Articles tagged with Genetic Engineering
A study led by Tokyo University of Science researchers identified Dectin-1's role in promoting colorectal cancer by enhancing PGE2 production and suppressing IL-22BP expression. The study used mouse models and clinical samples to validate the findings, which have immediate clinical implications for CRC patients.
A study found that regular exercise increases mitochondrial fusion, benefiting muscle cells and maintaining physical fitness even in old age. Daily sessions of exercise throughout life delay the accumulation of dysfunctional mitochondria and decline in physical fitness.
The funding will support preclinical research using genetically modified pigs, aiming to improve compatibility and reduce immune rejection in xenotransplantation. The goal is to enable human clinical trials and address the organ shortage crisis.
Scientists from CSIC and UPV create modified ABA receptor activated by iSB09 molecule, increasing drought tolerance in plants. The combination efficiently activates the ABA pathway, triggering adaptive mechanisms and reducing water loss.
Chinese scientists have identified a key gene involved in crop alkaline tolerance, which may greatly improve crop yield in sodic environments. The study found that the gene negatively regulates alkaline stress by modulating the efflux of H2O2 under environmental stress.
Two novel genetically defined mouse models replicate two subtypes of human multiple myeloma, revealing the interaction of genetic aberrations as a key factor in development. The models will aid in identifying specific therapeutic strategies for individualized treatment.
Scientists create modified E. coli bacteria that cannot be infected by viruses while minimizing gene escape into the wild. This breakthrough technology has implications for reducing viral contamination in biotechnology production, such as insulin production and biofuel manufacturing.
A study by Kumamoto University researchers reveals LSD1's role in regulating skeletal muscle response to environmental stress. The findings suggest that LSD1 moderates muscle adaptation to environmental conditions, with potential implications for maintaining muscle health and preventing diseases such as sarcopenia.
Scientists have genetically modified potatoes and tomatoes to produce betacyanin, a pigment with anti-inflammatory properties. The transgenic vegetables demonstrated enhanced accumulation of the pigment, which showed improved effects in reducing inflammation in macrophage-like cells and murine models of colitis.
Researchers from Rice University have developed a new approach to control gene expression using proteolysis targeting chimeras (PROTACs). By reengineering the PROTAC molecular infrastructure, they demonstrated the ability to achieve chemically induced dimerization (CID), allowing for precise control over gene activation in specific loc...
Researchers found that cells don't pick certain sites to methylate, but rather where not to, due to the joints of messenger RNA. This discovery has implications for gene therapies, disease treatment, and our understanding of biology and evolution.
Researchers at Duke University have created a new approach to controlling cellular biochemical processes by building synthetic compartments that isolate biomolecules. This technique has the potential to be used to understand and fight disease, including the spread of antibiotic-resistant pathogens.
Researchers at NYU Langone Health and the University of Toronto have developed a new AI tool called ZFDesign, which enables customizable protein editing for treating genetic diseases. The tool promises to accelerate gene therapy development on a large scale, offering a potentially safer alternative to CRISPR.
Researchers found that Sirtuin 7 regulates brown adipose tissue functions, leading to suppressed energy expenditure and thermogenesis. The study reveals a molecular pathway involving protein deacylation and mRNA binding, which will have implications for treating hypermetabolic conditions like cancer and obesity.
New research from the University of Sheffield reveals genetically modifying rice to reduce stomata can make it more salt-resistant and survive in environments with high salt levels. This adaptation could help tackle food insecurity caused by climate change.
A multidisciplinary team of UC students developed a new understanding of spinal column formation and reengineered the process in mutant zebrafish. This breakthrough could lead to possible treatments for scoliosis in humans.
Researchers genetically engineered yeast to produce vindoline and catharanthine, two pharmacologic precursors of the powerful anticancer drug vinblastine. The team successfully optimized biosynthetic pathways using advanced genetic engineering and synthetic biology-based approaches.
A WSU-led survey found that US consumers value grape taste more than gene editing, with appearance and pesticide concerns ranking second and third respectively. Most participants were indifferent to the use of CRISPR technology in table grapes.
Smidt Heart Institute researchers have identified a way to control the natural 'fight back' response of heart cells against RNA therapies, leading to increased effectiveness. By targeting specific microRNAs, they were able to stabilize the heartbeat and boost gene expression.
A global registry for gene-drive modified organisms could facilitate transparent communication, monitor ecological impacts, and inform local decision-making. Experts agree that a registry is necessary for the fair development, testing, and use of gene-drive technologies.
Researchers highlight recent progress in organotypic models, which offer a balance between the accessibility and control of in vitro context. These models have been used to study various aging-related phenotypes, including skin, gut, and skeletal muscle, providing valuable insights into the underlying mechanisms.
Researchers genetically engineered a microbial community that can convert CO2 into sugar and produce useful chemicals, effectively acting as a living carbon sink. The community, consisting of bacteria and cyanobacteria, produces chemicals with a negative carbon balance.
G-Quadruplex DNA structures play a crucial role in regulating genes and cell processes, but their visualization is challenging due to the dynamic nature of double standard DNA. Fluorescence-active small molecule probes have emerged as a real-time visualization method, enabling researchers to detect G-quadruplexes with high selectivity.
A recent study found that science misinformation about genetically modified crops reached a quarter of a billion people globally. The majority of articles containing GMO-related keywords contained false information, especially on human health concerns, which had the highest readership.
Osaka University researchers have synthesized a fluorescent protein with the shortest emission wavelength to date, enabling the simultaneous tracking of multiple processes in cells. The new protein, Sumire, exhibits improved brightness and stability compared to existing fluorophores.
Scientists have created a way to track brain diseases like depression, Alzheimer's, and strokes using fluorescent mouse blood. The method allows for months-long study of blood flow in the brain, providing new insights into disease progression and development.
MU researchers, including Jay J. Thelen and Dong Xu, are exploring genetic modification to increase seed oil production in camelina and pennycress for biofuel use in the aviation industry. The team aims to create a sustainable 'green energy' source as an alternative to petroleum-based fossil fuels.
Scientists at NTU Singapore have successfully modified a plant protein to increase vegetable oil yield. By improving the binding affinity of WRI1, the team was able to enhance oil accumulation in seeds by 15-18% under laboratory conditions.
Researchers from North Carolina State University have developed a new method for identifying genes relevant to the aging process in the C. elegans roundworm model. By exposing thousands of worms to random genetic mutations, they can pinpoint which genes are associated with protein aggregation and reduced lifespan.
Researchers found a longer PR interval and prolonged QT duration in genetically modified pig hearts after transplantation into humans, indicating signs of electrical disease. The study provides a foundation for future research to better understand xenotransplantation's effects on the heart's electrical system.
Researchers at Leibniz-HKI discovered a yellow natural substance that regulates the multicellular stage of the amoeba <em>D. discoideum</em>. The polyketide, dictyoden, prevents premature hatching from spores, maintaining the development cycle. The study provides insights into the complex transition from single- to multicellularity.
Engineered duckweed produces up to 10% oil content, a 100-fold increase over wild-type plants, with synergistic effects seen when combining gene modifications. The oil-rich plant can be easily harvested for biofuels or bioproducts, reducing competition with food crops and environmental waste.
Scientists have identified long interspersed nuclear element-1 (L1) RNA as a promising new target for treating progeroid syndromes. Increased L1 RNA expression in cells from patients with these disorders led to deactivation of an enzyme, causing cell aging.
Researchers engineered mosquitoes to produce compounds that stunt malaria parasite growth, reducing the risk of disease transmission. The technique could be combined with gene drive technology to drastically cut malaria transmission in real-world settings.
Researchers have genetically engineered human muscle cells to take up more sugar from the blood, reducing blood glucose levels by 20% in diabetic mice. The new tissue also shows promise for a single injection of tissue providing long-lasting glucose control.
A study published in The BMJ found that adopting a healthy lifestyle can reduce the risk of type 2 diabetes by up to 90% in women with a history of gestational diabetes. Women who adhered to five key lifestyle factors had a significantly lower risk of developing type 2 diabetes, regardless of their weight or genetic risk.
A new study published in The Crop Journal has identified the gl9 gene variant as a key factor in increasing grain size and reducing chalkiness in rice. By introducing this allele into elite rice varieties, scientists have improved grain length, width, and weight, leading to enhanced appearance quality and yield.
Researchers have genetically engineered yeast to produce vindoline and catharanthine, the precursors to vinblastine, a widely used anti-cancer drug. This breakthrough may lead to new sources of these compounds and reduce dependence on plant farming and logistics challenges.
A team of researchers from Ritsumeikan University in Japan has elucidated the mechanism behind the liquid-solid phase transition of FUS protein that leads to ALS. They discovered a new therapeutic target, arginine, which suppresses FUS aggregation and could delay ALS progression.
Researchers successfully engineered E. coli collected from human and mice gut microbiomes, showing potential to treat diseases such as diabetes. The engineered bacteria retain their activity for the entire lifetime of the host and positively influence diabetes progression in mice.
Washington University in St. Louis' Zhang lab has been awarded a $458,490 NSF grant to refine their synthetic biology platform for producing muscle fibers with improved material properties. The team plans to examine genetic changes associated with titin protein and create fibers with defined sequences to study material properties.
Scientists at Okayama University designed and tested a modified cholera toxin to study glycosylation in eukaryotic cells. They tracked the toxin's movement through organelles using bioluminescence, gaining insights into protein modification. This method may lead to new treatments for diseases caused by enzyme deficiencies.
Researchers have developed a new quantitative approach to predict and customize site-specific recombination, enabling more efficient genetic and cell therapies. The tool combines high-throughput experiments with machine learning models to control the rate of DNA editing, paving the way for personalized treatment.
Researchers at the University of Maryland identified AGL62 as the trigger for fruit and seed development in flowering plants. The study showed that AGL62 stimulates auxin production, which regulates endosperm growth and fruit enlargement.
Researchers have discovered that Schwann Cell Precursors are the origin of tuberous sclerosis complex tumours in the kidney. Lab-grown 'mini-kidneys' were used to create a genetic profile similar to TSC tumours, revealing the diversity in tumour size and cellular makeup within patients.
A novel single-cell RNA sequencing technique, TAS-Seq, has been developed to provide higher-precision data than current methods. The new method detects more genes and identifies highly variable genes, making it a sensitive high-throughput scRNA method.
A UVA researcher is using a harmless amoeba to develop an innovative treatment for deadly C. difficile infections in young children. The approach has the potential to deliver specific antibodies directly to the gut, reducing the need for antibiotics and addressing a growing public health threat.
A new study examines mathematical models designed to draw inferences about how evolution operates at the level of populations of organisms. The researchers conclude that such models must be constructed with care, avoiding unwarranted initial assumptions and weighing existing knowledge.
A massive analysis of data from over 700 studies revealed that genetically modified Bt corn has no negative effects on most invertebrate groups, including ladybeetles and lacewings. However, populations of Braconidae insects were reduced with Bt corn.
Researchers studied meiotic cohesin complexes' effect on chromosome structure and genomic integrity in embryonic stem cells. Maintaining adequate levels of REC8 and STAG3 factors ensures chromosomal stabilization and sister chromatid cohesion.
Researchers at University of Illinois at Urbana-Champaign have developed PlasmidMaker, an automated platform for designing and constructing plasmids. The platform uses Pyrococcus furiosus Argonaute-based artificial restriction enzymes to assemble DNA fragments with greater flexibility and precision.
Researchers at Texas A&M AgriLife Research have developed a mechanism to make temporary genetic changes in mosquitoes that self-delete over time. This technology has the potential to help manage mosquito populations and prevent vector-borne diseases like West Nile virus without permanently altering wild populations' genetic makeup.
Researchers have successfully generated large numbers of virus-resistant immune cells from monkeys using CRISPR/Cas9 gene editing. This breakthrough could lead to the development of a new treatment for HIV/AIDS by providing an alternative to current therapies that require lifelong medication and can cause side effects.
Researchers developed a full-function bioelectronic photocell using genetically modified proteins attached to a carbon nanotube. The system can change its electronic properties in response to light, operating as a spotlight or memory cell. This discovery opens the door to environmentally friendly electronic elements, memory devices, an...
A recent study analyzing traditional and social media trends on biotechnology found a significant drop in the salience of the GMO issue between 2018 and 2020. The research suggests that misinformation about GMOs is losing its ability to persuade, even on social media.
A team of researchers identified a stem rust resistance gene from wild goat grass species Aegilops sharonensis, which can be cross-bred into wheat for immunity against deadly crop pathogens. The genetic potential of this hardy relative has been largely unexplored and holds promise for reducing the threat of the stem rust disease.
A new study led by Kelly Monaghan at West Virginia University suggests that interrupting the immune response may improve multiple sclerosis outcomes. The researchers found that targeting a specific protein called CCL17 can prevent the disease from attacking the central nervous system, leading to milder symptoms and delayed paralysis.
Researchers at UC Davis have developed genetically modified lettuce producing a drug to protect against bone density loss in microgravity. The transgenic lettuce combines parathyroid hormone with an antibody protein, allowing for stable production and potential self-administration by astronauts.
Researchers have identified a single gene, FOXG1, that can control brain cell growth in humans. The discovery provides hope for developing new treatments for neurodevelopmental disorders and stopping brain tumor cells from growing.
Researchers found that mosquitoes' odor sensors shut down when forced to produce odor-related proteins, ignoring common insect repellents. This 'expression' process allows mosquitoes to adapt to their surroundings and avoids human scents.