Articles tagged with Tissue Regeneration
Researchers at the National University of Singapore have developed a method to rejuvenate fibroblasts by geometrically confining them on micropatterns. The resulting cells recover their ability to contract and exhibit reduced DNA damage and enhanced cytoskeletal gene expression.
Researchers identified a novel strategy to address underlying causes of LAD1 patients' symptoms by mimicking the efferocytosis process, which was absent in these individuals. The study found that small-molecule compounds that stimulate this process alleviated signs of inflammation and promoted bone regeneration in animal models.
Researchers have found that reprogrammed stem cells between days 15 and 28 of maturation can successfully restore heart tissue. This 'window of opportunity' makes it possible to use stem cells that the body recognizes as its own, allowing for more effective regenerative medicine.
Researchers at CU School of Medicine have discovered that precise motor learning stimulates cellular processes to improve recovery after nerve cell damage. The study found that mature oligodendrocytes can contribute to repairing the nervous system by generating new myelin sheaths.
Researchers at Temple University Health System use Lin28 to fuel axon regrowth in mice with spinal cord injury or optic nerve damage, enabling repair of the body's communication grid. The study shows significant improvements in coordination and sensation after Lin28 treatment.
Zebrafish can regenerate their hearts after cardiac arrest due to faster and more complete scar tissue healing than other animals. A UTA engineer is using an EKG jacket and super-resolution microscope to study this phenomenon and its potential applications for human heart attack treatment.
Researchers have developed a simple method to prepare 3D keratin scaffold models that mimic the structure and biological function of native extracellular matrix. The study demonstrates the ability of cells to grow on these scaffolds without morphological changes or apoptosis, making them promising candidates for tissue engineering.
Researchers at ITMO University and S.N. Fyodorov Eye Microsurgery Complex introduced a laser method for cataract surgery that stimulates tissue regeneration while destroying the cloudy lens. The technique has been clinically proven to reduce corneal endothelial cell loss by 1.8 times.
Researchers at University of California, Irvine have published a comprehensive overview of skin cell changes before wound healing. The study provides insights into the underlying mechanisms driving poor wound healing in diabetic patients.
Researchers developed a method to engineer specific populations of neurons to manufacture electronic-tissue composites within living cells. This approach enables targeted use of electrical fields for therapeutic applications, such as pain relief and tissue regeneration.
Researchers successfully harnessed an evolutionarily conserved mechanism to promote tissue repair and suppress inflammation in aged tissues. This approach improved the success of stem cell-based therapies for retinal disease, restoring vision in old, blind mice.
Kessler Foundation receives a $250,000 grant from the Derfner Foundation to expand regenerative rehabilitation research and develop new treatments for musculoskeletal and neurological injuries. The lab will focus on restoring function to individuals with disabilities caused by injuries, disease, and aging.
A collaborative project led by UCSC aims to develop innovative technology for improving wound healing, funded by up to $16 million from DARPA. The team will use bioelectronic devices, machine learning, and regenerative medicine to control physiological processes involved in wound healing.
Researchers at Wake Forest Institute for Regenerative Medicine have developed a way to accelerate functional muscle regeneration by integrating neural cells into 3D bioprinted skeletal muscle constructs. The study, published in Nature Communications, demonstrates the potential for these constructs to restore normal muscle weight and fu...
Researchers at Rutgers University have developed a new 'bio-ink' for 3D printing that can serve as scaffolds for growing human tissues. The ink combines modified hyaluronic acid and polyethylene glycol to form a gel with controlled stiffness and binding sites for cells, enabling precise tissue growth and repair.
Researchers have identified a genetic signaling pathway that limits tissue growth in planarian flatworms, allowing for precise regeneration and repair. The mob4 gene suppresses tissue growth by preventing the production of Wnt, a protein involved in cancer cell regeneration.
Researchers found that stress activates nerves that release norepinephrine, which causes premature depletion of pigment-producing cells. This leads to permanent damage and loss of stem cells, resulting in gray hair. The study advances understanding of stress impact on the body and paves way for new treatments.
Researchers developed a synthetic conduit that bridges large nerve gaps, supporting recovery and accelerating neuronal healing. The device boosts nerve regeneration and improves motor skills in macaques, showing superior recruitment of cells that insulate nerves.
Scientists have devised a method to sort out which heart cells can replicate and which cannot, a critical step toward treatments that may one day help the heart heal itself after injury. This technique combines molecular beacon technology and fluorescence activated cell-sorting to specifically isolate cells that successfully divide.
Researchers have identified a molecule called TET1 that enables adult liver cells to regenerate. The discovery provides a potential target for drugs to treat chronic liver diseases, where regeneration is impaired.
Scientists discover molecular coordination tool and specialized lymphatic capillaries that transport immune cells and drain excess fluids from tissues, controlling fluid composition and cell synchronization during hair follicle stem cell activity.
Scientists have developed a new material that controls cell immune response, using inhibitors placed directly in the material. The polycaprolactone scaffolds are biodegradable and release the inhibitors gradually, which can reduce negative consequences after heart attacks and strokes.
Researchers have discovered that dental epithelial stem cells from young mice can regenerate mammary glands and produce milk-producing cells. This breakthrough highlights the exceptional plasticity of these stem cells, which can generate not only dental tissues but also other cell populations.
Scientists are developing new electrically active materials to repair damaged heart tissue. These materials can conduct electricity, stimulate heart muscle growth, and potentially overcome scar tissue that interferes with healthy heart function.
Researchers develop a novel therapy to protect neurons and stimulate regrowth of blood vessels in damaged tissue. In preclinical trials, rats injected with the hydrogel retained more functioning neurons and formed new blood cells at the injury site.
Researchers at Istituto Italiano di Tecnologia have developed a new technique called Optoceutics, which uses visible light to specifically direct the fate of tissue cells. This breakthrough has significant potential for regenerative medicine and treating cardiovascular diseases.
The International Association for Dental Research celebrates its centennial with a special article highlighting key successes in tooth bioengineering and regenerative dentistry. Researchers discuss promising developments, including whole tooth tissue engineering and the potential for improved dental repair therapies.
Researchers found that stem cells transform into immune cells to perpetuate inflammation in chronic sinusitis, preserving the potential to regenerate olfactory tissue. This discovery may lead to better treatments for anosmia, a condition where people lose their sense of smell.
Scientists are developing novel tissue engineering techniques using everyday materials such as ice, eggshells, and spinach. These biomaterials are more functional, sustainable, and cost-effective than traditional methods.
Researchers have discovered key molecules that help form the periodontal ligament, a tissue crucial for tooth stability. The study sheds light on how these molecules work together to control cell functions, which could lead to new dental treatments for gum disease and other conditions.
Researchers from UCLA School of Dentistry developed a new hydrogel that promotes tissue repair and regeneration, inducing stem cell migration to enhance bone healing. The clay-enhanced hydrogel has a more porous structure, improving its ability to deliver cells to defective areas.
A new method of tooth repair has been discovered by scientists, who found that a gene called Dlk1 enhances stem cell activation and tissue regeneration in tooth healing. This mechanism could provide a novel solution for tooth problems such as decay and trauma treatment, and further studies are needed to validate the findings.
Scientists at UC Davis have traced the fate of hydra's cells, revealing how three lines of stem cells become nerves, muscles or other tissues. This high-resolution map will help researchers understand regulatory gene networks in place early in evolution.
A recent study proposes a quality control framework for umbilical cord blood-sourced allografts, outlining future safety and potency benchmarks. The study identifies a unique liaison among the UCB-sourced allograft, host mesenchymal stem cells, and their secreted exosomes that influences tissue regeneration in vivo.
Children's Hospital Los Angeles researcher Dr. Mark Frey will investigate epithelial growth and regeneration in the intestinal tract, with a focus on proteins ErbB3 and ErbB4, to minimize chemotherapy and radiation toxicity.
Researchers have identified a protein, TSPYL5, that allows cancer cells to survive indefinitely. Targeting this protein may help develop new therapies for children with ALT-type cancer, which currently lacks effective treatments.
Researchers at the University of Bristol have made a world-first discovery by hijacking bacteria's homing ability to guide stem cells to cardiac tissue. The breakthrough could improve treatment for cardiovascular disease, which causes over a quarter of all deaths in the UK.
Researchers have identified the key challenges and breakthrough technologies for applying skeletal muscle progenitor cells in cell therapy. The study highlights the importance of suitable scaffolds and extracellular matrices in regulating progenitor cell behavior, which is crucial for successful tissue regeneration.
Researchers at the University of Portsmouth used synchrotron X-ray computed tomography to examine the performance of four different bone-biomaterial systems. They found that strain can be used to understand and potentially predict clinical outcomes of biomaterials in a living body.
Three researchers win IADR Innovation in Oral Care Awards for developing novel treatments for craniofacial bone defects and periodontitis, with focus on growth-factor-free approaches.
Researchers discovered a molecular mechanism that allows cancer cells to regenerate and evade therapy, but found treatments that can target these cells. The study provides a new logic for identifying therapies that can kill hard-to-kill cancer cells.
Research on Drosophila reveals that Ets21c promotes intestinal epithelial renewal, but its loss accelerates tissue turnover and makes flies vulnerable to stress. The study contributes to understanding regenerative processes under favourable and stressful conditions.
Researchers at Wake Forest Institute for Regenerative Medicine have successfully engineered vascularized functional renal tissues using a novel biomimetic scaffold. The study's findings suggest that this approach may be a more feasible and practical treatment strategy for patients with chronic kidney disease.
Researchers at the University of Cambridge have identified a specialized population of skin cells called Regeneration-Organizing Cells (ROCs) that coordinate tail regeneration in frogs. These ROCs work together to regenerate a tail with the right size, pattern, and cell composition after amputation.
Researchers at CNIC have identified a cellular and molecular mechanism that can induce productive angiogenesis in ischemic tissues. The newly discovered mechanism suggests that manipulating it could lead to optimal therapeutic angiogenesis, which may help treat cardiovascular disease.
Researchers at Tufts University have created a computational model that explains how fragments of flatworms determine which end should form a tail and which should form a head. The model predicts the outcomes of genetic, pharmacological, and surgical manipulations, such as worms with two heads or two tails.
Researchers at Tokyo University of Science have discovered a demethylase enzyme that primes gene expression in plants, allowing them to regenerate tissues. This breakthrough could lead to faster and more efficient food production, helping to address global hunger.
Trodusquemine has shown promise in stimulating heart muscle regeneration in mice after an artificially induced heart attack, and slowing heart and skeletal muscle degeneration in a mouse DMD model. Novo Biosciences aims to develop a dosing regimen for juvenile DMD patients and define toxicity in juvenile animal models.
A study by UT Southwestern Medical Center researchers identified genetic mutations that accumulate in the adult liver and can promote tissue regeneration. The findings suggest that certain mutations provide liver cells with fitness advantages, allowing them to grow and survive better after environmental insults.
Scientists discover a new population of immune cells that can aid in regenerative processes, enabling the creation of stable blood vessels.
A team of biomedical engineers has developed a stem cell cardiac patch made with tissue engineered with tiny blood vessels to mimic real heart muscle. The patch can connect to native vasculature, bringing nutrients and oxygen, making it potentially effective for treating myocardial infarction.
Researchers have developed a new method to study gene expression and its relationship with cell behavior, including regeneration. The method, called single-cell-digital gene expression (1cell-DGE), allows for the analysis of RNA from individual living cells in intact tissue without compromising positional information.
A new review of 12 spaceflight experiments and simulated microgravity studies found that microgravity does not hinder stem cell-dependent tissue regeneration, but rather accelerates it. This valuable in vivo data has implications for human tissue repair and regeneration during spaceflight.
A new thixogel called CNF hydrogel has been developed by SUTD researchers, offering improved cell encapsulation and delivery. The hydrogel combines the benefits of both solid and liquid forms, providing a protective environment for cells while conforming to host tissue geometry.
Researchers have developed a nanofibrous membrane that enhances periodontal tissue regeneration and is absorbed by the body when healing is complete. The membrane, made from biocompatible polymers, promotes bone mineralization and regrows lost gum tissue in rats with periodontal defects within eight weeks.
Researchers at UCLA have developed a new membrane class that can regenerate gum tissue and bone, offering a viable solution for periodontitis. The membranes have tissue and bone regeneration properties along with a flexible coating that adheres to biological surfaces.
Researchers developed a biomaterial called GelCORE that can seal cuts or ulcers on the cornea and encourage regeneration of corneal tissue without surgery. The technology uses light-activated chemicals and has shown promising results in preclinical studies.
Researchers at Wake Forest Institute for Regenerative Medicine have made breakthroughs in treating chronic kidney disease with cell therapy. Amniotic fluid-derived stem cells injected into diseased kidneys showed improvement in kidney function and structural recovery after 10 weeks, reducing damage to capillary clusters.
The University of Texas at San Antonio's Biomedical Engineering Research for Active military and Veterans (BRAVe) program aims to engage and retain undergraduate students in research projects, including tissue regeneration and non-invasive recovery. The program, funded by a $352,414 NSF award, will pair participants with faculty mentor...
Researchers at the Marine Biological Laboratory (MBL) have identified key genes that promote spinal cord regeneration in axolotls. By activating these genes, scientists were able to force human cells to undergo regeneration, highlighting similarities between species.