Research on how genes and species change over time. Covers ancient DNA, longevity in bats, plant lineages, and insect evolution.
Researchers identify OmpU protein variants associated with antimicrobial resistance in Vibrio cholerae bacteria. Understanding the evolutionary origins of AMR can inform the development of effective therapeutics against resistant infections.
A new study has provided insight into the mysterious evolution of DNA rings in tumors, revealing that nearly one-third of all tumors have these genetic structures. The researchers used a technology to trace the path of DNA ring development in neuroblastoma cells, finding that large rings contain cancer genes spurring cell growth.
Researchers reconstruct bacterial genomes of Ice Age microorganisms, reviving ancient natural products and discovering new chemical diversity. The team uses synthetic molecular biotechnology to produce chemicals encoded by ancient genes, unlocking the secrets of Earth's past microbes.
Researchers at the Stowers Institute for Medical Research have revealed the dynamics of a new, young chromosome in fruit flies similar to those found in humans associated with treatment-resistant cancer and infertility. The B chromosomes are maintained by meiotic drive, enabling them to persist in a genome.
Researchers have sequenced the genomes of Leatherback and Green sea turtles, revealing similarities in their immune systems and evolution. The study provides clues for understanding fibropapillomatosis, a cancer affecting these species, and informs conservation efforts.
A team of researchers has developed a non-destructive method to extract DNA from bones and teeth, allowing for direct attribution of cultural objects to specific individuals. The breakthrough enabled the recovery of ancient human DNA from a 20,000-year-old pendant, providing insights into Paleolithic societies.
The study reveals that mammals diversified before the K-Pg extinction, driven by continental drifting and stability following the mass extinction. This led to the rich diversity of mammal lineages, including carnivores, primates, and hoofed animals.
Researchers have analyzed DNA samples from over 50 institutions, including Balto at the Cleveland Museum of Natural History, to shed light on extraordinary feats in mammals. The study has identified unchanged DNA across millions of years of evolution and pinpointed genetic variants associated with rare human diseases.
A new study finds that modern-day Scottish, Welsh and Northern Irish people share a common genetic heritage with ancient Pictish populations, contradicting long-held assumptions of exotic origins. The research also reveals surprising genetic similarities between Picts and present-day groups in the UK.
Researchers have created a new manual to study human diseases, using evolutionary genomics to analyze genetic risk. The manual reveals the importance of highly constrained genes that unite mammals, providing insights into neurological disorders and psychiatric conditions.
The study of Balto's genome provides new insights into the genetics of working dogs, revealing they were more genetically diverse and healthier than modern breeds. The analysis also identified beneficial adaptations in genes related to physical traits such as weight and skin thickness.
Researchers have compared the genes of 240 species of mammals, including a famous sled dog named Balto, to gain insights into biological and evolutionary processes. The study identifies pinpointing genes that underlie complex traits like hibernation and brain size.
A large-scale genomic study of 240 mammal species reveals previously uncharacterized regulatory elements in the human genome, linked to disease risks and distinctive traits. The research provides insights into the evolutionary development of mammalian genomes and their potential applications in medical research.
Researchers have made an important human discovery by analyzing the genome of a 3,000-year-old individual found in a cave in Southeast Alaska. The study confirms that some modern Alaska Natives still live almost exactly where their ancestors did over 3,000 years ago.
The study of nematodes' body size can inform scientists' understanding of cellular growth, with the goal of discovering novel genes that control cell size and potential targets for cancer treatment. Nematodes are a model species for biological studies due to their quick growth rate and ability to produce hundreds of eggs.
A new group of DNA viruses, mirusviruses, has been discovered in marine plankton, linking them to both giant viruses and herpesviruses. The discovery reveals that the ancestors of herpes viruses once infected single-cell organisms, while the majority of mirusvirus genes share similarities with those of giant viruses.
The new CALANGO software helps untangle genetic factors associated with shared characteristics, such as antibacterial resistance and agricultural improvements. It enables scientists to explore vast amounts of genomic data across thousands of organisms.
Antarctic icefish have evolved special adaptations to cope with extreme cold, including antifreeze glycoproteins and changes to the rhodopsin protein. These changes enable them to see under sea ice and adapt to red-shifted wavelengths in low-light conditions.
A team of researchers compared 1,800 de novo proteins from fruit flies and humans with computer-generated proteins, revealing small but significant differences in their stability and solubility. The study suggests that natural selection may play a role in the early emergence of these proteins.
Researchers at Rutgers University have sequenced the complete DNA sequence of the little skate, identifying key genes responsible for its distinctive wing-like pectoral fins. The study reveals extensive rearrangements in fin formation genes and conservation of chromosomal identity across cartilaginous fish.
Researchers at University of California - San Diego found that vertebrates acquired a special protein from bacteria more than 500 million years ago. This discovery reveals a new piece of genetic material introduced from foreign bacterial genes, leading to unique functionality in vertebrate eyes.
Researchers discovered that skates' remarkable fins result from changes in their genome's non-coding regions and three-dimensional complexes called topologically associated domains (TADs). These alterations drove the evolution of unique gene-expression patterns, enabling the development of exceptionally wide fins.
Researchers used ancestral sequence reconstruction to study protein interactions in cyanobacteria, finding that they can evolve independently of direct selection pressure. The discovery challenges classical evolutionary theory and suggests that fortuitous compatibility may be the basis for a significant fraction of cellular interactions.
In a 50-generation evolutionary experiment, male beetles from lineages with intense sexual selection produced lower quality offspring after DNA-damaging radiation. This suggests that males invest more in competition at the expense of DNA repair, impacting future offspring survival and fertility.
A recent study on the pike icefish revealed significant genetic changes as it migrated from Antarctic to temperate waters. The researchers found divergent genes associated with the physiology that needed to change in response to the new environment, including mutations in the antifreeze glycoprotein gene.
A study from the University of Gothenburg reveals that wastewaters harbor unique characteristics allowing antibiotic resistance genes to evolve. The researchers found key components necessary for gene movement in wastewater samples worldwide, not in human or animal guts.
A genome-wide association study identified a new quantitative trait locus, STP1, encoding a Sugar Transporter Protein that alters soluble solid content. Knockout of STP1 led to decreased SSC in fruits, highlighting ZAT10-LIKE transcription factor's role in regulating sugar transporters.
Researchers from Spain, Italy and Norway uncover a cluster of water channel genes in teleosts that allow eggs to float. The study reveals unique mechanisms for hydrating maturing eggs, which determines their buoyancy.
Genetic welding proposes using CRISPR-Cas9 technology to rapidly change evolutionary courses in animals or plants. Cutting argues that this method requires scientific and ethical scrutiny before its application.
Researchers found that a large genetic region responsible for immune responses showed rapid evolution and more Mesolithic hunter-gatherer ancestry, suggesting that genetic variants already present in Europe were passed down preferentially. This suggests that diversity in immune genes may be just as important as adaptation to lifestyle.
Researchers found that the Alba morph in female Colias butterflies evolved once near the last common ancestor over 1.2 million generations ago. The genetic basis of Alba was identified as a regulatory region in DNA, maintained through gene flow and balancing selection.
Researchers used demographic modeling to reconstruct wheat's evolutionary history during the Holocene, revealing its origins near the Caspian Sea and slow speciation process. The study also found that crop relatives are valuable for breeding resilient crops but face decline due to changes in human diets and climate change.
A genomic study of ancient humans on the Tibetan Plateau reveals a single origin for ancient humans, deriving from a northern East Asian population. The study also found distinct genetic patterns in different regions of the plateau, indicating three regional groups with unique historical patterns that began to merge after 2500 BP.
Researchers identify egg yolk proteins retained in viviparous sharks and rays, which may provide nutrition to developing embryos. The study suggests that these proteins have evolved a new function in cartilaginous fishes, potentially facilitating the transition from egg-laying to live birth.
Scientists create modified E. coli bacteria that cannot be infected by viruses while minimizing gene escape into the wild. This breakthrough technology has implications for reducing viral contamination in biotechnology production, such as insulin production and biofuel manufacturing.
Researchers analyzed ancient DNA from Cueva del Malalmuerzo in southern Spain, uncovering the oldest known human genome from this region. The study found a direct genetic link between the new genome and earlier populations in Belgium and beyond, shedding light on the Iberian Peninsula's role as an Ice Age refuge.
The study of 356 prehistoric hunter-gatherers from across Eurasia sheds light on the movements and genetic replacements of ancient populations. Genetic analysis reveals that populations in western Europe took shelter during the Last Glacial Maximum, while those in central and southern Europe died out or replaced with new gene pools.
A new snake family, Micrelapidae, was identified through an international study led by Tel Aviv University researcher Prof. Shai Meiri. The family includes only three species, two in Africa and one in Israel, and diverged from the rest of the evolutionary tree about 50 million years ago.
A new phylogenetic tree analysis by the University of Vienna has provided fresh insights into the evolutionary history of sharks and rays. The study found that the Late Jurassic shark Protospinax annectans was a highly evolved species, contrary to previous hypotheses about its position in the family tree.
Scientists have reconstructed the evolutionary history of flavin-containing monooxygenases (FMOs), a class of detoxifying enzymes present in all lifeforms. The study reveals that a single ancestral gene diverged into two distinct functions, with one gene triggering a different breakdown reaction.
Researchers estimate transcription error rates in human cells and identify genetic and epigenetic factors responsible for inaccuracies. Inaccurate transcription produces truncated or altered proteins, leading to disease.
A single gene controls a switch between two alternative cell fates in a species of sea anemone, enabling the transition from a piercing cell to a sticky cell. This finding suggests that the nematocyte cell may have evolved from a spirocyte thanks to the development of the NvSox2 gene.
Researchers found no relationship between growth rate and body size in theropod dinosaurs, with some giants growing slowly and smaller ones rapidly. This study opens the door to future investigations into how animals regulate their growth.
New research on malaria-infected bonobos shows that the infection harms them, too, with symptoms including fever and increased mortality risk. The study also finds that bonobos have a protective variant of an immune gene similar to one found in humans, suggesting a selective advantage for those individuals.
A recent study by the University at Buffalo has discovered that genetic variations affecting immunity and metabolism have been preserved in humans for millions of years. This finding supports the theory of balancing selection, which suggests that certain genetic traits can be beneficial or harmful depending on environmental conditions.
A new genomic study found signs of TB adaptation in ancient Andean populations, thousands of years before European contact. The study suggests that Indigenous people in present-day Ecuador developed an immune response to tuberculosis around 3,000 years ago, when agriculture began proliferating in the region.
Researchers have created detailed genetic maps of green and leatherback sea turtle genomes, providing insights into their unique adaptations and evolutionary history. The study reveals that genetic differences between the two species are mainly found on microchromosomes, which may hold the key to each species' survival.
Researchers have discovered thousands of new miniproteins in human organs, which challenge the assumption that they are insignificant and functionless. The proteins were found to interact with older proteins, suggesting a key role in cellular functions.
Researchers identified a new gene, glubschauge, regulating sex-specific eye morphology in honeybees. Switching this gene off in females and adding it to males resulted in the development of characteristic eye forms.
Researchers have discovered that fungi in orange lichens can transport toxic pigments out of their cells, creating a 'sunscreen effect'. This mechanism allows the lichens to reflect harmful radiation while still allowing some solar radiation to pass through for photosynthesis.
A team of researchers at UConn has discovered the genetic basis for the emergence of a new species of monkeyflower, which lost its yellow pigment but gained pink and later red. The study reveals that unique genes are responsible for this phenomenon, contradicting previous theories on evolution.
Lichen-forming fungi have evolved unique gene clusters to produce orange 'sunscreen' pigments, allowing them to thrive in sunny environments. The discovery of a critical ABC transporter gene within the pigment gene cluster provides a potential hypothesis for toxicity avoidance in these organisms.
The cichlid fish species Lamprologous callipterus has a unique reproductive system where males are 12 times bigger than females, but also has a smaller male morph that is 60 times smaller. A new study found that the genetic mechanism underlying this size-determining sex chromosome is linked to the growth hormone regulator gene GHRHR.
Conflicts between divergent goals can continue indefinitely through evolutionary time, causing devastating damage to complex organisms and social structures. Modular design is a crucial enabler of complex adaptation and transformative changes in social organisation.
An international team of researchers has created a detailed genetic map of two sea turtle species, revealing surprising similarities and differences. The study finds that green turtles have evolved more immune-related genes, while leatherbacks have historically lower population levels and reduced genetic diversity.
Researchers at Lund University identified two areas in the genome that decide whether a willow warbler migrates across the Iberian Peninsula or the Balkans. This discovery sheds light on the genetics behind songbirds' migratory behaviour and has implications for understanding how species adapt to climate change.
A study at Nagoya University found that specific neurons in fruit flies process and distinguish between different courtship songs, differing between species. The researchers used calcium imaging to determine how these neurons respond to different courtship songs, finding that the responses varied between species.
Researchers discovered a single protein called Gr8a that plays an inhibitory role in mating decision-making, helping flies avoid inter-breeding with the wrong partner. The findings provide insight into how signal production and perception are tied together, shedding light on pheromone communication.
A new study analyzes the microstructure of eggshells from living and extinct flightless birds, shedding light on their evolutionary history. The research finds that wedge-like microstructures in rhea eggs evolved from ancient ancestors, while prism-like structures in ostrich and tinamous eggs likely developed independently.
A new study by University of California, Berkeley researchers suggests that iconic desert plants came preadapted to stresses of arid living. The rock daisy study found these pioneers developed adaptations on dry, exposed rock outcrops within older areas, making it easier for them to thrive in expanding deserts.