Articles tagged with Tissue Growth
Scientists at NPL developed a functional model of the native extracellular matrix, providing structural support for cells to aid growth and proliferation. The model could lead to advances in regenerative medicine by mimicking the complex nano-to-microscale structure of the ECM.
A new substance, F-ara-Edu, labels DNA with little to no impact on genome function, allowing for the visualization of DNA synthesis in vivo. This approach enables the identification of virus infection and cancerous growth sites due to abundant DNA replication in these tissues.
Researchers from Yale have devised a way to monitor the growth of laboratory-engineered blood vessels after implantation in patients using MRI and nanoparticle technology. This advance allows for noninvasive monitoring of engineered tissues, which is crucial for personalized medical treatments.
Researchers have developed a fast new method for mapping blood vessels that could aid cancer research by analyzing the vascular network of organs in less than two days. The technique uses knife-edge scanning microscopy to create detailed 3D maps of blood vessels, from arteries and veins to smallest capillaries.
A new study has identified Dpp and Pentagone as key players in the scaling process of a fruit fly's wing. The research found that the feedback loop between Dpp and Pentagone regulates proportional tissue growth, keeping body proportions constant despite external factors like nutrition and temperature.
Researchers at Harvard discovered that a simple balance of forces determines the formation of the vertebrate gut's predictably loopy shape. The gut grows faster than its attached mesentery tissue, causing it to coil as the elastic forces build up.
A novel nanostructure mimics vascular endothelial growth factor to promote blood vessel growth, potentially treating conditions like peripheral arterial disease. The nanostructure shows promise in restoring blood flow and has a longer half-life compared to the natural protein, enhancing its potency.
Researchers are working on developing new treatments for brain aneurysms using gel-based delivery systems and mathematical modeling. The goal is to prevent the growth of aneurysms and improve cardiovascular health outcomes, ultimately reducing mortality rates from heart disease and stroke.
Composted dairy manure solids significantly improve soil physical and chemical properties, reducing density and pH while increasing organic matter and nutrient concentrations. The treatment also enhances the establishment and growth of selected ornamental plants.
Researchers at Cornell University have developed dermal templates made of type 1 collagen that promote vascular growth and encourage healthy skin to invade wounded areas. The templates are designed to improve healing outcomes and reduce the need for invasive surgeries.
Scientists at the University of Hull have identified a cellular mechanism controlling tissue factor inclusion in endothelial microparticles, which may help treat cardiovascular disease and cancer. The on-off switch, involving tandem amino acids, regulates phosphate molecule addition to control tissue factor release.
Researchers compared two pulp extraction techniques on dental pulp stem cells (DPSC) quality and quantity. The study found that the second technique resulted in higher stem cell integrity, growth rate, and quality, while also improving quantity.
Plant-based researchers are developing adaptive structures inspired by Mimosa's ability to twist, bend, stiffen, and heal. Artificial cells mimic the mechanisms behind plants' nastic motions, leading to innovative technologies like shape-changing robots and morphing wings for airplanes.
Researchers discovered that SIRT1 inhibits prostatic intraepithelial neoplasia (PIN), a precursor to prostate cancer, by promoting autophagy. The study suggests that activating SIRT1 could block prostate cancer and promote longevity.
Researchers discovered that the peptide angiotensin-(1-7) inhibits both the growth of human breast tumors and the growth of cancer-associated fibroblasts, reducing tumor size by 40% and fibrosis by 64-75%. This finding offers a potential new treatment option for breast cancer.
A study published in PLoS Biology found that p53 determines organ size by regulating tissue growth. The protein's activation in response to stress leads to a coordinated reduction in the growth of healthy tissues, allowing damaged areas to repair themselves.
Scientists identify specific receptors, TLR-2 and dectin-1, that can be targeted to stop damage while promoting nerve cell growth after a spinal cord injury. An experimental compound was found to activate the TLR-2 receptor alone, enhancing axon growth without causing cell death.
Researchers use snapdragon flower as model to study genetic and chemical cues that shape biological structures, revealing key role of genes in controlling cell growth and orientation. The study also suggests evolutionary tinkering played a role in shaping complex forms.
Researchers successfully differentiate embryonic stem cells into lung tissue using a natural cell-depleted lung matrix, demonstrating improved cell retention and organization. This breakthrough finding holds promise for developing clinical applications for engineered lung tissue.
A new study has uncovered the genetic mechanisms controlling the growth of collateral circulation, which can provide oxygen to starved tissues in the event of a heart attack or stroke. The researchers identified a section of DNA involved in variation in collateral vessel density and diameter.
Researchers discovered that galectin-3 promotes angiogenesis by binding to specific cell-adhesion proteins, suggesting potential therapeutic targets. Targeting the protein with inhibitors significantly reduced angiogenesis in mice, offering new approaches for treating diseases caused by excessive blood vessel growth.
Alana Oldham and colleagues found that water stress, due to gravity's effect on the water column, drives leaf anatomy and morphology in redwoods. This reduces photosynthesis in the upper canopy, but increases water-stress tolerance traits below.
A new study published in the Journal of Chemical Physics suggests that decompression sickness is caused by the formation and loss of small gas bubbles in soft tissues. The researchers propose a model where these bubbles are stabilized by pockets of reduced pressure, allowing them to persist despite their expected collapse.
Scientists at Massachusetts General Hospital have developed a technique to grow transplantable replacement livers using the structural tissue of rat livers. The approach involves decellularizing the liver and reseeding it with liver cells, resulting in normal liver function for up to 10 days in culture.
A study at Baylor College of Medicine found that eliminating tumor suppressor C/EBP alpha is key to cancer development in the aging liver. Another protein, gankyrin, is elevated first, leading to degradation of C/EBP alpha and allowing uncontrolled growth.
Researchers have developed a new technique to study the structural properties of tissues by sucking cells into a pipette, providing information on adhesion and elasticity. This approach complements existing methods and allows for measurements on living tissue in its natural environment.
Researchers identified a novel sequence bias that regulates genomic expression rates, providing insights into how cells respond to injuries and poisons. This discovery could lead to more efficient production of therapeutic agents and research reagents.
Researchers at Washington University School of Medicine found that a growth factor gene plays a critical role in palate development, suggesting a new target for preventing and treating cleft palate. The study's findings could lead to the development of drugs that activate or inhibit the gene to ensure normal palate growth.
Researchers identified a molecule, MMP2, that controls fibroblast growth factor (FGF) signaling in fruit flies, allowing them to study the process of tissue invasion. This finding may provide new insights into how cancer cells spread and could lead to the development of new treatments.
Researchers at Georgia Tech have developed bioengineered hydrogels that induce significant vasculature growth in damaged tissue. The hydrogels release VEGF, stimulating blood vessel formation, and degrade in a controlled fashion, allowing for functional vascularization and integration with host circulatory system.
Scientists develop a laboratory chip with nanoscopic features that enables heart cells to grow and function like natural heart muscle. The 'nanosense' allows cells to collect instructions from the physical patterns on the chip, guiding their behavior.
Michael Crickmore's prize-winning essay describes his research on the molecular basis of size differences in animals. He found that a delicate balance of size-regulating genes and signaling pathways control tissue development and shape specialized cells.
A University of Florida researcher is developing a micro-endoscope that can inspect tissues beneath the surface, revealing abnormal cell groups or growth patterns before they form tumors. This technology has shown promising results in laboratory tests and could allow for earlier detection and more precise tumor removal.
Researchers have discovered an alternative spliced form of tissue factor that contributes to cancer growth and angiogenesis. The protein is found in various tissues but plays a key role in promoting the development of new vessels to fuel tumor growth.
Blood vessels can spur their own growth and deliver oxygen to tissues and tumors through internal cues. The study found that a protein called Flt-1 plays a key role in regulating this process.
Researchers have identified a new nerve growth factor, MANF, that can halt the progress of Parkinson's disease and restore damaged cells in rats. The study shows promising results, suggesting that MANF may be a highly significant finding in respect to growth factor therapy for PD.
Researchers at Tufts University have created skin-like tissues using human embryonic stem cells, which can be used to treat oral and skin conditions. The breakthrough uses three-dimensional tissue engineering techniques to mimic the growth environment of human skin.
Researchers discovered that uterine stromal cells increase estrogen production through the enzyme aromatase, supporting decidualization and blood vessel growth. Progesterone supplementation is necessary for successful pregnancy, highlighting the benefits of local estrogen production.
Researchers from Caltech found that contact inhibition is a tunable system influenced by growth factors like EGF. They discovered a threshold of sensitivity to EGF that can be manipulated to control cell division and tissue growth.
Researchers at Harvard University have developed a framework for studying the arrangement of tissue networks created by cell division across various organisms. The model reveals that regular features in tissues can indicate properties about the cell division mechanism itself.
Researchers have developed a method to generate complex, multilayer oral tissues using human embryonic stem cells. The tissues mimic normal oral cavity tissues and show promise for treating oral diseases through transplantation.
Researchers at Duke University have developed an approach using magnetism to manipulate human cells, forming chains that can promote the growth of blood vessels. The iron-containing nanoparticles used by the researchers are suspended within a liquid known as a ferrofluid, allowing them to readily manipulate the chain formation.
Researchers from Case Western Reserve University, Duke and University of Massachusetts created magnetic particles that nudge free-floating human cells to form chains in response to external magnetic fields. These chains may accelerate the creation and growth of tiny blood vessels.
Researchers at Duke University Medical Center discovered a missing enzyme that can resist the normal effects of a heart attack, allowing mice to retain nearly normal heart function. The findings suggest a potential therapy for stimulating blood vessel growth and preventing future attacks.
Researchers propose a new model explaining how cancer cells grow and spread, attributing inefficiency to pressure differences between tumor cells and host tissues. Understanding this process is crucial for developing effective treatments for metastatic cancer.
A team of researchers at the University of Oklahoma Health Sciences Center discovered a new enzyme that plays a primary role in how cancer tumors expand and spread. The enzyme, called sFAP, helps create scaffolding for cancer cells to attach, divide, and migrate.
Researchers at University of Bristol discover how bodies respond to internal distress signals, revealing potential for targeted stem cell therapy in heart patients. Kinin-sensitive EPCs identified as key to repairing blood supply and improving outcomes.
Researchers at UC Riverside have discovered a mechanism that allows plants to bypass the negative effects of aluminum toxicity, enabling them to grow normally in soils with high levels of toxic aluminum. By manipulating a DNA surveillance system called AtATR, scientists can enhance aluminum tolerance and increase crop productivity.
Researchers have developed a genetically engineered mouse model of chronic sinusitis, which mimics the disease's symptoms and provides a new tool for studying and treating the condition. The 'stuffy nose' mice suffer from reversible loss of smell due to inflammation, offering hope for developing new therapies.
Scientists gather to present research on using mechanics to study and explain biology, highlighting the role of faint pushes and pulls in cellular signaling. The symposium aims to develop fundamental math and mechanics to understand biological processes like embryo development and growth.
A joint Argentinian-French study suggests that elastic stresses may play a crucial role in determining leaf venation patterns. By developing a numerical model, the researchers found simulated patterns with statistical properties similar to natural ones, challenging the existing view of auxin's role in vein formation.
Researchers identify genetic mutations in MTHFR and Factor V as significant contributors to blood clots and tissue injury in the placenta. These mutations may lead to increased risks of preterm birth, intrauterine growth restriction, and preeclampsia.
Gynecomastia, benign enlargement of male breast tissue, affects 40-50% of males at some point in their lives. The condition can be treated with medication or surgery, and awareness is key to correct diagnosis and reassurance for affected men.
Researchers have developed an anti-cancer therapy using eIF4E-specific antisense oligonucleotides (ASOs), which effectively knock down the protein's expression in human tumors. The treatment has been shown to inhibit tumor growth without compromising normal tissue function, suggesting a promising approach for cancer treatment.
Researchers at Virginia Tech have introduced a DNA targeting component in light-activated molecular systems, allowing for more selectivity in attacking cancer cells. The new system uses visible light to signal the synthesized bioactive molecules to cleave DNA, reducing damage to healthy tissue.
Plant researchers Sigal Savaldi-Goldstein and Joanne Chory have uncovered the mechanism behind plant growth, showing that the epidermis is the driving force behind cell expansion. The study, published in Nature, reveals a previously unknown mode of communication between shoot tissues.
Researchers have used hot nanoprobes to slow tumor growth in laboratory mice without damaging surrounding healthy tissue. The next step is clinical testing in patients with aggressive human breast cancers.
Researchers found an association between the use of products containing lavender oil and/or tea tree oil and prepubertal gynecomastia in young males. Laboratory studies confirmed that these oils can mimic estrogen effects and inhibit androgen effects, leading to breast tissue growth.
A new study published in PNAS shows that combining anti-angiogenic agents can increase the effectiveness of treatment for tumors and retinopathy. The therapy, which targets multiple angiogenic pathways, resulted in complete inhibition of pathological neovascularization in over 60% of treated eyes.
Researchers at EMBL have identified a microRNA called bantam as the key regulator of the Hippo signaling pathway, which controls cell division and death. Without bantam, tissues grow too slowly and remain smaller than normal.