Articles tagged with Tumor Cells
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Certain types of aggressive breast cancer cells bypass tumor suppression mechanisms due to the presence of Her2 proteins. The study found that protein Lip produced by these cells deactivates protective responses such as TGF-β and OIS, allowing them to grow uncontrolledly.
Researchers at MIT discovered that restoring the p53 gene function can slow down the spread of malignant lung tumors in mice, but not in benign ones. The study suggests that p53 restoration could help prevent aggressive cancers from metastasizing.
Johns Hopkins researchers have identified a protein mechanism that coordinates and regulates the dynamics of shape change necessary for cell division. The discovery has immediate medical implications, as cell division is a major target of anticancer drugs.
Researchers create a nanobioconjugate drug that specifically targets glioblastoma multiforme by blocking the production of laminin-411, promoting tumor cell death. Human clinical trials are anticipated to begin soon, offering new hope for brain cancer treatment.
A new study identifies a novel cancer-specific protein present in various types and stages of tumors. The PL2L protein might play a role in tumor initiation and progression, offering a potential target for anticancer therapies.
Researchers have found that cancer cells are accompanied by growth-enabling stromal cells when they travel to new sites in the body. This discovery challenges current understanding of metastasis and has implications for effective treatments.
A new clinical study reveals a technique called partial wave spectroscopic microscopy can differentiate individuals with lung cancer from those without, even in lifetime smokers or COPD patients. The findings suggest that this minimally invasive test could lead to personalized screening for lung cancer, the leading cause of cancer deat...
A novel nanoscale protein measurement technology, NIA, can be used in clinical trials to learn how drugs work and tailor therapy for each patient. The test distinguishes tumor cells from normal cells using protein profiles in the RAS and MAP kinase pathways.
Researchers have identified LIMK as a crucial regulator of actin cytoskeleton dynamics in cancer metastasis. Inhibiting LIMK function blocks collective invasion of tumor cells, preventing metastasis in breast and squamous carcinoma cells.
Scientists at the University of Granada have developed a new therapy for skin and lung cancer using a suicide coliphage-gene, demonstrating effectiveness in vitro and in vivo. The treatment involves inducing cell death in tumour cells, potentially reducing the need for chemotherapy.
Researchers found that fat-derived stem cells are safe to use in breast tissue reconstruction after mastectomy as long as there is no evidence of active cancer. The study suggests that dormant cancer cells are not sensitive to the growth signals sent by the stem cells.
Researchers at Salk Institute discover a novel mechanism by which adenovirus disables p53 in infected cells, paving the way for targeted cancer therapies. The study reveals two key proteins, E1B-55K and E4-ORF3, that work together to neutralize p53's tumor suppressor function.
A CSHL-led team found that increased IL-6 secretion can lead to decreased sensitivity to Tarceva, a targeted therapy for lung cancer. They also discovered that tumor cells with up-regulated TGF-β and increased IL-6 secretion were resistant to treatment independently of the EGFR pathway.
Researchers have identified a new cellular communication mechanism in glioblastoma cells, which could be targeted to slow tumor growth. If blocked, this pathway may significantly reduce GBM malignancy.
A new cellular mechanism has been identified for modulating blood vessel permeability, which could have a significant impact on the treatment of cancerous tumours. Nitrosylation of beta-catenin protein by nitric oxide increases vascular permeability, potentially leading to the blockage of tumour growth.
Researchers found that prostate basal cells can spawn tumors in the prostate gland, providing a new originator of prostate cancer. The study used human prostate tissue samples to develop new techniques and identified unique cell surface markers to distinguish luminal cells from basal cells.
Scientists discovered that inhibiting a protein called N-cadherin prevents cancer cells from forming groups and migrating. This new approach could lead to more effective therapies for cancer treatment.
Agricultural Research Service chemist Thomas Wang found that resveratrol, a bioactive compound in grapes and plant foods, can inhibit cancer cell growth but also increase tumor vessel development with prolonged exposure. The study suggests that diet complexity and gene expression are key layers in cancer development.
The current standard of care for brain cancer triggers biological responses that may feed the disease, according to Boston College researchers. This can lead to an escalation of conditions favorable to tumor cell survival and growth.
A team of investigators has identified a series of proteins that may make it easier to diagnose the more metastatic forms of prostate cancer. The study uncovers a protein named Siah2, which initiates a cascade of molecular events that turns a non-malignant tumor into a metastatic neuroendocrine tumor.
Researchers at Oregon State University discovered that the genetic regulator Ctip2 controls the formation of T cells, a type of white blood cell crucial for immune function. This finding may lead to new immune system-based therapies for diseases like HIV/AIDS and autoimmune disorders.
Researchers identified a protein marker, CD271, on cancer cells in human melanomas that evade current treatments. The cancer-initiating cells were found to be self-renewing and differentiating into other tumor cell types, making them resistant to therapies.
Scientists have created a novel type of immune system cell called Induced T to Natural Killer Cells (ITNK cells) that can kill cancer cells in lab tests and mouse models. These reprogrammed killer cells are more efficient at targeting tumour cells than unmodified Natural Killer cells.
Researchers found that high interleukin-10 levels in tumor cells are associated with worse prognosis after autologous melanoma cell vaccine treatment. High IL-10 levels can downregulate the immune response, decreasing the effectiveness of the vaccine.
Researchers found that blocking a receptor thought to mediate cell suicide in normal cells paradoxically stopped tumor growth. The study suggests using a drug that blocks the receptor to treat cancer. Further research will explore how this receptor promotes tumor growth and develop new therapies.
Two teams of researchers identified biomarkers that predict excellent graft function in kidney transplant recipients who stop taking immunosuppressive drugs. A molecular signature indicative of future organ failure was also found. The signatures may help physicians design personalized treatment regimens for kidney transplant recipients.
Melanoma cells can self-renew and induce new tumors, defying the traditional cancer stem cell model. Targeting both bulk tumor cells and slow-growing JARID1B-positive subpopulations is proposed as a dual therapy to combat therapy resistance.
Researchers have developed a powerful new technique for analyzing genome data from single tumor cells. The breakthrough allows scientists to study the biology of tumor development and identify dangerous cells in small samples. By profiling individual cells, researchers can understand genetic changes that occur as cancer progresses.
Researchers have found that parvoviruses can completely regress malignant brain tumors in rats and human gliomas. The viruses target cancer cells without affecting healthy tissue, making them a potential new approach to treating glioblastoma.
Researchers at the University of Kentucky Markey Cancer Center have discovered a key molecular mechanism behind breast tumor cell spread. The finding focuses on Snail's interaction with LSD1 enzyme, which regulates DNA structure and shuts down E-cadherin gene expression, leading to metastasis.
A new study has found that genetically short-circuiting the ability of cancer stem cells to absorb a key nutrient can kill many colon cancer cells. The approach targets tumor cell 'factories' and could potentially reduce recurrence rates of colon cancer. However, further research is needed to ensure the treatment does not harm normal s...
Cancer cells require actin, microtubules, and intermediate filaments to break through the basement membrane and escape. The study found that these components collaborate in a specific order to facilitate metastasis.
Researchers at Fox Chase Cancer Center have isolated an engineered antibody, GS45, that targets the Müllerian Inhibiting Substance Type II Receptor on ovarian cancer cells. This unique target is scarce in normal tissue, reducing the risk of side effects associated with traditional targeted therapies.
Scientists have discovered that residual glioblastoma cells have different properties than those found in the tumor mass, making them more mobile and resistant to treatment. This breakthrough could lead to new therapeutic approaches against this aggressive brain cancer.
Researchers found that the Retinoblastoma protein targets DNA replication genes during cellular senescence, preventing cancer cells from replicating. This mechanism is crucial for tumor suppression, and its disruption can lead to genomic instability and malignant tumors.
Researchers found that stress-activated protein protects fugitive ovarian cancer cells from programmed death, allowing them to escape the primary tumor and metastasize. The study suggests that restoring cancer cells' vulnerability to anoikis could suppress tumor growth and metastasis.
Researchers developed a combinatorial approach using viruses to destroy tumors, which was shown to provide substantial regression and cure of tumors in mice. By targeting tumor blood vessels, this approach could potentially treat a wide range of cancers, offering new hope for cancer treatment.
A new microchip-based device enhances rapid and comprehensive analysis of circulating tumor cells, revealing key biological properties. The improved system allows for better monitoring of prostate cancer treatment responses.
Researchers identify Decapentaplegic protein as key player in cell migration, found in healthy Drosophila melanogaster cells. The protein triggers cell mobility and invasion, benefiting metastasis.
Researchers have discovered that blocking Mcl-1, a protein inhibiting Bak activation, enables TRAIL to activate Bak and kill resistant tumor cells. This strategy has potential for improving the efficacy of anti-cancer treatment.
Scientists at Dana-Farber Cancer Institute have developed a laboratory technique that more closely simulates the real-world conditions in which tumor cells mingle with normal cells, improving the accuracy of anti-cancer drug screenings. This new 'cell-specific in vitro bioluminescence imaging' (CS-BLI) technique can identify compounds ...
A new study suggests that stimulating human lung cancer cells with TLR7 or TLR8 agonists can lead to increased tumor cell survival and resistance to chemotherapy. This approach is being investigated as an adjuvant for anticancer immunotherapies, but caution should be exercised due to these potential risks.
Researchers have identified a potential therapeutic target for brain cancer, the A20 protein, which is highly expressed in glioblastoma stem cells. Decreasing levels of A20 in these cells reduces their growth and induces cell death, increasing survival rates in animal models.
A team of scientists is researching self-cannibalizing cancer cells to develop new therapies. Cancer cells can stop proliferating and consume themselves when stressed, allowing them to survive enormous amounts of stress.
Researchers found that tumor suppressor p53 limits the growth of cells with incorrect numbers of chromosomes and prevents their progression toward cancer. Cells lacking p53 become aneuploid after induced missegregation, indicating that the p53 pathway normally serves to limit the propagation of cells with odd numbers of chromosomes.
Yale researchers found that cancer-causing mutations can cooperate to promote tumor development even when located in different cells within a tissue. Stress conditions like wounds can trigger cancer formation by activating signaling process JNK.
Researchers discovered that distinct cancer-causing mutations in neighboring cells can cooperate to promote tumorigenesis. The study found that the genetic cooperation occurs through a signaling pathway that activates cellular proliferation and stress response pathways.
Researchers at Purdue University have developed nanoprobes that deliver cancer drugs directly to tumor cells, reducing damage to healthy cells. The nanoprobes mimic the natural delivery system of endosomes and can track their distribution within cells.
MIT chemists develop a new platinum compound called mitaplatin that selectively destroys tumor cells while leaving normal cells intact. The compound combines cisplatin and dichloroacetate to target cancer cells' altered mitochondrial properties.
A new study from Cold Spring Harbor Laboratory has found that certain types of aggressive tumors lacking p53 protein can be stopped in their tracks when TAp63, a sister protein, steps in. Researchers were able to shut off tumor growth by increasing TAp63 levels, which induced senescence and prevented cancer cell division.
A new Notre Dame study provides insights into the molecular basis by which tumor cells modulate their surroundings to favor cancer progression. The research identifies a unique population of microvesicles enriched in proteases, which facilitate tissue breakdown and remodeling at distant sites.
Scientists at MIT have discovered that tumors can arise from different types of cells in the pancreas, depending on whether they are injured or inflamed. This finding could lead to new treatments and early diagnosis methods for pancreatic cancer.
A new study published in Nature reveals that the loss of a gene called PTEN from surrounding cells can dramatically alter the tumor environment, fostering tumor growth. The findings suggest a new role for PTEN in suppressing cancer development and could lead to entirely new treatments targeting both cancer cells and their surroundings.
A team of researchers has identified a biochemical signaling pathway that protects normal tissues from radiation damage. Blocking this pathway increases tumor death in mouse experiments, offering hope for new cancer therapies.
Researchers at the University of Florida have found that inflammation in the colon tissue can trigger the transition from a non-cancerous state to cancer. The study suggests that targeting specific immune system hormones may be a key to preventing or inhibiting cancer growth, with potential implications for diagnostic tests and therapy.
Researchers at Yale University have discovered a novel mechanism that stops cancer cells from growing and dividing. The 'on-off switch' mechanism involves a tiny bit of genetic material that regulates the function of tumor-suppressor proteins, preventing cancer cells from proliferating.
Researchers at University of Iowa have modified siRNA to be injectable into the bloodstream, targeting specific genes overexpressed in cancer cells. The new compound triggers tumor regression without affecting normal tissues.
Researchers at Harvard Medical School found that separated cells lose energy-harvesting ability and eventually starve due to metabolic defects. Increasing antioxidant activity restores metabolic function, allowing cells to use alternative energy sources, raising the possibility of early-stage tumor cell survival.
Researchers at Case Western Reserve University School of Medicine have discovered the prion protein as a novel biomarker for pancreatic cancer. The study found that the prion binds to filamin A in human pancreatic cancer cells, disrupting cell organization and signaling, and leading to aggressive tumor growth.
Researchers found that estrogen temperes the killing activity of cytotoxic T cells through the molecule EBAG9. In its absence, CTLs release more tumor-killing enzymes, making them more effective at attacking cancer cells.