Articles tagged with Tumor Cells
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Researchers found stem-like cancer cells that share characteristics with healthy stem cells, including unlimited lifespan and migration properties. These cells were localized in the same tissue location as bladder stem cells and showed increased activity in genes related to cell proliferation and metastasis.
Researchers at the University of Kentucky discovered that tumor-suppressor protein Par-4 is secreted by most human and rodent cells and can target large numbers of cancer cells by binding to receptors on the cell surface.
Researchers at Cedars-Sinai Medical Center have isolated stem-like cells from benign pituitary tumors and shown they can generate new tumors in laboratory mice. The study supports the cancer stem cell hypothesis, suggesting similar mechanisms may be involved in malignant and benign tumor formation.
Researchers at Yale University School of Medicine and the University of California Davis have discovered a protein, PRCP, that regulates appetite suppression by breaking down alpha-MSH in mice. Administration of PRCP inhibitors reduced food intake in both normal and obese mice.
Researchers propose a novel two-agent combination therapy that selectively kills tumors while sparing healthy cells. The approach leverages the frequent absence of methylthioadenosine phosphorylase in various lethal cancers, allowing for increased doses and reduced toxic side effects.
Researchers at Dartmouth Medical School have developed a Trojan horse nanoparticles to target ovarian cancer, reprogramming protective cells into killers. The approach triggers an inflammatory immune response, directly killing tumor cells and potentially complementing current therapies.
Researchers discovered that cancer cells and their neighboring cells share similar structural abnormalities on the nanoscale level, validating the 'field effect.' This finding could lead to early detection of cancer through simple blood or tissue tests.
Researchers discovered that certain carbohydrates on normal cells and enzymes like β3GnT1 function as tumor suppressors. Upregulation of β3GnT1 reduced tumor activity and metastasis in breast and prostate cancers. The study provides new insights into the role of complex carbohydrates in cancer.
Researchers at Cedars-Sinai have developed a novel gene therapy that uses immune cells to target glioblastoma multiforme. A specific biomarker, HMGB1, has been identified as an effective tool to monitor tumor response to this treatment.
Researchers propose that cancer stem cells could provide an important avenue for controlling cancer if targeted by new treatments. The subpopulation of malignant cells may be the root cause of cancer, offering a potential new approach for therapy.
A recent study published in Science found that the STAT3 protein plays a key role in converting normal cells to cancerous cells by regulating gene expression in both the cell nucleus and mitochondria. This discovery may lead to the development of targeted cancer therapies.
A study published in Science Express demonstrates the first definitive link between mutations in the DICER1 gene and cancer. Children with pleuropulmonary blastoma carried a mutation in one of their two DICER1 gene copies, which may disrupt normal lung development and communication.
The Damon Runyon Cancer Research Foundation has awarded prestigious fellowships to 17 outstanding postdoctoral scientists conducting innovative cancer research. The fellows will receive $140,000 each to work on projects aimed at improving cancer treatments and diagnostics.
Scientists at the University of Gothenburg have discovered a 'water gate' in yeast cells that regulates water flow, which may lead to new cancer drugs. The discovery has potential applications in human cancer research and could result in inhibitors for human aquaporins.
Scientists have identified a new approach to detect and treat Peutz-Jeghers syndrome, a rare inherited cancer syndrome, by exploiting tumors' weak spot in glucose metabolism. They found that targeting mTOR pathway with rapamycin can stop tumor growth, offering new treatment options.
A single gene, EBNA1, plays a crucial role in the activation of EBV genes responsible for indiscriminate tumor cell growth. The LSUHSC research team discovered that oxidative stress regulates EBNA1's ability to activate these genes, leading to potential therapeutic approaches using existing treatments like Vitamin K.
Scientists have found that replacing microRNAs in liver cancer cells can be lethal, while leaving healthy cells unaffected. The study used a special delivery virus to introduce the microRNA into mice with liver cancer, resulting in rapid death of tumor cells.
Researchers uncover molecular mechanism that enables tumor cells to attract new blood vessels continuously in the brain, even when oxygen is still abundant. The discovery could provide a basis for therapies targeting activated integrin alpha-vbeta3 to inhibit metastatic brain disease.
PTEN is often inactivated in breast cancer, leading to poor patient outcomes. Researchers found that a drug called perifosine specifically targets the breast cancer stem cell population by inhibiting the Akt pathway, reducing tumor-forming cells by up to 90%.
Researchers successfully engineer MSCs to deliver cancer-killing protein TRAIL, destroying tumor cells while sparing normal cells. In mouse models, the genetically modified stem cells reduced breast and lung cancer growth by up to 80%.
The study found that miR-196a promotes the metastasis of tumors by activating oncogenic pathways, leading to increased lung metastases in animal models. Additionally, high levels of miR-196a were associated with poor patient survival in pancreatic cancer patients.
Researchers have developed a four-in-one agent that can detect, target, and disable tumor cells while also making them visible through MRI and microscopic imaging. The agent uses siRNAs to suppress specific genes in cancer cells, providing a new approach to targeted gene suppression in cancer treatment.
Researchers found that lithium promotes DNA repair in healthy cells but not in brain tumor cells, protecting healthy hippocampal neurons from radiation-induced damage. This mechanism could provide a way to increase the radiation dose to kill tumor cells while sparing healthy tissue.
A new nanoparticle has been developed to deliver a tumor suppressor gene to cancer cells, restoring normal gene function and bypassing healthy tissue. This breakthrough method shows promise in reducing the probability of recurrent tumors.
Researchers at Georgetown University Medical Center have discovered that phenethyl isothiocyante (PEITC) can selectively deplete mutant p53 in tumor cells. This restoration of wild-type function increases the sensitivity of mutant p53-expressing tumor cells to PEITC-induced cytotoxicity.
Scientists studying a new cancer treatment discovered that protein levels, not genetics, determine the effectiveness of the medication. This finding offers an alternative explanation to the cancer stem-cell hypothesis and holds promise for designing more effective anti-cancer treatments.
Researchers at Mayo Clinic have discovered the molecular interplay that enables invasive tumor cells to move and invade other parts of the body. By manipulating this process, they hope to develop treatments to stop cancer from spreading.
A new anti-cancer agent, BPH-715, has been developed that is highly effective at inhibiting multiple enzymes in the cancer pathway. The compound has shown promising results in cell culture and animal studies, demonstrating its potential as a treatment for various cancers.
Researchers at Brown University have created a twin nanoparticle that specifically targets Her-2-positive breast cancer cells, releasing chemotherapy drugs into the infected cells. The system successfully killed up to 80% of cancer cells in laboratory tests.
A new study reveals that standard brain tumor treatment may increase the number of cancer stem-like cells, making patients more vulnerable to tumor recurrence. Researchers found that a common chemotherapy drug, temozolomide, increases the aggressiveness of surviving cancer cells.
A new study suggests that green tea components may negate the effects of bortezomib (Velcade) in patients taking this medicine. The EGCG polyphenol in green tea bound to boronic acid-containing compounds like bortezomib cancels out their antitumor effects.
Researchers found that two proteins, Kif2b and MCAK, work together to ensure proper chromosome segregation during cell division. Increasing these proteins in tumor cells restored nearly normal accuracy of chromosome segregation, providing insight into mechanisms of cell division in tumor cells.
Canadian researchers have identified a new protein, ARF1, that plays a critical role in breast cancer cell growth and tumour spread. Targeting this protein with drug therapy may provide hope to women with invasive breast cancers.
Researchers at Cedars-Sinai Medical Center developed a gene therapeutic approach that results in tumor regression and long-term survival. The approach uses proteins to draw dendritic cells into the brain tumors, stimulate an anti-tumor response, and increase survival time by six months.
Researchers at the Salk Institute have developed a new glioblastoma mouse model that closely resembles human brain tumors. The model uses modified viruses to shuttle cancer-causing oncogenes into adult mice, allowing scientists to study the development and progression of glioblastoma.
Researchers discovered that compounds like sulforaphane inhibit cell proliferation and kill precancerous cells, similar to anticancer drugs. This finding suggests that consuming cruciferous vegetables like broccoli may help prevent breast cancer.
Researchers discovered that bone marrow-derived dendritic cells (BM-DCs) pulsed with tumor lysates can stimulate T cells to attack and kill gastric cancer cells. This finding suggests a potential new approach for treating advanced gastric cancer.
Scientists use a special glass 'window' to visualize individually-labeled tumor cells as they move through the body's microenvironments. The technique allows researchers to identify critical interactions driving intravasation and develop microenvironment-specific drugs.
Researchers at Albert Einstein College of Medicine have identified a protein called Menainv, which is present in invasive cells within a breast tumor. This protein enables tumor cells to become invasive and metastasize to other parts of the body.
Scientists identified a protein called Akt as the key to exploiting a vulnerability in cancer cells. By targeting this protein, researchers were able to selectively kill cancer cells while sparing normal cells.
A new study reveals that cellular senescence, a natural process for fighting cancer in younger persons, can actually promote cancer in older individuals by triggering the secretion of proteins that cause inflammation. This process is linked to almost every major disease associated with aging, including many cancers.
A new study found that senescent cells secrete proteins into their environment, causing inflammation and setting conditions for the development of age-related diseases, including cancer. The research provides a molecular description of how this process drives aging and age-related disease.
Researchers identified a potential new target for anticancer therapeutics by showing that well-oxygenated tumor cells use lactate as a fuel source, which is released by hypoxic tumor cells. Inhibiting this protein MCT1 disrupts the symbiotic relationship between tumor cell types and leads to decreased tumor growth in mice models.
Researchers have identified a potential new target for anticancer therapeutics by showing that well-oxygenated tumor cells use lactate as a fuel, while hypoxic cells use glucose. Inhibiting this protein MCT1 disrupts the symbiotic relationship between the two cell types, leading to decreased tumor growth in mouse models.
Researchers found lactic acid is an important energy source for tumor cells and discovered a way to destroy hard-to-kill cells by preventing lactate delivery. Blocking lactate transport kills oxygenated cells that starve hypoxic cells, offering a novel approach to treating tumors.
A team of researchers at Cold Spring Harbor Laboratory has discovered 13 new tumor-suppressor genes in liver cancer, which can help improve diagnosis and treatment. The study used a powerful genetic screen to validate the functional contributions of these genes in living animals.
A study by UNC researchers found that palladin, a protein expressed mostly in invasive breast cancer cells, plays a crucial role in their ability to migrate and spread. Knocking down palladin expression reduced the ability of breast cancer cells to metastasize.
A recent study discovered that the Overexpressed in Lung Cancer 1 (OLC1) gene is consistently expressed at high levels in most lung cancers, particularly in smokers. OLC1 overexpression was also shown to induce tumor formation in tissue culture cells and mouse models of lung cancer.
Researchers from Universite de Montreal and Maisonneuve-Rosemont Hospital discovered a new biochemical pathway controlling DNA repair, which may lead to improved cancer treatment. The ATR protein plays a key role in this process, and its deficiency is often found in tumour cells.
Researchers at Baylor College of Medicine have developed a new treatment approach for neuroblastoma using T-lymphocytes with an artificial receptor that targets cancer cells. The treatment showed promise in early clinical trials, with one patient achieving complete remission and others experiencing stable disease for over a year.
Researchers develop a novel designer molecule that targets malignant melanoma cells using two different routes: triggering the immune system to attack and switching off a specific gene, driving cancer cells to suicide. Initial experiments in mouse models show significant inhibition of metastasis growth and tumor shrinkage.
Researchers identified a molecular reason why MEK inhibitors are limited in their ability to kill B-RAF mutant tumor cells, suggesting a new antitumor approach. MicroRNA15a modulates the expression of Cdc25A and affects hepatic cystogenesis in a rat model of polycystic kidney disease.
Researchers have identified a new combination therapy that targets tumors with B-RAF mutations by combining MEK inhibitors with BH3 mimetics, showing promise in treating melanomas and other solid tumors.
Researchers identified a molecular mechanism involved in the development of cancer stem cells, which can lead to malignant brain tumors. Targeting this signaling pathway with gene therapy may prevent tumor recurrence.
A new study published in the Proceedings of the National Academy of Sciences found that apigenin, a naturally occurring compound in fruits and vegetables, improves cancer cells' response to chemotherapy. By localizing tumor suppressor p53 in the cell nucleus, apigenin facilitates cell death and stops tumor growth.
Researchers create customizable biological computer using synthetic RNA that can detect tumor cells and respond to biochemical signals. The device has potential medical applications, including targeted gene therapies and cancer treatment.
Researchers have found that Hodgkin lymphoma cells produce the cytokine IL-21, which helps them evade immune system detection. This discovery could lead to new therapy strategies for the disease, including blocking IL-21 production.
Researchers have found a new technique to quickly and reversibly fine-tune protein activity in cells and living mammals, providing a powerful tool for identifying protein functions. The technique involves pairing specially engineered proteins with the drug Shield-1, which prevents their degradation.
Researchers found erlotinib to effectively block EGFR, improving survival in patients with pancreatic cancer. In vitro studies revealed erlotinib's ability to repress cell growth, induce apoptosis, and suppress angiogenesis.
Researchers at the University of Pittsburgh have found that a virus, Merkel cell polyomavirus (MCV), is the cause of Merkel cell carcinoma, an aggressive form of skin cancer. The virus infects normal cells before they turn into cancer cells, and its replication can lead to the death of cancer cells.