Articles tagged with Animal Models
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Scientists have developed a specific mechanistic explanation of beta waves, suggesting that excitatory synaptic stimulation from the thalamus drives pyramidal neurons to produce these waves. The theory is supported by computer models and measurements in animal models.
Scientists at Stowers Institute for Medical Research discovered a unifying cellular mechanism underlying Treacher Collins syndrome, a rare congenital disorder. Loss-of-function mutations in genes TCOF1, POLR1C, and POLR1D cause the condition, which affects craniofacial development and survival of progenitor neural crest cells.
Researchers found that folates can stimulate stem cell proliferation independently of their role as vitamins, using an in vitro culture and animal model system. The discovery provides evidence for a new pathway involving bacterial folate, which may have implications for human health.
Researchers have discovered three new compounds that inhibit insulin-regulated aminopeptidase (IRAP), showing promise in improving cognitive functions in animal models. The inhibitors block human IRAP at low concentrations with rapid reversibility.
A new study finds that bipolar patients' blood is toxic to brain cells and affects neuron connectivity. The more episodes a patient has, the more cellular components are produced that impair the brain's ability to deal with environmental changes.
Scientists at McGill University have identified novel gene mutations that cause hereditary spastic paraplegia (HSP), a debilitating disease characterized by weakness or spasticity in the lower limbs. The discovery will aid in the development of treatments for HSP, with researchers predicting improved diagnosis and treatment options.
Researchers developed a new long-acting formulation of raltegravir for pre-exposure prophylaxis, showing significant protection against multiple strains of HIV in animal models. The study found that the injectable provided strong suppression of viral load and could potentially improve adherence to medication regimens.
Researchers at Ohio State University have engineered new calcium receptors to enhance or preserve heart function in mice without harmful effects. The study shows improved cardiovascular performance and reduced mortality compared to control groups.
The article presents findings from the first reported autopsy of a patient with MERS coronavirus infection, revealing diffuse damage to lungs and identification of anti-MERS-CoV antibodies in specific cells. These results contradict previous assumptions and suggest that lung targeting is crucial for infectious control strategies.
Researchers at MIT and Bristol University found that mixotrophic organisms can increase the average size of plankton by up to 35%, leading to a greater flux of sinking organic carbon particles. This could enhance the ocean's ability to sequester carbon dioxide, potentially mitigating climate change.
A University of Exeter study found humans have limited ability to avoid becoming obese, especially in winter. The research suggests that the urge to maintain body fat is stronger in winter when food is scarce.
A new model has been developed to track animal movements using solar geolocators, providing more precise locations and behavioral data for migratory species. The FLightR R package enables accurate estimates of migration routes with increased precision than traditional methods.
Researchers at Scripps Florida Institute have been awarded $6 million to develop an innovative HIV/AIDS vaccine that has shown promise in animal models. The approach works by blocking key sites on the virus's surface, preventing it from attaching and invading human immune cells.
A team of researchers at the University of Kansas has identified a potential neuroprotective mechanism for Alzheimer's disease, focusing on the ApoE2 gene. The study suggests that ApoE2 carriers may be resistant to Alzheimer's disease due to enhanced brain energy metabolism.
A new study published in PLOS Computational Biology found that rodents behave like a self-organizing system when huddling together to regulate their temperature. This allows the group to better adapt to changing temperatures, with individual behaviors improving the ability of the whole group to regulate its temperature.
SLU researchers suggest approach to fight common virus in immunosuppressed patients by targeting Type 1 interferon pathway. The study found that disrupting the STAT2 gene in Syrian hamsters resulted in 100-1,000 times more virus replication compared to wild-type control animals.
Animal models are still crucial for medical research, according to experts, as they have led to tremendous progress in treating human and animal diseases. The authors argue that alternative methods, such as in vitro research, are not yet ready to replace animal models entirely.
Researchers Ache and Dürr develop a computational model of a descending mechanosensory pathway involved in active tactile sensing, capturing key properties of diverse neurons. The model is validated against real neuron coding properties and provides a common framework for modeling diverse neuron types.
Scientists at UC San Diego discovered that freshwater planarians are comparably sensitive to tested chemicals as zebrafish larvae and nematodes, but offer unique advantages such as studying genetically identical adult and developing animals. This could reduce the use of laboratory mammals in toxicology tests.
A recent study by University of Warwick researchers found that animals capable of mentally simulating environments require a primitive sense of self. This suggests that self-awareness is likely common among animals and not exclusive to humans.
The Genetics Society of America has awarded travel grants to 15 undergraduate students to present their research findings at the 20th International C. elegans Meeting. Recipients include students from institutions such as Pennsylvania State University, Washington State University, and Rutgers University.
Researchers used modern carnivore models to infer prehistoric diets, finding a strong signal driven by ancestry and skull size. They successfully distinguished between hypercarnivores and generalists using biomechanical attributes, shedding light on extinct species like Thinocyon velox and Oodectes herpestoides.
A novel in vitro live-cell platform allows direct visualization of endothelial cell injury patterns after clot removal. Researchers validated their findings with in vivo testing, offering significant promise for future device design and improving post-stroke recovery outcomes.
Researchers at Neuromed Institute discovered a molecular mechanism causing ADHD symptoms, linked to PI3K gamma enzyme dysregulation and hyperactivation of Locus Ceruleus brain area. This finding offers a new understanding of the disease, paving the way for innovative therapeutic approaches.
A $2.3 million network will investigate molecular mechanisms of rare diseases in yeast, worms, flies, fish, mice and humans. The goal is to understand disease mechanisms and identify therapeutic pathways for treatment.
The Genetics Society of America has awarded seven researchers with poster prizes for their outstanding contributions to yeast genetics research. The winners were selected from nearly 400 research posters presented at the 2014 Yeast Genetics Meeting, which took place in Seattle, WA.
GeroScopeTM is a system that evaluates age-related changes in human tissue and predicts the efficacy of drugs with known molecular targets. The technology will be presented at the FEBS-EMBO 2014 Conference, allowing delegates to learn about its functionality.
Comprehensive maps of epigenetic marks reveal patterns for safe restoration and provide a framework for testing disease models and drug candidates. These findings hold promise for diagnosing and treating diseases caused by gene expression deregulation, including cancer and autoimmune disorders.
Researchers propose 'One Health' model to guide sustainable growth of aquaculture industry, addressing animal health and environmental impacts. The model connects experts from various fields to develop sustainable operations ensuring adequate human nutrition and healthy environments.
A recent study used 7.0T magnetic resonance spectroscopy to analyze biochemical metabolism in the hippocampus of Alzheimer's disease rats. The findings revealed reduced N-acetylaspartate and elevated creatine and choline wave crests, indicating neuronal damage and inflammation.
Researchers used a 3D printer to recreate the snake's UFO-like cross-section and found that it generates sufficient lift at most angles. However, they also discovered a massive spike in lift when tilting the model at 35 degrees and an unexpected vortex sucking the rod down.
Researchers found that antioxidant extracts from spearmint and rosemary reduce deficits in mild cognitive impairment, a precursor to Alzheimer's disease. The study suggests these herbal compounds might have beneficial effects on altering age-associated cognitive decline.
A new compound has been found to inhibit cognitive impairment in animal models of Alzheimer's disease, showing a 60% improvement in learning and memory. The research uses the Endothelin system to target potential treatments for AD.
Studies on armadillos, fruit flies, nematodes, and monkeys reveal insights into progressive blindness, brain structure, and decision-making. The findings also highlight the importance of animal models in understanding human brain function and developing medical diagnostic devices.
A recent study by researchers at the University of Liverpool found that incorporating uncertainties into infectious disease models can significantly improve their effectiveness. The study analyzed previous outbreaks in the UK and found that many models provided only cursory reference to uncertainties, yet still informed policy decisions.
A study published in PeerJ found that nearly 50% of scientific resources are unidentifiable due to a lack of detail in journal articles. Researchers developed guidelines for reporting research resources to aid reproducibility, but these did not improve identification rates.
Scientists have successfully transmitted HIV in a mouse model of heterosexual intercourse, shedding light on the complexities of viral transmission and potential prevention methods. The study's findings suggest that hormonal factors in the female reproductive tract can impact host susceptibility to HIV infection.
Scientists have developed lab-born human tissue structures to study and treat tumor growth, offering a more accurate alternative to animal testing. The new method uses biochemistry and cell types to replicate human conditions, paving the way for personalized medicine.
Researchers found that globally ordered motion breaks down in overcrowded swarms, and a power law describes the average alignment in the direction of motion. Computer simulations revealed new features of individual animal behavior when confronted with high densities and close neighbors.
Researchers created a novel low-power device that enables the recording of complex neural signals in freely moving subjects for over 16 months. The device, which transmits data wirelessly, has the potential to revolutionize brain-computer interfaces and help people with severe paralysis control devices with their thoughts.
A study has identified two enzymes elevated in prediabetes that could lead to new therapies for vascular complications and help predict who is at risk of developing diabetes. Elevated arginase and indoleamine 2,3 dioxygenase trigger a stress response that damages blood vessels and immune cells.
A CSHL-led team has developed a new method to model human genetic diseases caused by errors in RNA splicing. The approach, called TSUNAMI, uses targeted 'negative ASOs' to cause missplicing and pathogenesis, offering a unique window into disease progression.
Researchers at UC San Diego developed a method to model an organism's metabolism and gene expression simultaneously. The technology enables detailed calculations of the total cost of synthesizing chemicals, including biofuels, by accounting for material and energy requirements.
A naturally occurring line of immunodeficient pigs can support the growth of human tumors, making them a promising large animal model for studying human cancers. The ability of human melanoma cells and pancreatic carcinoma cells to grow in these pig models could lead to significant advancements in cancer research and drug discovery.
Presentations at the Genetics Society of America's Model Organism to Human Biology meeting revealed key findings on cancer genomic pathways. Researchers identified mediators of metastasis and potential drug targets in model organisms such as zebrafish, fruit flies, and roundworms.
Researchers at the University of Alberta discovered a link between DHA intake and improved memory, with higher levels of DHA in the hippocampus leading to better cell communication. Supplementing with DHA may help prevent age-related declines in brain DHA levels.
The FASEB MARC Program has awarded a $1,650 travel grant to Shanelle Joseph from Southern University and A tM College for her poster/platform presentation at the 2012 meeting. The program aims to increase underrepresented minority engagement in biomedical research.
Researchers found that high levels of interleukin-6 (IL-6) prolong inflammation in obese mice with acute pancreatitis. IL-6 is also linked to the severity of the disease in obese subjects.
Researchers at Tufts University have identified a self-correcting mechanism by which developing organisms recognize and repair head and facial abnormalities. This process allows craniofacial structures to move and remodel themselves to compensate for defects, restoring normal shape and position.
A new study model has found that cerebral vessel function is altered in just 30 days of obstructive sleep apnea exposure, increasing the risk of stroke. The model developed by researchers at Baylor College of Medicine reveals a link between OSA and stroke, highlighting the need for early diagnosis and treatment.
Scientists at UNC have developed a new method for delivering long-lasting pain relief through PAPuncture, which mimics the molecular mechanism behind acupuncture. The treatment has been shown to provide up to six-day pain relief in animal models and may be applicable to any area where regional anesthesia is performed.
Researchers have developed a new technique to visualize fat distribution in lab mice using X-ray computed tomography (CT), allowing for non-invasive and longitudinal studies. This method provides detailed images of fat volumes within the mouse, enabling researchers to study adipose content at high levels.
A PET imaging agent has been shown to reverse neurotoxicity and improve motor skills and memory in animal models of Parkinson's disease. The compound works as a scavenger of peroxynitrite, reducing neuronal death and promoting revival of neuronal function.
Scientists at Scripps Research Institute created compounds that dramatically alter the biological clock, resulting in weight loss and improved metabolic markers in diet-induced obese mice. The study suggests potential effectiveness in treating obesity, diabetes, high cholesterol, and sleep disorders.
Researchers present new information on neural diseases and kidney stones using the fruit fly Drosophila melanogaster model. Studies reveal links between cellular changes and behaviors in flies with human counterparts such as ataxia-telangiectasia and Rett Syndrome.
The study aims to investigate the pathobiology of acute lung injury (ALI) and develop novel therapeutic approaches. Researchers will focus on the role of sphingosine-1-phosphate (S1P) in lung cell signaling and inflammation.
Young house spiders exhibit perfect angles and regular patterns in their webs, but as they age, their webs deteriorate. The research suggests that degeneration of the central nervous system may be behind this decline, providing a model for understanding aging mechanisms in humans.
A newly developed compound, SR1001, has been shown to effectively suppress the severity of multiple sclerosis in animal models with minimal side effects. The discovery holds promise for treating other autoimmune diseases and targets a specific cell type involved in autoimmunity.
A consortium of scientists has been awarded $7.5 million to develop novel compounds that could become treatments for nicotine addiction and possibly other drug addictions.
A synthetic derivative of turmeric has been found to be highly neuroprotective against ischemic stroke and traumatic brain injury in animal models. The compound, CNB-001, improved behavioral and molecular deficits in both conditions, offering potential clinical promise for current treatment-limited diseases.