Articles tagged with Tissue Samples
Researchers find SARS-CoV-2 infects sustentacular cells in the olfactory epithelium of COVID-19 patients, replicating vigorously within these cells. The virus does not appear to infect nerve cells, instead affecting sensory neurons indirectly through insufficient support from sustentacular cells.
Scientists have discovered that Tasmanian devils' whiskers can capture seasonal dietary changes over at least nine months and potentially up to a year. The long, wiry whiskers hold chemical imprints from food the devils ate in the past, offering a way to monitor the endangered native species with minimal disruptions to their habitats.
Researchers at Göttingen University have developed a new X-ray imaging method to detect changes in neuronal cell nuclei, indicating altered activity of neurons. This technique enabled the identification of changes in neurons in Alzheimer's disease.
A new confocal platform using artificial intelligence and multiple lenses improves volumetric resolution by over 10-fold while reducing phototoxicity. The platform uses Deep Learning algorithms to distinguish between high-quality images with low signal-to-noise ratio and better images.
Researchers at Cornell University have launched scMuscle, a large single-cell database that provides a comprehensive picture of the dynamics of muscle repair. The database houses transcriptomic data from approximately 365,000 cells involved in muscle injury across various ages and experimental conditions.
A study by West Virginia University researcher Sunil Sharma found that rural COVID patients who end up in an intensive care unit are more likely to die within 30 days compared to their urban counterparts. The researchers also discovered that rural patients with COVID-linked ARDS have a higher mortality rate, even when controlling for d...
Researchers at the University of Waterloo have created a deep neural network that detects disease biomarkers with high accuracy, achieving 98 per cent detection of peptide features. This breakthrough could enable earlier and more accurate disease detection through tissue sample analysis.
Researchers from University of Copenhagen discover a protein analysis that can predict COVID-19 patient death or hospitalization with high accuracy, predicting 78.7% of hospitalizations and 93.9% of non-serious infections. This discovery has the potential to save lives by identifying high-risk individuals.
Researchers developed a non-toxic, small-molecule probe that provides real-time visualization of disease progression, overcoming limitations of MRI and PET imaging. The probe binds copper ions and detects dysregulated levels, accurately identifying Wilson's disease and other maladies.
A new study at Ohio State University's Comprehensive Cancer Center is using rapid autopsies to gather biological samples after death to better understand how cancer cells overcome different treatments. This approach has already led to novel findings about drug resistance mechanisms, including the recent approval of a targeted therapy f...
Researchers at UCLA have developed a computational technique powered by artificial intelligence that transforms images of tissue previously stained with H&E into new ones with added special stains. The process takes less than one minute per tissue sample, significantly improving diagnoses in medical conditions such as organ transpl...
Researchers used a hamster model to study COVID-19 lung damage, discovering that the immune system's response plays a crucial role in disease progression. They found that certain cells involved in lung immunity ingest the virus, triggering an inflammatory response that can be brought under control by T cells.
Researchers developed a non-invasive optical technique using spectroscopy to identify structural changes in the brain and diagnose Alzheimer's disease. The new technology has potential as a simple, completely non-invasive method of early detection and could also assess treatment effectiveness.
A new diagnostic kit developed by University of Queensland vets can detect the Hendra virus in horses faster than ever before, with results available in under an hour. This rapid testing protocol has the potential to save countless lives by preventing outbreaks and reducing case fatality rates.
Researchers developed a simplified method to calibrate optical tweezers for measuring viscoelasticity in living cells. The new method reduces measurement time to just a few seconds, allowing for the study of dynamic processes that can't be captured with longer measurements.
A team of MIT and Harvard University researchers has developed a modified version of two-photon imaging that can image deeper within tissue and perform the imaging much more quickly than what was previously possible. This technique allows for high-resolution images of structures such as blood vessels and individual neurons within the b...
Researchers at the University of São Paulo discovered that SARS-CoV-2 infects and replicates in salivary glands, leading to high viral loads in saliva. The study suggests that tissues specializing in saliva production serve as reservoirs for the virus.
The MasSpec Pen technology has been shown to accurately identify healthy and cancerous tissue in pancreatic cancer surgeries, giving patients the greatest chance of survival. The device is over 100 times faster than current gold standard diagnostic methods.
A study by University of California San Diego researchers found that lobsters can absorb vaporized THC through their gills and exhibit reduced locomotor activity. However, the effects on detection of hot water stimuli were minimal, leaving it unclear whether this constitutes feeling pain.
A genomic study of 51 high-quality samples reveals the Chinese mountain cat is a wildcat subspecies (Felis silvestris bieti) and was not directly involved in feline domestication in China. This finding supports the theory that housecats originated solely from African wildcat domestication, but raises conservation concerns for the species.
A new study reveals that a changing parasite is behind the intensification of oyster disease in the Chesapeake Bay region. The emergence of a more virulent form of Perkinsus marinus, caused by evolutionary pressures from a non-native parasite MSX, led to a sharp increase in disease prevalence and deadliness.
Researchers at Karolinska Institutet discovered industrial chemicals in the organs of fetuses conceived decades after many countries banned the substances. The study found that 15 out of 22 persistent organic pollutants were present in every organ, with four chemicals detected in all tissues in all fetuses.
A novel calibration procedure developed by scientists enables precise super-resolution brain imaging at greater depth. The method corrects spherical aberration of the depletion beam, allowing for high-quality images of biological tissue.
A new study reveals that high genetic running capacity promotes more efficient amino acid metabolism in skeletal muscle, potentially contributing to healthier metabolism with aging. Adipose tissue may also play a key role in promoting healthy aging, contradicting previous assumptions.
Researchers developed Seq-Scope technology to visualize all gene expression from a tissue sample, offering ultra-high-resolution imaging. The method, using high-throughput sequencing and barcode-based spatial coordinates, enables diagnosis of diseases at the microscopic scale.
Researchers at UC San Diego developed a high-throughput 3D bioprinting technology that can produce 96-well arrays of living human tissue samples in just 30 minutes, accelerating preclinical drug screening and disease modeling. This could potentially reduce the time and cost associated with drug development.
Researchers found that Bdelloid rotifers can persist for at least 24,000 years in the Siberian permafrost and survive. The study suggests that these tiny animals have a mechanism to shield their cells and organs from harm at extremely low temperatures.
A University of Kentucky team will study the culprit behind thoracic aortic aneurysms with a $5.6 million grant from the NIH. The goal is to find new medical options to prevent surgical intervention.
A new study suggests that night shift work is associated with menstrual irregularity and an increased risk of developing endometriosis. Researchers found altered expressions of core clock genes in ectopic and eutopic endometrial tissues, indicating a disturbance of biological timing.
A century ago, human populations consumed a more diverse diet than today. The rise of industrial agriculture and globalization led to a significant narrowing of dietary breadth for modern human populations.
A new optical diffraction tomography technique allows for high-resolution imaging of thick tissue sections without chemical staining, increasing diagnostic speed and accuracy. The method has been demonstrated to visualize individual cells and multicellular tissue architectures with subcellular resolution.
A team of scientists created a cell atlas using autopsy samples from COVID-19 patients, revealing how infected cells and lungs responded to the virus. The study found repeated attempts by the lungs to repair themselves failed due to viral-induced changes in cellular programs.
Researchers have created two unique collections of over 20,000 biological samples from laboratory rats to study the biological bases and consequences of cocaine and oxycodone addiction. The biobanks provide deeper insight into the paths and pathologies of these addictions.
Researchers have developed ultrasonically oscillating needles that provide sufficient tissue samples for 21st century diagnostic needs, potentially reducing pain and trauma. The technology increases biopsy yields by 3 to 6 times compared to traditional needles, enabling high-tech cancer treatment options.
Researchers have developed a novel method to detect and manipulate the terahertz optoacoustic signal of water, enabling sensitive detection of solutes like ions with an order of magnitude greater sensitivity than traditional spectroscopy. This breakthrough allows for nondestructive analysis of aqueous solutions and tissues, opening up ...
Researchers analyzed tissue samples from 385 brains with Alzheimer's disease, identifying the SERPINA5 gene as strongly associated with tau protein tangle progression. The study aimed to clarify the relevance of gene expression changes in Alzheimer's disease and provide new targets for treatment.
Researchers develop innovative spin-to-charge conversion method to achieve high-fidelity readout of qubits, surpassing traditional resonance fluorescence method with an error rate of 4.6%. This breakthrough enables the realization of fault-tolerant quantum computing and improves detection efficiency for quantum sensors.
Researchers found that high-fiber compounds reduced the expression of a gene and cytokine receptor involved in viral cell entry and inflammation. The findings suggest that high-fiber diets may help control inflammation caused by COVID-19, which can lead to gastrointestinal symptoms and changes in gut microbiota.
Researchers used advanced technology to create a detailed map of diseased lung tissue in severe COVID-19 patients. The study revealed that cells called alveolar epithelial cells are the main targets of infection by SARS-CoV-2, and provided new insights into the causes of damage.
Researchers have developed a new method to prevent ice crystal formation during cryopreservation, enabling cells and organs to survive and even proliferate after thawing. The technique uses nanocomposites to regulate ice nucleation and reduce damage caused by crystallization.
Researchers detected pesticides in 38% of mussel and clam samples, with some containing herbicides, fungicides, and insecticides. The study's findings have implications for developing more sustainable forestry practices to reduce harm to aquatic life.
Researchers at Purdue University developed a method to detect pathogens in cells using Doppler technology, allowing for quick diagnoses and effective treatments. This innovation enables scientists to identify harmless microbes and determine the correct antibiotic to use against antibiotic-resistant bacteria.
Researchers at OHSU have developed a new method to quickly map single-cell genomes and clarify spatial cell positions within complex tissues. This technique has the potential to precisely identify and target cells in diseases like cancer or stroke, allowing for novel therapies.
A new study by USask researchers found that a shorter form of a brain protein, Aβ38, halts damage-causing mechanisms of its longer counterpart, Aβ42. This discovery could help identify people at highest risk for developing Alzheimer's and slow or prevent its onset.
A study found that surgery to repair an inflamed gut may trigger a second immune system attack, which could lead to pouchitis. Researchers analyzed tissue samples and gene activity in patients who developed pouchitis after J-pouch surgery.
Scientists studied gene expression patterns in Drosophila to understand the circadian rhythm, finding that individual flies have unique rhythms and genetic variations can affect behavior. The study also reveals genes that regulate circadian rhythms in humans, potentially impacting metabolic patterns and disease
Researchers developed a new AO module comprising two deformable phase plates, enabling direct integration with existing microscopes. The system successfully corrected sample-induced aberrations in synthetic samples, demonstrating improved image quality and doubling the aberration correction range.
A team of researchers has developed a method to synchronize X-ray and laser pulses, enabling precise measurements of Auger decay in neon gas. This breakthrough could help evade radiation damage in experiments studying exotic states of matter.
Researchers demonstrate that Raman spectroscopy can distinguish between healthy tissue, OSCC, and non-cancerous lesions with high accuracy. The technique could enable non-invasive cancer screening in the dentist's chair, reducing diagnostic delays and invasive procedures.
The new technique allows researchers to study whole neural circuits in high detail and at scale. They used it to create a comprehensive map of neuronal circuits that control motor function in fruit flies, discovering new sensory neurons.
Researchers found microvascular blood vessel damage and inflammation in brains of patients who died from COVID-19, suggesting a non-infectious response. The study suggests that the body's inflammatory response to SARS-CoV-2 may cause brain damage.
Researchers found that biodiversity hotspots like the Amazon rainforest are formed through gradual accumulation of species over time, while coldspots provide more opportunities for rapid diversification. This study reveals a paradox in diversity formation, challenging previous assumptions.
A study found COVID-19 in post-mortem corneal tissue, highlighting the importance of donor screening processes. The research team discovered that even healthy donors with negative nasopharyngeal swabs tested positive for COVID-19 RNA, posing a transmission risk to recipients.
The Pancreatic Cancer Research Fund Tissue Bank has been established to provide quality-controlled tissue and fluids for research on pancreatic diseases. The bank holds over 45,000 unique samples, including blood, urine, saliva, and tissue from patients with various types of pancreatic cancer and pancreatitis.
A new study finds that roly polies and other terrestrial bugs are transferring high levels of mercury to steelhead trout, a threatened species in coastal California. The research confirms earlier findings that mercury can accumulate in the top of the food chain in coastal ecosystems.
Researchers have developed an AI-based algorithm called OxyGAN to accurately measure tissue oxygenation from single snapshots. This approach uses a conditional generative adversarial network to learn realistic output images and determine correct reconstructions for given input data, demonstrating robustness in measuring oxygen levels.
A University of Michigan-led research team found that toxic mercury pollution from fish carcasses reaches the deepest ocean trenches, including the Mariana Trench. The study suggests that most of this mercury comes from human activities, posing a threat to seafood safety and human health.
Researchers from MIPT and Harvard have developed an algorithm to automate the process of growing retinal cells in vitro, reducing processing time from two hours to 34 minutes. The approach enables high-throughput tissue production for drug tests and cell transplantation experiments.
Scientists have developed an optical elastography technique that can detect biomechanical alterations in cells and tissues non-invasively. The new technique uses Brillouin microscopy to highlight microscopic processes driving mechanical modification in biological tissues.
Researchers at Washington State University have discovered mavacamten, a molecule that suppresses excessive force generated by hyper-contractile muscle cells in the human heart. The drug reduces maximal force of contraction by nearly 20-30% compared to controls, suggesting its potential as a treatment for hypertrophic cardiomyopathy.