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Long-term survival after breast cancer diagnosis

Researchers developed a new method to assess breast cancer patients' prognosis by analyzing 185 genes. The study found that tumors with specific gene expressions can predict long-term survival, even among women with multiple positive nodes.

SourceRush University Medical Center·DateMay 31, 2003
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Researchers discover possible new mechanism for high blood pressure

Scientists have identified a key protein involved in regulating blood pressure, RGS2, which works by stopping the action of angiotensin II and enabling arterioles to relax. This discovery may lead to new ways of diagnosing and treating high blood pressure in individuals with underlying genetic defects or differences.

SourceWashU Medicine·JournalJournal of Clinical Investigation·DateFeb 15, 2003

Computer scientist locates more than 1,000 novel genes in mouse and human

A team of researchers led by Michael R. Brent developed a new computer program to predict genes by analyzing patterns of evolutionary conservation. They identified 1,019 predicted novel mouse genes with high accuracy, including those involved in Duchenne muscular dystrophy and neural development.

SourceWashington University in St. Louis·JournalProceedings of the National Academy of Sciences·DateFeb 4, 2003

DNA transcription is tuned to specific cells

Research in mice reveals that TAFII105 is a cell-type specific component of the transcription machinery, controlling egg formation and potentially linked to female infertility. The study provides new avenues for understanding the complex transcriptional mechanisms underlying cell-specific gene expression.

SourceHoward Hughes Medical Institute·JournalScience·DateSep 13, 2001

Does chromosome 4 hold the secret to human longevity?

A genome-wide study of 308 long-lived individuals revealed a significant correlation between allele sharing on chromosome 4 and longevity. This suggests that the region may contain genes influencing human lifespan, with potential applications in preventing age-associated diseases such as heart disease and Alzheimer's disease.

SourceHoward Hughes Medical Institute·JournalProceedings of the National Academy of Sciences·DateAug 27, 2001