Articles tagged with Genetic Engineering
The biopharmaceutical industry is shifting towards more sustainable operations, with companies adopting environmentally friendly practices that also offer economic benefits. Key findings include the potential for waste reduction through process intensification and purification bottlenecks.
Researchers at UC San Diego successfully synchronized bacterial genetic clocks to blink in unison and alter their blinking rates in response to environmental conditions. The achievement is a crucial step towards creating genetic sensors that can monitor temperature, poisons, and other hazards.
The BIOFAB facility aims to produce thousands of standardized DNA parts, shortening the development time and lowering the cost of synthetic biology for academic or biotech laboratories. The project will enable researchers to mix and match genetic parts in synthetic organisms to produce new drugs, fuels, or chemicals.
Researchers at the University of Minnesota have discovered a molecular security system in human cells that deactivates and degrades foreign DNA. This discovery could lead to major improvements in genetic engineering and gene therapy technologies.
Advances in qPCR technology are expanding its applications in basic research and diagnostics, enabling more efficient detection and quantification of specific DNA sequences. Companies like Qiagen and Bio-Rad Laboratories are developing new methods to improve multiplex PCR and sample preparation.
NGS technologies offer streamlined workflows, massive parallelism, and cost reduction through targeted sequencing of specific genes or regions. Researchers are applying NGS to various fields, including hereditary cancer research and bacterial gene expression studies.
The article presents optimized ChIP protocol for mammalian cells, while recombineering methods are used to construct targeting vectors for conditional knockout mice. These techniques provide efficient and precise genetic modifications.
Scientists have developed a therapy using genetically engineered Bacteroides ovatus that activates a human growth factor to treat bowel disorders like inflammatory bowel disease. The treatment reduces rectal bleeding, accelerates gut lining healing, and prevents disease onset.
Scientists have discovered a bowl-shaped molecule that can pull carbon dioxide out of the air, offering new possibilities for reducing greenhouse gas emissions. The molecule's unique properties make it suitable for industrial use in removing CO2 from ambient air and potentially even from living organisms.
The development of genetically modified trees is being obstructed by anti-biotech groups and regulations that prioritize process over product. Researchers argue that a regulatory environment focused on scientific case-by-case assessments is necessary to unlock the full potential of forest biotechnology.
Researchers are exploring various methodologies to meet biofuel needs, including Edenspace Systems' Energy Corn and Coskata's Flex Ethanol technology. These approaches aim to lower fossil fuel reliance and mitigate global warming concerns.
The ACLU is challenging the patentability of two human genes linked to breast and ovarian cancer, alleging that gene patents stifle life science research. The organization claims that the patents are invalid and unconstitutional, with supporters arguing that they would harm patients and limit medical research.
Newly emerging biotechnology clusters globally showcase life science expertise across various disciplines. China's Shanghai and Beijing are home to the largest groupings of biotech companies, while Brazil has strong centers in Belo Horizonte, São Paulo, and Rio de Janeiro.
A novel digital gene-expression profiling technique is gaining traction, offering a fully quantitative approach to gene-expression analysis. The method has been shown to provide robust and comparable expression profiling data, making it an attractive alternative to traditional microarray-based platforms.
The Madoff scandal has led to a shift away from risky investments, affecting endowment institutions and university research projects. Academic medical and bio-related research are tightening their belts as a result of the general economic situation.
Biomanufacturers are developing fully disposable bioprocess streams to minimize validation studies, sterilization, and cleaning procedures. Companies like GE Healthcare and Pall offer disposable products that reduce inventory costs and improve flexibility in bioprocessing.
Biotech scientists are applying genomics technologies to toxicology research to better understand the effects of novel drug candidates. This trend towards predictive toxicogenomics aims to develop a new compound's mechanism of action and predict toxicity, with several companies and consortia already working on this technology.
Companies like UCB Pharma and CeeTox are using cell-based assays to assess the toxic characteristics of small molecule compounds. This early identification can improve clinical trial results and reduce the time to market.
Developing nations offer a ready supply of patients, large potential markets, and reduced competition for clinical trial sites. Companies conduct trials primarily in cities due to the presence of doctors, staff, and equipment similar to those found in Western conditions.
A new genomics tool identifies artificial vector sequences by clustering shared DNA regions, allowing for high sensitivity and specificity in detecting engineered pathogens. The tool's potential is being explored to combat malicious genetic engineering applications.
Researchers are studying the effects of over- or underexpression of specific miRNAs on disease development and inhibition. For instance, scientists identified miR-373 and miR-520c, which promote tumor metastasis.
The NIH is awarding $105 million to 41 innovative investigators through the Pioneer and New Innovator Awards. These grants will support groundbreaking research in various fields, including neuroscience, physics, and biology.
Iron deficiency affects an estimated 2 billion people, leading to poor pregnancy outcomes, impaired school performance, and decreased productivity. Genetic engineering can increase iron content in staple crops like rice and improve bioavailability by introducing genes that break down phytate.
Researchers develop genetically engineered proteins to form erasable chemical detectors. They also create self-grown forests of molecular 'bottlebrushes' that keep themselves contamination-free. Additionally, they design auto-assembled DNA 'towers' that could serve as anchors for the tiniest devices.
A new GM mosquito sexing technique allows for the quick identification of males, paving the way for releasing sterile males to control mosquito populations. This could lead to a significant reduction in malaria cases and population growth.
Researchers successfully treated a laboratory model of GM1 – gangliosidosis using genetically modified bone marrow cells that produce an enzyme breaking down excess GM1. The treatment restored the activity of degenerating brain cells, suggesting a potential cure for this neurodegenerative disease.
Despite China's genetically modified (GM) rice ambitions, poverty and unequal land distribution will persist, hindering efforts to eliminate hunger. The Lancet notes that GM technology is not a solution to food insecurity, but rather a Band-Aid on the symptoms of deeper issues.
A recent study found that genetically modified rice in China reduces pesticide use by 80% and increases crop yields by up to 9%. The research also indicates no significant impact on farmers' health. The study provides valuable information for developing countries considering genetically modified food crops.
The new technique improves specificity of human estrogen receptor alpha by 100 million times, allowing for targeted activation or deactivation of genes in living systems. This breakthrough could lead to advances in gene therapy, metabolic engineering, and animal disease model studies.
Researchers at St. Jude Children's Research Hospital have developed a technique to produce large numbers of genetically modified NK cells that can effectively target and eliminate leukemia cells. The new technology has the potential to be used as a treatment for leukemia patients undergoing hematopoietic cell transplantation.
The US Constitution offers a set of shared values that can help frame the debate on genetic engineering of humans, including promotion of welfare, science, and equal protection. Policymakers will likely debate the benefits and potential harm to future children and the public.
Researchers found that mice with enhanced neuronal excitability outperformed their wild-type counterparts in the Morris water maze, a test for learning and memory. The study suggests that manipulating neuronal excitability and synaptic plasticity may be effective in ameliorating age-related cognitive decline.
A genetically modified bacterium, Lactococcus, has been engineered to produce a therapeutic protein that protects the epithelium and heals intestinal tissues. The bacteria shows great promise in treating both acute and chronic intestinal inflammation, including Crohn's disease.
A team of scientists identified genomic regions in wild tomato species that boost yield and drought resistance, outperforming commercially available hybrids. Their approach harnesses natural biodiversity to enrich the genetic basis of cultivated plants.
Researchers at UC Davis suggest using transposons to introduce genes that block malaria in mosquitoes, which could spread through the population via natural selection and eventually eliminate malaria transmission.
Research reveals that beavers' selective herbivory affects plant types in their community, favoring hybrid cottonwoods with lower tannin levels. This study suggests a link between terrestrial and aquatic ecosystems through genetically-based plant traits.
A new report from Ohio State University recommends prioritizing the risks and benefits of genetically engineered organisms (GEOs) before release. The panel suggests developing regulations based on scientific findings and implementing measures to prevent unwanted side effects.
Purdue scientists Rick Howard and colleagues discovered that genetically modified fish have a reproductive advantage, but their offspring are less likely to survive. This paradox could lead to a population dwindling in size and potentially disappearing entirely if not managed carefully.
Researchers discover transgenic mosquitoes are severely impaired in development and reproduction, laying fewer eggs and having lower egg-adult survivorship. This finding has major implications for the competitiveness of transgenic mosquitoes against non-engineered wild-types.
Despite 80% of processed American food containing genetically modified ingredients, only 26% of Americans believe they have ever eaten GM foods. A new study found that self-reported and objective knowledge of biotechnology remains low in the US, but opinions on GM foods are open to change.
Researchers have developed genetically modified fat that protects mice from obesity and insulin resistance by increasing adiponectin production. The study suggests that knocking out the Dgat1 gene perturbs the metabolic function of fat tissue, leading to increased energy expenditure and improved insulin sensitivity.
A recent study by Imperial College London found that genetically modified mosquitoes (GM) lose their test marker gene rapidly when interbred with unmodified mosquitoes, posing challenges for malaria control. The researchers suggest using crossing regimes to minimize deleterious mutations and improve the competitiveness of GM mosquitoes.
A computer model reveals that genetically modified organisms (GMOs) can lead to the extinction of natural populations in as few as 20 generations. The research also identifies an 'invasion risk' where introduced genes spread through the population without reducing overall size.
A new peptide-based vaccine has been shown to reduce arterial plaque formation by 60-70% in mice with high cholesterol levels, according to a study led by Cedars-Sinai's P.K. Shah and the Swedish team of Gunilla Nordick-Fredricksson. The vaccine targets the major protein component of low-density lipoprotein (LDL) cholesterol.
A research team found that a small fraction of nerve cells in the retina express melanopsin, which detects light levels and regulates the body's daily cycles. These cells connect to brain areas controlling the clock and pupil response, suggesting a non-visual role for melanopsin.
Scientists have identified several proteins that can block myostatin activity, leading to increased muscle growth in mice. The study suggests that these proteins may be effective muscle-enhancing agents for both human and agricultural applications.
The American Association for the Advancement of Science recommends that human trials of inheritable genetic changes should not be initiated until reliable techniques for gene correction or replacement are developed. Serious ethical and religious issues also must be addressed as research policy is formulated, including concerns about ju...
Researchers at Rosetta Inpharmatics used high-quality gene expression data and computational methods to identify novel gene functions. The company's approach enables the deciphering of previously uncharacterized genes, with applications in new drug discovery and development.
Renowned scientist J. Craig Venter will discuss his work on decoding the human genome at the American Chemical Society meeting. He co-founded Celera Genomics to sequence the entire human genome by 2001 and is this year's honoree for the David Perlman Memorial Lectureship.
Researchers successfully engineered a genetic toggle switch to control the activity of genes between stable on and off states. The toggle represents core technology for genetic control devices with potential applications in diabetes, biological warfare agent detection, and cell-based computing.
A group of Oregon State University scientists emphasize the potential benefits of genetic engineering in forestry, including faster-growing trees that can reduce the burden on native forests. They argue against 'genetic extremism' and call for a more careful analysis of the issues based on science.
A new CRADA and licensing agreement have been signed between NREL and Arkenol Holdings, which could further bring down the cost of making ethanol from biomass and boost the US biofuels industry. The agreements focus on developing new strains of genetically altered bacteria for use in converting rice straw to ethanol.
A panel of GMO experts will discuss the differences between genetic engineering and traditional breeding methods, as well as the regulatory frameworks for GMOs in the US and Europe. Key findings include varying attitudes towards labeling and education about rDNA technology across regions.
Researchers genetically altered mice adrenoceptor 2C expression to study stress response. The results showed differential behavioral responses in treated vs. untreated mice, as well as changes in plasma corticosterone levels and brain dopamine/serotonin content. This study highlights the importance of single-gene mutations in respondin...
Researchers have discovered that sons conceived through ICSI can inherit the same genetic defects in their fathers, including AZFc deletions. This finding raises ethical questions about assisted reproduction techniques and potential remedies for affected males.
A recent study published in the New England Journal of Medicine found that genetic testing and dietary modification can save the lives of children born with a defect in fatty acid breakdown. The research team identified 24 infants with liver, heart, or muscular abnormalities and found that dietary treatment was crucial for survival.
Scientists at UNC Chapel Hill and Bern University have developed a new RNA repair technique to block defective processing in cells' messenger RNAs. This method has shown promising results in increasing healthy protein production and could potentially treat or even cure beta thalassemia.
A new form of gene therapy has been tested to prevent blockages that occur after bypass surgery, with four patients showing successful results. The treatment aims to reduce cell growth and atherosclerosis in grafted vessels, which can fail due to up to 50% of cardiac and leg bypass surgeries.
Researchers create unnatural polyketides with anti-bacterial properties by altering enzyme feedstocks, promising to multiply the power of combinatorial biosynthesis and generate hundreds of new compounds for lead molecule discovery