Researchers at Sanford Burnham Prebys discovered that blocking an energy transfer enzyme shifts mammalian hearts into a regenerative state, promoting regeneration and improving recovery after a heart attack. By modulating heart cell metabolism, scientists can potentially awaken the heart's dormant regenerative abilities.
The Terasaki Institute faculty has developed a next-generation immunomodulatory wound dressing platform designed to accelerate healing in chronic wounds. The platform is designed to deliver oxygen directly to the wound and use a specialized peptide to encourage immune cells to support healing.
Researchers develop biodegradable nanobone material that activates body's own healing properties to regrow bone, reducing need for invasive procedures. The material generates 80% more new bone than a material control and activates a key bone-repair growth factor with 10 times the level achieved using conventional methods.
Researchers developed a wearable patch that uses room light to treat skin wounds, promoting wound closure and tissue regeneration. The patch, made of a stretchable silicone elastomer, emits red light that activates a photosensitizer, inducing collagen crosslinking and alleviating inflammation.
Researchers found specialized astrocytes in mouse brains that can repopulate damaged areas and rebuild cells. These 'regenerative' astrocytes send newly formed cell nuclei to the site of injury, knitting the network back together.
Scientists have uncovered a new mechanism used by heart cells to resist reprogramming and found that carbohydrate sulfotransferase 7 (CHST7) is the most potent preventer of reprogramming in mouse and human cells. By targeting CHST7, researchers may develop treatments to help the heart fix itself after injury.
Researchers have discovered a hidden network of specialized mesenchymal support cells in the intestine that work together to maintain its inner lining. The study found four distinct populations of cells with unique genetic programs, each occupying specific locations and influencing stem cell activity and immune responses.
The Institute for Bioengineering of Catalonia (IBEC) will participate in the ALIVE program, a six-year European grant focusing on the physics of living matter. The project aims to understand how tissues behave by measuring and modeling information flows.
The Journal of Regeneration aims to explore regeneration across diverse disciplines and kingdoms of life, covering research from molecular genetics to clinical translation. The journal seeks to examine recurring principles shared between animals and plants, including cellular plasticity and epigenetic remodelling.
Researchers found that discarded sea cucumber tissue can grow, diversify cells, and reorganize itself in natural seawater, challenging assumptions of tissue immortality. This discovery has profound implications for biomedical sciences and engineering, with potential applications in tissue regrowth and anti-microbial healing.
Researchers have created lab-grown human skin organoids that can form complex microvascular networks similar to those in native human skin. These self-organizing structures function similarly to native skin, responding to inflammatory stimuli and re-growing after injury.
A new University of Michigan-led research has identified a connection between keratin 16 and type 1 interferon in the molecular pathways of pachyonychia congenita. The study found that losing or altering K16 causes amplification of the inflammatory response, but also helps pump the brakes on that response.
Researchers at Pohang University of Science & Technology discovered a way to prime skin cells for regeneration before injury, enabling rapid and effective healing. This approach, called mosaic partial reprogramming, reshapes surrounding cells and tissue microenvironment to accelerate wound healing.
Using AI-driven analytical methods, researchers have created a custom OCT system that enables the objective measurement of wound progress over time. The platform shows that stiffer mechanical properties improve wound healing outcomes, with faster transition to intact regenerated tissue.
In a breakthrough study, researchers successfully integrated neuronal precursor cells into biobots, resulting in the formation of functional nervous systems. This development has significant implications for neuroscience, bioengineering, and regenerative medicine, enabling the investigation of fundamental questions about the origin of ...
Researchers at Penn State have developed a new class of tunable biomaterials, known as granular aerogel scaffolds, to support tissue regeneration and vascularization in wound healing. The material offers improved cell infiltration and may help rapidly form new blood vessels and regenerate damaged tissue.
Researchers developed a rapid and non-destructive method to monitor iron flux in mesenchymal stromal cells (MSCs) using micromagnetic resonance relaxometry (µMRR). This breakthrough enables real-time insights into MSC's ability to form quality cartilage tissue, paving the way for more consistent manufacturing of MSC-based therapy.
Aging muscles heal more slowly after injury due to increased levels of protein NDRG1 in aged muscle stem cells. NDRG1 helps stem cells survive longer but reduces their ability to activate and repair tissue.
Researchers at Sanford Burnham Prebys found that transplanted stem cells develop neurons with unique codes to navigate and form connections in the brain. These codes guide the growth of axons and explain why most neurons of a particular subtype send axons to specific brain regions.
Researchers at Cold Spring Harbor Laboratory have devised a new approach to stimulate cell growth and repair in the intestine using CAR T-cell therapy. This therapy has shown promising results in improving gut health in both young and old mice, with significant reductions in inflammation and improved nutrient absorption.
Muscle stem cells secrete c1qtnf3, which redirects macrophages from immune to regenerative functions, promoting tadpole tail regeneration. This discovery offers insights into the regenerative capabilities of certain animals and paves the way for further research into potential applications in mammals.
Lehigh University researchers used machine learning to compare bone marrow extracted from the hip and shoulder, finding six proteins that distinguish between the two extraction sites. This study may lead to standardized BMAC extraction protocols and personalized treatments based on protein concentrations.
Prostacyclin has been found to promote fetal membrane repair through the proliferation and migration of amnion mesenchymal cells. This discovery provides new insight into the mechanisms of fetal membrane healing, which could lead to new therapeutic strategies for managing preterm birth and infant mortality.
Researchers discovered a mutation in the POT1 gene that prevents telomeres from repairing, leading to pulmonary fibrosis. This study highlights the importance of personalising treatments for diseases caused by dysfunctional telomeres.
Researchers have created 'skin in a syringe' by mixing cells with gelatine beads, allowing for 3D printing of functional dermis. This technology could lead to new ways to heal burns and severe wounds with minimal scarring.
Researchers have established apple snails as a system to study eye regeneration, which may hold the key for restoring vision due to damage and disease. The team discovered that the snail eye is anatomically similar to humans and can regrow itself, with genes such as pax6 playing a crucial role in development.
Researchers discover Hand2 gene plays key role in providing positional information for limb regeneration in axolotls. The discovery provides new insights into how cells 'remember' their position and switch on signals to regenerate structures correctly.
Researchers at the Marine Biological Laboratory found that activating specific neurons in the axolotl brain is essential for tail regeneration. The study suggests a comparable group of neurons may impact regenerative responses in mammals.
Researchers explore emerging technologies like Kerecis and NovoSorb BTM, which integrate antimicrobial properties into dermal substitutes. The review highlights the need for integrated antimicrobial agents to reduce antibiotic reliance and promote scarless healing.
Researchers have discovered that planarians can regenerate body parts and even grow new heads, reversing signs of aging such as lost neurons and muscle mass. This finding has implications for understanding age-related decline in mammals, including humans.
Researchers from Emory University are using the International Space Station to study cardiac cells and accelerate the development of cell-based regenerative therapies. The team's findings have led to multiple peer-reviewed publications and could significantly advance methods to produce cardiac cells for heart disease treatment.
Researchers at the University of Houston College of Pharmacy have identified a potential therapeutic target to repair injured muscles. They discovered that fibroblast growth factor–inducible 14 (Fn14) plays a crucial role in regulating satellite cell stability and function, which are responsible for muscle growth, repair, and regenerat...
Researchers have characterised how dying cells contribute to the body's regeneration process, suggesting a new mechanism for tissue repair. The study found that cells released from necrosis play a role in signaling the production of other cells involved in controlling natural cell death and inflammation.
A new Northwestern Medicine study suggests that muscle injuries heal faster when they occur during the body’s natural waking hours. The findings could have implications for shift workers and may also prove useful in understanding the effects of aging and obesity.
Researchers developed a hybrid bioink that maintains physiological properties of adipose tissue, promoting differentiation and regeneration. Bioprinted adipose tissues promoted wound healing in mice by inducing re-epithelialization, tissue remodeling, and blood vessel formation.
A new Northwestern Medicine study reveals that macrophages in newborns use a process called efferocytosis to produce thromboxane, which triggers the production of a bioactive lipid that signals heart muscle cells to divide and regenerate. This process is less effective in adults, leading to scar-tissue buildup and often heart failure.
Researchers at POSTECH developed an innovative injectable adhesive hydrogel that regenerates bone using harmless visible light. The hydrogel addresses limitations of existing treatments by simultaneously achieving cross-linking and mineralization without separate bone grafts or adhesives.
Researchers from Korea University have developed a groundbreaking technique to transform fibroblasts into mature cardiomyocytes, holding promise for regenerative medicine in treating cardiovascular disease. The method combines fibroblast growth factor 4 (FGF4) with vitamin C to accelerate cell maturation and enhance function.
A research team led by a physician-scientist found that artificial heart patients can regenerate heart muscle cells, which may lead to new ways to treat and potentially cure heart failure. The study showed that these patients' hearts regenerate muscle cells at more than six times the rate of healthy hearts.
A new study reveals that combining intermittent fasting with localized Wnt3a treatments can rejuvenate bone repair in older mice, suggesting a potential therapeutic approach to restore bone healing in aged animals. The treatment also showed promise in improving the repair and function of other aging tissues.
The NSF-Piedmont Triad Regenerative Medicine Engine has awarded $2.5 million in grants to six innovative companies to support the commercialization of regenerative medicine products. The funding is expected to catalyze technological advancements, strengthen the local economy, and drive regional competitiveness.
A team of researchers at Penn State developed a novel bioprinting technique that uses spheroids to create complex tissue, producing tissue 10-times faster and with high cell density. The technique enables the rapid fabrication of functional tissues and organs, opening new opportunities for regenerative medicine.
A new study published in Nature Aging details the changes in muscle regeneration over time, finding that immune cells exhibit differences in abundance and reaction time between age groups. The research also identifies altered stem cell states, leading to discoordination in the process of muscle repair in older mice.
Researchers discovered that sea anemones reshape their entire bodies to maintain the same overall form after injury, contrary to other regenerating animals. This process involves molecular changes across the body, including the activation of metalloproteases, to restore proportionate shape and function.
Researchers have developed a 3D artificial skin model with all three layers, simulating diseases and injuries more accurately. The model can replace animals in toxicological studies of medicines and cosmetics, enabling the development of new treatments without animal testing.
The study found that both axolotls and fruit flies exhibit distinct lipid adjustments during regeneration, with males increasing circulating lipids and females storing lipids in the liver. Insulin signaling pathways play a crucial role in adapting lipid metabolism to meet the needs of cell proliferation.
Researchers have successfully regenerated human epidermal keratinocytes into sweat gland-like cells using a combination of chemicals. These cells, called ciSGCs, restored thermoregulatory sweating and released bioactive factors to stimulate tissue repair in burned skin.
Researchers from Kyushu University have developed an antibody that targets and prevents the dysfunction of hepatocyte growth factor (HGF), a critical protein for skeletal muscle development, regeneration, and repair. The new antibody, 1H42F4N, blocked nitration of HGF and did not disrupt its activity.
Researchers from the University of Vienna have discovered that marine worms regenerate lost body parts by dedifferentiation, where cells return to a stem cell-like state. This process allows them to form new segments quickly, with specific gene expression and transcription factors involved.
Researchers developed a dual-function molecule (LXW7)2-SILY to remodel native extracellular matrix at ischemic sites, enhancing endothelial cell adhesion and survival. This approach improved vascularization, blood perfusion, and tissue regeneration in mouse hindlimb ischemia models.
Researchers develop biocooperative materials by harnessing blood-clotting and peptide self-assembly to repair bones in animal models. The new approach enables the creation of regenerative materials that can be easily assembled, manipulated, and 3D printed while maintaining normal healing functions.
Researchers developed porous dermal fillers that accelerate tissue healing and regeneration for diabetic wounds. The novel approach combining electrospinning and electrospraying technologies creates biocompatible microspheres that promote cell migration, granulation tissue formation, and neovascularization.
Researchers at MD Anderson Cancer Center have made significant advancements in understanding tissue regeneration, with a focus on epigenetic regulation and retrotransposon suppression. MicroRNAs have also been identified as potential biomarkers for COVID-19 severity in cancer patients, while a novel protein complex drives lung regenera...
GeniPhys secures $500k NSF grant to support regulatory and commercial readiness of Collymer SAS for soft tissue restoration in advanced wound care. The technology promotes regenerative remodeling without inflammatory response, facilitating faster healing and tissue repair.
Researchers found that maintaining optimal levels of DEAF1 is crucial for muscle repair and regeneration, and that restoring balance with DEAF1 may counteract some effects of aging on muscle tissue. This could lead to improved treatments for sarcopenia and cachexia, conditions affecting millions of older adults and cancer patients.
Researchers at UCSF have identified a molecular pathway that controls the formation of scar tissue in spinal cord injuries. By activating this pathway, they were able to reduce scarring and promote healing in mice with spinal cord injuries.
Scientists from Sun Yat-sen University developed groundbreaking tubular scaffolds made from electrospun membranes that enhance bone regeneration in critical skull defects. The scaffolds mimic natural bone structures and provide an optimal microenvironment for adipose-derived stem cells to thrive, accelerating healing.
Researchers have discovered that administering regulatory T cells (Tregs) can enhance tissue healing, promoting bone volume, muscle growth, and skin wound closure. The key role of interleukin-10 (IL-10) in supporting tissue repair has also been identified.
Researchers have elucidated how new arteries form in the heart using single-cell sequencing and 3D mapping. Pre-arterial cells play a major role in growing new arteries, contradicting current thinking about artery development. This discovery opens possibilities for developing treatments that stimulate regenerative pathways.
Researchers at Queen Mary University of London have identified a neurohormone responsible for triggering arm detachment in starfish. The team's discovery sheds light on the complex interplay of neurohormones and tissues involved in autotomy, a well-known survival strategy in the animal kingdom.