Articles tagged with Genetic Engineering
Researchers have genetically engineered a rat model of Down syndrome to test new therapies and explore the condition's unique genetics. The rats exhibit cognitive impairments, anxiety, and hyperactivity similar to humans with Down syndrome, providing a valuable tool for medical research.
Scientists at the University of Texas at Austin have redesigned a key component of the widely used CRISPR-based gene-editing tool Cas9 to be thousands of times less likely to target the wrong stretch of DNA. The new version, called SuperFi-Cas9, is as efficient as the original but reduces off-target interactions, making it potentially ...
Researchers at TUM have successfully produced succinic acid using the marine bacterium Vibrio natriegens, which has rapid growth and substrate uptake rates. The team is now working to optimize the process for industrial-scale production using renewable raw materials.
Researchers at the University of Cincinnati found that female mosquitoes have a higher abundance of tRNA modifications than males, which could underlie factors associated with female reproduction. This study aims to develop new methods of control for mosquito-borne diseases, such as malaria and yellow fever.
CROPSR, an open-source software tool, accelerates CRISPR experiment design and evaluation by addressing challenges in complex crop genomes. The genome-wide approach significantly shortens the time required to design a CRISPR experiment, reducing failed experiments.
Harris Wang, a synthetic and systems biologist at Columbia University, received the Vilcek Prize for Creative Promise in Biomedical Science for his development of tools to track and engineer microbes. His research aims to improve diagnostic and therapeutic applications using genomic technologies.
Researchers developed Inducible Directed Evolution (IDE), a new technique for controlling directed evolution in bacteria, allowing up to 30 gene modifications at a time. This approach enables finely tuned changes to bacteria, making it suitable for biopharmaceutical and chemical manufacturing industries.
A cloud-based repository called CellRepo has been launched to track and organize digital data from engineered microorganisms. The database uses cell barcodes to monitor and track organisms, enabling faster tracing of lab origins and design details.
A new, reliable kill switch has been developed to eliminate genetically modified microbes that pose environmental risks. By inserting multiple kill switches into the microbial DNA, a success rate of one in billion microbes was achieved during experiments.
Neuroscientists have designed neural organoids with both mature neurons and astrocytic glial cells to study interactions between brain cells. The new technology enables the emulation of brain activity during healthy and disease states, opening doors to rapid drug screening for neurological diseases.
Markita del Carpio Landry, a young immigrant scientist, receives the Vilcek Prize for Creative Promise for her groundbreaking research on neurochemical communication and gene-editing technologies. Her work aims to address medicine's most compelling problems, including aberrations in neurotransmitter signaling.
A new study suggests that widespread use of genetically modified crops in the EU could prevent the release of 33 million tons of CO2 equivalents, equivalent to 7.5% of annual greenhouse gas emissions from agriculture. This is mainly due to reduced land-use change and preservation of the Amazon rainforest.
Researchers at the University of California San Diego have developed a method to reverse insecticide resistance in mosquitoes using CRISPR/Cas9 technology. By replacing an insecticide-resistant gene with its susceptible counterpart, they have successfully restored genetic susceptibility to these chemicals.
Researchers successfully engineered mesenchymal stromal cells to carry and deliver therapeutics specifically to targeted tissues, offering a precise and reliable approach for treating diseases. This novel cargo-carrier, dubbed 'Cargocytes,' retains most of its cellular functionality while greatly enhancing therapeutic capacity.
The Feed the Future Insect-Resistant Eggplant Partnership will accelerate the application of biotechnology to enhance food and nutritional security in Bangladesh and the Philippines. The project aims to reduce pesticide use and improve farmers' livelihoods through the development of locally adapted eggplant varieties.
A new report by The Hastings Center suggests that releasing gene-edited species into the wild demands deep public engagement. The report proposes a path forward for inclusive, values-based decision-making through public deliberation.
Researchers at NYU Langone Health have successfully performed their second xenotransplantation procedure using a genetically engineered pig kidney. The procedure, part of an ongoing study, demonstrates continued promise for these genetically engineered organs as a renewable source of life-saving gifts.
IN8bio is developing a genetically modified gamma-delta T cell technology to treat glioblastoma multiforme. Preclinical studies published in Scientific Reports show significant improvement in survival outcomes, and a Phase I clinical trial is underway at UAB.
Researchers have expanded the number of naturally occurring CRISPR-Cas systems, giving a wealth of potential new tools for large-scale gene editing. The discovery could lead to treating complex diseases associated with multiple genes.
Researchers at the University of Tsukuba discovered a male-biased protein expression in primordial germ cells of fruit flies. The study used the Gal4-UAS system to induce gene expression and found that male cells had more protein synthesis occurring, with stronger GFP expression.
Acetobacterium woodii bacteria can efficiently metabolize CO2 into formate, providing a sustainable alternative to oil-based products. This process can be genetically modified to produce ethanol or lactic acid, enabling the recycling of CO2 and carbon monoxide.
Scientists at Washington University in St. Louis have created a biocompatible adhesive hydrogel that can stick to various surfaces underwater, with properties similar to natural mussel foot protein and spider silk. This breakthrough has potential applications in tissue repair, particularly for tendon-bone repair.
Researchers found that people with ALS have higher levels of arachidonic acid, a lipid involved in inflammation, and that tampering with this pathway can reduce muscle-weakening symptoms. The study suggests that targeting the arachidonic acid pathway may offer potential new therapies for Lou Gehrig's disease.
Researchers created novel frog models to replicate polycystic kidney disease, allowing for real-time observation of disease processes. AI analysis enabled rapid assessment of disease in the tiny animals.
A team led by NYU Langone's Robert Montgomery successfully transplanted a genetically engineered pig kidney into a human body, marking a major step forward in xenotransplantation. The procedure, performed on September 25, 2021, used a GalSafeTM pig with the alpha-gal biomolecule removed to avoid rejection.
Researchers have successfully used double-stranded RNA (dsRNA) molecules as a bio-fungicide to suppress the production of a toxin in soybean plants. The study found that dsRNAs produced in bacterial cells can effectively manage fungal diseases, reducing the need for toxic chemicals and potentially mitigating fungicide resistance.
Researchers at Dartmouth College have identified proteins PYE and ILR3 that help protect plants from damage during iron deficiency. These proteins enable the plant to optimize its light protection mechanisms, allowing it to continue photosynthesizing without suffering tissue damage.
Scientists at KU Leuven developed a method to multiply coconut trees faster and store them more efficiently, preserving genetic diversity and meeting the demand for coconuts. The technique allows thousands of new specimens with the same genetic profile to be obtained, offering potential for coconut plantations worldwide.
Researchers at Washington University in St. Louis have developed a method to produce synthetic muscle protein using microbes, which can be spun into fibers with exceptional toughness and strength. The resulting material has potential biomedical applications, such as sutures and tissue engineering.
Researchers at McGill University have developed a new way to track genetically modified animals using artificial transgenes. The discovery provides a powerful tool for locating and managing escaped or released GM animals.
A team of scientists led by Assistant Professor Lae-Hyeon Cho identified a single mutation in the gene that codes for cytidine triphosphate synthase (CTPS), an enzyme crucial for early endosperm development. The study showed that overexpressing CTPS in genetically modified rice plants results in a larger endosperm, opening up opportuni...
Princeton University researchers have created the world's smallest mechanically interlocked biological structure, a deceptively simple two-ring chain made from tiny strands of amino acids. The study demonstrates that these structures can toggle between at least two shapes, laying the groundwork for a biomolecular switch.
Researchers identified a novel lncRNA, Teshl, which plays a crucial role in the development of Y-bearing sperm and regulates sex chromosome gene expression. The study provides new insights into sex ratio variations and suggests that genetics may be a key factor in human male infertility.
Researchers successfully tested gene drive technology to control malaria-carrying mosquitoes in large cages mimicking natural environments. The technology, which spreads a genetic modification blocking female reproduction, worked as expected and showed significant population decline within one year.
Researchers have successfully genetically modified grass to detoxify residues of the military explosive RDX, contaminating groundwater and posing a threat to drinking water supplies. The genetically modified switchgrass plants removed 27 kg of RDX per hectare, offering a cost-effective and sustainable solution for environmental cleanup.
Researchers genetically modified mosquitoes to express antimalarial genes, which were then passed on to their offspring. The approach shows promise in reducing mosquito populations and combating malaria.
A new mouse model created by researchers at the University of Bonn reveals that GPI anchor deficiencies, a group of rare diseases, are caused by impaired transmission of stimuli at brain synapses. The mice exhibited cognitive deficits, altered social behavior, and increased susceptibility to epilepsy, mirroring human symptoms.
Scientists at UC Santa Barbara have developed a new approach to addressing the challenge of antibiotic-resistant bacteria by replacing antibiotics with fluoride. The method uses a genetically engineered cell that can survive in the lab but dies when exposed to fluoride, preventing its propagation into the natural environment.
A global research team led by the University of Göttingen explains how plant genetic engineering can combat micronutrient malnutrition. Biofortification using conventional breeding methods has already been successful in improving nutrition and health, but genetic engineering offers a way to further enhance benefits.
Scientists at KIT have successfully introduced genetic information into a multicellular cyanobacterium, Phormidium lacuna, using natural transformation. This breakthrough opens up possibilities for basic research and biotechnical applications, including the synthesis of biofuels like ethanol and hydrogen.
Bangladeshi farmers achieving higher yields and revenues through insect-resistant genetically engineered eggplant, providing a more sustainable crop option. The study found that Bt brinjal varieties earned growers 21.7% higher revenue, equivalent to around $664 per hectare.
A Japanese survey reveals differing perceptions of gene-edited crops among experts and the general public. Experts see benefits, while the public perceives risks despite acknowledging value. The findings shed light on the deficit model's boundaries in science communication.
The TU Dresden team presented their DipGene project, a DNA sequence-specific diagnostic method applicable in bacteria and human genomic DNA. The method is faster and cheaper than PCR, taking only five to ten minutes to detect predispositions to monogenic diseases.
Researchers have characterized three genes associated with insecticide resistance in malaria mosquitoes, found to cause resistance to all four classes of public health insecticides. This breakthrough work provides much-needed tools for monitoring the growing problem through molecular testing.
Scientists at EPFL have engineered aerolysin, a bacterium-produced toxin, to form narrow pores that can sense biomolecules with high resolution. This discovery opens new opportunities for sequencing biomolecules, such as DNA and proteins, and could lead to breakthroughs in gene sequencing and diagnostics.
A novel transfection method called nano-electro-injection delivers DNA into immune cells two to three times more efficiently than conventional methods. This technique improves the process of generating high-quality genetically modified immune cells for cancer immunotherapy, reducing cell stress and improving cell health.
Scientists have developed a new genetic tool called iSuRe-Cre that provides certainty in Cre-inducible genetic modifications. This innovation increases the efficiency and reliability of gene function analysis in mice, allowing for precise investigation of gene role during organ development, physiology, and disease.
A multi-institution research team, led by Worcester Polytechnic Institute's Eric Young, is developing a biosecurity tool to identify genetically engineered organisms in the environment. The tool uses unique DNA signatures to distinguish between engineered and naturally occurring microorganisms.
Scientists studied the impact of fragmentation on Dahl's toad headed turtle populations in Colombia, finding restricted gene flow and genetic erosion. They recommend gene flow restoration via genetic rescue to counteract these threats and provide guidance for this strategy.
The NIH supports an international moratorium on clinical germline editing due to safety, ethical, and philosophical concerns. The call comes after irresponsible research in China, where twins were born with altered DNA before implantation.
The proliferation of genetically modified seeds in India has led to 'choice overload,' where farmers struggle to make decisions due to a vast array of options. Farmers prioritize community expectations and social status over yield, driven by the desire to be successful and modern.
A study by the University of Exeter found that innuendo alone in news coverage can lead people to believe false information, spreading conspiracy theories. The research suggests that journalists should avoid including 'errant data' that may be misconstrued when there is uncertainty about facts.
A Pew Research Center survey finds that majority of Americans accept genetic engineering of animals to prevent disease transmission and grow organs for transplants. However, others oppose the use of technology to improve meat quality or revive extinct species, citing concerns about ecosystem risks.
A groundbreaking study by Oregon State University demonstrates the potential for genetically modified forest trees to prevent new seedlings from establishing. Researchers successfully engineered containment traits that limit the spread of genetically modified or exotic poplar trees, mitigating societal concerns over gene flow.
A recent study by Professor Jesper Lassen found no correlation between public reservations about genetically modified foods and parliamentary debate. Politicians focus on benefits and risks, ignoring the moral and ethical dimensions that concern citizens most.
Researchers have developed a new method for synthesizing insulin using self-assembly of polypeptide chains, achieving a 40% efficiency rate. This approach enables the production of customized insulin compounds without relying on genetic engineering, which could lead to the development of novel insulin preparations.
Scientists have developed a method to efficiently genetically modify T-cells from mice, allowing for targeted gene surgery and potential therapeutic applications. The technique involves using plasmids and CRISPR-Cas9 molecular scissors to introduce specific changes into the cells.
A new study shows that innuendo and pointing suspicion in news coverage can significantly increase belief in false facts. Researchers found that even implicit hints at conspiracy theories can lead to increased conspiracy beliefs, while debunking information can only partially reduce these levels.
Researchers discovered a chemical, HP-I, that regulates female mosquito sexual proclivities, helping females avoid multiple mates and reducing disease transmission. The protein's role in inter-species sex also holds promise for understanding complex reproductive patterns between different mosquito species.
A Japanese research team developed a refrigeration preservation technology that extends mouse sperm freezing period from three days to 10 days. This breakthrough enables safe and easy transportation of genetically modified mice worldwide, accelerating international collaborative research.