Researchers at Kumamoto University and collaborators developed a method to produce human trophoblast stem cells from late-gestation placentas, opening a new avenue for studying pregnancy complications. The resulting patient-derived models reproduce key features associated with preeclampsia, enabling the uncovering of molecular mechanis...
A study by the Sant Pau Research Institute found that placental insufficiency during pregnancy is associated with higher risk of memory alterations years after childbirth. Women with angiogenic imbalance had a higher frequency of memory problems, even after accounting for other clinical factors.
Researchers have successfully developed human placental stem cells from full-term pregnancies, sharing characteristics with early pregnancy cells. These Ch-TS cells can develop into key cell types essential for proper placental function, offering a more relevant model to study late-stage complications.
Research by UCL and Yale University reveals that platelet cells were crucial for the evolution of eutherian mammals, including humans. The discovery suggests that these cells enabled haemochorial placentation, allowing mothers to prevent haemorrhaging at birth.
Researchers found that high uterine artery blood flow resistance in early pregnancy is associated with a 5-fold increased risk of preeclampsia, fetal growth restriction, and stillbirth. Increased cell death and reduced IGF2 expression may be causal factors of abnormal placental development.