New clues to why some animals live longer
A study by University of California, Riverside scientists found that alternative RNA processing, or
Tissue Samples
Articles tagged with Tissue Samples
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A natural compound against stroke? Psychoactive agent protects brain vessels and reduces inflammation
Researchers found that DMT reduces infarct volume and edema formation in rat stroke models by restoring blood-brain barrier function and reducing inflammatory cytokines. The compound's dual action may complement existing treatments, offering a novel approach to stroke therapy.
New technology to obtain more information from the same tissue sample
Researchers have developed a groundbreaking method called PathoPlex that can analyze over 100 different proteins in the same small piece of tissue, revealing complex disease processes. This technology combines advanced image processing with machine learning to map human disease in detail.
Light-based data made clearer with new machine learning method
Researchers at Rice University developed a new machine learning algorithm that excels in interpreting light signatures of molecules, materials and disease biomarkers. The tool can detect subtle signals in optical spectroscopy, enabling faster medical diagnoses and sample analysis.
Micronanoplastics found in artery-clogging plaque in the neck
A recent study found that people with plaque in their neck arteries have higher amounts of tiny plastic particles compared to those with healthy arteries. The concentration of these plastics was significantly higher in individuals who had experienced a stroke, mini-stroke, or temporary vision loss due to clogged blood vessels.
Titanium particles are common around implants
A new study from the University of Gothenburg found that titanium micro-particles are consistently present at all examined implants, even those without signs of inflammation. The researchers identified 14 genes that may be affected by these particles, but further research is needed to understand their impact on tissue health.
We know nanoplastics are a threat—this new tool can help us figure out just how bad they are
Researchers developed an ultra precise technique to count and analyze nanoplastics in water, soil, and plant tissues. The OM-SERS setup uses lasers, gold nanoparticles, and microfluidics to detect specific types of plastics and their concentrations.
Alzheimer’s treatment may lie in the brain’s own cleanup crew
A new Northwestern University study found that enhancing the brain's immune cells can clear Alzheimer's plaques and restore a healthier brain environment in immunized patient brains. The findings could reshape the future of Alzheimer's treatments by shifting the focus from removing plaques to harnessing the brain's natural defenses.
Bioanalytical assays for oligonucleotide therapeutics
The article discusses the need for bioanalytical assays to measure immune responses to oligonucleotide therapeutic drugs, especially when they include carriers or conjugates. Highly specific antibodies may enhance the development and production of ONTs, expanding studies on their safety and efficacy.
How our lungs back up the bone marrow to make our blood
Researchers at UCSF have discovered that human lung tissue contains hematopoietic stem cells (HSCs) capable of producing red blood cells, platelets, and immune cells. The finding suggests the lungs could be a potent source for life-saving stem cell transplants, particularly for patients with leukemia.
Boosting the gut barrier offers hope for Crohn’s disease
Researchers at University of Gothenburg have identified a critical mechanism to slow down Crohn's disease progression by repairing the protective barrier of the gut. By reinforcing the gut's natural defenses, new drug targets may be developed to treat the disease.
Age, burial environment don’t hinder soft tissue preservation in dinosaurs
Researchers at North Carolina State University found that soft tissue preservation in fossils does not seem to depend on the species, age or burial environment. The team was able to retrieve vessels from six dinosaur specimens, including four Tyrannosaurus rex and one Brachylophosaurus canadensis, using a suite of analytical tools.
Fraunhofer IAF launches virtual application lab for quantum sensing
The virtual application laboratory provides comprehensive technical knowledge and interactive measurement scenarios for quantum sensors. Industry can interactively assess the potential of this technology for their needs, with expert knowledge available through accompanying resources.
Researchers map the brain's self-healing abilities after stroke
A new study from the University of Southern Denmark reveals that the brain's self-healing abilities are hindered by inflammation after a stroke. The researchers mapped specific cells that play a central role in rebuilding myelin, but found gender differences in how men and women respond to injuries.
Epilepsy patient samples offer unprecedented insights on brain ‘brakes’ linked to disorders
Researchers have created a detailed structural map of GABA A receptors in the human brain, revealing how they assemble and interact with drugs. The study provides new insights into treating epilepsy, anxiety, depression, and insomnia, and paves the way for customized therapies.
Epigenetic clocks reveal biological age at cell-type resolution
Researchers developed a new tool to measure biological aging in individual cell types, providing insights into diseases like Alzheimer's and liver pathologies. The study found that certain brain cells and liver cells show signs of accelerated aging, making it a better tool for detecting diseases.
A new blood test reveals hearts at risk of rejection
A new blood test reveals heart transplant patients at risk of rejection by analyzing DNA fragments in their blood. This non-invasive test is comparable to existing US tests and could save millions in public healthcare costs.
The distinct nerve wiring of human memory
Researchers uncover human hippocampal CA3 region's unique neural connectivity and synaptic properties. The team found that the human CA3 network codes information efficiently to maximize associations and memory storage, with sparser connections and more reliable synapses compared to mouse models.
Noninvasive imaging method can penetrate deeper into living tissue
A new noninvasive imaging method developed by MIT researchers can penetrate deeper into living tissue than previous techniques, producing richer and more detailed images. This breakthrough enhances biological research capabilities, enabling scientists to study immune responses and develop new medicines with greater accuracy.
New mouse models offer valuable window into COVID-19 infection
Researchers at La Jolla Institute for Immunology have developed six lines of humanized mice to study human cases of COVID-19, shedding light on SARS-CoV-2's movement through the body and varying symptoms. The models help understand how different genetic backgrounds influence disease progression.
Study identifies possible novel species in fish genus endemic to Neotropics
Researchers confirm 15 new species in Characidium genus, including genetic distance smaller than 2% between species with significant morphological differences. The study highlights the need for reevaluation of species classification and evolutionary history.
A new data biorepository at UF may help move the needle on pain
Researchers at UF are creating a data biorepository to explore pain pathways and create custom treatments. They're collecting and analyzing human tissue samples and using AI to map and understand the complex relationship between neurons and pain.
Neurological symptoms are common - and similar- in severely ill children with different conditions
A new study by ISGlobal reveals that nearly half of children with severe illnesses in low- and middle-income countries exhibit neurological symptoms before death. The most common causes of death were lack of oxygen, meningitis, and cerebral malaria. However, lumbar punctures are seldom performed, making diagnosis challenging.
Artificial intelligence improves lung cancer diagnosis
A new AI-based digital platform has been developed to analyze tissue sections from lung cancer patients, making diagnosis faster and more accurate. The platform uses algorithms that enable fully automated analysis of digitized tissue samples, allowing for personalized therapy based on molecularly specific genetic changes.
New microscope offers faster, high-resolution brain imaging
Researchers developed a new two-photon fluorescence microscope that captures high-speed images of neural activity at cellular resolution, providing insights into brain function and neurological diseases. The microscope uses an adaptive sampling scheme to image neurons in real time, reducing damage to brain tissue.
Imaging technique uncovers protein abnormality in motor neurone disease
Researchers have identified a metal deficiency in SOD1 protein associated with motor neurone disease using native ambient mass spectrometry imaging. This breakthrough could lead to new insights and treatments for the disease, which affects around 5,000 people in the UK.
Scientists revolutionize microscopy by reimagining the logic of imaging
A new microscopy method, Tempo STEM, significantly reduces radiation required by 'shutting off' the beam at peak efficiency. This approach eliminates excess damaging irradiation and avoids sample transformation or destruction.
LJI scientists capture immune cells hidden in nasal passages
Researchers at La Jolla Institute for Immunology have discovered immune cells, such as tissue resident memory cells, in the upper airway that can fight infections and build long-term immunity. These findings may lead to better vaccines and a deeper understanding of immunity against respiratory pathogens.
Unraveling a key junction underlying muscle contraction
University of California San Diego researchers used cryo-electron microscopy to capture the first 3-D images of a key muscle receptor, shedding light on why newborn humans develop slowly while cows mature quickly. The study's findings may help develop future treatments for muscular disorders.
Injury dressings in first-aid kits provide a new technique to reveal shark species after bite incidents
Researchers have discovered a method to identify shark species using medical gauze from first-aid kits after bite incidents. This approach can provide accurate and timely information on species, aiding prevention measures and reducing incidents.
First ever 3D reconstruction of 52,000-year-old woolly mammoth chromosomes thanks to serendipitously freeze-dried skin
A team has assembled the genome and 3D chromosomal structures of a 52,000-year-old woolly mammoth for the first time. The preserved chromosomes revealed the mammoth's genomic organization and active genes in its skin tissue.
UEA leads Europe-wide project to revolutionise childhood bone cancer treatment and research
A new Europe-wide clinical framework aims to collect high-quality biological samples from patients, enabling researchers and clinicians to understand the genetic, biological, and other factors involved in childhood bone cancer. This will guide the development of tailored treatments for each patient's cancer type.
Important step forward in stem cell therapy for rare bowel disease
A new study demonstrates the potential of stem cell therapy to treat Hirschsprung disease by generating nerve cell precursors that produce missing nerves in the intestine. Transplanted gut samples showed improved functionality, suggesting a breakthrough for this rare condition.
Clarifying the cellular mechanisms underlying periodontitis with an improved animal model
A new animal model has been developed to study periodontitis, allowing researchers to analyze tissue components simultaneously. The study found that the expression of the Il1rl1 gene was higher in peri-root tissue five days after ligation, highlighting its role in inflammation and osteoclast differentiation.
Mayo Clinic researchers’ new tool links Alzheimer’s disease types to rate of cognitive decline
Researchers created a corticolimbic index tool that categorizes Alzheimer's disease into three subtypes based on brain changes. The study found demographic and clinical differences among sex, age at onset, and rate of cognitive decline.
Advanced cell atlas opens new doors in biomedical research
Researchers at Karolinska Institutet developed a Single Cell Atlas (SCA) platform to profile human biology through multi-omics technologies. The extensive collection of data provides unique insights into individual cell properties and tissue interactions.
Early dinosaurs grew up fast, but they weren’t the only ones
A study found that early Mesozoic animals, including dinosaurs, grew quickly around 230 million years ago. This feature is not unique to dinosaurs but was shared by several non-dinosaur reptiles as well.
Researchers can reveal illegal timber exports
Researchers from the University of Gothenburg developed a new method to identify the origin of harvested trees using chemical footprints in wood tissue. The study focused on Eastern European countries, but the method is applicable worldwide, tackling over half of tropical timber's illegal harvest.
Polarization-sensitive tomography made easy with T2oFu
The T2oFu method offers a new approach to quantitative phase and polarization-sensitive tomography, enabling high-contrast images of muscle fibers with implications for diagnosing skeletal myopathies. The technique has been successfully tested on heart tissue samples with cardiac amyloidosis, providing promising results.
COVID-19 virus can stay in the body more than a year after infection
Research from UCSF found COVID antigens lingering in blood up to 14 months and tissue samples for over two years after infection. The persistence of these fragments may drive long COVID symptoms and associated risks.
Enhanced 3D chemical imaging with phase-modulation
A new method for phase-modulated stimulated Raman scattering tomography enables rapid, label-free 3D chemical imaging of live cells and tissues. This technique improves lateral resolution and imaging depth compared to conventional methods.
Study details toxic elements found in stranded whales, dolphins over 15 years
Researchers analyzed tissue and fecal samples from 90 stranded marine mammals to study the distribution of toxic elements. The study found that Risso's dolphins and short-finned pilot whales had high concentrations of mercury, cadmium, and lead, while dwarf sperm whales had low levels.
Advancing biomedical diagnostics: Compact photoacoustic sensing instrument for breast tissue characterization
Researchers developed a compact, cost-effective PA sensing instrument for biomedical tissue diagnosis, showcasing its potential to streamline sampling processes and improve diagnostic accuracy for breast disease. The instrument successfully differentiated various tissue types based on quantitative spectral parameters.
COPD: The effect of low-dose cadmium, a highly toxic metal, on airway epithelial cells
Cadmium exposure from cigarette smoke can lead to increased ANO1 expression in airway epithelial cells, exacerbating COPD. MicroRNA-381 negatively regulates ANO1, but its downregulation by cadmium could worsen disease severity.
When lab-trained AI meets the real world, ‘mistakes can happen’
A new study by Northwestern University found that lab-trained AI models are easily misled by tissue contaminants, resulting in errors in diagnoses and vessel damage detection. The researchers suggest improving the problem of quantifying and addressing biological impurities in AI models to enhance accuracy.
URI professor leads effort demonstrating success of new technology in conducting deep-sea research on fragile organisms
A team of researchers led by URI Professor Brennan Phillips successfully demonstrated new technologies for capturing preserved tissue and high-resolution images of deep-sea animals in minutes, preserving them for advanced genomic study. This breakthrough enables faster species discovery and can inform extinction prevention efforts.
New AI tool brings precision pathology for cancer and beyond into quicker, sharper focus
The iStar tool uses advanced techniques to capture both detailed views of individual cells and broader tissue patterns, enabling doctors to diagnose cancers that might otherwise go undetected. It also predicts gene activities at near-single-cell resolution, paving the way for molecular disease diagnosis.
Deadly frog disease more prevalent in central Florida than expected, UCF study finds
A new study found that a deadly frog disease, Perkinsea, is more widespread in Central Florida than expected, infecting over a third of sampled frogs. The disease is linked to cooler temperatures and higher precipitation, posing a concern for threatened species like the gopher frog.
Visualizing nerves with photoacoustic imaging
Researchers developed a noninvasive technique to visualize and differentiate nerve tissue using multispectral photoacoustic imaging. The study revealed the optimal wavelengths for identifying nerve tissue, which could improve nerve detection and segmentation techniques.
The best thing since sliced tissue
Researchers at Gladstone Institutes create Gaussian Process Spatial Alignment (GPSA) to analyze 2D data from tissue slices and generate a 3D 'atlas' of the tissue. This allows for deeper understanding of biological tissue samples, enabling more precise predictions of gene expression and treatment outcomes.
Towards organ preservation: Animal resistance to cold reflected in stem cells
Researchers have found that mouse stem cells mimic their parent animals' cold resistance, generating energy differently at low temperatures. This discovery opens up new avenues for studying organ preservation and human hibernation using in vitro models.
Microplastics found embedded in tissues of whales and dolphins
A study by Duke University researchers has found microplastics in the fats and lungs of two-thirds of marine mammals, suggesting that ingested plastics can travel into tissues. The presence of polymer particles and fibers in whales' fat and organs may cause harm, including hormone disruption.
Brillouin microspectroscopy as a noninvasive tool for evaluating vocal fold elasticity
Researchers demonstrate the potential of optical imaging for safely measuring vocal fold elasticity and pliability. The study found good agreement between Brillouin microspectroscopy results and conventional elasticity measurements.
Microplastics found in human heart tissues, both before and after surgical procedures
A pilot study reveals microplastics in heart tissue samples from patients undergoing cardiac surgery, with evidence suggesting direct introduction during procedures. The findings suggest various microplastics can accumulate and persist in the heart's innermost tissues.
New prostate cancer biomarkers provide hope to millions of men
Researchers at the University of South Australia have discovered three new biomarkers for prostate cancer that can accurately visualize and grade the disease. The breakthrough technology will enable clinicians to determine which patients require immediate treatment, potentially saving thousands of lives annually.
Research analyzes kidney functions and predictors of disease
A study analyzing kidney functions and predictors of disease has identified 28 altered cellular states in injured kidneys. The researchers mapped kidney cell interactions with active immune responses, establishing a data source for therapeutic development.
Malaria in the Medici era
Researchers detected Plasmodium falciparum, the deadliest form of malaria, in mummified tissues from Medici family members. The parasite was identified through microscopic and molecular analyses, revealing characteristic ring-shaped structures and Maurer's clefts.
‘Village’ approach to transform stem cell research
A powerful new stem cell technique has enabled large-scale studies of the relationship between human genetics and biology, accelerating research and potential personalized treatments.
BORIS gene mutation and expression: Link to breast cancer progression
Researchers analyzed BORIS mutations and protein expression in breast cancer tissue samples, finding frequent mutations associated with breast carcinoma progression. The study suggests the BORIS gene as a potential biomarker for breast cancer.
How the Amazon rainforest is likely to cope with the effect of future drought
A new study assesses the Amazon's response to drought, identifying the regions most vulnerable to climate change. Trees in the western and southern parts of the forest are at high risk due to rising temperatures and changing rainfall patterns.