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Life Sciences

Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.

447,757 articles | 2542 topics

Health and Medicine

Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.

431,843 articles | 751 topics

Social Sciences

Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.

260,756 articles | 745 topics

Physical Sciences

Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.

257,913 articles | 1552 topics

Applied Sciences and Engineering

Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.

225,386 articles | 998 topics

Scientific Community

Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.

193,043 articles | 157 topics

Space Sciences

Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.

29,662 articles | 175 topics

Research Methods

Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.

21,889 articles | 139 topics

Mathematics

Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.

3,023 articles | 113 topics

Simple genetic circuit forms stripes

Researchers designed a synthetic genetic circuit that creates a striped pattern, using genes from one species of bacterium and inserting them into another. By controlling the rate at which cells move, they can create distinct patterns with concentric rings of crowded and dispersed bacterial cells.

Genetic switch underlies noisy cell division

Researchers have identified a specific gene circuit that acts as a 'switch' to tell cells when to divide. This discovery may help scientists better understand cell biology and establish a library of cancer-causing pathways.

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Understanding a cell's split personality aids synthetic circuits

Researchers at Duke University discovered that some bacteria exhibit bistability, allowing individual cells to respond differently to external commands. This phenomenon enhances the efficiency of synthetic circuits, which could produce proteins, chemicals, or deliver targeted drugs.

MIT, BU engineer cellular circuits that count events

Researchers have developed cells that can count up to three cellular events, mimicking computer chips with simple circuits. The RTC Counter uses a series of genes activated in a specific order, while the DIC Counter stores digital memory by encoding 'bits' of information.

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SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.

Howard Hughes Medical Institute names 3 new Caltech investigators

Three Caltech researchers, David Chan, Michael Elowitz, and Grant Jensen, were selected as new HHMI investigators. They will focus on mitochondrial dynamics, genetic circuits, and biological imaging to advance scientific knowledge dramatically. The selection brings the total number of HHMI investigators at Caltech to 10.

Gene triggers obsessive compulsive disorder-like syndrome in mice

Researchers created OCD-like behaviors in mice using genetic engineering and reversed them with antidepressants and targeted a key brain circuit. The study suggests new strategies for treating the disorder by understanding the role of the SAPAP3 gene in glutamate-mediated communications.

Brain's reward circuitry revealed in procrastinating primates

Researchers found that monkeys with impaired dopamine receptors were more productive and accurate in their tasks, while those without the receptors procrastinated. The study uses a gene knockdown technique to deplete D2 receptors, leading to improved performance.

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First genetic toggle switch engineered at Boston University

Researchers successfully engineered a genetic toggle switch to control the activity of genes between stable on and off states. The toggle represents core technology for genetic control devices with potential applications in diabetes, biological warfare agent detection, and cell-based computing.

Butterflies Help Reveal The Source Of Life's Little Luxuries

Scientists from the University of Wisconsin-Madison describe a genetic trick that helps explain the diversity of patterning and color on butterfly wings. This trick is also believed to be used among animals, enabling the emergence of new morphological characteristics through evolution.