Articles tagged with Tissue Regeneration
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A team of scientists designed a bioreactor device that induces partial hindlimb regeneration in adult frogs by stimulating tissue repair at the amputation site. The device triggers complex downstream outcomes, resulting in bigger, more structured appendages.
Researchers at Tufts University have discovered that delivering progesterone via a wearable bioreactor can induce partial limb regeneration in adult frogs. This breakthrough could lead to new treatments for amputation injuries, potentially benefiting millions of people worldwide.
Researchers analyzed postnatal mouse hearts to understand regenerative capacity and biochemical processes affected by myocardial infarction (MI). Key findings include novel changes in metabolism, such as temporal regulation of mevalonate and ketone body metabolism.
Scientists at Tufts University have found that amputation of one limb immediately reflects in the bioelectric properties of the opposing, un-damaged limb in developing frogs. The phenomenon, dubbed 'bioelectric injury mirroring,' indicates that information about damage to tissues is available within 30 seconds.
Biomedical engineers at Duke University discovered that immune cells, specifically macrophages, play a critical role in regenerating lab-grown adult muscle tissue. The discovery could lead to new treatments for degenerative muscle diseases and enhance the survival of engineered tissue grafts.
Researchers discovered that older mice exhibit increased tissue regeneration and decreased scar formation in skin wounds. The findings were confirmed in human studies, suggesting that aging suppresses the circulating factor SDF1, which promotes scar formation. The study's authors hope to develop a drug to prevent scarring in humans.
Researchers have successfully conducted a Phase I clinical trial in China, showing that stem cells extracted from baby teeth can regrow dental tissue, promoting healthy root development and increased blood flow. The treatment has been found safe and effective, with patients regaining sensation in their injured teeth.
Researchers discovered long noncoding RNAs play a key role in regulating genetic circuits responsible for regeneration in highly regenerative animals. The discovery may lead to the development of drugs to trigger humans' dormant pathways for regeneration.
Researchers at UIC are developing a new exosome-based approach to regenerate bone and tissues, with the goal of reducing side effects and advancing therapies. Engineered exosomes may aid regeneration faster than growth factors, with fewer complications.
Scientists discovered that neural stem cells in spinal cords are the limiting factor for tail regeneration. Unlike salamanders, lizard neural stem cells cannot produce diverse cell types needed for bony vertebrae development. This finding may aid understanding of why humans can't regenerate their tails.
The MDI Biological Laboratory has received a five-year, $12 million NIH Center of Biomedical Research Excellence (COBRE) grant to support its regenerative biology research. The funding will accelerate efforts to develop new drugs for tissue regeneration and extend healthy lifespan.
A Northwestern University team developed a regenerative bandage that heals diabetic wounds 33% faster than current market products, leveraging the body's natural wound-healing process. The bandage uses an antioxidant hydrogel with a thermally responsive segment of laminin to facilitate tissue regeneration and counter inflammation.
Researchers developed a peptide-infused dressing that promotes dermal cell adhesion and proliferation, accelerating wound closure and tissue regeneration in diabetic mice. The dressing showed significant benefits compared to control treatments.
Researchers in Brazil have discovered that sun coral can regenerate at a faster rate as water temperature increases, making it a formidable invasive species. The study's findings suggest that the genus Tubastraea, which comprises seven species, including two invasive ones, can thrive in various marine environments.
Researchers investigated the molecular mechanisms underlying myocardial regenerative ability in newborn mice, identifying fructose-induced glycolysis as a key factor for cardiac muscle cell proliferation. The study provided insights into the loss of regenerative capacity and potential new treatments for heart disease.
Researchers at Queen Mary University of London have developed a new method to create materials with remarkable precision and order, resembling dental enamel. This breakthrough could lead to the prevention and treatment of tooth decay and sensitivity, benefiting over 50% of the world's population.
Researchers at UCLA used a bioengineered gel to regenerate neurons and blood vessels in mice with stroke-damaged brains. After 16 weeks, the gel helped fill in the stroke cavity, resulting in improved motor behavior in the affected mice.
A team of researchers has successfully designed and produced individualized, computer-modeled regenerative heart valves grown from human cells. These bioengineered replacements can grow and regenerate themselves without causing immune reactions in patients' bodies, addressing a major limitation of current artificial implants.
Researchers at Kessler Foundation are investigating a new treatment using micro-fragmented adipose tissue injection to alleviate chronic shoulder pain in wheelchair users with SCI. The pilot study has shown promising results, with all six participants experiencing improved range of motion and reduced pain.
Researchers discovered that fish regenerate skin without scarring by controlling the proliferation of stem cells in the basal layer. This mechanism may be applicable to other vertebrates, including humans, for treating various skin diseases and regenerative medicine research.
Researchers have discovered that certain genes are shared between salamanders and humans, which could lead to new therapeutic targets for treating spinal cord injuries. By studying the molecular mechanisms at work in salamanders, scientists hope to understand why humans cannot regenerate nerves after injury.
Researchers at UNLV have found that frog embryos can regenerate their entire eye within 3 to 5 days after injury, contradicting previous claims. This breakthrough has potential implications for human tissue regeneration and may lead to the development of new treatments for eye injuries.
Dr. Charles N. Serhan received the ASIP 2018 Rous-Whipple Award for his work on molecular and cellular basis of inflammation and its resolution, recognizing his discovery of endogenous anti-inflammatory mediators that activate anti-microbial defense mechanisms.
Researchers from Uppsala University identified over 1,000 genes involved in rebuilding Stentor cells after damage, with the mouth part requiring roughly ten times as many genes to regenerate as the tail.
The National Institutes of Health (NIDCR) established the DOCTRC Program to develop resources and strategies for regenerating dental, oral, and craniofacial tissues. Two national resource centers were established: The Michigan-Pittsburgh-Wyss Resource Center and the Center for Dental, Oral, and Craniofacial Tissue and Organ Regeneration.
The symposium reviewed current developments and challenges in 3D printing and bioprinting for regenerating complex dental, craniofacial, and oral tissues. Researchers showcased their work on guided self-assembly, 3D-printed constructs, and geometric controls of periodontal tissue regeneration.
Researchers developed two nanofiber dressings that use naturally-occurring proteins to promote healing and regrow tissue. The dressings, inspired by fetal tissue and soy-based molecules, showed significant improvements in wound healing, including 84% tissue restoration within 20 days.
Using a stab injury model in adult zebrafish, researchers discovered that neural stem cells can regenerate brain tissues in the optic tectum. New neurons were generated from radial glia through Wnt signaling, providing insights into regenerative processes and potential applications for human CNS restoration.
Researchers identify four genes that enable adult cardiomyocytes to divide and multiply, regenerating heart tissue in animal models. The technique could also be used to coax other types of adult cells to divide again, potentially treating brain damage, diabetes, hearing loss, and blindness.
Scientists identified a new type of lung stem cell that can regenerate lung tissue after injury. The discovery could lead to innovative treatments for lung diseases in both children and adults, including premature infants and those with chronic obstructive pulmonary disease.
Researchers have identified a lung stem cell that repairs the organ's gas exchange compartment and restores respiratory function after severe influenza and other respiratory ailments. The discovery provides new insights into lung regeneration and identifies novel genetic and epigenetic pathways important for lung regeneration.
A low-calorie diet has been shown to enhance intestinal regeneration after injury in mice, with reserve stem cells playing a key role. The study found that calorie restriction expanded reserve stem cells five-fold and improved their ability to regenerate tissue, implicating them as critical players in this process.
Researchers created biodegradable bandages with antibacterial properties, accelerating tissue regeneration twice as quickly as usual. The bandages also prevent scarring and promote normal skin covering tissue regeneration.
Scientists at Cincinnati Children's Hospital Medical Center have developed an experimental molecular therapy that restores nerve insulation in mice, improving limb function and reducing discomfort. The treatment targets the enzyme HDAC3, which is involved in epigenetic changes that restrict myelin regeneration.
Researchers found that outcomes for alternatives to whole liver transplantation, such as splitting a liver or using a part from a living donor, have improved for pediatric patients. These findings suggest opportunities for an increased organ supply and better use of those organs, potentially saving more lives.
Researchers have developed a method for marking dividing stem cells with three different labels, increasing accuracy and speed of analysis. This allows study of new populations of stem cells, including those in the brain and other tissues.
A study by CNIC scientists discovered that cardiomyocytes from the innermost heart regions can contribute to the regeneration of the external heart wall in zebrafish. This finding reveals a new way to rebuild a damaged heart and has implications for human heart regeneration.
Researchers at UC San Diego have identified a new genetic pathway that plays an active role in neuron damage regeneration. The discovery of the PIWI-interacting small RNA (piRNA) pathway could offer therapeutic targets for helping neurons regrow after traumatic injuries and stroke.
The study provides a complete genome assembly of the planarian flatworm Schmidtea mediterranea, revealing novel giant repeat elements, new genes, and the absence of certain essential genes. The discovery has potential implications for understanding regeneration research and stem cell biology.
Researchers have sequenced the axolotl genome, the largest genome ever to be decoded, to study molecular basis of regrowing limbs and other forms of regeneration. The analysis discovered several genes that are expressed in regenerating limb tissue and revealed key roles for PAX3 and PAX7 genes in muscle and neural development.
Researchers have developed a new technique using optical coherence elastography to measure the mechanical properties of heart tissue after a heart attack. The method reveals differences in tissue mechanics between healthy and scarred tissue, providing insights into developing therapies to regenerate damaged heart tissue.
Researchers at AgeX Therapeutics, Insilico Medicine, and the Biogerontology Research Foundation used deep learning techniques to analyze gene expression data in embryonic stem cells. They identified genes, including COX7A1, that contribute to the regenerative capacity of embryos and ESCs, with potential applications in cancer therapies.
The study found that genes responsible for repairing spinal cords in fish, such as the lamprey, are also present and active in mammals, including humans. This discovery could lead to new therapeutic approaches for spinal cord injuries in humans.
Researchers have identified genes implicated in the remarkable regenerative capacity of embryos and ESCs. COX7A1 was found to be dysregulated in various cancer types, suggesting its potential as a novel cancer therapy.
Scientists at Imperial College London develop a new 3D printing technique that can replicate biological structures, paving the way for tissue regeneration and replica organs. The method uses cryogenics to create super soft scaffolds that mimic the mechanical properties of organs like the brain and lungs.
Researchers at Instituto de Medicina Molecular found a specific non-coding RNA molecule, Zeb2-NAT, which can be reduced to regenerate old cells. By manipulating this molecule, it's possible to induce cellular regeneration and potentially treat diseases associated with cellular aging.
A new study uses deep learning methods to identify genes involved in embryonic development, fetal transition, and cancer. The research may lead to innovative strategies for induced tissue regeneration and cancer treatment.
Researchers discovered that TOR signaling becomes activated in stem cells during regenerative responses, leading to the loss of stem cell status. Inhibiting TOR with rapamycin prevented this loss and reversed age-related decline in mouse trachea and muscle tissues.
Tufts researchers have developed a method to regenerate adult stem cells in the nasal tissue, improving sense of smell in mice. The discovery uses Yamanaka factors and offers a more efficient alternative to existing induced pluripotent stem cell technology, with implications for treating various tissue degeneration associated with aging.
A team of researchers discovered that different subtypes of muscle cells play critical roles in orchestrating tissue regeneration in flatworms. Removing specific muscle groups was shown to disrupt the regeneration process, revealing essential functions for longitudinal and circular fibers.
Researchers have developed a method to prolong the survival of stem cells, which could aid in tissue regeneration after blood flow obstruction. By attaching vascular endothelial growth factor to microscopic particles, they increased stem cell lifespan and improved their ability to form new blood vessels.
Researchers at the University of Guelph have discovered the type of stem cell responsible for a gecko's ability to regrow its tail. The study found that the gecko's spinal cord contains radial glia stem cells, which proliferate and form new tissue after injury.
Red-toothed shrews experience a dramatic decrease in braincase size from summer to winter, with some organs even shrinking by 30%. This seasonal change may help them conserve energy during food scarcity.
Researchers found that mechanical tension plays a crucial role in the regeneration of zebrafish hearts, with supersized cells leading the way and smaller cells multiplying to cover the surface. The study's findings open up new possibilities for developing bioengineering approaches to human heart disease.
A new study by James Godwin found that macrophages are essential for heart regeneration in salamanders, suggesting a potential solution to the human disease. The research has significant implications for regenerative medicine and may lead to the development of drug therapies to promote scar-free healing.
Scientists have identified a metabolic pathway that governs the loss of the human heart's ability to regenerate tissue. This discovery could potentially lead to the development of drugs to reactivate regeneration in adult hearts, allowing them to repair muscle damage caused by heart attacks and recover full pumping capacity.
The LSU Health New Orleans Cardiovascular Center of Excellence will receive funding to study the effectiveness of MSI-1436, a novel drug that stimulates heart muscle regeneration. The drug has shown promising results in small animal models and Phase 1 clinical trials for obesity and type-2 diabetes.
Researchers at UBC Okanagan campus have created a new bio-ink made from cold-soluble gelatin, which shows promise for creating artificial organs. The hydrogel is thermally stable at room temperature, making it suitable for use in 3D bio-printing.
Scientists successfully aggregate cells using only magnets without an external matrix, forming a deformable tissue that can be stretched or compressed at will. This breakthrough approach could revolutionize regenerative medicine by providing a powerful tool for biophysical studies and tissue engineering.
MSI-1436 has shown promise in adult zebrafish and mice by regenerating damaged heart muscle and improving heart function; a two-year grant will test its effectiveness in pigs to move the drug into clinical trials.