Articles tagged with Ciliogenesis
Scientists discover that multiciliated cells use cell division to control hair-like projections called cilia. This adaptation breaks the cancer-preventing rule of making only four centrioles per cell, producing hundreds instead.
Researchers developed a new OCT approach to directly image coordination of tiny hair-like structures in live organisms, giving a powerful tool to investigate cilia's role in the female reproductive system. The technique revealed unexpected behaviors that contradict current views and suggested new roles for cilia.
A new study reveals that flow-sensing cilia activate BICC1 to regulate organ laterality, with a complex network involving ANKS3 and ANKS6. The discovery provides fundamental insights into gene expression and opens avenues for therapies of genetic disorders.
The NSL complex controls intraciliary transport genes essential for cilia formation and function. Loss of the complex leads to impaired assembly and activation of these genes, resulting in ciliopathies characterized by hearing loss, visual impairment, and kidney disease.
The study reveals the structure of the 15-subunit IFT-B complex, a crucial component in cilia formation and maintenance. The complex's elongated and flexible nature is consistent with previous low-resolution reconstructions, and two configurations are identified that may drive bi-directional movement.
Researchers developed a mathematical model of cilia beating due to mechanical instability caused by the cilium motor protein dynein. This knowledge will aid in understanding and treating cilia-related diseases.
Scientists have created cilia-free human pluripotent stem cells that exhibit symptoms of ciliopathy, such as polycystic kidney disease. These cells can be used to study the cause of these diseases and guide therapy development.
Researchers at the Medical University of South Carolina identified mutations in ciliary genes causing bicuspid aortic valve and aortic valve narrowing. The study revealed that disruption of cilia development leads to BAV disease and calcification on the aortic valve.
Researchers at MUSC report findings on the mechanisms underlying impaired ciliogenesis and abnormal kidney development characteristic of PKD. Depletion of dynamin-binding protein or Tuba disrupts renal ciliogenesis, leading to uncontrolled production of cysts.
Researchers captured highest-resolution images of human cilia using advanced imaging technique that preserves native structure and detects defects. This innovation provides a new window into the biology of ciliopathies, allowing for more accurate diagnoses and potential treatments.
A recent NIH study has identified a crucial gene involved in the early development of cilia, which are essential for cell communication and sensory systems. Without this gene, mice failed to grow cilia, leading to embryonic death, highlighting the importance of Cc2d2a in cilia formation.
Researchers at Penn State University have identified a critical protein required for the growth of cilia on cell surfaces. This discovery has significant implications for understanding and treating diseases related to cilium development, such as polycystic kidney disease, blindness, and neurological disorders.
Researchers at the Salk Institute discovered a gene called multicilin that tells cells to develop multiple cilia, tiny structures moving fluids through the lungs and brain. This finding may help create new therapies using stem cells to replace damaged lung tissues with healthy ones.
A team of Brandeis researchers has created artificial cilia-like structures that spontaneously organize into active bundles and beat in a periodic manner. This breakthrough offers a new approach for studying the beating patterns of real cilia, which could lead to advances in nanotechnology.
New research reveals FoxJ1 helps create left-right asymmetry by orchestrating the formation of nodal cilia, which generate fluid flow to orient tissues. The study finds that increasing FoxJ1 levels leads to the formation of ectopic cilia, challenging current theories on its role.
Researchers developed a novel fabrication technique that uses magnetic actuation to assemble large arrays of three-dimensional microstructures. The method involves casting individual components in place and using a magnetic field to fold them into shape.