Articles tagged with Tissue Regeneration
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Researchers at Nagoya University identified a gene that enables African clawed frog tadpoles to regenerate nerves. Introducing this gene into mice with spinal cord injuries led to partial recovery of motor functions. The study suggests a new therapeutic approach for treating spinal cord injuries.
Harvard researchers identify how chronic stress impairs hair follicle stem cells, leading to delayed regeneration and hair loss. The study found that the stress hormone corticosterone delays stem cell activation, while Gas6 pathway activation promotes hair growth.
A new biomaterial, a boron-loaded alginate hydrogel, has been designed to accelerate muscle regeneration after injury. The hydrogel stimulates integrins, which promotes tissue formation and reduces recovery time by half.
A new study by Kyoto University scientists has shown an antibody for USAG-1 to stimulate tooth growth in mice with congenital tooth agenesis. The antibody, which targets the factor that antagonizes BMP and Wnt signaling, is promising for a potential therapeutic framework for regenerating teeth.
Researchers discovered a powerful approach for treating diabetic foot ulcers by targeting a gene that controls tissue growth and regeneration. The new treatment has shown promising results in animal models and human skin equivalents, and may hold potential for repairing internal organs.
A computational guide to lead cells down desired differentiation paths uses a novel computer-guided design tool to predict effective combinations of transcription factors. The approach significantly increases the efficiency of cell conversions, generating higher numbers of immune cells and skin cells than other methods.
Researchers from Children's Hospital of Philadelphia have determined the process of lung alveolus formation and identified signaling hubs that coordinate cell development. The study provides crucial insights into developing therapies to regenerate critical lung tissue and repair damaged tissue at a cellular level.
Researchers developed injectable porous scaffolds that facilitate faster and better spinal cord healing by mimicking natural tissue. The highly regular pore structure improved cell infiltration, gene delivery, and tissue repair after spinal cord injury.
Purdue researchers developed a regenerative tissue filler that restored breast shape and consistency, supported new breast tissue formation, and prevented wound contraction and scar formation. The filler represents the first planned medical product using innovative collagen polymer technology.
Researchers have developed an injectable hydrogel that could help repair and prevent further damage to the heart muscle after a heart attack. The study found that timely injection of the hydrogel resulted in less fibrosis and an increase in new blood vessels, preserving cardiomyocytes and supporting functional recovery.
Researchers have developed a new method, Cre-Controlled CRISPR, which combines the benefits of the Cre/lox system and CRISPR/Cas9 genetic scissors for conditional gene inactivation. This approach allows for faster and easier gene editing with reduced labor needed to flank genes with lox sequences.
Researchers developed a novel protocol for artificial muscle regeneration using direct cell reprogramming and natural-synthetic hybrid scaffold. The bioengineered muscle fiber constructs showed improved mechanical stiffness, enhanced muscle differentiation, and functional recovery in a mouse model with severe muscle loss.
Researchers at Monash University have discovered a biological process that prevents the human body from regenerating new cells or tissue after birth. By demethylating specific genes, they can reawaken progenitor cells to become insulin-producing beta cells, offering a potential breakthrough for treating Type 1 and Type 2 diabetes.
Researchers at JAIST and RIKEN identify COOH-PLL as an effective cryoprotectant that prevents cellular damage during freezing. The team uses NMR spectroscopy to characterize the molecule's behavior, enabling the design of new polymeric cryoprotectants.
Researchers from Osaka University successfully generated functional conjunctival tissue in a dish, enabling the study of conjunctivae and the development of novel drugs for dry eye disease. The newly formed tissue contained goblet cells that produce mucins, mimicking human conjunctival biology.
Researchers have mapped the origins of the embryonic mouse heart at single-cell resolution, identifying a pool of progenitor cells that form heart muscle cells and the early epicardium. This understanding could improve regenerative heart therapies and inform congenital heart defect research.
A new study published in The American Journal of Pathology reports that neutralizing tumor necrosis factor (TNF) can prevent rejection and tissue injury after cell transplantation, improving graft survival and regenerative medicine outcomes. TNF is identified as a master switch for orchestrating cytokines and inflammatory signals.
A recent study by Brazilian researcher Emmanuel Albuquerque de Souza shows that maresin and resolvin produced from omega-3 fatty acids can stimulate periodontal ligament stem cells even in the presence of inflammation. This finding has significant implications for regenerative therapy in treating periodontal disease.
Researchers at Aalto University have developed a technique to guide bacterial colonies into creating highly customized three-dimensional objects made of nanocellulose. The objects show great potential for medical use, including supporting tissue regeneration and replacing damaged organs.
A new hydrogel biomaterial triggers an adaptive immune response, leading to improved tissue repair and stronger healed skin. The material, developed at Duke University, demonstrates a regenerative immune response that can potentially heal skin injuries like burns and cuts more effectively than current wound-healing hydrogels.
Researchers at Helmholtz Munich have found a promising therapeutic approach against COPD by blocking lung epithelial cell death and triggering tissue regeneration. The novel treatment targets the lymphotoxin beta receptor signaling pathway, leading to improved lung function and reduced comorbidities.
Scientists at IST Austria identified a molecular compass that perceives auxin concentration and allows cells to synchronize their behavior for coordinated vein formation and regeneration. This phenomenon also applies to wound healing, enabling the growth of more mechanically resistant plants.
Researchers have developed a device inspired by an octopus's sucker that can transfer thin, delicate tissue grafts and biosensors quickly and safely. The device uses a temperature-responsive hydrogel to create suction, allowing for rapid handling of fragile materials.
A study by the University of Jena found that a toxic substance from Staphylococcus aureus stimulates immune cells to produce anti-inflammatory messenger substances, reducing inflammation and promoting tissue healing. The researchers also demonstrated that these substances promote tissue regeneration in an animal model.
A bioceramic scaffold promotes bone regeneration and repair large bone defects without the need for bone grafts. The study found that the bioceramic converted into well-vascularized bone tissue with a structure similar to native bone.
A research team at Pohang University of Science & Technology has developed a technology that allows for the rapid harvesting of human bone marrow-derived mesenchymal stem cell sheets using poly(N-isopropylacrylamide) (PNIPAAm) nanotopography. This breakthrough reduces the harvest time from one week to just two days, making it possible ...
Researchers in China and Switzerland created biodegradable electronic blood vessels that can be actively tuned to address body changes after implantation. These flexible vessels mimic natural blood vessels and demonstrate promise as surrogate arteries in rabbits.
Researchers at the University of Washington and Rice University are working on a novel technology that uses thermofluidic systems to manipulate gene expression in cells within 3D artificial organs. This could lead to the creation of functional artificial liver tissues that can be used for studying disease and developing new treatments.
A new study by SISSA and the University of Trieste shows that carbon nanotube implants can restore motor functions in animals with spinal injuries. The research reveals nerve fibre regrowth and promotes recovery through mechanical and electric properties of regenerative scaffolds.
A study by Children's Hospital of Philadelphia researchers has identified a cellular pathway that can be targeted with a naturally occurring drug to stimulate lung tissue regeneration. The findings could lead to better therapies for patients with lung diseases, including acute respiratory distress syndrome (ARDS) due to COVID-19.
Researchers aim to determine if cellular mechanisms responsible for regenerating tendons in axolotls also apply to human tendon injuries. The study will explore the role of fibroblasts and extracellular matrix in tendon healing.
Researchers at EPFL create miniature intestines using stem cells and hydrogel scaffolds, achieving high physiological relevance. The new organoids can regenerate, model inflammatory processes, and host-microbe interactions, opening up exciting perspectives for disease modeling, drug discovery, diagnostics, and regenerative medicine.
Researchers discover that West African lungfish can regenerate lost tails using similar molecular mechanisms as amphibians, suggesting a common ancestor possessed this trait. The study provides new insights into the evolutionary origin of tail regeneration and offers potential opportunities for regenerative medicine.
Researchers found that Nicotiana promotes tissue adhesion and maintains grafts with a broad range of species. The study successfully grafted a tomato scion onto a Florist's daisy rootstock, producing a small fruit.
A newly developed oxygen-releasing bioink has been shown to enhance the ability of implanted cells to grow and regenerate new tissue. The bioink was tested extensively to optimize its properties, delivering oxygen to cells in tissue constructs for the necessary period for blood vessels to develop fully.
Researchers at the University of Bayreuth have developed new biomaterials based on spider silk proteins that prevent colonization by bacteria and fungi, while also aiding human tissue regeneration. These nanostructured materials are ideal for implants, wound dressings, and other medical devices.
The study developed a composite material that can be used for regenerating bone tissue, comprising a scaffold made of fibroin and loaded with magnetic nanoparticles. The material stimulates cell growth and differentiation when exposed to a magnetic field, mimicking the cellular microenvironment.
Researchers at Wake Forest Institute for Regenerative Medicine have developed an optimized cellular platform for delivering Factor 8 to treat patients with hemophilia A. The new approach uses human placental cells to produce therapeutic levels of Factor 8, potentially providing a long-term correction for the disease.
A new imaging technique, DEEP-Clear, developed by MDI Biological Laboratory scientist Prayag Murawala enables unprecedented insight into subcellular structures and tissues. The method expands the range of animal models that can be studied, processes that can be explored, and biological questions that can be addressed.
Researchers are developing biomaterials to boost the body's natural healing process, with two approaches: incorporating cells or designing materials to stimulate cellular response. This can lead to improved success rates in tissue regeneration, reducing regulatory barriers and increasing available options.
Scientists have developed a method to culture human pancreatic slices for nearly two weeks, allowing them to study the regeneration of insulin-producing beta cells. The discovery has important therapeutic implications for treating diabetes.
Scientists have developed a device that can manipulate and measure cells' movements in response to electric fields, enabling new possibilities for tissue engineering. The SCHEEPDOG system allows researchers to program complex cell maneuvers, such as full circles, with thousands of neighboring cells executing on command.
Researchers have created a technology to print tissues directly in the body, using a specially-formulated bio-ink that can be crosslinked safely using visible light. This breakthrough enables minimally-invasive laparoscopic options for tissue repair and engineering, saving time and cost.
A new study suggests that plasma exchange can rejuvenate tissues and reverse signs of aging in mice by diluting old blood plasma. The technique shows promise for improving health in older people and treating age-associated diseases. Researchers are now finalizing clinical trials to explore its potential in humans.
Researchers from Nanjing University and University of Macau successfully transformed a mouse's spleen into a fully functional liver, overcoming key challenges in tissue engineering. The innovative approach could potentially provide a new solution for patients with end-stage organ failures due to limited donor availability.
Researchers from SUTD and NTU developed insightful analyses of in vitro skeletal muscle tissue models, reviewing state-of-the-art bioengineering approaches for mimicking skeletal muscle tissues. Despite progress, challenges remain in replicating native muscle functionality, including proper innervation and vascularization.
University of Arkansas researchers are working on a therapeutic drug that can regenerate heart tissue and prevent myocardial infarction. The project aims to improve current methods of controlled release by targeting specific biochemical events during heart failure.
Researchers at the National University of Singapore have developed a method to rejuvenate fibroblasts by geometrically confining them on micropatterns. The resulting cells recover their ability to contract and exhibit reduced DNA damage and enhanced cytoskeletal gene expression.
Researchers identified a novel strategy to address underlying causes of LAD1 patients' symptoms by mimicking the efferocytosis process, which was absent in these individuals. The study found that small-molecule compounds that stimulate this process alleviated signs of inflammation and promoted bone regeneration in animal models.
Researchers have found that reprogrammed stem cells between days 15 and 28 of maturation can successfully restore heart tissue. This 'window of opportunity' makes it possible to use stem cells that the body recognizes as its own, allowing for more effective regenerative medicine.
Researchers at CU School of Medicine have discovered that precise motor learning stimulates cellular processes to improve recovery after nerve cell damage. The study found that mature oligodendrocytes can contribute to repairing the nervous system by generating new myelin sheaths.
Researchers at Temple University Health System use Lin28 to fuel axon regrowth in mice with spinal cord injury or optic nerve damage, enabling repair of the body's communication grid. The study shows significant improvements in coordination and sensation after Lin28 treatment.
Zebrafish can regenerate their hearts after cardiac arrest due to faster and more complete scar tissue healing than other animals. A UTA engineer is using an EKG jacket and super-resolution microscope to study this phenomenon and its potential applications for human heart attack treatment.
Researchers have developed a simple method to prepare 3D keratin scaffold models that mimic the structure and biological function of native extracellular matrix. The study demonstrates the ability of cells to grow on these scaffolds without morphological changes or apoptosis, making them promising candidates for tissue engineering.
Researchers at ITMO University and S.N. Fyodorov Eye Microsurgery Complex introduced a laser method for cataract surgery that stimulates tissue regeneration while destroying the cloudy lens. The technique has been clinically proven to reduce corneal endothelial cell loss by 1.8 times.
Researchers developed a method to engineer specific populations of neurons to manufacture electronic-tissue composites within living cells. This approach enables targeted use of electrical fields for therapeutic applications, such as pain relief and tissue regeneration.
Researchers at University of California, Irvine have published a comprehensive overview of skin cell changes before wound healing. The study provides insights into the underlying mechanisms driving poor wound healing in diabetic patients.
Researchers successfully harnessed an evolutionarily conserved mechanism to promote tissue repair and suppress inflammation in aged tissues. This approach improved the success of stem cell-based therapies for retinal disease, restoring vision in old, blind mice.
Kessler Foundation receives a $250,000 grant from the Derfner Foundation to expand regenerative rehabilitation research and develop new treatments for musculoskeletal and neurological injuries. The lab will focus on restoring function to individuals with disabilities caused by injuries, disease, and aging.
A collaborative project led by UCSC aims to develop innovative technology for improving wound healing, funded by up to $16 million from DARPA. The team will use bioelectronic devices, machine learning, and regenerative medicine to control physiological processes involved in wound healing.