Articles tagged with Tissue Regeneration
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A comprehensive atlas of ageing human muscle reveals genetic and cellular processes behind muscle deterioration, including new cell populations that may explain age-related differences. The study also identifies compensatory mechanisms to counteract ageing, offering avenues for future therapies.
A team of scientists has created a single-cell atlas for the highly regenerative worm Pristina leidyi, revealing new insights into its regenerative abilities. The study characterizes all major annelid cell types and provides molecular signatures that could inform stem cell technologies and regenerative medicine.
Researchers discovered that neonatal spinal cord ECM significantly enhanced NPC proliferation, migration, and differentiation compared to adult ECM. This study highlights the critical role of early developmental spinal cord ECM in orchestrating spinal cord regeneration processes.
The study reveals Brat's role in regulating wing imaginal discs regeneration by modulating downstream growth factors. Flies with reduced Brat demonstrated improved wing regeneration but also exhibited deficiencies in cell-fate specification, highlighting the delicate balance required for proper regeneration.
Scientists have created a new approach for treating tendon-bone injuries by combining manganese silicate nanoparticles with cells to create an immunomodulatory scaffold. This innovation promotes integrated regeneration and functional recovery in patients, offering a promising solution for improving life quality.
Researchers from Kyushu University and Harvard Medical School have identified proteins that can reprogram fibroblasts into cells with properties similar to limb progenitor cells. The new method simplifies the process of regenerating human limbs after amputation and could one day be used to give snakes back their legs.
The study found that ginseng can significantly reduce post-exercise muscle damage in healthy adults and improve muscle regeneration. Taking ginseng systematically for a long time can also mitigate the response of biological markers responsible for exercise-induced muscle damage and inflammation.
Neural stem cells developed into nerve cells when adhering to hydrogels with high positive charge, while those on lower positively charged gels became glial cells. The ability to influence differentiation could aid in nerve and glial cell regeneration and treatment of diseases like multiple sclerosis.
A study published in Nature Communications reports the discovery of a wound-homing molecule called CAR peptide, which accelerates tissue repair by activating natural healing pathways. The treatment shows promise for treating various injuries, including muscle ruptures and bone fractures, without forming less functional scar tissue.
A KAIST research team has developed a biomimetic scaffold that generates electrical signals to promote bone tissue growth, providing a new method for utilizing the unique osteogenic abilities of hydroxyapatite. The flexible and free-standing scaffold demonstrated remarkable potential for promoting bone regeneration in rats.
Researchers at Ann & Robert H. Lurie Children's Hospital of Chicago have made a major breakthrough in bladder tissue regeneration by using bone marrow cells. The study, published in PNAS Nexus, demonstrates the ability to regenerate healthy bladder tissue after two years of monitoring.
Researchers develop nanofibrous matrices containing MXene nanoparticles to aid in muscle regeneration. The study reveals molecular mechanisms behind the effects of MXene nanoparticles on muscle growth, suggesting a promising avenue for treating volumetric muscle loss and muscle-related ailments.
Researchers mapped dental pulp and periodontal ligament stem cells' genomes, revealing significant differences in their differentiation potential. The study identifies the genetic composition and mechanisms of differentiation, paving the way for targeted regenerative therapies.
Researchers successfully created a rat-derived lung in mouse model using reverse-blastocyst complementation and tetraploid-based organ complementation. The study identified crucial factors required for functional lung formation, including fibroblast growth factor 10 (Fgf10) and its interaction with Fgfr2b.
Researchers have discovered that jellyfish use stem-like proliferative cells to form a blastema, which helps regenerate functional tissue across the missing appendage. This study provides insight into the mechanism of blastema formation and may improve our own regenerative abilities.
Researchers have discovered a new control mechanism that drives the maturation of human stem cell-derived heart muscle cells, providing fresh insight into cardiac regenerative therapy and disease modeling. The study identifies RBFox1 as a key intrinsic regulator of heart muscle cell maturation.
A recent study published in Advanced Science has successfully regenerates thyroid glands in the spleen, restoring hormone levels and physiological homeostasis in mice with total thyroidectomy. The innovative approach leverages the spleen's unique properties to create a favorable environment for thyroid regeneration.
A clinical trial found that stem cell-based therapy reduced daily hardship and improved physical and emotional health in patients with advanced heart failure. Patients who received the treatment had lower death and hospitalization rates compared to those on standard care.
Researchers at ADA Forsyth have discovered the regenerative properties of Resolvins, specifically RvE1, which promotes pulp regeneration and reduces bacterial invasion in dental pulp. The technology has far-reaching potential for regenerative medicine beyond oral health, including growing bones in other parts of the body.
Researchers developed an adhesive gel to seal and heal challenging gastrointestinal tract-to-skin connections, showing promising results in studies. The gel's unique composition ensures it can effectively seal fistulas, preventing further complications and aiding in healing.
Researchers at Nagoya University have discovered a unique healing mechanism in newts that could aid humans in recovering faster from tendon injuries. By understanding how newts regenerate damaged tendons without scar tissue, scientists hope to develop more effective treatments for human athletes.
Researchers from the Institute for Basic Science developed a novel approach to healing muscle injury using conductive hydrogels and robot-assisted rehabilitation. The injectable tissue prosthesis enhances gait in rodent models without nerve stimulation, while improving long-term muscle tissue regeneration.
Researchers developed a low-cost anti-inflammatory hydrogel containing annexin A1 that accelerated complete skin wound healing in mice with induced type 1 diabetes. The hydrogel modulated the wound microenvironment and favored tissue regeneration, reducing inflammation and improving blood vessel formation.
The study found that satellite cells possess an inherent capacity to sense and respond to regenerative cues independent of external signals from non-myogenic cells. Macrophages played a crucial role in regulating MuSC proliferation and differentiation, but their reduction led to impaired cell division and increased fibrosis.
A UCLA-led team has identified RBFox1, an RNA splicing regulator, as a key player in promoting human stem cell-derived heart muscle cell maturation. This finding offers a deeper understanding of heart muscle cell development and hints at future therapeutic applications for regenerative therapies.
Macrophages produce polyamines spermidine and spermine, which benefit epithelial cells, promoting their proliferation and defense mechanisms. This "commensal metabolism" supports the efficient self-renewal of the intestinal epithelium.
A Kyoto University team reveals the Dumpy protein as the key factor in controlling 3D tissue structures through external cues. This finding challenges traditional understanding of morphogenesis and opens up new avenues for manufacturing controllable 3D tissue folding with coordinated cell behaviors.
Researchers at UNIST developed a microfluidic system to process blood into artificial tissue scaffolds for vascular regeneration. Autologous blood-based implants demonstrated superior wound closure rates, increased epidermis thickness, and enhanced collagen deposition in rodent skin wounds.
Scientists at the Terasaki Institute for Biomedical Innovation have developed a new bioink that enhances the formation of mature skeletal muscle tissue from muscle precursor cells, increasing efficiency and potential therapies for muscle loss or injury. The bioink's sustained delivery of IGF-1 promotes muscle regeneration and repair.
The Bioaction project leverages bacteria as allies in promoting tissue regeneration, offering a paradigm shift in addressing infections. By developing functional bio-hydrogels, the project aims to accelerate healing and stimulate bone growth, reducing reliance on extended antibiotic therapies.
Researchers have found that injuries on one part of an organism can trigger a whole-body response aiding wound healing and tissue regeneration. This coordination is crucial for successful regeneration in certain organisms such as planarians, zebrafish, and axolotls.
Researchers developed bio-piezoelectric smart scaffolds for next-generation bone tissue engineering, demonstrating potential for clinical applications. The scaffolds can reconstruct desired tissue EM through non-invasive ultrasonic stimulation, promoting cell adhesion and osteogenic differentiation.
A novel hydrogel has been developed to induce endometrial regeneration and elucidate its mechanism, offering new hope for patients struggling with infertility. The gel, made from uterus-derived decellularized extracellular matrix, successfully regenerated the endometrium in mice, creating a favorable environment for embryo implantation.
Researchers at DTU Health Tech created a multi-levelled scaffold that enables near-perfect bone healing in just eight weeks, without using growth factors or endocrine factors and cells. The scaffold combines essential bone minerals with mechanical properties matching human bone compressive strength.
Monasterio Ocares recognized for his research on oral tissue regeneration and intestinal disorders' impact on oral homeostasis. He receives funding to continue studying mechanisms of initiation and resolution of intestinal disorders in the mouth.
A novel study found that honokiol promotes healing of rotator cuff injury and may be an effective treatment for humans. The study suggests that SIRT3 activation plays a protective role in alleviating aging-induced fibrocartilage degeneration and promoting rotator cuff healing.
A new chemical compound named '1938' has been identified that can stimulate nerve regeneration after injury and protect cardiac tissue from damage. The compound activates the PI3K signalling pathway and has shown increased neuron growth in nerve cells and improved recovery in animal models.
African spiny mice have been found to produce bone plates similar to those of armadillos, a discovery that challenges previous understanding of mammalian armor. The plates, known as osteoderms, provide protection and are distinct from scales found in other animals.
Scientists have developed a new method to deliver genetic information to stem cells using nanoparticles coated with a specific polymer, enabling more efficient control over cellular differentiation. This innovation has the potential to improve the efficiency and effectiveness of regenerative medicine treatments.
Researchers discovered ERK signalling is a crucial switch between scarring and regeneration, with prolonged activation promoting regenerative success. Modulating ERK activity could potentially stimulate regeneration in clinical settings.
Researchers found that senescent cells promote regeneration by secreting factors that stimulate nearby muscle tissue to produce new muscle cells. The presence of these cells enhances the regeneration process, allowing salamanders to grow lost limbs in a matter of weeks.
Researchers developed a novel approach that promotes bone regeneration in mice without implantation of bone tissue or biomaterials. By carefully stretching the skull along its sutures, they activated skeletal stem cells that reside in these wiggly seams, repairing damage to the skull that would not have healed on its own.
Researchers found that applying ice to minor muscle damage in rats enhances muscle repair and reduces inflammation. The study used an animal model of mild injuries and showed that icing attenuates the recruitment of pro-inflammatory macrophages, preventing injury expansion. This contradicts previous findings on the negative effects of ...
Researchers at Tokyo Medical and Dental University have developed a polymeric nanoparticle gene delivery system that promotes bone formation after traumatic inflammation. The therapy inhibits excessive inflammation and prevents residual ridge resorption, leading to improved tissue healing after tooth extraction.
A new study found a protein that regulates macrophage function, clearing residues from regenerating muscle and recovering regenerative capacity in aged mice. The discovery holds promise for regenerative medicine and aging, potentially improving the success of current stem-cell based therapies.
Researchers discovered that mechanical loading can exacerbate inflammation in aged muscles, hindering healing. However, combining mechanotherapy with anti-inflammatory treatment significantly improves healing in aged muscles.
A team of researchers developed a transfer-tattoo-like cell sheet that can be directly applied to targeted surfaces, facilitating cutaneous wound healing and promoting skin tissue regeneration. The system leverages natural cell migration between surfaces, eliminating the need for external stimuli and detachment processes.
Scientists create hybrid composite scaffolds with aligned nanofibrous architectures to improve cell seeding efficiency, proliferation rates, and morphogenesis. The findings have potential applications in tissue repairing and regenerative medicine.
A new coating material developed by Korean researchers facilitates bone regeneration and attracts osteo-progenitor cells, significantly improving the success rate of dental implants. The coating, loaded with BMP-2, prevents non-osteogenic cell invasion and induces high bone differentiation in a short period.
Researchers at Hokkaido University used hydrogel materials in combination with neural stem cells to grow new brain tissue in areas of brain damage. The study showed that immune cells and blood vessels grew within the hydrogels, leading to some degree of integration between the hydrogel and host brain tissue.
Researchers at Northwestern University developed a first-of-its-kind small, flexible, stretchable bandage that accelerates healing by delivering electrotherapy directly to the wound site. The bandage healed diabetic ulcers 30% faster than in mice without the bandage.
Researchers found that platelet depletion increased amyloid plaque size and neuronal damage in APP-PS1 mice. However, platelets may have a beneficial role in limiting plaque growth and attenuating neuritic dystrophy at advanced stages of Alzheimer's disease.
Researchers at MLU and partners developed a new process coating implant materials with a gene-activated biomaterial that induces stem cells to produce bone tissue. This method, published in Advanced Healthcare Materials, stimulates bone healing in a targeted manner with fewer side effects than existing methods.
Researchers at Rice University have developed a self-assembling peptide ink that enables the 3D printing of complex structures with cells, which can then be used to grow mature tissue in a petri dish. The ink allows for control over cell behavior using structural and chemical complexity.
Researchers developed an injectable biomimetic hydrogel composite loaded with stem cells that promotes regenerative healing in animal models of Crohn's perianal fistulas. The treatment reduced fistula size by six-fold compared to surgery, offering a potential new paradigm for treating this condition.
Collagen deposition at injured sites in the gut stimulates cellular reprogramming, converting mature cells into fetal-like cells to generate new tissue. This process has implications for understanding intestinal inflammation and potentially colorectal carcinogenesis.
Researchers discovered that damaged cells and aging induce high levels of oxidative stress and DNA damage in a subset of cells, leading to senescence. Senescent cells repress muscle regeneration by releasing inflammatory factors, while also promoting fibrosis, highlighting the need to remove these cells for improved repair.
The research team successfully transplanted a stem cell sheet onto the heart, promoting angiogenesis and improving cardiac function. The technique has improved integration and engraftment rates, addressing challenges in patch-based treatments for myocardial infarction.
Scientists at Duke University have made a breakthrough in controlling gene expression in response to injury, using a segment of fish DNA called TREE. The method successfully targeted gene activity to specific regions and time windows, showing promise for regenerating damaged tissues in mammals.
Researchers at Indiana University School of Medicine developed a minimally invasive nanochip device that can reprogram tissue function by delivering specific genes. The technology has shown promise as a treatment for traumatic muscle loss, with improved muscle function observed in rats following volumetric muscle loss.