Articles tagged with Tissue Samples
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Researchers developed an AI-based method for virtual staining of histopathological tissue samples, producing images that closely resemble actual chemical-stained samples. This reduces chemical burden and manual work while enabling the use of tissues for other purposes.
Researchers assembled the largest atlas of post-zygotic genome mutations in healthy human tissue, providing insight into genetic underpinnings of disease. The study found that most detectable mutations occurred later in life, but some arose systematically and predictably as people age.
This technology uses light and sound to create images of the inside of the body. The research team developed a novel method that eliminates the need for ultrasonic transducers, allowing for non-contact photoacoustic signal detection and improved sensitivity. The technique has great application potential in various biomedical research.
Scientists have developed a new microscopy method that allows for non-invasive observation of mechanical properties in developing embryos. The line-scanning Brillouin microscopy (LSBM) technique provides faster imaging, reduced light-induced damage, and simultaneous visualization of biomolecules.
A new forensic science study investigates the decay of infant and juvenile bones, providing insights into decomposition rates and bone degradation. The research helps forensic scientists estimate the time elapsed since remains were at a location and identify suitable bones for DNA sampling.
An international team of researchers has received $3 million to study how early gut development shapes children's health. They will collect tissue samples from diverse groups to understand the impact of environment, genetics, and other factors on gut development.
A new AR system using HoloLens enables doctors to perform transperineal prostate interventions with high accuracy and flexibility. The system provides a 3D immersive experience, allowing doctors to guide needles to their target with ease.
Researchers created adaptive optical phantoms by combining multiple pigments to mimic target tissue's optical properties, successfully validating them in extensive experiments. The new platform enables broader band spectra for emerging hybrid modalities and novel instruments.
Researchers developed high-throughput Raman microscope for rapid large-area imaging hundreds of times faster than traditional approach. The new technique enables label-free molecular analysis and multiplex chemical imaging, holding promise for efficient medical diagnoses and drug development.
The Chan Zuckerberg Initiative grant will support advanced imaging training for over 2,000 scientists through a combination of hands-on events and online resources. Array tomography, an imaging technique that offers higher resolution and detailed molecular labeling, will be a key focus of the project.
Scientists discovered high levels of toxic chemicals, including 4-nonylphenol from toilet paper, in the bodies of orcas in B.C., which may contribute to their population decline. Forever chemicals like 7:3-fluorotelomer carboxylic acid were also found, highlighting the need for pollution management and regulation.
Researchers from prominent institutions discuss hepatocellular carcinoma's pathogenesis, genomic heterogeneity, and targeted therapy options. The review aims to characterize HCC's complexities and develop clinically relevant biomarkers for better management.
Researchers have identified a rare gene mutation that causes severe childhood obesity, leading to a constant feeling of hunger and decreased sensation of satiety. The discovery provides a new understanding of the genetic mechanisms underlying monogenic human obesity.
Researchers developed a laser-based approach to perform microbiopsies, enabling fast, painless tissue sampling with minimal damage. The novel technique uses laser ablation to extract tiny tissue volumes, which can be analyzed using virtual H&E imaging and other techniques in minutes, not hours.
A study suggests that visceral fat cells, rather than subcutaneous fat cells, are more susceptible to infection by the COVID-19 virus. This increased susceptibility leads to a higher viral load and production of pro-inflammatory cytokines, which can exacerbate severe disease.
A new deep learning-based framework reduces autofocusing and image acquisition times for virtual staining of unlabeled tissue sections. The approach achieves high-quality staining with minimal loss of image sharpness and contrast.
Researchers at the University of Copenhagen have made a breakthrough in understanding schizophrenia by analyzing individual brain cells. The study identified specific neurons and networks affected by the disease, suggesting that targeting these areas could lead to new treatment options.
Researchers identified protein levels that were higher or lower than normal in tissues from individuals at different stages of type 2 diabetes. The study found a correlation between metabolic pathway disturbances and disease progression, suggesting new potential causal mechanisms for the disease.
Researchers found that previously deployed military personnel had more retained dust in their lungs compared to civilian controls, with smaller particle sizes. The study suggests that even low sandstorm exposure led to increased dust accumulation, highlighting the need for mitigation strategies.
A Brazilian study reveals that SARS-CoV-2 targets astrocytes in the brain, reducing neuron viability and causing damage. Infection was confirmed using MRI scans of mild COVID-19 patients and experiments on human nerve cells.
Researchers at UEA discovered that 'normal' prostate cells in men with prostate cancer have specific genetic changes that facilitate the growth and spread of cancer. The study suggests treating the whole prostate, not just affected areas, may be more effective.
Scientists have discovered a link between air pollution and lung cancer in people who have never smoked. Exposure to particulate matter (PM2.5) has been shown to promote cancerous changes in airway cells with EGFR and KRAS gene mutations, driving them towards a cancer stem cell-like state.
A novel method developed by Brazilian researchers can analyze bacterial samples without isolating live bacteria, making it easier to detect antibiotic resistance in Streptococcus pneumoniae. The technique was tested on 873 samples and found that 51% were sensitive to antibiotics, while 17% were resistant.
Researchers developed a novel way to visualize densely packed molecules using expansion microscopy, allowing for the first time their imaging. The technique enables visualization of nanostructures found in neurons and Alzheimer's-linked amyloid beta plaques.
Researchers have discovered that reduced TGFBR2 abundance is significantly associated with hepatocellular carcinoma (HCC) in patients with cirrhosis. An AI-based process accurately identified HCC tissue, confirming the biomarker's potential for early detection.
Researchers developed a label-free Raman spectroscopy approach with enhanced sensitivity and speed, allowing for non-invasive imaging of biological samples. The new CARS microscopy system can acquire microscopic images and identify biomolecules with unprecedented resolution and speed.
A newly identified species of Liberibacter, a family of bacteria known for causing citrus greening disease, is rapidly evolving its ability to infect insect hosts. The research team found 21 genes associated with infectious qualities and identified mutations affecting pilus proteins that allow the bacteria to move into host insects.
Researchers have mapped RNA diversity in human tissues at unprecedented depth, discovering tens of thousands of novel transcripts. The study used long read sequencing to catalog the genetic code's transcripts, shedding light on how genetic and environmental differences affect gene regulation.
Researchers at the University of Birmingham developed a new technique using mass spectrometry to analyze drug-protein interactions in real tissue samples. This allows scientists to predict the therapeutic effect of drugs earlier, enabling more effective treatment options.
Researchers found clots in small venous and arterial blood vessels in normal-looking skin from patients with severe COVID-19, distinguishable from other forms of respiratory illness. Antiviral proteins and interferon-induced inflammatory proteins were also detected, associated with disease severity.
A study by researchers at Uppsala University found that crocodiles can regenerate their hair cells due to the activation of support cells and efferent nerves. This discovery may lead to new treatments for people with impaired hearing, who affect over 1.2 billion worldwide.
Researchers at the Field Museum used innovative techniques to extract usable DNA from centuries-old specimens, including a two-foot-long greenish-brown snake from Borneo. The study successfully determined the snake's family affiliation, providing insights into biogeography and evolutionary history.
A novel single-cell RNA sequencing technique, TAS-Seq, has been developed to provide higher-precision data than current methods. The new method detects more genes and identifies highly variable genes, making it a sensitive high-throughput scRNA method.
A new study published in Microbiology Spectrum found that nasopharyngeal swabs were the most effective method for detecting COVID-19, with detection rates ranging from 92 to 100%. Saliva and anterior nares tests had lower detection rates, particularly in asymptomatic patients.
Researchers at TU Wien develop a method to guide individual cells with laser precision, enabling reproducible production of artificial tissue and testing new drugs without animal testing. The technique involves adding special molecules to hydrogel surrounding cells, which become softer and more permeable when activated by a laser beam.
A new study applies 'Deep Visual Proteomics' to cancer cells, revealing mechanisms driving tumor development and exposing therapeutic targets. The method integrates advances from four technologies to analyze protein landscapes, providing insights into cancer vulnerabilities.
Researchers created multi-tissue cell atlases to transform our knowledge of biology, infection, and disease. The studies revealed novel cell functions, immune cell types, and disease genes across the human body.
Scientists created a comprehensive map of cells across multiple human tissues, revealing new insights into the cellular and genetic underpinnings of complex diseases. The study's findings have the potential to improve our understanding of disease risk and develop more targeted therapies.
Researchers have created a massive single-cell atlas across human tissues, pinpointing specific cell types involved in multiple diseases. The study uses machine learning methods to query the resulting map, enabling comparisons across tissues and cells from frozen tissue.
Researchers at Mount Sinai have discovered a previously unknown mechanism by which not-yet-malignant breast cancer cells can travel to other organs and 'turn on' to become metastatic. The study identified potential diagnostic biomarkers, including the transcription factor NR2F1, that could help predict relapse.
Scientists have constructed a detailed map of lung development after birth, providing insights into the genetic and epigenetic factors that affect lung health. The study used next-generation single-cell sequencing technologies to analyze over 80,000 human and mouse lung cells, revealing clues on how cell types communicate and develop.
Researchers developed new method to visualize CNS fibroblasts and their intercellular interactions in the CNS. The technique provides a detailed picture of CNS fibroblasts, including their location, size, morphology, and gene/protein expression patterns.
Scientists at Scripps Research have developed a new tissue-clearing method that makes it easier to analyze large biological samples and study diseases. The HYBRiD method combines elements of prior approaches and uses hydrogels to protect molecules, enabling routine use in high-level biosafety facilities.
A National Jewish Health-led study found that over a third of identified genetic risk factors for asthma are associated with altered function of airway epithelium. The research discovered genetic changes in genes related to mucus production and type 2 inflammatory pathways, increasing asthma risk.
Researchers develop innovative non-contact agitation technology to assess motility and invasive capacity of cancer cells in tissue sections. The study reveals significant increases in Rac/Cdc42 activity in tumor areas, with stronger correlations found in advanced cancer stages.
Researchers used single cell RNA-sequencing to identify specific cells and genes in maize roots responsible for nitrate uptake. The study provides valuable insights into optimizing root nutrient uptake ability in crops.
Researchers identified peripheral tissues as source of blood amyloid beta, which regulates blood glucose levels and suppresses insulin secretion. The study suggests a possible mechanism linking type 2 diabetes to Alzheimer's disease development.
A new fluorescent DNA label has been developed to visualize disrupted DNA architecture in cancer cells, with promising results for improved cancer diagnoses and risk stratification. The study showed that the label can distinguish normal tissue from precancerous and cancerous lesions.
Researchers found that bilobalide, an active ingredient in Ginkgo biloba extract, protects the heart from ischemic injuries by preserving ATP generation and enhancing metabolic flux. The study suggests that bilobalide may provide a new herbal therapy for treating myocardial ischemia.
Researchers at UC Davis MIND Institute found a novel gene linked to autism spectrum disorder in newborns. The study analyzed DNA methylation signatures in the placenta, which reflected fetal brain development and early autism diagnosis.
Researchers from Tel Aviv University have engineered 3D human spinal cord tissues and implanted them in lab models with long-term chronic paralysis, resulting in an 80% success rate in restoring walking abilities. The team aims to conduct clinical trials in human patients within a few years to make the treatment commercially available.
Scientists from Japan and USA develop a microfluidic device for purification of tuberculosis genomic DNA fragments, enabling accurate diagnosis of diseases. The device uses transient ITP and electrokinetic trapping to detect and purify small cfDNA fragments.
Researchers used energy dispersive diffraction to create high-resolution 3D maps of bioapatite arrangements within shark centra, revealing key structures and their functions. The study provides insights into the structure-function relationship of the shark skeleton and could be applied to other organisms.
Researchers have discovered live cells in human breast milk, which may provide insights into breast cancer development and improve breastfeeding outcomes. The study, led by Dr. Alecia-Jane Twigger, found that these living cells can be used to study mammary gland function and identify potential early indicators of future breast cancer.
Plant scientists can now image above and below-ground structures with unprecedented clarity, revealing new insights into biological processes. The development of three-dimensional X-ray microscopy enables the observation of microscopic molecular and cellular processes driving plant phenotypes.
Researchers find SARS-CoV-2 infects sustentacular cells in the olfactory epithelium of COVID-19 patients, replicating vigorously within these cells. The virus does not appear to infect nerve cells, instead affecting sensory neurons indirectly through insufficient support from sustentacular cells.
Scientists have discovered that Tasmanian devils' whiskers can capture seasonal dietary changes over at least nine months and potentially up to a year. The long, wiry whiskers hold chemical imprints from food the devils ate in the past, offering a way to monitor the endangered native species with minimal disruptions to their habitats.
Researchers at Göttingen University have developed a new X-ray imaging method to detect changes in neuronal cell nuclei, indicating altered activity of neurons. This technique enabled the identification of changes in neurons in Alzheimer's disease.
A new confocal platform using artificial intelligence and multiple lenses improves volumetric resolution by over 10-fold while reducing phototoxicity. The platform uses Deep Learning algorithms to distinguish between high-quality images with low signal-to-noise ratio and better images.
Researchers at Cornell University have launched scMuscle, a large single-cell database that provides a comprehensive picture of the dynamics of muscle repair. The database houses transcriptomic data from approximately 365,000 cells involved in muscle injury across various ages and experimental conditions.