Articles tagged with Tissue Growth
Genetic variations in metallothionein and zinc transporter genes impact zinc homeostasis and immune function. SNPs may influence the response to zinc supplementation in individuals with certain non-communicable diseases.
Scientists developed a hybrid biosensor scaffold material based on cellulose matrices labeled with pH- and calcium-sensitive fluorescent proteins. This allows visualization of cell growth and metabolism in engineered tissues by microscopy. The study was published in Acta Biomaterialia and has promising prospects for regenerative medicine.
Researchers found significant gaps in understanding microplastic effects, with concentrations detected being orders of magnitude lower than those affecting organisms in lab tests. The study highlights a need for more environmentally realistic studies and better monitoring of specific environmental regions.
Researchers at UNIGE discovered that African elephant skin channels are true fractures of the animal's brittle skin, created by local bending mechanical stress. This unique adaptation allows them to absorb and retain more water than flat surfaces, cooling down through evaporation.
The Cluster of Excellence PoL aims to understand the organization of living matter and its mechanisms. The researchers hope to shed light on tissue formation and structure, which will provide solutions to pressing bioengineering and health issues.
The Human BioMolecular Atlas Program (HuBMAP) aims to create a 3D map of the human body showcasing how tissues differ on a cellular level. This will provide scientists with a deeper understanding of tissue organization, growth, and function, ultimately leading to disease prevention.
Scientists discovered that pollen tubes exert forces similar to car tire pressure as they navigate through plant tissue to fertilize eggs. The research found that cells can 'feel' and respond to physical resistance in their environment, leading to changes in growth patterns.
Scientists at Kyoto University have discovered a protein, AIP1, that plays a crucial role in regulating cell arrangement during wing development in fruitflies. The study reveals how cells sense and respond to tissue tension, which is essential for shaping tissues like wings.
A team of researchers measured the force exerted by plant sperm cells as they navigate female flower tissues using microfluidic technology. The study found that the cellular pressure driving invasion corresponds to that of a car tire, and the pollen tubes adapt their growth pattern in response to physical resistance.
Researchers found that cells undergo self-destruction via trigger waves that travel at a constant speed of nearly 30 micrometers per minute. This process enables large distances to be covered without losing strength or speed, challenging previous assumptions about cell death propagation.
Researchers have identified a mechanism by which fat is transferred into tissues, revealing that blocking key receptors can limit fat delivery. Disabled mice on high-fat diets showed no weight gain, while control mice gained twice as much weight.
A recent study published in Biomaterials found that stiffer breast tissue creates an environment more prone to cancer. Cancer cells can manipulate surrounding healthy cells to their own benefit, favoring tumor growth in stiff tissues.
Researchers at Shinshu University used molecular simulations to understand the binding mechanism of antifreeze glycoproteins in polar fish. The study revealed that AFGPs can 'walk' on ice surfaces, selectively binding to growth points and preventing ice recrystallization.
The American Society for Gastrointestinal Endoscopy has released new guidelines for the use of endoscopic eradication therapy in patients with Barrett's esophagus, a precursor to esophageal adenocarcinoma. The guidelines support evidence-based recommendations and clinical guidelines addressing key issues related to Endoscopic Eradicati...
Research at the University of Helsinki found that diabetic retinopathy is characterized by the growth of new lymphatic vessels in the eye. The study suggests that targeting both lymphangiogenesis and angiogenesis may lead to novel treatments for ischemia and inflammation-associated retinal diseases.
Researchers develop method to grow tiny brain models from human cells, revealing physical forces behind brain folding and potential links to microcephaly, epilepsy, and schizophrenia.
Researchers created a robot to aid in treating babies with oesophageal atresia, a rare genetic disease that affects the infant's oesophagus. The robot stimulates cells by gently pulling on tissue using sensors.
Researchers from NTU Singapore and CMU have developed a technique to direct the growth of hydrogel to mimic plant or animal tissue structure and shapes. The team's findings suggest new applications in tissue engineering and soft robotics, where hydrogel is commonly used.
Researchers at Toyohashi University of Technology developed an ultrastretchable bioprobe using Kirigami designs, reducing strain-force characteristic and enabling low-invasive biological signal recording. The Kirigami-based bioprobes can follow the shape of spherical and large deformable biological samples.
Researchers at the University of Pennsylvania have developed a new dental material that can kill bacteria and resist biofilm growth without harming surrounding tissue. The material is effective with minimal toxicity and can withstand severe mechanical stress.
Researchers found that stem cell injections improved circulation, induced gene expression changes, and reduced inflammation in diabetic mice with peripheral artery disease. The study suggests that stem cell treatment could help alleviate symptoms in severe PAD patients.
Researchers at the University of Michigan found that some obese adults store their body fat more healthily than others, breaking down fat at slower rates and having fewer inflammatory cells. Aerobic exercise may lead to healthier fat storage, with regular exercisers showing increased blood vessels in their fat tissue.
New research reveals fossils from 374-million-year-old tree trunks show interconnected xylem strands that conducted water to branches and leaves. These ancient trees had a unique growth mechanism, with individual strands growing their own rings like mini-trees.
Researchers describe elegantly simple solution to complex problem of how tissues branch and grow, revealing self-organising process that generates space-filling networks. This discovery has huge implications for basic biology, offering new insights into cancer development and potential applications.
Georgina Stooke-Vaughan is investigating the mechanical development of the eye in zebrafish using a novel fluid-based method. The study aims to understand how cells divide, move and position themselves to form the complex organ.
Researchers develop iron-based synthetic antifreeze mimicking natural Antifreeze Proteins (AFPs), which can slow ice crystal growth, making airplane wings safer, ice cream smoother and human tissue for transplantation more stable.
Researchers at the University of Bristol have made a groundbreaking discovery that could lead to a new treatment for heart attacks. Pericytes, cells surrounding blood vessels, stimulate new blood vessel growth with the help of hormone leptin, which may help restore blood supply to damaged heart muscle after a heart attack.
Researchers found that celecoxib, an anti-inflammatory drug, protects stem cells from harsh inflammation during wound repair. The study showed that celecoxib promoted stem cell survival and differentiation into skin cells, leading to better wound healing outcomes.
A new study suggests that ovarian tissue freezing is a superior option to egg freezing for preserving fertility, reversing menopause, and promoting natural conception. Nearly 37% of women who underwent the procedure were able to have children later in life, with nearly two-thirds experiencing restored natural fertility.
The study reveals that morphogens, such as Dpp, are necessary for tissue growth but their concentration gradients do not direct wing growth. The research suggests an alternative mechanism regulates the size of the final wing structure.
A new study challenges the long-debated 'late equals large' hypothesis, which proposes that brain proportions are shaped by a universal rule related to size. The research found that this hypothesis does not work when considering brain growth in different mammals, including marsupials.
A recent gene sequencing study has identified unusual genetic mutations in women with benign endometriosis, a painful disorder marked by uterine tissue growth outside the womb. The findings may eventually help scientists develop molecular tests to distinguish between aggressive and clinically indolent types of endometriosis.
Researchers discovered specific genetic changes in placentas of women who gave birth to growth-restricted infants, which sabotage placental blood vessel growth and fetal nourishment. These changes can be used as a biomarker to predict normal pregnancy and newborn health.
A Purdue University study reveals Listeria monocytogenes can live within romaine lettuce tissue throughout plant growth stages. Exposure to the bacteria can lead to infection in as little as 30 minutes, posing a risk to vulnerable populations.
Activating innate immunity enhances nuclear reprogramming, leading to induced pluripotent stem cells that can regenerate into various tissues. This discovery could revolutionize transplantation and improve wound healing or recovery after a heart attack.
Researchers used live cell time-lapse imaging to investigate maize mutant growth, finding that delays in cell division can lead to growth defects when paired with improper division plane orientation. This study provides crucial details for understanding plant growth and may have long-term implications for developing short-stature maize...
Plant tissues have a preferred direction of growth, essential for producing complex shapes. This characteristic is crucial for understanding how genes influence plant shape formation and could lead to better-adapted crop varieties.
Researchers develop a new peptide that suppresses abnormal blood vessel growth and leakage in the eye, causing regression of established vessels. The peptide lasts longer than current treatments, potentially requiring only annual injections instead of monthly ones.
A new organ culture system developed by Tufts University researchers enables tests of BPA's direct effects on developing fetal mouse mammary tissue. BPA significantly increased tissue growth at environmentally relevant doses, while higher levels inhibited growth.
A Stanford study suggests that the development of face recognition entails brain tissue growth, particularly in regions that distinguish faces from other objects. The research found microscopic tissue growth in these regions, which continues into adulthood and contributes to the differences between face and place recognition areas.
Researchers developed a novel image-based simulation approach that accounts for realistic architectural non-idealities and flow physics in tissue engineering scaffolds. This technology allows for correlating cell behavior and tissue growth with flow, tracking relationships over time via repeated scanning.
A novel signaling pathway involving CDC-42 GTPase directs the movement of cells during intercalation, a process shaping skin tissue in embryonic C. elegans. The study identifies a key regulator determining polarity and guiding cell migration.
Iowa State researchers developed a method to design and fabricate microfibers that support cell growth, which could be used to reconnect nerves and regenerate damaged tissues. The fibers are flexible, biocompatible, and biodegradable, and have been shown to promote neural stem cell survival, differentiation, and proliferation.
A recent study has identified a potential biomarker for assessing pancreatic tumor grade, which could improve diagnostic techniques and treatment strategies. Annexin 6-expressing vesicles were found to support increased tumor growth and metastasis in pancreatic ductal adenocarcinoma tumors.
A new study identifies a previously unknown 'off-switch' for cancer based on the protein TMX1, which can slow down tumor growth and promote resistance to cell death mechanisms. This breakthrough offers hope for developing new therapeutic approaches and improving chemotherapy efficiency.
A UBC research team created a comprehensive model of creping to improve the quality of tissue paper. The new model allows manufacturers to tailor the creping process for optimal softness, flexibility, and strength.
A new study reports that Greenland sharks live at least 272 years and reach sexual maturity at 156 years old. The species now holds the record for the longest-lived vertebrate on Earth.
Researchers at Johns Hopkins University have discovered a protein that boosts the growth of damaged muscle tissue, potentially contributing to treatments for age-related muscle degeneration and diseases like muscular dystrophy. The protein, β1-integrin, promotes stem cell growth and restoration after muscle injury, with results showing...
Researchers have developed a new technique to improve heart tissue transplants by identifying specific patterns of proteins and molecules that promote growth. This study has moved the goal of using patient's own genetic material to grow body tissue closer, with potential applications for other types of tissue regeneration.
Scientists have created a high-tech material that connects neurons in vitro and is compatible with living organisms in vivo. The 'carbon sponge' stimulates growth of nerve fibers and enables functional connections between different neural populations.
Researchers have developed a new method to grow blood vessels in a 3D scaffold, reducing transplant rejection risks and increasing tissue integration. The technique uses human platelet lysate gel and endothelial progenitor cells, paving the way for fully vascularized tissues or organs.
A new study suggests that sodium bicarbonate can reverse the effects of mucormycosis-promoting processes in DKA, a life-threatening condition. The researchers identified key host factors and fungal cell surface proteins that enhance infection and damage.
A new study reveals how cancer cells turn healthy cells to the 'dark side' by using a mutant KRAS gene to release unique growth signals. This discovery could open up new approaches to cancer treatment by understanding the communication loop between cancer-causing genes and healthy stromal cells.
A new NIH study has identified the protein calpain 14 as a possible cause of tissue damage in patients with eosinophilic esophagitis. The researchers found that calpain 14 regulates another protein, desmoglein 1, which is critical for maintaining the integrity of esophageal tissue.
Scientists create miniature retinal organoids that mimic the structure of real retinas, offering new perspectives on retina growth, injury, and repair. The protocol increases yield by up to 4-fold compared to previous methods, enabling researchers to study retinal disease mechanisms and develop therapies for age-related blindness.
A new study provides insight into the role of RNA editing in cancer, identifying over 2,000 genes with significant changes in RNA editing levels between tumor and normal tissues. Researchers found that these changes may be linked to different clinical outcomes.
Researchers found that pyruvate kinase M2 (PKM2) aids wound healing by promoting the development of new blood vessels at the wound site. PKM2 treatment aided early wound closure and promoted higher levels of vessel growth, suggesting its functional role in the wound healing process.
Nanoparticulate drug carriers show promise in targeted cancer therapy, increasing therapeutic concentrations at tumor sites while minimizing harm to healthy tissues. This approach has the potential to improve treatment efficacy and reduce systemic toxicity.
Dartmouth scientists have made a breakthrough in synthesizing rare natural products that promote regeneration and growth of injured nerve cells. The discovery opens up new possibilities for developing therapeutic agents based on these complex compounds.
Researchers at IST Austria have received ERC Starting Grants for their innovative projects in biochemistry and computer science, exploring the mechanisms of self-organizing properties of bacterial cells and developing new cryptographic schemes.