Articles tagged with Tissue Regeneration
The MDI Biological Laboratory has received a $456,500 NIH grant to study chemotherapy-induced peripheral neuropathy. Dr. Sandra Rieger's research will focus on the molecular mechanisms underlying paclitaxel-induced peripheral neuropathy and its potential applications for other sensory neuropathies.
A new regenerative bandage heals diabetic foot ulcers faster and promotes healing without cancer risk, according to Northwestern University researchers. The bandage delivers a protein that recruits stem cells and creates new blood vessels, improving wound repair.
Researchers at MDI Biological Laboratory decipher genetic code controlling limb regeneration in zebrafish, axolotl, and bichir, revealing common genetic regulators. The discovery may lead to new therapies for wound healing and prosthetic device development, but a timeline for regrowing limbs remains uncertain due to funding constraints.
Kelly Schultz's NIH-funded project focuses on characterizing how mesenchymal stem cells interact with synthetic material to advance biomaterial design and tissue engineering. By understanding cell behavior in 3D environments, researchers hope to engineer cells to move faster, enabling quicker wound healing and tissue regeneration.
Researchers at Tokyo Institute of Technology identified fgf20a and fgf3/10a as major fibroblast growth factor ligands involved in fin regeneration. Fgf signalling acts directly on fin ray mesenchyme to form a blastema, promoting cell proliferation and tissue recovery.
Researchers at Drexel University discovered that a specific type of ceramic scaffold causes macrophages to transform into an M2c phenotype, promoting bone regeneration. Direct contact between macrophages and scaffolds is essential for this process.
Researchers utilized Regeneration Intelligence to evaluate signaling pathways in lung and liver fibrosis and glaucoma, identifying potential biomarkers and therapeutic targets. The study suggests that pathway signatures may play a role in aging-related diseases.
Researchers at Pitt School of Medicine identify mechanism by which bioscaffolds influence cellular behavior, promoting tissue repair and reconstruction. The study reveals the presence of nanovesicles in bioscaffolds, which enable cellular communication and facilitate regenerative processes.
A study suggests that stem cell infusion could help restore the trabecular meshwork, which drains fluid from the eye and prevents glaucoma. Researchers are confident that this approach may hold promise for primary open angle glaucoma, but further studies are needed to confirm its effectiveness.
A key gene called AUF1 determines whether adult stem cells can regenerate muscle after injury and with age. The study found that mice engineered to lack the AUF1 gene showed reduced stem-cell-driven repair, leading to muscle breakdown.
Researchers at the University of Pittsburgh School of Medicine and McGowan Institute for Regenerative Medicine showed significant improvement in strength and range of motion, as well as evidence for skeletal muscle regeneration in patients treated with bioscaffolds. The study demonstrated the effectiveness of regenerative medicine in i...
Researchers have developed a new technique to improve heart tissue transplants by identifying specific patterns of proteins and molecules that promote growth. This study has moved the goal of using patient's own genetic material to grow body tissue closer, with potential applications for other types of tissue regeneration.
Researchers found that a protein called b1-integrin is crucial for muscle regeneration in aged muscles. The team's study provides a promising target for therapeutic intervention to combat muscle aging or disease. By restoring the function of b1-integrin, regenerative abilities were restored to youthful levels in mice with aged muscles.
Scientists at the Buck Institute used a naturally occurring anti-inflammatory factor called MANF to promote tissue repair and regenerative success in the retina of mice. The discovery holds promise for treating chronic inflammatory diseases of the eye, including macular degeneration.
The MDI Biological Laboratory will host a lecture series on the science of aging, featuring leaders in the field who will discuss life-extending treatments and cellular recycling processes. The lectures will explore how these advances may lead to therapies that prolong healthy lifespan and address age-related diseases.
The MDI Biological Laboratory is launching a new signature course on aging research, bringing together experts to study the molecular mechanisms of aging across various species. The course will focus on current paradigms of aging research and emphasize the advantages of using animal models to study human aging.
The FDA draft guidelines aim to restrict the use of human cell and tissue products in various surgical procedures, potentially hindering the development of new therapies. This could impact surgeons performing reconstructive surgeries, such as breast, chest, and abdominal wall reconstructions, as well as pelvic floor reconstruction.
Researchers discovered that heart muscle cell chromosomes rapidly erode after birth, limiting their ability to proliferate and replace damaged heart tissue. Maintaining telomere length may boost regenerative capacity, improving cardiac tissue recovery after a heart attack.
Researchers found that sea urchins with shorter life expectancies do not experience a decline in regenerative capacity with age, contradicting the prevailing theory on evolution of aging. The study suggests that aging may not be inevitable and could be influenced by other factors.
Researchers have developed a new method to grow blood vessels in a 3D scaffold, reducing transplant rejection risks and increasing tissue integration. The technique uses human platelet lysate gel and endothelial progenitor cells, paving the way for fully vascularized tissues or organs.
A team of biologists at New York University found that plants can reconstitute their stem cells from mature cells by replaying embryonic development. This process involves the recruitment of specialized cells to create a new set of stem cells, highlighting the importance of tissue behavior over stem cell properties.
Researchers have discovered a new mechanism for wound healing called wound-induced polyploidy (WIP), which maintains tissue size and function by enlarging existing cells rather than dividing new ones. This discovery has significant therapeutic potential for treating various human diseases.
TP508 has significantly increased survival and delayed mortality when injected up to 24 hours after lethal radiation exposure in controlled preclinical studies. The award brings total NIAID funding to over $6M and allows Chrysalis to complete FDA approval studies.
Researchers found that nicotinamide riboside improves mitochondrial function in stem cells, leading to better regeneration processes in aged mice. The compound also showed promising effects on the brain and skin, with potential implications for regenerative medicine.
The MDI Biological Laboratory has received a $20,000 grant from the Glenn Foundation For Medical Research to support a two-week research training course on aging biology. The course will use four animal models to study molecular pathways and explore evolutionarily conserved mechanisms of aging.
Researchers from Johns Hopkins Medicine found that immune cells associated with allergies can promote healing of mouse muscle wounds when paired with biomaterial scaffolds. The discovery suggests a pivotal role for type 2 helper T cells in regulating the regenerative process, which may lead to novel strategies for tissue regeneration.
Researchers at MDI Biological Laboratory have identified a common mechanism underlying peripheral neuropathy, which causes pain and numbness in the hands and feet. The discovery raises hope for the development of drug therapies to treat this condition, affecting nearly 8 million people in the US.
Researchers found that genetically modified cord blood cells carrying VEGF and GDNF transgenes can promote tissue sparing, axonal regeneration, and motor function recovery in rats with spinal cord injuries. The study suggests these cells may be a promising strategy for enhancing posttraumatic spinal cord regeneration.
A team of US doctors successfully reconstructed a severely damaged oesophagus using commercially available FDA-approved stents and skin tissue in a critically ill patient. The patient, who was paralyzed from an earlier car accident, continues to eat a normal diet with no swallowing problems seven years after the procedure.
Researchers have discovered regulatory sequences in zebrafish that can turn on genes involved in regeneration, which also exist in humans. These 'tissue regeneration enhancer elements' or TREEs may hold the key to improving human regenerative capabilities through genome editing technologies.
Researchers have developed a stem cell repair system similar to salamander limb regeneration, capable of regenerating human tissue damaged by injury, disease or ageing. The technique involves reprogramming adult fat cells into induced multipotent stem cells (iMS) that can repair multiple tissue types.
Researchers found that larval newts use stem/progenitor cells for muscle regeneration, while metamorphosed newts recruit skeletal muscle fiber cells. The study also revealed that skin, bone, muscle, and nerve tissues can regenerate faithfully in both stages of development.
Scientists have successfully directed stem cell-derived neurons to regenerate lost tissue in damaged corticospinal tracts of rats. This breakthrough improves forelimb movements and upends the existing belief that corticospinal neurons lack internal mechanisms for regeneration.
An international team at the MDI Biological Laboratory is studying the role of dietary restriction in extending human lifespan. Researchers are investigating how lower amounts of food or food with lower energy content affect molecular regulators of gene expression, a key player in aging.
Scientists have developed a system to track individual cells in regenerating skin tissue using color-coding, enabling the study of cellular responses to injury and tissue regeneration. The Skinbow system uses technicolor zebrafish with permanent barcodes on their cells, allowing researchers to monitor cell movements and changes over time.
Research published in Nature found that brief restriction of amino acids can dampen intestinal inflammation in mice, mediated by the GCN2 molecule. Mice fed low protein diets or lacking GCN2 were protected from colitis-like symptoms.
Researchers at Tel Aviv University have developed a cyborg cardiac patch that combines organic and engineered parts to regulate its own function, monitor vital signs remotely and release medication on demand. The invention has the potential to revolutionize cardiac research and treat heart disease.
Scientists at IRB Barcelona have identified two molecular signals and a pathway that allows differentiated cells to regain their stem cell properties. This discovery has implications for cell reprogramming, regenerative medicine, and understanding cancer.
A team of researchers at Massachusetts General Hospital has successfully regenerated functional heart muscle in decellularized human hearts using stem-cell derived cells. The study involved the use of induced pluripotent stem cells (iPSCs) reprogrammed from skin cells, which were then differentiated into cardiac muscle cells and reseed...
A new treatment approach has been developed to remove congenital cataracts in infants and allow remaining stem cells to regrow functional lenses. The method produced fewer surgical complications and resulted in superior visual function compared to the current standard-of-care.
Assistant Professor Voot Yin has identified the role of microRNA miR-101a in stimulating heart muscle cell growth and removing scar tissue. This breakthrough research holds promise for developing new drugs to regenerate damaged heart tissue and potentially treating other diseases involving muscle damage.
A University of Alberta study found PRP injections to be effective in improving tissue healing, reducing pain, and increasing mobility in patients with chronically sore shoulders. The treatment involves injecting platelet-rich plasma into the affected area to augment the body's natural healing response.
Researchers at MDI Biological Laboratory have discovered two drugs that could reverse peripheral nerve damage caused by chemotherapy, with applications also for diabetes and traumatic injuries. The drugs reduce MMP-13 activity, preventing degeneration of axons and restoring touch response in zebrafish.
Regenerative medicine scientists at Wake Forest Baptist Medical Center have developed a novel 3D printing system that can produce living tissue structures with functional blood vessels. The system uses bio-degradable materials and water-based gels to promote cell growth, enabling the creation of complex tissues such as bone, muscle, an...
Researchers at Sanford Burnham Prebys Medical Research Institute have identified the protein complex controlling muscle gene expression, resolving a longstanding issue in muscle regeneration. The discovery sheds light on molecular targets for regenerative medicine-based interventions to treat muscle degenerative disorders.
Researchers examine human digit healing and regenerative potential, identifying key components required for complex tissue development. The goal of epimorphic regeneration, which would enable humans to grow entire limbs, is considered a radical approach that could transform prognosis and quality of life for amputees.
Researchers at the Wyss Institute have discovered that cyclic mechanical stimulation can improve muscle regeneration and reduce scarring, opening doors for new non-biologic therapies. The study used murine models of muscle injury and found a two-and-a-half-fold improvement in muscle regeneration with both magnetized gel and robotic cuf...
Researchers discovered that human macrophages can divide and self-renew by activating a gene network similar to one found in embryonic stem cells. This finding could provide new directions in regenerative medicine and therapies, potentially replacing diseased tissue without using embryonic or induced pluripotent stem cells.
Dartmouth scientists have made a breakthrough in synthesizing rare natural products that promote regeneration and growth of injured nerve cells. The discovery opens up new possibilities for developing therapeutic agents based on these complex compounds.
A new study by Penn and Delaware researchers sheds light on the mechanics and biology of natural and engineered tissue, informing ways to treat injuries like knee meniscus tears and age-related tissue degeneration. The team developed micro-engineered models that replicate key features of degenerating native tissue, enabling testing of ...
Researchers at UT Southwestern Medical Center found that stopping the production of new neurons in the brain following TBI can help reduce epileptic seizures, cognitive decline, and impaired memory. This process, called neurogenesis, is sometimes hyperexcitable, disrupting neural circuits and causing recurring seizures.
Researchers use super-resolution technologies to observe muscle stem/progenitor cells migrating into place guided by 'ghost fibers,' remnants of the old extracellular matrix left by dying muscle fibers. This study reveals that these ghost fibers serve as architectural units guiding the regeneration of muscle tissue.
Researchers at Karolinska Institutet have successfully engineered new diaphragm tissue in rats using stem cells and 3D scaffolds, which can regrow with the same complex mechanical properties as natural diaphragm muscle. The technique offers hope for a cure for congenital diaphragm malformations and possible future heart muscle repairs.
Researchers at Oregon State University have developed a new method for vitrification that minimizes cell damage during the freezing process. This approach has shown significant improvement in healthy cell survival rates, paving the way for wider use of extreme cold preservation for tissues and organs.
A NASA study found that exposure to microgravity inhibits the ability of mouse embryonic stem cells (mESCs) to differentiate and generate most cell lineages. This inhibition has significant implications for human tissue engineering and the use of stem cells to regenerate adult tissues.
Researchers have sequenced the genome of Macrostomum lignano, a flatworm that can regrow its body parts, to gain insights into its regenerative abilities and advance stem cell biology. The genome's complex structure holds promise for studying developmental pathways and gene expression involved in regeneration.
Researchers have discovered how zebrafish rebuild their skeleton after losing parts of their fins. A critical enzyme called Cyp26b1 helps to regulate retinoic acid levels, allowing osteoblasts to revert and form new bone tissue. The regeneration process relies on a complex navigation system involving signaling proteins and cell types.
A study by Swiss researchers evaluated the therapeutic potential of human fetal progenitor tenocytes (hFPTs) for tendon regeneration. The research found that hFPTs can stimulate adult tenocytes and potentially accelerate healing, with the possibility of reducing scarring.
Scientists at the University of York have developed a technique to rejuvenate human cells from older people with osteoarthritis, allowing them to repair worn or damaged cartilage and reduce pain. The researchers recreated similar conditions in the laboratory by growing human cells as 3D aggregates, enabling them to generate new tissues.
Hybrid hepatocytes, discovered by researchers at University of California - San Diego School of Medicine, have been found to proliferate and replenish liver mass after chronic liver injuries, showing promise as a therapeutic option for liver diseases. Unlike induced pluripotent stem cells, hybrid hepatocytes do not contribute to cancer.