Articles tagged with Tissue Regeneration
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Researchers at Tufts University successfully regrow a functional, nearly complete limb on adult frogs using a five-drug cocktail and silicone wearable bioreactor dome. The treatment sets in motion an 18-month period of growth restoring a fully functional leg.
A pre-clinical study showed that the use of extracellular matrix supports improved nerve fibre regeneration across large nerve defects. The team's novel ECM-loaded medical device increased pro-repair inflammation, blood vessel density, and regenerating nerves, offering a promising alternative to current therapies.
Fibrodysplasia ossificans progressiva (FOP) may be rooted in impaired and inefficient muscle tissue regeneration, which enables unwanted bone growth. This discovery could lead to new therapies targeting both extra-skeletal bone formation and muscle function.
Researchers successfully reprogrammed a mouse spleen to perform liver functions without transplanting cells or tissue from another body. The study demonstrates the potential of transforming an existing organ to perform liver functions, avoiding safety issues associated with traditional methods.
Researchers have developed a novel strategy to enhance the reprogramming efficiency of human fibroblasts, significantly increasing their ability to become functional heart muscle. This approach uses endothelial cell plasticity to facilitate the desired change, offering new hope for patients with congestive heart failure.
Researchers at Brigham and Women's Hospital discovered a new mediator, 4S, 5S-epoxy-resolvin, that resolves acute inflammation and stimulates tissue regeneration. The study found that this mediator also controls granuloma formation in human leukocytes.
Researchers at Indiana University have developed a silicon device that can change skin tissue into blood vessels and nerve cells. The technology, called tissue nanotransfection, is being explored for use in treating conditions such as stroke and diabetes-related nerve damage.
Researchers have identified the specific genetic regulatory elements responsible for Hydra head regeneration, showing that dynamic chromatin remodeling and transcription factor motifs play a crucial role. This discovery sheds light on the complex developmental processes involved in this remarkable regenerative ability.
A new study reveals that extracellular vesicles deliver genetic instructions for the longevity protein Klotho to muscle cells, which declines with age. This finding suggests that EVs could be developed into novel therapies for healing damaged muscle tissue and improving functional recovery in older individuals.
Researchers at A*STAR's Institute of Molecular and Cell Biology have discovered a novel protein therapy using Agrin to promote wound healing and repair. The study found that timely induction or exogenous supplementation of Agrin accelerates the healing process, preserving the mechanical architecture of injured skin layers.
Researchers at RCSI University of Medicine and Health Sciences have developed a new method to enhance wound healing using 3D printing of platelet-rich plasma. The technique showed promising results in improving vascularisation and reducing fibrosis, leading to faster and more successful wound healing.
Researchers at McGill University create injectable hydrogel that forms stable structure allowing cells to grow and repair injured organs. The material's toughness and porosity make it suitable for heart, muscle, and vocal cord repair.
A simple change in the way donor cells are processed can maximize a single cell's production of extracellular vesicles, which are small nanoparticles naturally secreted by cells. The finding offers new avenues for research around cellular therapies, where transplanted cells are used to help the body heal or work better.
A team of researchers has created a detailed map of the proteins in human lungs, shedding light on how the organs develop and function. The study found that the immune system in the lungs continues to mature after birth, providing new avenues for understanding diseases such as asthma and COVID-19.
A recent study by James Godwin, Ph.D. has identified the liver as a primary reservoir for pro-regenerative macrophages essential to limb regeneration in axolotls. The research paves the way for regenerative medicine therapies in humans, potentially treating diseases like heart and lung disease with scar-free healing.
In chronic damage, new cholesterol production determines the efficiency of repair, with nerve cells contributing to replenishing myelin-forming cells. Treatment with a cholesterol-enriched diet enhances oligodendrocyte progenitor cell proliferation.
Researchers discovered that spiny mice can regenerate severely damaged kidneys without scarring, a process triggered by unique transcriptional programs in their genome. This finding offers new hope for treatments of end-stage kidney disease and fibrotic diseases.
Scientists at Lewis Katz School of Medicine discovered that reintroducing the protein LIN28 into adult heart stem cells improves their chances of survival. This breakthrough could lead to new treatments for heart disease using stem cell therapy.
A recent study reveals that muscle regeneration after physiological damage relies on the rearrangement of nuclei, accelerating repair of contractile units. Nuclei are attracted to injury sites and deliver mRNA molecules to initiate protein synthesis for muscle repair, offering a new insight into muscle biology.
A USC-led study has improved lizard tail regeneration through stem cell-based therapy, leading to the creation of tails with skeletal and nerve tissue on both sides for the first time in history. This breakthrough informs efforts to improve wound healing in humans, particularly for injuries that don't naturally regenerate.
Researchers identified a pattern that links the accumulation of amyloid beta (Aβ) proteins with a reduction of serotonin, which may help predict who will develop late-life depression. The study found that individuals expressing this pattern had more severe depressive symptoms.
A Harvard study found that massage therapy using mechanotherapy rapidly clears immune cells from severely injured muscles, enhancing regeneration. The treatment also removed inflammatory cytokines, leading to greater repair and strength recovery in injured muscles.
A team of researchers has identified a cellular mechanism that enables embryonic stem cells to maintain their state as stem cells. The study, published in Cell Reports, reveals the genetic ingredients required for ESCs to decide whether to divide or differentiate.
Researchers at IOCB Prague have developed a novel antibacterial material called NANO-LPPO that can prevent infection and facilitate treatment of skin wounds. The material combines lipophosphonoxins with a nonwoven nanotextile, which releases active substances in response to bacterial presence.
A new study provides evidence supporting the involvement of aquaporins in corneal cell proliferation and nerve regeneration, suggesting AQP5 induction as a potential therapy to accelerate corneal defect resurfacing. The study found that AQP5 deficiency can slow down corneal epithelial repair, but its specific mechanism remained unclear.
A clinical trial conducted by TTUHSC researchers found that corneal epithelial stem cell-derived eye drops significantly improved symptoms of severe dry eye disease, with patients experiencing a 23% improvement in SPEED questionnaire scores and a 17.1% improvement in OSDI scores. No adverse reactions were reported during the 12-week tr...
Researchers link repeated injury to airway stem cells with chronic lung disease, suggesting that biological aging of these cells may contribute to the development of this condition. The study found that injury caused activation of a subset of stem cells, leading to their premature aging and loss of functional capacity.
A study found that treating wounds with mesenchymal stromal cell secretions significantly reduced MRSA viability and stimulated the surrounding skin cells to build a defense. The treatment has potential as an alternative to antibiotics, reducing antibiotic resistance in both veterinary and human medicine.
Researchers developed lab-grown cochlear organoids to screen FDA-approved drugs for hair cell-inducing properties. The study identified Regorafenib as a potent stimulator of hair cell formation, even regenerating lost cells in mouse tissues.
Researchers at Max-Planck-Gesellschaft engineered synthetic exosomes that regulate cellular signaling during wound closure, leading to faster healing and improved formation of new blood vessels. The study provides a systematic understanding of extracellular vesicle communication and its potential therapeutic application.
The study found that a specific type of glycosaminoglycan in the scaffold led to greater blood vessel development and immune cell activation. Researchers aim to further understand these interactions to develop biomaterials for bone repair.
A multi-center study found micro-fragmented adipose tissue injections to be highly effective in reducing knee pain, improving function, and enhancing quality of life. Positive effects were observed for up to 12 months, with notable differences in efficacy among demographics.
Researchers from Terasaki Institute for Biomedical Innovation develop methods to enhance mechanical properties of hydrogels, including toughness, stretchiness, and adhesive strength. By introducing dopamine and alkaline conditions, they create gel-like materials with improved biocompatibility and regenerative capabilities.
A new clinical study reveals that treatment with mesenchymal stromal cells reduces inflammation in patients with chronic obstructive pulmonary disease (COPD). The study provides insights into the therapeutic potential of MSCs as a novel treatment for COPD, which is a leading cause of morbidity and mortality worldwide.
Researchers used autologous adipose micrografts to treat tendon injuries in sheep, achieving similar diameter and hardness to healthy tendons within two months. The study suggests a safe, reliable, and relatively fast way to promote tendon healing, with potential for human treatment.
A University at Buffalo-led study found that photobiomodulation therapy sped up recovery from burns and reduced inflammation in mice by activating endogenous TGF‐beta 1, a protein controlling cell growth and division. The findings may improve therapeutic treatments for burn injuries worldwide.
The Wake Forest Institute for Regenerative Medicine and local partners receive an NSF grant to develop a regional regenerative medicine educational network. The project aims to address the workforce needs of the rapidly evolving field, focusing on skilled technician development in biomanufacturing.
Researchers from USC Stem Cell discovered a latent regenerative potential in the inner ear's sensory cells. They found that epigenetic modifications regulate hair cell development and identified a key histone decoration, H3K4me1, that keeps supporting cells primed for transdifferentiation.
A new study finds that autodegredation, a process where mature cells break down specialized structures, enables regeneration in adult tissues. Genes Atf3 and Rab7b are upregulated during this process, allowing cells to return to the cell cycle and potentially contributing to cancer development.
Alastair Sloan, Head of School at the Melbourne Dental School, has received the 2021 IADR Isaac Schour Memorial Award for his significant contributions to tissue engineering and dental biology. He was recognized for his work on regeneration of mineralized tissues and behavior of dental pulp stem cells.
Lauren Katz, a postdoctoral researcher at UNC Chapel Hill, received the IADR Osteology Foundation New Investigator Award for her work on craniofacial skeletal muscle regenerative potential. Her goal is to develop therapeutic options for patients with congenital and acquired craniofacial defects.
Martha Somerman received the AADR Jack Hein Public Service Award for her exemplary work promoting oral health research to a wide constituency. She has over 150 peer-review publications and contributed to 20 books or book chapters.
A national survey reveals a pronounced lack of needed skills in the regenerative medicine biomanufacturing workforce, highlighting key findings and recommendations to address this gap. The study suggests five strategies for developing the workforce ecosystem, including faculty development opportunities, work-based learning, and policy ...
Researchers have developed 3D-printed tissue scaffolds that degrade harmlessly while promoting tissue regeneration. The scaffolds showed excellent biocompatibility and the ability to support cell migration, ingrowth of tissues, and revascularisation.
Catherina Becker, a neurobiologist, has been awarded the prestigious Humboldt Professorship to strengthen CRTD's research on spinal cord regeneration in zebrafish. Her team has made significant discoveries on the mechanisms behind successful spinal cord regeneration.
Researchers discovered that stimulating environments preserve a young DNA methylation landscape in the aged mouse hippocampus, leading to greater neuroplasticity. This finding suggests that active lives may help preserve mental fitness in old age, with implications for human brain health and disease prevention.
Biologists at St Petersburg University studied mechanisms of regeneration of marine animals and found that suppression of FGF protein activity disrupts the ability of Alitta virens to restore lost body segments. Similar proteins are found in humans, suggesting potential therapeutic approaches for regenerative medicine.
Researchers at Pohang University of Science & Technology developed a new method for regenerating damaged conjunctiva using mussel adhesive protein, achieving stable tissue adhesion and biodegradation. The technique replaces traditional sutures in ocular surface reconstruction.
Researchers discovered differences in molecular signaling that promote regeneration in axolotls, while blocking it in adult mice. This finding brings science closer to developing regenerative medicine therapies for humans.
A new study published in Nature Communications reveals clues about molecular changes underlying muscle loss tied to aging. The researchers found that using molecular compounds increased the regeneration of muscle cells in mice by activating precursors of muscle cells, called myogenic progenitors.
Two Lehigh University Rossin College PhD students, Mari-Therese Burton and Nicole Malofsky, have been selected for prestigious national STEM research fellowships. Burton will focus on high-entropy alloys, while Malofsky will work on biomaterials for corneal regeneration.
Researchers have developed biofabricated muscle substitutes that can restore significantly injured skeletal muscles with unprecedented efficiency. These biocompatible gel-like structures mimic the native muscle structure and can be created using 3D bioprinting, allowing for faster and more effective recovery from severe muscle mass loss.
Researchers created a bioengineering approach for functional muscle regeneration by combining biochemical signals and topographical cues. The technique improved muscle function restoration in injured rats, with over 80% recovery rate, and integrated well with neural and vascular systems.
A new 3D bioprinting technique uses multicompartmental bioprinting to direct cell orientation within deposited hydrogel fibers. The method provides favorable environments for cell proliferation and morphological cues to guide cell alignment.
New research reveals coral can fight back against juvenile crown of thorns starfish with stinging cells, damaging their arms and delaying growth. The study shows coral's defensive mechanism may not be enough to protect it from other threats like climate change.
A team led by Iain Drummond, Ph.D. has identified the signaling mechanisms underlying podocyte formation, a crucial process in kidney function. The discovery could lead to new therapies to stimulate regeneration of these cells, vital for ridding the body of toxins and treating conditions like chronic kidney disease.
Researchers developed an acellular product, PEP, derived from platelets that heals ischemic wounds by delivering healing messages to cells. The study demonstrates restoration of skin integrity and function in preclinical animal models.
A team of researchers has created the first-ever single-cell atlas of the human teeth, revealing cellular heterogeneity and stem cell populations with great regenerative potential. The study highlights the importance of microenvironmental specificity in functional differences between stem cells in various tooth compartments.
Researchers from Niigata University used 3D imaging to analyze the morphology of the human uterine endometrium and adenomyotic lesions. The study reveals a unique plexus network structure in the basal glands, which is detected in all samples regardless of age or menstrual cycle phase.
Researchers at the University of Georgia have developed a hydrogel, known as 'brain glue,' that mimics the composition and mechanics of the brain. The gel has been shown to protect against loss of brain tissue after severe TBI and may aid in functional neural repair.