Articles tagged with Tumor Cells
EMBL Monterotondo researcher Rocio Sotillo has won a $650,000 Howard Hughes Medical Institute award to support her research on cancer and chromosomal errors. She will use the prize to establish an independent research programme and develop new ways to grow lung cancer cells in three-dimensional cultures.
A study published in The Journal of Cell Biology reveals how DGK-alpha, a lipid-converting enzyme, enables invasive cancer cells to recycle integrins, providing better traction on fibronectin fibers. This process is essential for tumor progression and metastasis.
The study highlights the chain reaction required to prevent tumor formation, involving protein kinase ATM and its regulation of p53 and Mdm2. This new understanding may lead to the development of new therapeutic approaches to cancer.
Researchers found a strong link between an inherited TP53 gene mutation and chromothripsis, a condition where chromosomes shatter and reassemble incorrectly. This discovery has significant implications for diagnosis and treatment, as patients with the mutation may be at high risk of developing certain types of cancer.
A study has identified a protein called hepsin that may trigger the spread of breast cancer in certain cases. Hepsin, a protease enzyme, was found to free tumor cells from their native tissue matrix, allowing them to invade other tissues and grow into aggressive tumors.
Researchers have discovered a way to selectively target the glutathione pathway in brain cancer cells, making them more susceptible to chemotherapy. The breakthrough could potentially improve treatment outcomes for the nearly 45,000 people diagnosed with brain cancer each year.
Research reveals that cancer cells use a positive feedback loop involving c-MYC and SIRT1 to drive continuous cell division and tumor growth. This mechanism undermines normal cell regulation, leading to uncontrolled proliferation and treatment resistance in certain types of cancer.
Researchers at Ohio State University found that normal cells in tumors can enhance cancer cell growth after losing a tumor suppressor gene called Pten. The study suggests interrupting signals between normal cells and cancer cells as a new approach to treating breast cancer.
Researchers have discovered a technique to keep normal cells and tumor cells taken from an individual cancer patient alive in the laboratory. This breakthrough could revolutionize personalized cancer medicine and regenerative medicine, enabling oncologists to find the right therapies for patients.
Researchers at IRB Barcelona have discovered a new genetic program that converts epithelial cells into mobile invasive cells, which is common in embryonic development and tumour progression. The GATA6 gene plays a key role in this process, triggering survival factors and degrading the cellular matrix to facilitate cell migration.
Researchers discovered a novel viral oncogenesis mechanism in which KSHV co-opts cellular signaling pathways and modifies the microenvironment for viral replication. The virus induces EndMT, giving rise to infected invasive cells, allowing efficient spread of the virus.
Scientists have identified a gene mutation that underlies the vast majority of cases of Waldenstrom's macroglobulinemia. The mutation causes tumor cells to produce a distorted protein, leading to activation of NF-kB and growth of Waldenstrom's tumor cells.
The seven winning Celldance 2011 videos demonstrate the structure and function of living organisms at a microscopic scale. The award-winning entries feature various cell types, including fibroblasts and tumor cells, showcasing their behavior and interactions.
A study published in the Journal of Experimental Medicine reveals that protein BMP7 signals prostate tumor cells to enter a state of dormancy. Withdrawal of this protein restarts tumor growth, offering potential new therapies to prevent recurrence.
Researchers have created a highly sensitive surface that enables multivalent binding, allowing for the efficient capture of circulating tumor cells from the blood. The combination of nanotechnology and biomimicry demonstrates great potential for detecting rare tumor cells.
A study by MIT cancer biologists reveals that platelets release chemical signals inducing tumor cells to become more invasive and form new tumors. The findings suggest that direct physical contact between platelets and tumor cells is necessary for metastasis, highlighting potential targets for drug development.
Researchers found that inhibiting Notch signalling converts triple-negative breast cancer cells into hormone-receptor positive cells, making them dependent on estrogen. This technique has potential for combination therapy, where a Notch inhibitor is used to make all cancer cells hormone-sensitive.
Researchers at CHEO have identified a series of genes that magnify the impact of oncolytic viruses, allowing for up to 10,000 times more potent killing of tumor cells. By short-circuiting these rescue systems, tumor cells can be triggered to commit suicide, preserving healthy cells.
A team of researchers at UC Santa Barbara has developed a novel technique using laser spectroscopy and silver nanoparticles to discriminate between cancerous and non-cancerous cells. The technology can help identify unique tumor cells that may spread to other parts of the body, improving diagnosis and treatment outcomes.
A new treatment for alveolar rhabdomyosarcoma has been discovered by IDIBELL researchers, using 2-deoxyglucose to inhibit glucose metabolism and cause cell death in tumor cells. The molecule is similar to those used in PET imaging techniques and shows low toxicity at high doses.
Researchers have successfully delivered chemotherapy to cancer cells inside tiny microparticles, reducing ovarian cancer tumours by 65 times more than traditional methods. The 'Trojan Horse' approach uses a special protein called CD95 to hijack cancer cells and deliver the chemotherapy cargo.
Researchers have discovered how p53 binds to Hsp90, revealing new insights into cancer development and potential therapeutic targets. The study found that p53 binds to both the middle and C-terminal domains of Hsp90, with negatively charged amino acids playing a crucial role in stabilizing the bond.
Researchers confirm vitamin D's role in slowing down colon cancer cell growth and proliferation. The study found that a lack of vitamin D increases the aggressiveness of colon cancer, highlighting its potential as an anti-tumor agent.
Researchers at St. Jude Children's Research Hospital identified a hybrid cell as the origin of childhood eye tumor retinoblastoma, which has been linked to multiple developmental pathways being turned on simultaneously. The study also found that blocking certain chemicals reduced growth in human retinoblastoma cells, providing a potent...
Researchers at Penn State College of Medicine have discovered a potential new cancer therapy that inhibits two key enzymes in mouse tumor cells, making them more sensitive to chemotherapy. The drug SLM3, which targets GSK-3ß and CDK1, has shown promising results in lab mice.
Researchers at the University of Pennsylvania have successfully treated advanced chronic lymphocytic leukemia (CLL) patients with genetically engineered 'serial killer' T cells. The treatment involves removing and reprogramming patient cells to target specific proteins, resulting in sustained remissions and reduced side effects.
Researchers identified genetic changes that led to the loss of E2A, a crucial gene regulator. The loss enables tumor cells to grow rapidly and uncontrolledly, contributing to the aggressive behavior of Sézary syndrome.
Scientists at USC have proven that oncogenes can convert normal cells into stem-like cells, leading to a new approach in treating diseases with stem cell therapy. The study successfully converted human skin cells into brain cells by suppressing p53, suggesting it determines cell fate rather than only cancer outcome.
A recent stem cell study has found that the protein molecule E-cadherin, which plays a key role in cancer, also regulates up to 25% of genes within cells. This unexpected discovery could lead to new cancer treatments by understanding why some cancer cells are difficult to eradicate.
The Damon Runyon Cancer Research Foundation has awarded prestigious fellowships to 18 outstanding postdoctoral scientists, providing them with independent funding to pursue novel ideas in cancer research. The fellowships will support research into various aspects of cancer, including gene expression, cell growth, and tumor development.
Researchers at Dana-Farber Cancer Institute have discovered a new approach to make more types of tumors susceptible to PARP inhibitor treatment. By blocking the cell-cycle protein CDK1, which supports BRCA1 repair function, cancer cells become vulnerable to DNA-damage agents and ultimately die.
A Duke University Medical Center research team has discovered new proteins in blood cells of patients with advanced prostate cancer and metastatic breast cancer. These proteins are associated with embryonic development and may help doctors gauge the progression or response to treatment more accurately.
A new study has identified PI3Kinase gamma as a crucial protein in tumor growth and inflammation. Disrupting this enzyme prevents tumor cells from attracting immune cells, slowing down tumor development and metastasis.
Researchers at Einstein College of Medicine identified a key player in breast cancer spread, CCL2, which recruits immune cells to facilitate tumor growth. By blocking CCL2 signaling, they found potential for halting or slowing metastatic disease.
A team of scientists has created a new 3D tumor model that can grow in a realistic and easily accessible substrate, speeding up cancer drug discovery. The model's 3D nature provides a more accurate representation of how tumors grow in the body, reducing the likelihood of promising drugs failing during animal testing.
Researchers at Instituto Gulbenkian de Ciência found that the actin-capping protein regulates the Hippo complex, leading to abnormal growth and tumour formation. The study provides insights into understanding proliferation gene activation in cancer research.
Researchers at Stanford University School of Medicine have separated two distinct ways in which the p53 protein works, with implications for developing treatments that mitigate radiotherapy and chemotherapy side effects. The study reveals that disabling one part of the protein could allow healthy cells to survive DNA damage without pro...
MIT scientists have designed a new type of nanoparticle that can target nearly any type of tumor by utilizing the acidic environment shared by most cancers. The particles are designed to break down in the slightly more acidic environment near a tumor, revealing another layer that can penetrate individual cells.
Researchers have developed a new technique that allows cancer-fighting cells to survive in patients' bloodstreams for over a year, without the need for toxic treatments. The study showed promising results, with one patient remaining cancer-free two years after treatment.
Researchers at the Salk Institute have uncovered a new structural beacon, called the C-tail, which is found in half of all telomeres in alternative lengthening of telomeres (ALT) tumors. This unique feature may be a key to understanding cancer cell immortality and developing effective treatments.
Binghamton University researchers are studying the role of tubulin tyrosine ligase (TTL) in cancer cells, which may lead to more effective treatments. The team has developed a new labeling technique to observe TTL's behavior in live cells, potentially allowing clinicians to personalize cancer therapies.
Researchers discovered a new way to combine anti-cancer drugs, using Gamitrinib to sensitize tumor cells to TRAIL. This combination approach kills glioblastoma cells in both mouse models and human glioblastoma cells, offering a potential treatment for aggressive brain cancer.
Researchers at Dana-Farber Cancer Institute have developed a laboratory model that mimics the process by which fallopian tube cells may morph into cancer cells. The model demonstrates that HGSOC begins in the fallopian tubes, providing powerful evidence for this theory.
Researchers found that healthy breast cells secrete interleukin 25 to actively kill nearby breast cancer cells without harming normal cells. This discovery suggests IL25 receptor signaling as a new therapeutic target for treating breast cancer.
A new fusion molecule with three parts activates the immune system to attack cancer cells directly, while keeping it dormant until needed. The approach has shown promising results in lab experiments and mice with cancer, inhibiting tumor growth and activating immune cells.
The sentinel node procedure has evolved to limit surgical overtreatment, but isolated tumor cells and micrometastases have led to increased surgeries. Current studies examine the role of radiotherapy, pathologic protocols, and prognostic impact of these findings on breast cancer patients.
Researchers have discovered a protein that improves vascular regeneration in mice with heart attacks, and found that manipulating this protein could be used to treat various vascular diseases. Additionally, studies on mouse models have revealed plasticity in the pathways that control insulin secretion, offering new insights into diabet...
Whitehead Institute researchers found that differentiated cells in breast tissue can convert to a stem-cell-like state, challenging scientific dogma. This behavior may have implications for cancer therapeutics and degenerative disease therapy.
Hebrew University researchers have discovered a new mechanism by which tumor cells become invasive, involving a program of genes that confer invasive properties on epithelial cells. The study suggests that p53, a key tumor suppressor, may play a critical role in cancer prevention through its inhibition of cell invasion.
Researchers discovered that cancer cells generate a 'stress response' signal that induces nearby macrophages to issue a similar stress response, promoting inflammation and tumor development. This finding presents a potential target for tumor-specific therapies.
Angelique Whitehurst receives grant to study genes that support tumor cell survival and develop new therapeutic targets. Her work aims to selectively destroy tumor cells while leaving normal tissue unharmed.
Researchers discovered that ionizing radiation drives overexpression and activity of MET through the ATM and NF-κB signaling pathways, making some tumor cells resistant to radiation. Inhibiting MET counteracted this increased invasiveness, promoting apoptosis in tumor cells and enhancing the effect of radiation.
A new microfluidic device, developed by MIT researchers, can detect single cancer cells in a blood sample and also identify viruses like HIV. This device has the potential to revolutionize cancer diagnosis and make it more accessible in developing countries.
The American Association for Cancer Research has awarded 50 Minority Scholar in Cancer Research Awards to early-career scientists from diverse backgrounds. The recipients, who were chosen based on their qualifications and potential impact, will receive funding and support to attend the annual meeting and present their research.
Researchers found that genes similar to those in intestinal stem cells are activated in colorectal cancer cells, predicting a higher risk of relapse. The discovery opens up new possibilities for diagnosing and treating colon cancer by targeting tumour stem cells.
Researchers at UCSD School of Medicine identified Twist1's role in promoting invadopodia formation and matrix degradation in tumor cells. This process facilitates the spread of cancer to surrounding tissues and other parts of the body.
Researchers at the University of Texas M. D. Anderson Cancer Center have identified a new mechanism driving lung cancer metastasis, involving the suppression of microRNA miR-200 by Jagged2. The study found that low levels of miR-200 may indicate susceptibility to Notch inhibitors currently in clinical trial.
A new analysis method by CSHL team suggests tumors grow through 'punctuated, clonal expansions,' providing insights into tumor growth and metastasis. By analyzing single cells from breast cancer samples, the researchers inferred three distinct subpopulations of tumor cells, each with highly similar genomic profiles.
Researchers at the University of Pennsylvania School of Medicine found that protein p53 controls glucose metabolism, enabling cells to grow uncontrollably in tumors. This discovery may lead to new cancer therapeutics by targeting an inefficient metabolic pathway.
Researchers at Trinity College Dublin have discovered how autophagy, a process of 'self-eating', safeguards against cancer development. The discovery highlights an unexpected role for Noxa in triggering the self-destructive process that kills fledgling tumour cells.