin promotes muscle growth without incorporating satellite cells into myofibers, raising hopes for treating muscular diseases. The research team identified a specific type of cell targeted by myostatin, paving the way for potential drug development.
Human HLA genes are evolving rapidly, improving disease-fighting abilities but complicating organ transplant matching. The vast number of variants makes it unlikely to identify a perfect match through worldwide searches.
Researchers have developed a new stem cell therapy that uses patient's own cells to regenerate craniofacial tissues, resulting in greater bone density and quicker bone repair. The treatment is best suited for large defects such as those resulting from trauma, diseases or birth defects.
The International Society for Advancement of Cytometry presented its 2012 awards to Dr. Leon Terstappen and Dr. Robert Leif, recognizing their innovative work in cytometry technology. The awards also honored Drs. Jan Visser and Peter Lansdorp for their significant contributions to the field and society.
Modified human stem cells helped enhance the activity of an enzyme called telomerase, which elongates telomere length. This technique increased telomere length and activity, as well as increasing cardiac stem cell proliferation, vital steps in combating heart failure.
Researchers at Dana-Farber Cancer Institute have identified a new type of energy-burning fat cell, called 'beige fat,' which may have therapeutic potential for treating obesity and diabetes. Beige fat cells can burn off calories rather than store them, unlike 'white fat' cells.
The foundation awarded three-year fellowships to postdoctoral scientists conducting basic and translational cancer research, providing them with independent funding to pursue novel projects. Recipients aim to understand molecular mechanisms of gene silencing, cellular cargo transport, and immune system interactions.
Researchers have identified Lyl-1 as a crucial transcription factor in producing early T-cell progenitors, which are the first cells on the path to becoming active T-cells. Without Lyl-1, these cells are severely impaired, and mice lacking the gene exhibit T-cell deficiency and leukemia-like symptoms.
Researchers at UBC successfully reversed diabetes in mice using stem cells, restoring insulin production and reversing the disease. The study re-created the 'feedback loop' that enables insulin levels to automatically rise or fall based on blood glucose levels.
Researchers used magnets to guide iron oxide nanoparticles-laden cells to damaged heart sites, improving homing and retention. Visualizations revealed a good correlation between MRI tracking and cell fate assessment.
Researchers at Kyoto University's iCeMS have developed a process to create custom-designed porous coordination polymer architectures for high-efficiency, low-cost gas and liquid separation. The new method, called 'reverse fossilization,' transforms inorganic materials into organic structures with preserved shape and form.
Scientists at the University of Liverpool have developed methods to track stem cells in the body, improving understanding of their behavior after transplantation. They use superparamagnetic iron oxide nanoparticles and advanced imaging systems to monitor stem cell movement and behavior.
A Johns Hopkins University team found a protein molecule, p190RhoGAP, that regulates cardiac stem cells to form healthy heart tissue or blood vessels. By altering its levels, the researchers were able to improve the effectiveness of stem cell therapy in treating heart attack patients.
A 10-year-old girl's successful transplantation of a tissue-engineered vein has dramatically improved her quality of life, avoiding complications associated with synthetic grafts and lifelong immunosuppressive drugs. The procedure restored normal blood flow and significantly enhanced her physical growth.
Researchers use green fluorescent protein to detect defective genes in children with glycosylation disorders, enabling the development of targeted therapies. The tool helps identify genes causing intellectual disability, digestive problems, seizures, and low blood sugar in children.
A phase III trial showed that haematopoietic stem cell transplantation (HSCT) significantly increases long-term survival compared to conventional treatment for patients with poor prognosis early diffuse cutaneous systemic sclerosis. The study found more deaths in the conventional group, with half of them being treatment-related.
Scientists at University College London have discovered a potential new method to regenerate damaged skeletal muscle tissue using stem cells derived from amniotic fluid. The treatment resulted in improved survival rates and muscle activity in mice with spinal muscular atrophy, a genetic disease affecting one in six thousand births.
Researchers at Northwestern University have identified the molecular trigger of uterine fibroids, a single stem cell mutation that activates other cells to grow uncontrollably. The study suggests a new direction for developing therapies to treat these tumors, which affect an estimated 15 million women in the US.
Researchers have discovered that the NKCC1 protein may hold key to understanding how glioblastoma, the deadliest type of brain cancer, moves and invades healthy brain tissue. Blocking NKCC1 with a cheap FDA-approved drug slows movement of glioblastoma cells, suggesting a potential new approach to treat this aggressive cancer.
Researchers have created a new instrument that rapidly analyzes the physical properties of cells to identify cancer and other cell states. The deformability cytometer measures cells' responses to fluid flow, providing valuable information about cell health.
A Duke University Medical Center team has developed a method to convert scar tissue in the heart into functioning heart muscle cells using microRNAs. This approach eliminates the need for stem cell transplantation, potentially treating millions of people with heart failure caused by scar tissue after a heart attack.
A new study finds that bile plays a critical role in the development of Barrett's esophagus, a precursor to rare and deadly esophageal cancer. Bile shuts off genes responsible for normal esophageal lining and turns on genes producing intestine-like tissue.