Articles tagged with Tissue Regeneration
Scientists develop a method to create replacement intestine tissue in the lab using a patient's own cells, which can help treat infants with short bowel and adults with large pieces of gut removed due to cancer or inflammatory bowel disease. The new technique also shows promise for engineering anal sphincters to treat fecal incontinence.
A team of researchers has developed a novel method to regenerate bone tissue using the protein signals produced by stem cells. The approach is more sustainable and less risky than current standard therapies, which rely on ground-up bones from cadavers.
A study published in Science Translational Medicine uses a computer simulation to replicate known individual outcomes and predict population results for traumatic injury. The model accurately predicted hospital length of stay and multi-organ dysfunction, but found limitations in extrapolating from single mechanisms to outcomes.
A recent study by Duke University researchers has shed light on the epicardium, a mysterious outer layer of the heart known to regrow cardiac tissue in zebrafish. The findings suggest that this layer is critical for regeneration and may hold key to repairing damaged hearts in humans.
Researchers discovered that controlling the innate immune system's reaction to tissue-engineered vascular grafts can reduce abnormal narrowing and increase graft performance. The study sets the stage for developing safe and effective vascular grafts for congenital heart disease treatment.
Researchers have developed a novel synthetic material that can self-assemble into nanostructures to support tissue growth and ultimately degrade. This biofunctional coating stimulates the formation of complex tissues, offering a promising approach to deliver cell and tissue therapies.
Researchers have developed a new method for muscle regeneration using autologous minced tissue grafts, which can restore functional muscle at the site of injury. The approach uses a collagen hydrogel-based expansion method and demonstrates similar functional recovery as donor muscle grafts with reduced tissue requirements.
Researchers found that lung tissue can repair itself by using mature lung cells to regenerate new ones. Type 1 cells can transform into Type 2 cells to produce surfactant and help with gas exchange. This discovery has implications for treating conditions like COPD.
Researchers at MIPT have successfully grown fully functional cardiac tissues from cardiomyocytes using a genetically modified spider silk substrate. The study, published in PLOS ONE, demonstrates the potential for regenerative medicine to overcome transplant rejection by finding suitable substrates for cell growth.
Researchers developed new plasma models applicable to medicine using data on oxygen ion transport and interaction with water molecules. These models account for how discharges are created in water vapour, enabling the development of novel therapeutic treatments for wound healing and dermatology.
Researchers found that cancer drug epothilone reduces scar tissue and stimulates growth in damaged nerve cells, promoting neuronal regeneration. The study suggests a potential new treatment for spinal cord injuries.
Researchers found that young mice don't possess cellular machinery for regeneration after weaning, leading to reduced insulin secretion and replication of beta cells. A new developmental step in beta cell maturation is triggered by dietary change from high-fat milk to chow.
Scientists found a receptor protein called gp130 that activates signaling pathways stimulating stem cell proliferation and survival, leading to healing and repair. This discovery has implications for developing new treatments for colorectal cancer and inflammatory bowel disease.
Researchers developed a new device, Bio-P3, to create and assemble 3D tissue constructs densely packed with living cells. The device can pick up, transport, and release multi-cellular microtissues with minimal effects on cell viability.
A study by UT Southwestern Medical Center investigators found that patients with heart failure who used left ventricular assist devices (LVADs) for six months or longer showed significant regeneration of heart muscle. Oxidative damage to a cell-regulator mechanism was prevented, leading to an increase in cardiomyocyte proliferation.
Researchers at Columbia University Irving Medical Center have developed a way to replace the meniscus with a personalized 3D-printed implant infused with human growth factors, promoting tissue regeneration in sheep. The therapy could provide an effective and long-lasting repair of damaged menisci, reducing the risk of arthritis.
The Deutsche Forschungsgemeinschaft (DFG) is funding eight new Collaborative Research Centers (CRCs), with a total budget of €62 million. The centers will focus on near-wall turbulent chemically reacting multiphase flows, spin excitations in semiconductor materials, and the discourse of weakness and resource regimes after acute trauma.
Researchers discovered that WNT signaling molecules are crucial for cellular reprogramming, a process similar to regenerative processes in organisms. This finding has significant implications for stem cell-based regenerative medicine, wound repair therapies and potential cancer treatments.
Researchers found that administering stem cell factor directly into damaged heart muscle after a heart attack can help repair and regenerate injured tissue. The study showed improved cardiac function, reduced cell death, and increased regeneration of heart tissue blood vessels.
Researchers have identified a type of adult lung stem cell that contributes to lung regeneration after damage. The study found that these cells, known as p63+/Krt5+, proliferate upon injury and form new alveoli near sites of inflammation, highlighting their potential for therapeutic strategies.
Researchers at Salk Institute have healed injured hearts of living mice by targeting four specific molecules that suppress regenerative programs. This finding provides proof-of-concept for a new type of clinical treatment to fight against heart disease, which kills over 600,000 people annually in the US.
Scientists successfully reconstructed a patterned piece of spinal cord in 3-D culture using mouse embryonic stem cells. The study demonstrates the potential for in vitro growth of spinal cord structures and shows correct spatial organization of motor neurons, interneurons, and dorsal interneurons along the dorsal/ventral axis.
Researchers at the University of Washington have developed a way to use high-intensity sound waves to create cellular scaffolding, a unique approach that could help overcome one of regenerative medicine's significant obstacles. The technique involves using boiling histotripsy to decellularize tissues, leaving behind a fibrous network t...
Researchers found that asynchronous cell repair causes muscle fibrosis in Duchenne muscular dystrophy patients, leading to progressive weakness and tissue replacement. This study suggests that resynchronizing regenerative processes could be a potential treatment for fibrosis.
Dr. Lijie Grace Zhang is developing a novel 3-D bioprinted smart vascularized nano tissue to address critical-sized bone defects and inadequate vascular networks in transplant patients. Her project combines nanobiomaterials, tissue engineering, and drug delivery with advanced 3-D bioprinting techniques.
A team led by Arun Sharma has developed a system to protect against inflammatory reactions that can hinder tissue growth and function. Using self-assembling peptide amphiphiles, they demonstrated superior bladder function in a urinary bladder augmentation model.
Researchers found MSCs in patient's blood after severe trauma, suggesting they are released from bone marrow into bloodstream following organ damage. The study provides conclusive evidence for the mobilization and migration of MSCs in humans.
Researchers used CRISPR/Cas9 to correct genetic mutations leading to Duchenne muscular dystrophy in a mouse model, preventing progressive muscle weakness and degeneration. The technique may lead to permanent correction of the disease, offering hope for future therapeutic applications.
Joan Brennecke's research on ionic liquids may lower energy required to capture carbon dioxide, while Ali Khademhosseini's work creates stretchy sealants for surgical applications.
Researchers have discovered that preventing abnormalities in the insulating sheath surrounding nerve cells is associated with better function following neurotrauma. Treatment strategies, including calcium channel inhibitors and red/near-infrared irradiation therapy, can preserve myelin and prevent long-term loss of function.
CNIO researchers identify Sox4 as a crucial gene in tissue maintenance, with implications for aging and cancer. Mice deficient in Sox4 exhibit accelerated aging, osteoporosis and age-related illnesses but resist cancer development.
A study published in Neural Regeneration Research found that fructose-1,6-diphosphate reduces mitochondrial swelling and increases synaptic active zone length in hippocampal CA1 area. The compound has neuroprotective effects against repeated febrile convulsions-induced hippocampal neuron and synapse damage.
Manuel Serrano proposes a new vision of cellular senescence as a mechanism to eliminate unwanted cells and promote tissue regeneration. Recent research reveals that senescence is not intrinsically negative for the organism, but rather a protective mechanism against cell damage.
The University of Chicago is creating a new professorship in tissue engineering, supported by a $3.5 million donation from the Millicent and Eugene Bell Foundation. This endowed chair will foster scholarship on tissue engineering at the MBL and Institute for Molecular Engineering.
Researchers have discovered the gene zic-1, which enables planarians to regenerate their heads after decapitation. The study suggests that this ancient mechanism could be used to create tissue organizers for enhancing injury repair in humans.
A new review article suggests that embryonic and induced pluripotent stem cells are not the only source of all three germ layers in the human body. Adult pluripotent stem cells are located throughout the body and can become every tissue, provided they receive the right instructions.
Researchers have successfully printed artificial vascular networks using a high-tech 'bio-printer', paving the way for large complex tissues and organs. The study achieved significant improvements in cell survival, differentiation, and proliferation.
A Harvard research team found that transplanting mesenchymal stem cells with blood vessel-forming cells improves results in mice. The co-transplantation method keeps the mesenchymal stem cells alive longer, enabling them to display their full regenerative potential and generate new bone or fat tissue.
Researchers discovered oxytocin's indispensable role in healthy muscle maintenance and repair, finding that it declines with age in mice. Administering oxytocin improved muscle healing in old mice, while blocking its effects compromised their ability to repair tissue.
A University of Rochester research team has created a technique that keeps stem cells in place, resulting in faster and better tissue regeneration. The key is encasing the stem cells in polymers that attract water and disappear when their work is done.
A Harvard-led team uses low-power laser therapy to stimulate human dental stem cells into forming dentin, a hard tissue similar to bone. The approach, led by David Mooney, could radically shift dental treatment and lead to broader clinical applications in regenerative medicine.
Researchers at Stanford University School of Medicine have identified a new cell-cycle phase in resting stem cells, dubbed an 'alert' state, which enables them to rapidly respond to tissue damage. This systemic response is distinct from fully resting or activated stem cells and has been observed in various types of injuries.
A study published in Neural Regeneration Research found that pro-urokinase is more effective than urokinase in dissolving blood clots and promoting angiogenesis. However, it did not reduce neuronal apoptosis after acute cerebral ischemia.
Researchers at the University of Illinois have developed materials that can heal and regenerate, filling in large cracks and holes by regrowing material. This technology has the potential to transform commercial goods and aerospace applications, enabling self-repairing plastics with vascular networks filled with regenerative agents.
New study finds that beta-catenin plays a critical role in promoting recovery of hematopoietic stem cells after radiation exposure. The researchers discovered that mice deficient in beta-catenin had impaired hematopoietic stem cell regeneration and bone marrow recovery after radiation.
Researchers discovered that salamanders can regenerate their hearts within six weeks by activating stem cells from the blood. This finding raises hope for new treatments for people with damaged tissue, potentially paving the way for clinical trials and improved therapies.
Researchers at Karolinska Institutet successfully transplanted a regenerated esophagus into rats, showing regeneration of nerves, muscles, epithelial cells and blood vessels. The breakthrough could improve survival and quality of life for patients with oesophageal disorders.
Ginsenoside Rb1 attenuates damage to cerebral cortex neurons by downregulating nitric oxide, superoxide, and tumor necrosis factor-α expression in hypoxia-activated microglia. The study suggests that ginsenoside Rb1 is a promising candidate for clinical use in preventing neuronal degeneration following cerebral ischemia.
Researchers isolated very small embryonic-like stem cells from human adult tissues and demonstrated their ability to differentiate into multiple cell types, including bone, neurons, and connective tissue. The study provides evidence that these multipotent stem cells could be used for regenerative therapies.
A new discovery identifies a key protein called PCAF that promotes nerve growth in the central nervous system, leading to increased nerve fibers regrowing. The study suggests that PCAF may be used to trigger nerve regeneration and potentially lead to recovery from spinal cord injury or brain trauma.
Researchers found that Kaixin Jieyu Fang reduces cerebral white matter damage by increasing Bcl-2 protein and mRNA expression, while decreasing Bax protein and mRNA expression. This compound may provide a potential therapeutic approach for treating vascular depression through its protective effects on the brain.
Researchers have discovered that zebrafish regenerates its caudal fin by a process involving V-ATPase, which pumps hydrogen ions to generate an electrical current. This finding has implications for understanding adult tissue regeneration and developing new therapeutic strategies.
Tracheal bioengineering should be demonstrated as both effective and safe before further transplants. The authors report high mortality and morbidity rates among patients who received bioengineered tracheas, casting doubt on the field's current state.
Researchers developed polymorphonuclear leukocyte-derived novel pro-resolving medicines (NPRMs) to deliver a lipoxin A4 analog to the site of surgery, controlling inflammation and promoting tissue and bone growth. The mini-pig model revealed significant pocket depth reductions and new bone formation in NPRM+LXA4-treated sites.
Researchers at Harvard Medical School and University of Sydney develop elastic hydrogel-based cardiac tissue that beats in synchrony with natural heart muscle. The breakthrough could lead to repairing damaged hearts without organ transplants, revolutionizing the treatment for millions worldwide.
Researchers create mathematical modeling tool to analyze image data and understand cell clustering mechanisms. This breakthrough could aid in growing human tissues like liver in laboratory settings.
Researchers have developed novel techniques for engineering lungs using 3D scaffolds, enabling high-throughput studies of human lungs and accelerating progress towards lung tissue regeneration. The new methods allow for selective injection of stem cells into decellularized lung segments while preserving vascular and airway channels.
Scientists have discovered a molecular 'switch' that regulates heart cell division and could potentially be used to regenerate damaged heart tissue. The discovery was made by studying infant siblings with a rare heart defect, who exhibited unusual heart cell proliferation.
A GW researcher has discovered that gene therapy can elicit a regenerative response in pig hearts after a heart attack. The treatment utilizes the Cyclin A2 protein to stimulate cellular division and promote cardiac repair.
A University of Southern California study identifies a new population of mesenchymal stem cells in nerve and artery bundles that help maintain homeostasis. The discovery reveals that these stem cells are rich in the bundles, which contain nerves and blood vessels, and are regulated by the protein Shh.