Articles tagged with Tumor Cells
Researchers discovered that cancer cells generate a 'stress response' signal that induces nearby macrophages to issue a similar stress response, promoting inflammation and tumor development. This finding presents a potential target for tumor-specific therapies.
Angelique Whitehurst receives grant to study genes that support tumor cell survival and develop new therapeutic targets. Her work aims to selectively destroy tumor cells while leaving normal tissue unharmed.
A new microfluidic device, developed by MIT researchers, can detect single cancer cells in a blood sample and also identify viruses like HIV. This device has the potential to revolutionize cancer diagnosis and make it more accessible in developing countries.
The American Association for Cancer Research has awarded 50 Minority Scholar in Cancer Research Awards to early-career scientists from diverse backgrounds. The recipients, who were chosen based on their qualifications and potential impact, will receive funding and support to attend the annual meeting and present their research.
Researchers found that genes similar to those in intestinal stem cells are activated in colorectal cancer cells, predicting a higher risk of relapse. The discovery opens up new possibilities for diagnosing and treating colon cancer by targeting tumour stem cells.
Researchers at the University of Texas M. D. Anderson Cancer Center have identified a new mechanism driving lung cancer metastasis, involving the suppression of microRNA miR-200 by Jagged2. The study found that low levels of miR-200 may indicate susceptibility to Notch inhibitors currently in clinical trial.
Researchers at UCSD School of Medicine identified Twist1's role in promoting invadopodia formation and matrix degradation in tumor cells. This process facilitates the spread of cancer to surrounding tissues and other parts of the body.
A new analysis method by CSHL team suggests tumors grow through 'punctuated, clonal expansions,' providing insights into tumor growth and metastasis. By analyzing single cells from breast cancer samples, the researchers inferred three distinct subpopulations of tumor cells, each with highly similar genomic profiles.
Researchers at the University of Pennsylvania School of Medicine found that protein p53 controls glucose metabolism, enabling cells to grow uncontrollably in tumors. This discovery may lead to new cancer therapeutics by targeting an inefficient metabolic pathway.
Researchers at Trinity College Dublin have discovered how autophagy, a process of 'self-eating', safeguards against cancer development. The discovery highlights an unexpected role for Noxa in triggering the self-destructive process that kills fledgling tumour cells.
Applied physicists found that migrating tissues exhibit similar behavior to colloidal glass, with cells flowing like a liquid until they reach a certain density threshold. This finding has significant implications for biological processes, including wound healing, cancer metastasis, and embryonic development.
Researchers at Emory and Georgia Tech developed nanoparticles to detect circulating tumor cells in blood samples from 19 head and neck cancer patients, achieving a positive signal for 17 patients. The 'one-tube' SERS technology could be faster and lower in costs than other detection methods.
Researchers found that photodynamic therapy can eliminate tumor-associated lymphatic vessels and in-transit tumor cells, reducing metastasis. This approach could be combined with existing surgical techniques to destroy lymphatic vessels draining from tumors.
A Princeton University research team has unraveled the mystery of how breast cancer tumors take root in the bone. The discovery highlights a specific protein called Jagged1 that sends destructive signals to cells, disrupting normal bone growth and paving the way for potential drug therapies.
A new study reveals that BRCA1 mutations regulate cell fate in breast tissue, leading to the formation of aggressive basal-like tumors. Cells with mutant BRCA1 exhibit elevated Slug levels and remain immature, stalled in a premature state of development.
Researchers are developing a new method to identify cell abnormalities, including cancer, by analyzing the shape and behavior of individual cells. They have created mathematical equations that describe cell appearance and motion, which could be used to gauge future stages of a disease.
Glioblastoma cells can transform into blood vessel cells when oxygen is scarce, making treatment efforts less effective. This transformation allows the tumor cells to continue receiving nutrients and oxygen, leading to a resurgence of cancer growth.
Research highlights the key role of estrogen signaling in maintaining energy balance, as well as the propagation of α-synuclein in Parkinson's disease. Additionally, a new immune cell activator has been identified to protect mice from tumors through an IFN-gamma-independent mechanism.
A recent study by Leif Ellisen and colleagues found that inhibiting certain microRNAs decreased tumor growth and made cells more sensitive to chemotherapy in a model of squamous cell carcinoma. The researchers identified a feedback loop between p63, microRNAs, and p73 that promotes cancer cell survival and chemoresistance.
Scientists have pinpointed the type of cell responsible for brain tumors known as oligodendrogliomas, a category of malignant brain tumors. The tumor originates in and spreads through glial progenitor cells, which are often referred to as 'daughter' cells of stem cells.
Researchers at Newcastle University found that the compounds in green tea are more effective against key triggers of Alzheimer's development when digested by enzymes in the gut. The study also suggests that these compounds have anti-cancer properties, slowing down the growth of tumour cells.
Researchers at Johns Hopkins Medicine discovered a potential therapy strategy by restoring lost microRNAs in human pancreatic tumor cells. The study found that these microRNAs put brakes on tumors when the KRAS gene is mutated, a common event in pancreatic cancer.
A new study reveals that aggressive tumor cells lack the strong molecular 'glue' responsible for binding normal cells together. This allows tumor cells to break away, detach from their neighbors, and spread to other regions of the body.
Mr Davis McCarthy has won a $150,000 scholarship to undertake a PhD at UC Berkeley, focusing on developing statistical analysis techniques to help biologists understand the mechanisms of diseases such as cancer and diabetes. He aims to make significant scientific contributions internationally.
Researchers found that p53 mutations can allow cancer cells to acquire stem cell-like characteristics, leading to increased tumor heterogeneity and aggressiveness. The study suggests that p53 plays a critical role in preventing the emergence of more aggressive cancer cells.
Researchers at the University of Georgia discovered a mechanism controlling cell movement linked to tumors becoming more aggressive. The misregulation of this switch may play a role in increased tumor cell movement and tumor aggressiveness.
Researchers at VCU Massey Cancer Center discovered a previously unknown mechanism in NSCLC cells that contributes to their ability to maintain and grow tumors. The study found that a protein factor regulates the expression of caspase-9, a main player in apoptosis, which could provide a new target for therapies.
Researchers at MIT discovered that restoring the p53 gene function can slow down the spread of malignant lung tumors in mice, but not in benign ones. The study suggests that p53 restoration could help prevent aggressive cancers from metastasizing.
Certain types of aggressive breast cancer cells bypass tumor suppression mechanisms due to the presence of Her2 proteins. The study found that protein Lip produced by these cells deactivates protective responses such as TGF-β and OIS, allowing them to grow uncontrolledly.
Johns Hopkins researchers have identified a protein mechanism that coordinates and regulates the dynamics of shape change necessary for cell division. The discovery has immediate medical implications, as cell division is a major target of anticancer drugs.
Researchers create a nanobioconjugate drug that specifically targets glioblastoma multiforme by blocking the production of laminin-411, promoting tumor cell death. Human clinical trials are anticipated to begin soon, offering new hope for brain cancer treatment.
A new study identifies a novel cancer-specific protein present in various types and stages of tumors. The PL2L protein might play a role in tumor initiation and progression, offering a potential target for anticancer therapies.
Researchers have found that cancer cells are accompanied by growth-enabling stromal cells when they travel to new sites in the body. This discovery challenges current understanding of metastasis and has implications for effective treatments.
A new clinical study reveals a technique called partial wave spectroscopic microscopy can differentiate individuals with lung cancer from those without, even in lifetime smokers or COPD patients. The findings suggest that this minimally invasive test could lead to personalized screening for lung cancer, the leading cause of cancer deat...
A novel nanoscale protein measurement technology, NIA, can be used in clinical trials to learn how drugs work and tailor therapy for each patient. The test distinguishes tumor cells from normal cells using protein profiles in the RAS and MAP kinase pathways.
Researchers have identified LIMK as a crucial regulator of actin cytoskeleton dynamics in cancer metastasis. Inhibiting LIMK function blocks collective invasion of tumor cells, preventing metastasis in breast and squamous carcinoma cells.
Scientists at the University of Granada have developed a new therapy for skin and lung cancer using a suicide coliphage-gene, demonstrating effectiveness in vitro and in vivo. The treatment involves inducing cell death in tumour cells, potentially reducing the need for chemotherapy.
Researchers found that fat-derived stem cells are safe to use in breast tissue reconstruction after mastectomy as long as there is no evidence of active cancer. The study suggests that dormant cancer cells are not sensitive to the growth signals sent by the stem cells.
Researchers at Salk Institute discover a novel mechanism by which adenovirus disables p53 in infected cells, paving the way for targeted cancer therapies. The study reveals two key proteins, E1B-55K and E4-ORF3, that work together to neutralize p53's tumor suppressor function.
A CSHL-led team found that increased IL-6 secretion can lead to decreased sensitivity to Tarceva, a targeted therapy for lung cancer. They also discovered that tumor cells with up-regulated TGF-β and increased IL-6 secretion were resistant to treatment independently of the EGFR pathway.
Researchers have identified a new cellular communication mechanism in glioblastoma cells, which could be targeted to slow tumor growth. If blocked, this pathway may significantly reduce GBM malignancy.
A new cellular mechanism has been identified for modulating blood vessel permeability, which could have a significant impact on the treatment of cancerous tumours. Nitrosylation of beta-catenin protein by nitric oxide increases vascular permeability, potentially leading to the blockage of tumour growth.
Researchers found that prostate basal cells can spawn tumors in the prostate gland, providing a new originator of prostate cancer. The study used human prostate tissue samples to develop new techniques and identified unique cell surface markers to distinguish luminal cells from basal cells.
Scientists discovered that inhibiting a protein called N-cadherin prevents cancer cells from forming groups and migrating. This new approach could lead to more effective therapies for cancer treatment.
Agricultural Research Service chemist Thomas Wang found that resveratrol, a bioactive compound in grapes and plant foods, can inhibit cancer cell growth but also increase tumor vessel development with prolonged exposure. The study suggests that diet complexity and gene expression are key layers in cancer development.
The current standard of care for brain cancer triggers biological responses that may feed the disease, according to Boston College researchers. This can lead to an escalation of conditions favorable to tumor cell survival and growth.
A team of investigators has identified a series of proteins that may make it easier to diagnose the more metastatic forms of prostate cancer. The study uncovers a protein named Siah2, which initiates a cascade of molecular events that turns a non-malignant tumor into a metastatic neuroendocrine tumor.
Researchers at Oregon State University discovered that the genetic regulator Ctip2 controls the formation of T cells, a type of white blood cell crucial for immune function. This finding may lead to new immune system-based therapies for diseases like HIV/AIDS and autoimmune disorders.
Researchers identified a protein marker, CD271, on cancer cells in human melanomas that evade current treatments. The cancer-initiating cells were found to be self-renewing and differentiating into other tumor cell types, making them resistant to therapies.
Scientists have created a novel type of immune system cell called Induced T to Natural Killer Cells (ITNK cells) that can kill cancer cells in lab tests and mouse models. These reprogrammed killer cells are more efficient at targeting tumour cells than unmodified Natural Killer cells.
Researchers found that high interleukin-10 levels in tumor cells are associated with worse prognosis after autologous melanoma cell vaccine treatment. High IL-10 levels can downregulate the immune response, decreasing the effectiveness of the vaccine.
Researchers found that blocking a receptor thought to mediate cell suicide in normal cells paradoxically stopped tumor growth. The study suggests using a drug that blocks the receptor to treat cancer. Further research will explore how this receptor promotes tumor growth and develop new therapies.
Two teams of researchers identified biomarkers that predict excellent graft function in kidney transplant recipients who stop taking immunosuppressive drugs. A molecular signature indicative of future organ failure was also found. The signatures may help physicians design personalized treatment regimens for kidney transplant recipients.
Melanoma cells can self-renew and induce new tumors, defying the traditional cancer stem cell model. Targeting both bulk tumor cells and slow-growing JARID1B-positive subpopulations is proposed as a dual therapy to combat therapy resistance.
Researchers have developed a powerful new technique for analyzing genome data from single tumor cells. The breakthrough allows scientists to study the biology of tumor development and identify dangerous cells in small samples. By profiling individual cells, researchers can understand genetic changes that occur as cancer progresses.
Researchers have found that parvoviruses can completely regress malignant brain tumors in rats and human gliomas. The viruses target cancer cells without affecting healthy tissue, making them a potential new approach to treating glioblastoma.
Researchers at the University of Kentucky Markey Cancer Center have discovered a key molecular mechanism behind breast tumor cell spread. The finding focuses on Snail's interaction with LSD1 enzyme, which regulates DNA structure and shuts down E-cadherin gene expression, leading to metastasis.
A new study has found that genetically short-circuiting the ability of cancer stem cells to absorb a key nutrient can kill many colon cancer cells. The approach targets tumor cell 'factories' and could potentially reduce recurrence rates of colon cancer. However, further research is needed to ensure the treatment does not harm normal s...
Cancer cells require actin, microtubules, and intermediate filaments to break through the basement membrane and escape. The study found that these components collaborate in a specific order to facilitate metastasis.
Researchers at Fox Chase Cancer Center have isolated an engineered antibody, GS45, that targets the Müllerian Inhibiting Substance Type II Receptor on ovarian cancer cells. This unique target is scarce in normal tissue, reducing the risk of side effects associated with traditional targeted therapies.