Articles tagged with Dna Damage
University of North Carolina at Chapel Hill scientists have found that the BRCA1 gene is necessary for transcription-coupled repair of certain types of DNA damage, which can lead to breast and ovarian cancer. The study provides direct evidence of the gene's role in DNA repair and may help develop new treatments for cancer.
Researchers create ultra-sensitive assay to detect DNA damage caused by ionizing radiation and cancer-causing chemicals, showing potential for early detection and treatment of genetic injuries. The new technique is 10,000 to 100,000 times more sensitive than existing methods.
A new study suggests that inhibiting poly(ADP-ribose) polymerase (PARP) enzyme may protect nerve cells from energy loss and prevent irreversible damage after a stroke. The research, published in Nature Medicine, found that genetically modified mice without the PARP gene experienced reduced brain damage compared to unaltered mice.
A team of researchers has found that most DNA mutations in yeast are caused by the activity of an enzyme called REV1. The enzyme helps cells evade quality control and can produce mutations when repairing damaged DNA, potentially leading to cancer.
A new DNA polymerase, dubbed zeta, allows yeast cells to replicate damaged DNA, increasing their odds of survival but also the risk of mutations. This enzyme is a last-gasp option for cells when all attempts to fix damaged DNA have failed, and its discovery sheds light on how organisms cope with this constant problem.
A University of Cincinnati biologist discovered a microbe that can repair its DNA with visible light, a process known as photoreactivation. This finding is significant for understanding how hyperthermophiles survive in geothermal habitats.