Articles tagged with Tissue Growth
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Dysfunction in mitochondrial respiration leads to imbalanced extracellular matrix (ECM) and tissue organization in cartilage. Research discovered the respiratory chain plays a key role in maintaining ECM balance.
Scientists create a cell culture system where blood vessels can grow within a framework made of synthetic materials. The team investigates material properties that promote blood vessel formation and refines the model to improve its performance, paving the way for growing implantable tissues.
A preclinical study found that high-fructose diets alter villi in the small intestine, leading to increased nutrient absorption and weight gain. Fructose's primary metabolite promotes elongation of villi and supports intestinal tumor growth.
A new ultrasonic method improves fetal weight prediction accuracy by analyzing three-dimensional limb volumes and abdominal circumferences. The algorithm outperforms traditional formulas in predicting macrosomia and birth weights.
Chromosomal instability linked to cellular senescence in Drosophila study reveals mechanisms that could lead to reduced tumour growth and malignancy. Senescent cells cause inflammation and promote abnormal tissue growth.
Scientists at the University of Helsinki discovered that ECM protein Lama5 guides the growth and differentiation of epithelial cells in breast tissue, especially during pregnancy. The production of Lama5 strengthens the functionality of hormone-sensitive cells, allowing them to relay signals and support tissue growth.
Scientists at the University of Tennessee Institute of Agriculture are working on developing biobased peptides to restrict ice crystal growth in freezing temperatures. Successful methods could improve frozen food quality, increase crop resistance to freezing temperatures, and enhance biomedical research.
New research reveals coral can fight back against juvenile crown of thorns starfish with stinging cells, damaging their arms and delaying growth. The study shows coral's defensive mechanism may not be enough to protect it from other threats like climate change.
Researchers from MIPT and ITMO University have created a system for controlled formation of melamine cyanurate crystals, which can be used to deliver drugs directly to specific tissues in the human body. The discovery opens up new possibilities for targeted drug delivery technology.
A team of researchers from the University of Warwick has discovered that even short chains of poly(vinyl alcohol) bind to ice and inhibit recrystallization. This finding sheds new light on the fundamental principles of ice recrystallization, enabling the design of more effective cryoprotectants.
A study found that early exposure to heat and low oxygen can leave lasting scars on oysters' ability to grow tissue. Oysters invested more in growing their shells than tissue when exposed to the double punch of low oxygen and warmer waters. This could pose a problem for anyone involved in the seafood industry.
Researchers from Osaka University and colleagues found that plant root tips converge to a dome shape, similar to arch bridges, due to localized tissue growth. This shape helps evenly distribute mechanical force, enabling roots to efficiently push through soil.
A new technique developed by Brown University researchers reveals the forces involved at the cellular level during biological tissue formation and growth processes. The technique makes use of cell-sized spheres made from a highly compliant polymer material, which can be placed in laboratory cultures of tissue-forming cells.
Researchers from Osaka University successfully generated functional conjunctival tissue in a dish, enabling the study of conjunctivae and the development of novel drugs for dry eye disease. The newly formed tissue contained goblet cells that produce mucins, mimicking human conjunctival biology.
Researchers developed ice recrystallization inhibitors to halt ice growth in frozen samples, improving cell recovery and function. The technology prevents cellular damage caused by ice crystals, allowing for more efficient storage and transport of biological materials.
Plant roots can sense compacted soils through ethylene hormone signals, hindering growth. Mutant roots insensitive to ethylene penetrate compacted soils more effectively.
The SCOUT pipeline enables quantitative comparisons among unique organoids by extracting comparable features. Researchers use it to identify patterns in cell configurations, highlighting similarities and differences across organs
A UMass Medical School study finds that low levels of PAPPA, commonly screened for chromosomal disorders, are associated with adipose tissue remodeling and gestational diabetes. The protein is linked to insulin-like growth factor-1 (IGF-1), which promotes healthy adipose tissue development during pregnancy.
A novel bypass route for coronary vessels in the heart has been discovered using the VEGF-B growth factor, which can stimulate new blood vessel growth in damaged areas. This finding opens up possibilities for treating myocardial infarction by re-activating embryonic vessel growth programs.
Researchers developed an algae-based 3D bioprinting method to incorporate vascular patterns within engineered tissues and provide a sustainable source of oxygen for human cells. The approach showed promise for applications in disease modeling, drug development, regenerative and personalized medicine.
Research using functional MRI found that brain networks involved in movement planning and execution are activated differently based on the type of movement performed, even when using different body parts. The study suggests that these brain functions emerge from innate constraints in early development.
Researchers found that a protein called Rictor plays a key role in regulating stem cell metabolism, which can help prevent hair loss. The study used a genetic mouse model to demonstrate that the absence of Rictor protein impaired stem cell function and led to hair loss.
Researchers have identified NRXN1, a cell adhesion molecule, as a potential target for antibody-drug conjugate (ADC) therapy in small cell lung cancer. The study found that targeting NRXN1 with ADCs exhibited anti-tumor activity in SCLC cells.
Researchers at EPFL create miniature intestines using stem cells and hydrogel scaffolds, achieving high physiological relevance. The new organoids can regenerate, model inflammatory processes, and host-microbe interactions, opening up exciting perspectives for disease modeling, drug discovery, diagnostics, and regenerative medicine.
Researchers document rapid acceleration and thinning of Pine Island and Thwaites Glaciers in Antarctica. The growth of damage areas on the ice shelves compromises integrity and drives further disintegration, highlighting the importance of incorporating damage processes into ice sheet models.
Researchers identified key drivers of secondary growth resumption in Northern Hemisphere conifers, including photoperiod and mean annual temperature. These factors interact with spring forcing and moisture availability to regulate wood formation.
Scientists have discovered a compound in the American beautyberry leaves that works in combination with oxacillin to knock down resistance to the drug methicillin-resistant Staphylococcus aureus, or MRSA. The study suggests a new potential therapy for treating antibiotic-resistant infections.
Researchers at CU Boulder have discovered a synthetic molecule that mimics natural antifreeze proteins, minimizing freeze-thaw damage and increasing the strength of concrete. This new method challenges conventional approaches and has the potential to reduce costs and decrease carbon emissions.
A preclinical study led by Children's Hospital Los Angeles surgeon Tracy Grikscheit successfully grew a fully functional gut nervous system in a pre-clinical model, offering hope for babies with Hirschsprung's disease. The study uses tissue engineering to grow the complete nervous system from scratch.
Scientists studied mouse tail skin expansion from birth to adulthood, finding that it grows by a factor of 15 through self-duplication of developmental progenitors. Cell proliferation rates decreased over time, while single-cell RNA sequencing revealed molecular features of developmental progenitors.
A new combination of 3D printing and acoustic droplet ejection technology enables precise control over growth factor presentation, promoting osteogenic differentiation in C2C12 mouse myoblast cells. This technique has vast potential for various tissue types beyond bone engineering.
Pulsed electromagnetic field therapy significantly decreases prostate volume and improves lower urinary tract symptoms in men with benign prostatic hyperplasia. Men without metabolic syndrome benefit most from the treatment.
Researchers have identified a gene linked to brain cancer in children that can aid in diagnosis and treatment. Elevated levels of the TPR gene were found in 38% of ependymoma cases, and its deletion led to reduced cancer growth and tumor shrinkage when treated with rapamycin.
Researchers at Stanford University have discovered the invisible pattern that growing neurons follow to form a brain using microscopy and mathematics. The technique could be used to coax stem cells to grow into replacement body parts, such as artificial organs.
Researchers at IRB Barcelona discovered that Dpp and Wg morphogens stimulate growth through independent pathways, regulating organ proportions. The findings have significant implications for understanding malformations and congenital diseases in humans.
Researchers have identified three proinflammatory mediators driving capillary regression, a common feature of many diseases. The study found that combining drugs to block these mediators can prevent capillary loss and improve outcomes.
Researchers have identified a genetic signaling pathway that limits tissue growth in planarian flatworms, allowing for precise regeneration and repair. The mob4 gene suppresses tissue growth by preventing the production of Wnt, a protein involved in cancer cell regeneration.
Old Ginkgo biloba trees display similar gene expression for flavonoids and other resistance genes in young and old trees. Increasing age is not accompanied by a significant decrease in leaf area or growth rate, suggesting that these trees may stay healthy due to robust stress defenses.
Researchers at the University of Birmingham propose a groundbreaking design approach for additive manufacturing inspired by human growth and development. By leveraging insights into developmental biology, they unlock new potential for the creation of innovative materials and products.
Researchers have identified a genetic program controlling the development of beige fat cells, which can convert energy into heat. The study's findings suggest that people with more thermogenic fat cells may be less likely to develop obesity and related metabolic disorders.
Researchers studied the cup-shaped traps of Utricularia gibba and found that differential rates and orientations of growth are involved in shaping. A polarity field comparable to that proposed for flat leaves was also detected, providing a unified explanation behind diverse leaf forms.
Researchers developed a framework to describe the process of ultrastructural morphogenesis of molluscan shells. They demonstrated that mineral phase growth is guided by regulating chemical and physical boundary conditions, influencing shell architecture and evolution.
Researchers analyzed 33 studies on laser-induced forward transfer (LIFT) bioprinting to optimize techniques and materials. They found that LIFT technology provides precise cell transfer and precise 3D printing capabilities, with potential applications in tissue transplantation.
New research suggests that understanding plant biological clocks can refine the use of chemicals like glyphosate, allowing for more efficient and sustainable agriculture practices. By applying treatments at optimal times, farmers can reduce herbicide usage, saving time and money while minimizing environmental harm.
Research reveals lavender oil exposure contributes to premature breast development in young girls and boys. Discontinuing use of lavender-containing products resolves the issue, suggesting essential oils mimic estrogen and block testosterone.
A new approach from Harvard researchers uses a biomaterial scaffold and childhood vaccines to attract and activate T cells that promote revascularization of ischemic tissues. The technique increases the concentration of T cells at the ischemic site and stimulates angiogenesis, blood flow, and muscle fiber regeneration.
Researchers identified a crucial protein, Tox, that triggers dysfunctional immune responses in the body. This 'exhaustion mode' can be beneficial as it prevents excessive damage to cells and tissue but also allows tumor growth.
Scientists at Stanford University School of Medicine have discovered a molecular pattern that flags prostate enlargement and identified two genes likely playing a role in its development. The researchers found that only certain cell types multiply, leading to a fundamental shift in the type of cells making up the prostate.
Researchers have created a new type of hydrogel that can grow new tissue to heal wounds, eliminating the need for external growth factors. The hydrogels are made with biomolecules anchored in crosslinkers and can be mixed at room temperature.
Researchers at Universite Paris-sud studied how collagen fibrils form complex tissues. They found that the fibers grow in a unique, parabolic profile, with a constant diameter throughout growth, similar to a sunflower's florets.
Researchers at CNIC have identified a cellular and molecular mechanism that can induce productive angiogenesis in ischemic tissues. The newly discovered mechanism suggests that manipulating it could lead to optimal therapeutic angiogenesis, which may help treat cardiovascular disease.
Researchers discovered that stem cells in the neural retina act as 'bosses' during growth, telling cells in the retinal pigment epithelium when to create more cells. The study reveals an unappreciated mechanism for growth coordination, where one tissue gives cues to synchronise the growth of nearby tissues.
Researchers at Kazan Federal University have developed a two-gene medication that recovers motor functions in rats after spinal cord injuries. The medication, which targets VEGF and FGF2 genes, stimulates axon growth and regeneration by increasing blood flow and neuron survivability.
New research suggests that moderate water intake can reduce kidney cyst growth and fibrosis in people with polycystic kidney disease (PKD). Increased water consumption was also found to have secondary benefits, including reducing high blood pressure and cardiovascular risks associated with PKD.
Research by De Rybel (VIB-UGent) and Helariutta (SLCU) reveals that DOF-type transcription factors control plant radial growth, enabling targeted breeding for higher biomass production. This understanding can improve atmospheric carbon sequestration and increase crop yields.
Researchers have discovered a crucial mechanism for removing faulty proteins from cells, which may aid understanding of neurological diseases and anaemia. By studying the yeast protein Hel2, they found that this process is essential for maintaining cellular health.
A team of researchers at Stanford University has discovered a signaling molecule that promotes the growth of small arteries leading into oxygen-starved heart tissues, offering hope for new treatments. The protein, CXCL12, is activated in response to low oxygen levels and helps heal damaged heart tissue.
International research teams identify key regulatory networks controlling radial growth in plants, enabling the development of more efficient carbon sinks and increased vegetable crop yields. The study reveals complex mechanisms behind plant stem cell activity and vascular tissue formation.
Genetic variations in metallothionein and zinc transporter genes impact zinc homeostasis and immune function. SNPs may influence the response to zinc supplementation in individuals with certain non-communicable diseases.
Scientists developed a hybrid biosensor scaffold material based on cellulose matrices labeled with pH- and calcium-sensitive fluorescent proteins. This allows visualization of cell growth and metabolism in engineered tissues by microscopy. The study was published in Acta Biomaterialia and has promising prospects for regenerative medicine.