CNIO researchers have discovered a previously unknown mechanism of action for the first oncogene, c-Src. The study reveals that c-Src can autonomously activate itself through autophosphorylation, leading to cancer formation. This finding has significant implications for the development of new drugs targeting this enzyme.
SourceCentro Nacional de Investigaciones Oncológicas (CNIO)·JournalNature Communications·TypeExperimental study·DateOct 31, 2023
Researchers from Rice University and Princeton University have developed a new technology that allows for the live monitoring of signaling protein networks in living cells. The 'live reporter' system uses unobtrusive proteins to tag specific proteins, which can activate fluorescent markers when they become phosphorylated.
SourceRice University·JournaleLife·TypeExperimental study·DateJul 10, 2023
Researchers investigated the roles of STAT3α and STAT3β in aggressive breast cancer and found that differential silencing of these isoforms leads to changes in STAT3 activation. This study emphasizes the importance of distinguishing between STAT3 isoforms for accurate cancer diagnosis and therapy.
SourceImpact Journals LLC·JournalOncotarget·TypeExperimental study·DateApr 26, 2023
Researchers discuss cortactin's impact on cancer progression by modulating the Wnt5a/ROR1 signaling pathway. Cortactin expression is found in various cancers, including breast and chronic lymphocytic leukemia, suggesting its potential role in promoting metastasis.
SourceImpact Journals LLC·JournalOncotarget·TypeCommentary/editorial·DateApr 4, 2023
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The study found that Ponatinib inhibits Src-mediated ESCC malignancy with no toxic effect on normal cells. Src interacts with Fyn or Lyn to form heterodimers, which play a key role in ESCC development. Overactivation of specific tyrosine residues can be used as biomarkers for ESCC prognosis.
SourceScience China Press·JournalScience China Life Sciences·DateApr 3, 2023
A team led by Professor Claire Eyers has made a major breakthrough in cell signalling research, revealing a diverse and complex phenomenon of protein modification. The study found that approximately one-third of unique 'non-canonical' phosphorylation sites exist in addition to the well-studied serine, threonine and tyrosine residues.
SourceUniversity of Liverpool·JournalThe EMBO Journal·DateNov 4, 2019
Researchers at RIKEN Brain Science Institute identified IRBIT as a key player in regulating dopamine levels in the brain. The absence of IRBIT leads to hyperactivity and abnormal social behavior in mice, highlighting its role in maintaining balance.
SourceRIKEN·JournalProceedings of the National Academy of Sciences·DateApr 13, 2015
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Scientists have found a novel way in which plants perceive pathogens to activate immunity, opening the door to improving crop disease resistance. The discovery reveals that phosphorylation of an amino acid called tyrosine is key for activating plant immune receptors.
SourceNorwich BioScience Institutes·JournalScience·DateMar 13, 2014
Researchers at the Salk Institute discovered that plants and animals employ similar mechanisms to process hormone signals, relying on tyrosine phosphorylation. This finding highlights the convergent evolution of signaling systems across kingdoms.
SourceSalk Institute·JournalGenes & Development·DateJan 31, 2011
Research identifies opposing roles for phosphorylated alpha-synuclein amino acids in Parkinson's disease. Phosphorylation at Tyr125 protects nerve cells from alpha-synuclein toxicity, whereas Ser129 phosphorylation increases toxic oligomers.
SourceJCI Journals·JournalJournal of Clinical Investigation·DateOct 12, 2009
A study by researchers at the University of Pittsburgh Medical Center found that exposure to methylisothiazolinone (MIT), a common ingredient in shampoos and personal care products, can restrict the growth of axons and dendrites of immature rat nerve cells. This may have potentially damaging consequences for human development.
SourceUniversity of Pittsburgh Medical Center·DateDec 5, 2004
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