Articles tagged with Genetic Engineering
Researchers successfully engineered E. coli collected from human and mice gut microbiomes, showing potential to treat diseases such as diabetes. The engineered bacteria retain their activity for the entire lifetime of the host and positively influence diabetes progression in mice.
Washington University in St. Louis' Zhang lab has been awarded a $458,490 NSF grant to refine their synthetic biology platform for producing muscle fibers with improved material properties. The team plans to examine genetic changes associated with titin protein and create fibers with defined sequences to study material properties.
Scientists at Okayama University designed and tested a modified cholera toxin to study glycosylation in eukaryotic cells. They tracked the toxin's movement through organelles using bioluminescence, gaining insights into protein modification. This method may lead to new treatments for diseases caused by enzyme deficiencies.
Researchers have developed a new quantitative approach to predict and customize site-specific recombination, enabling more efficient genetic and cell therapies. The tool combines high-throughput experiments with machine learning models to control the rate of DNA editing, paving the way for personalized treatment.
Researchers at the University of Maryland identified AGL62 as the trigger for fruit and seed development in flowering plants. The study showed that AGL62 stimulates auxin production, which regulates endosperm growth and fruit enlargement.
Researchers have discovered that Schwann Cell Precursors are the origin of tuberous sclerosis complex tumours in the kidney. Lab-grown 'mini-kidneys' were used to create a genetic profile similar to TSC tumours, revealing the diversity in tumour size and cellular makeup within patients.
A novel single-cell RNA sequencing technique, TAS-Seq, has been developed to provide higher-precision data than current methods. The new method detects more genes and identifies highly variable genes, making it a sensitive high-throughput scRNA method.
A UVA researcher is using a harmless amoeba to develop an innovative treatment for deadly C. difficile infections in young children. The approach has the potential to deliver specific antibodies directly to the gut, reducing the need for antibiotics and addressing a growing public health threat.
A new study examines mathematical models designed to draw inferences about how evolution operates at the level of populations of organisms. The researchers conclude that such models must be constructed with care, avoiding unwarranted initial assumptions and weighing existing knowledge.
A massive analysis of data from over 700 studies revealed that genetically modified Bt corn has no negative effects on most invertebrate groups, including ladybeetles and lacewings. However, populations of Braconidae insects were reduced with Bt corn.
Researchers studied meiotic cohesin complexes' effect on chromosome structure and genomic integrity in embryonic stem cells. Maintaining adequate levels of REC8 and STAG3 factors ensures chromosomal stabilization and sister chromatid cohesion.
Researchers at University of Illinois at Urbana-Champaign have developed PlasmidMaker, an automated platform for designing and constructing plasmids. The platform uses Pyrococcus furiosus Argonaute-based artificial restriction enzymes to assemble DNA fragments with greater flexibility and precision.
Researchers at Texas A&M AgriLife Research have developed a mechanism to make temporary genetic changes in mosquitoes that self-delete over time. This technology has the potential to help manage mosquito populations and prevent vector-borne diseases like West Nile virus without permanently altering wild populations' genetic makeup.
Researchers have successfully generated large numbers of virus-resistant immune cells from monkeys using CRISPR/Cas9 gene editing. This breakthrough could lead to the development of a new treatment for HIV/AIDS by providing an alternative to current therapies that require lifelong medication and can cause side effects.
Researchers developed a full-function bioelectronic photocell using genetically modified proteins attached to a carbon nanotube. The system can change its electronic properties in response to light, operating as a spotlight or memory cell. This discovery opens the door to environmentally friendly electronic elements, memory devices, an...
A recent study analyzing traditional and social media trends on biotechnology found a significant drop in the salience of the GMO issue between 2018 and 2020. The research suggests that misinformation about GMOs is losing its ability to persuade, even on social media.
A team of researchers identified a stem rust resistance gene from wild goat grass species Aegilops sharonensis, which can be cross-bred into wheat for immunity against deadly crop pathogens. The genetic potential of this hardy relative has been largely unexplored and holds promise for reducing the threat of the stem rust disease.
Researchers at UC Davis have developed genetically modified lettuce producing a drug to protect against bone density loss in microgravity. The transgenic lettuce combines parathyroid hormone with an antibody protein, allowing for stable production and potential self-administration by astronauts.
A new study led by Kelly Monaghan at West Virginia University suggests that interrupting the immune response may improve multiple sclerosis outcomes. The researchers found that targeting a specific protein called CCL17 can prevent the disease from attacking the central nervous system, leading to milder symptoms and delayed paralysis.
Researchers have identified a single gene, FOXG1, that can control brain cell growth in humans. The discovery provides hope for developing new treatments for neurodevelopmental disorders and stopping brain tumor cells from growing.
Researchers found that mosquitoes' odor sensors shut down when forced to produce odor-related proteins, ignoring common insect repellents. This 'expression' process allows mosquitoes to adapt to their surroundings and avoids human scents.
Researchers have genetically engineered a rat model of Down syndrome to test new therapies and explore the condition's unique genetics. The rats exhibit cognitive impairments, anxiety, and hyperactivity similar to humans with Down syndrome, providing a valuable tool for medical research.
Scientists at the University of Texas at Austin have redesigned a key component of the widely used CRISPR-based gene-editing tool Cas9 to be thousands of times less likely to target the wrong stretch of DNA. The new version, called SuperFi-Cas9, is as efficient as the original but reduces off-target interactions, making it potentially ...
Researchers at TUM have successfully produced succinic acid using the marine bacterium Vibrio natriegens, which has rapid growth and substrate uptake rates. The team is now working to optimize the process for industrial-scale production using renewable raw materials.
Researchers at the University of Cincinnati found that female mosquitoes have a higher abundance of tRNA modifications than males, which could underlie factors associated with female reproduction. This study aims to develop new methods of control for mosquito-borne diseases, such as malaria and yellow fever.
CROPSR, an open-source software tool, accelerates CRISPR experiment design and evaluation by addressing challenges in complex crop genomes. The genome-wide approach significantly shortens the time required to design a CRISPR experiment, reducing failed experiments.
Harris Wang, a synthetic and systems biologist at Columbia University, received the Vilcek Prize for Creative Promise in Biomedical Science for his development of tools to track and engineer microbes. His research aims to improve diagnostic and therapeutic applications using genomic technologies.
Researchers developed Inducible Directed Evolution (IDE), a new technique for controlling directed evolution in bacteria, allowing up to 30 gene modifications at a time. This approach enables finely tuned changes to bacteria, making it suitable for biopharmaceutical and chemical manufacturing industries.
A new, reliable kill switch has been developed to eliminate genetically modified microbes that pose environmental risks. By inserting multiple kill switches into the microbial DNA, a success rate of one in billion microbes was achieved during experiments.
Neuroscientists have designed neural organoids with both mature neurons and astrocytic glial cells to study interactions between brain cells. The new technology enables the emulation of brain activity during healthy and disease states, opening doors to rapid drug screening for neurological diseases.
A cloud-based repository called CellRepo has been launched to track and organize digital data from engineered microorganisms. The database uses cell barcodes to monitor and track organisms, enabling faster tracing of lab origins and design details.
A new study suggests that widespread use of genetically modified crops in the EU could prevent the release of 33 million tons of CO2 equivalents, equivalent to 7.5% of annual greenhouse gas emissions from agriculture. This is mainly due to reduced land-use change and preservation of the Amazon rainforest.
Markita del Carpio Landry, a young immigrant scientist, receives the Vilcek Prize for Creative Promise for her groundbreaking research on neurochemical communication and gene-editing technologies. Her work aims to address medicine's most compelling problems, including aberrations in neurotransmitter signaling.
Researchers at the University of California San Diego have developed a method to reverse insecticide resistance in mosquitoes using CRISPR/Cas9 technology. By replacing an insecticide-resistant gene with its susceptible counterpart, they have successfully restored genetic susceptibility to these chemicals.
Researchers successfully engineered mesenchymal stromal cells to carry and deliver therapeutics specifically to targeted tissues, offering a precise and reliable approach for treating diseases. This novel cargo-carrier, dubbed 'Cargocytes,' retains most of its cellular functionality while greatly enhancing therapeutic capacity.
The Feed the Future Insect-Resistant Eggplant Partnership will accelerate the application of biotechnology to enhance food and nutritional security in Bangladesh and the Philippines. The project aims to reduce pesticide use and improve farmers' livelihoods through the development of locally adapted eggplant varieties.
A new report by The Hastings Center suggests that releasing gene-edited species into the wild demands deep public engagement. The report proposes a path forward for inclusive, values-based decision-making through public deliberation.
Researchers at NYU Langone Health have successfully performed their second xenotransplantation procedure using a genetically engineered pig kidney. The procedure, part of an ongoing study, demonstrates continued promise for these genetically engineered organs as a renewable source of life-saving gifts.
IN8bio is developing a genetically modified gamma-delta T cell technology to treat glioblastoma multiforme. Preclinical studies published in Scientific Reports show significant improvement in survival outcomes, and a Phase I clinical trial is underway at UAB.
Researchers have expanded the number of naturally occurring CRISPR-Cas systems, giving a wealth of potential new tools for large-scale gene editing. The discovery could lead to treating complex diseases associated with multiple genes.
Researchers at the University of Tsukuba discovered a male-biased protein expression in primordial germ cells of fruit flies. The study used the Gal4-UAS system to induce gene expression and found that male cells had more protein synthesis occurring, with stronger GFP expression.
Acetobacterium woodii bacteria can efficiently metabolize CO2 into formate, providing a sustainable alternative to oil-based products. This process can be genetically modified to produce ethanol or lactic acid, enabling the recycling of CO2 and carbon monoxide.
Scientists at Washington University in St. Louis have created a biocompatible adhesive hydrogel that can stick to various surfaces underwater, with properties similar to natural mussel foot protein and spider silk. This breakthrough has potential applications in tissue repair, particularly for tendon-bone repair.
Researchers found that people with ALS have higher levels of arachidonic acid, a lipid involved in inflammation, and that tampering with this pathway can reduce muscle-weakening symptoms. The study suggests that targeting the arachidonic acid pathway may offer potential new therapies for Lou Gehrig's disease.
Researchers created novel frog models to replicate polycystic kidney disease, allowing for real-time observation of disease processes. AI analysis enabled rapid assessment of disease in the tiny animals.
A team led by NYU Langone's Robert Montgomery successfully transplanted a genetically engineered pig kidney into a human body, marking a major step forward in xenotransplantation. The procedure, performed on September 25, 2021, used a GalSafeTM pig with the alpha-gal biomolecule removed to avoid rejection.
Researchers have successfully used double-stranded RNA (dsRNA) molecules as a bio-fungicide to suppress the production of a toxin in soybean plants. The study found that dsRNAs produced in bacterial cells can effectively manage fungal diseases, reducing the need for toxic chemicals and potentially mitigating fungicide resistance.
Researchers at Dartmouth College have identified proteins PYE and ILR3 that help protect plants from damage during iron deficiency. These proteins enable the plant to optimize its light protection mechanisms, allowing it to continue photosynthesizing without suffering tissue damage.
Scientists at KU Leuven developed a method to multiply coconut trees faster and store them more efficiently, preserving genetic diversity and meeting the demand for coconuts. The technique allows thousands of new specimens with the same genetic profile to be obtained, offering potential for coconut plantations worldwide.
Researchers at Washington University in St. Louis have developed a method to produce synthetic muscle protein using microbes, which can be spun into fibers with exceptional toughness and strength. The resulting material has potential biomedical applications, such as sutures and tissue engineering.
Researchers at McGill University have developed a new way to track genetically modified animals using artificial transgenes. The discovery provides a powerful tool for locating and managing escaped or released GM animals.
Princeton University researchers have created the world's smallest mechanically interlocked biological structure, a deceptively simple two-ring chain made from tiny strands of amino acids. The study demonstrates that these structures can toggle between at least two shapes, laying the groundwork for a biomolecular switch.
A team of scientists led by Assistant Professor Lae-Hyeon Cho identified a single mutation in the gene that codes for cytidine triphosphate synthase (CTPS), an enzyme crucial for early endosperm development. The study showed that overexpressing CTPS in genetically modified rice plants results in a larger endosperm, opening up opportuni...
Researchers identified a novel lncRNA, Teshl, which plays a crucial role in the development of Y-bearing sperm and regulates sex chromosome gene expression. The study provides new insights into sex ratio variations and suggests that genetics may be a key factor in human male infertility.
Researchers successfully tested gene drive technology to control malaria-carrying mosquitoes in large cages mimicking natural environments. The technology, which spreads a genetic modification blocking female reproduction, worked as expected and showed significant population decline within one year.
Researchers have successfully genetically modified grass to detoxify residues of the military explosive RDX, contaminating groundwater and posing a threat to drinking water supplies. The genetically modified switchgrass plants removed 27 kg of RDX per hectare, offering a cost-effective and sustainable solution for environmental cleanup.
Researchers genetically modified mosquitoes to express antimalarial genes, which were then passed on to their offspring. The approach shows promise in reducing mosquito populations and combating malaria.
A new mouse model created by researchers at the University of Bonn reveals that GPI anchor deficiencies, a group of rare diseases, are caused by impaired transmission of stimuli at brain synapses. The mice exhibited cognitive deficits, altered social behavior, and increased susceptibility to epilepsy, mirroring human symptoms.
Scientists at UC Santa Barbara have developed a new approach to addressing the challenge of antibiotic-resistant bacteria by replacing antibiotics with fluoride. The method uses a genetically engineered cell that can survive in the lab but dies when exposed to fluoride, preventing its propagation into the natural environment.
A global research team led by the University of Göttingen explains how plant genetic engineering can combat micronutrient malnutrition. Biofortification using conventional breeding methods has already been successful in improving nutrition and health, but genetic engineering offers a way to further enhance benefits.